Martin Gibala

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance
    Martin J Gibala
    Department of Kinesiology IWC AB122, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
    J Physiol 575:901-11. 2006
  2. ncbi request reprint Protein metabolism and endurance exercise
    Martin J Gibala
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Sports Med 37:337-40. 2007
  3. ncbi request reprint High-intensity interval training: a time-efficient strategy for health promotion?
    Martin J Gibala
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Curr Sports Med Rep 6:211-3. 2007
  4. pmc Physiological adaptations to low-volume, high-intensity interval training in health and disease
    Martin J Gibala
    Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1 Canada
    J Physiol 590:1077-84. 2012
  5. doi request reprint Molecular responses to high-intensity interval exercise
    Martin Gibala
    Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
    Appl Physiol Nutr Metab 34:428-32. 2009
  6. doi request reprint Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle
    Martin J Gibala
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Appl Physiol 106:929-34. 2009
  7. doi request reprint Metabolic adaptations to short-term high-intensity interval training: a little pain for a lot of gain?
    Martin J Gibala
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Exerc Sport Sci Rev 36:58-63. 2008
  8. ncbi request reprint PDH activation by dichloroacetate reduces TCA cycle intermediates at rest but not during exercise in humans
    M J Gibala
    Copenhagen Muscle Research Center, Rigshospitalet, DK 2200 Copenhagen N, Denmark
    Am J Physiol 277:E33-8. 1999
  9. pmc Exercise with low muscle glycogen augments TCA cycle anaplerosis but impairs oxidative energy provision in humans
    Martin J Gibala
    Copenhagen Muscle Research Centre, Rigshospitalet section 7652, DK 2200 Copenhagen, Denmark
    J Physiol 540:1079-86. 2002
  10. pmc Anaplerosis of the muscle tricarboxylic acid cycle pool during contraction: does size matter?
    Martin J Gibala
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    J Physiol 548:334. 2003

Collaborators

Detail Information

Publications38

  1. pmc Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance
    Martin J Gibala
    Department of Kinesiology IWC AB122, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
    J Physiol 575:901-11. 2006
    ..05). Given the large difference in training volume, these data demonstrate that SIT is a time-efficient strategy to induce rapid adaptations in skeletal muscle and exercise performance that are comparable to ET in young active men...
  2. ncbi request reprint Protein metabolism and endurance exercise
    Martin J Gibala
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Sports Med 37:337-40. 2007
    ....
  3. ncbi request reprint High-intensity interval training: a time-efficient strategy for health promotion?
    Martin J Gibala
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Curr Sports Med Rep 6:211-3. 2007
  4. pmc Physiological adaptations to low-volume, high-intensity interval training in health and disease
    Martin J Gibala
    Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1 Canada
    J Physiol 590:1077-84. 2012
    ..Finally, we provide insight on the utility of low-volume HIT for improving performance in athletes and highlight suggestions for future research...
  5. doi request reprint Molecular responses to high-intensity interval exercise
    Martin Gibala
    Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
    Appl Physiol Nutr Metab 34:428-32. 2009
    ....
  6. doi request reprint Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle
    Martin J Gibala
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Appl Physiol 106:929-34. 2009
    ....
  7. doi request reprint Metabolic adaptations to short-term high-intensity interval training: a little pain for a lot of gain?
    Martin J Gibala
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Exerc Sport Sci Rev 36:58-63. 2008
    ....
  8. ncbi request reprint PDH activation by dichloroacetate reduces TCA cycle intermediates at rest but not during exercise in humans
    M J Gibala
    Copenhagen Muscle Research Center, Rigshospitalet, DK 2200 Copenhagen N, Denmark
    Am J Physiol 277:E33-8. 1999
    ....
  9. pmc Exercise with low muscle glycogen augments TCA cycle anaplerosis but impairs oxidative energy provision in humans
    Martin J Gibala
    Copenhagen Muscle Research Centre, Rigshospitalet section 7652, DK 2200 Copenhagen, Denmark
    J Physiol 540:1079-86. 2002
    ....
  10. pmc Anaplerosis of the muscle tricarboxylic acid cycle pool during contraction: does size matter?
    Martin J Gibala
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    J Physiol 548:334. 2003
  11. ncbi request reprint Myofibrillar disruption following acute concentric and eccentric resistance exercise in strength-trained men
    M J Gibala
    Department of Kinesiology Neurology and Neurological Rehabilitation, McMaster University, Hamilton, ON, Canada
    Can J Physiol Pharmacol 78:656-61. 2000
    ..Moreover, it appears that fibre disruption induced by habitual weightlifting exercise is essentially repaired after 5 days of inactivity in trained men...
  12. ncbi request reprint Low glycogen and branched-chain amino acid ingestion do not impair anaplerosis during exercise in humans
    M J Gibala
    Departments of Kinesiology and Medicine, McMaster University, Hamilton, Ontario L8S 4K1
    J Appl Physiol 87:1662-7. 1999
    ..Moreover, it appears that low resting glycogen per se does not impair the increase in TCAI during moderate exercise...
  13. pmc Dissociation between muscle tricarboxylic acid cycle pool size and aerobic energy provision during prolonged exercise in humans
    Martin J Gibala
    Copenhagen Muscle Research Centre, Rigshospitalet section 7652, DK 2200 Copenhagen, Denmark
    J Physiol 545:705-13. 2002
    ..We conclude that there is a progressive decrease in muscle [TCAI] during prolonged exercise in humans; however this decrease does not compromise aerobic energy provision and is not attributable to the depletion of muscle [glycogen]...
  14. doi request reprint Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes
    Jonathan P Little
    Dept of Kinesiology, McMaster University, Hamilton, Canada
    J Appl Physiol 111:1554-60. 2011
    ..05). Our findings indicate that low-volume HIT can rapidly improve glucose control and induce adaptations in skeletal muscle that are linked to improved metabolic health in patients with type 2 diabetes...
  15. pmc A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms
    Jonathan P Little
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Physiol 588:1011-22. 2010
    ..The results also suggest that increases in SIRT1, nuclear PGC-1alpha, and Tfam may be involved in coordinating mitochondrial adaptations in response to HIT in human skeletal muscle...
  16. doi request reprint Carbohydrate feeding during recovery alters the skeletal muscle metabolic response to repeated sessions of high-intensity interval exercise in humans
    Andrew J R Cochran
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON L8S 4K1, Canada
    J Appl Physiol 108:628-36. 2010
    ....
  17. ncbi request reprint Effect of endurance training on muscle TCA cycle metabolism during exercise in humans
    Krista R Howarth
    Exercise Metabolism Research Group, Department of Kinesiology, IWC Rm AB122, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Appl Physiol 97:579-84. 2004
    ..6 +/- 0.3 mmol/kg dry wt; P < 0.05), which is consistent with reduced carbon flux through alanine aminotransferase. We conclude that, after aerobic training, cycle endurance capacity is not limited by a decrease in muscle [TCAI]...
  18. doi request reprint Acute endurance exercise increases the nuclear abundance of PGC-1alpha in trained human skeletal muscle
    Jonathan P Little
    Department of Kinesiology, McMaster University, Ivor Wynne Centre, Hamilton, ON L8S 4K1
    Am J Physiol Regul Integr Comp Physiol 298:R912-7. 2010
    ....
  19. pmc Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans
    Kirsten A Burgomaster
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Physiol 586:151-60. 2008
    ....
  20. ncbi request reprint Tricarboxylic acid cycle intermediates accumulate at the onset of intense exercise in man but are not essential for the increase in muscle oxygen uptake
    Jens Bangsbo
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Pflugers Arch 452:737-43. 2006
    ..Am J Physiol 282:R273-R280, 2002), the present data suggest that muscle TCAI accumulate during the initial seconds of exercise; however, this increase is not essential for the contraction-induced increase in mitochondrial respiration...
  21. ncbi request reprint Short-term training attenuates muscle TCA cycle expansion during exercise in women
    Kristen D Dawson
    Department of Kinesiology, McMaster University, Hamilton, ON, Canada L8S 4K1
    J Appl Physiol 95:999-1004. 2003
    ..05). We conclude that 1). the contraction-induced increase in flux through AAT is reduced after 5 days of aerobic training and 2). the muscle glycogenolytic response during exercise after STT in women is similar to that in men...
  22. ncbi request reprint Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans
    Kirsten A Burgomaster
    Exercise Metabolism Research Group, Dept of Kinesiology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Appl Physiol 98:1985-90. 2005
    ..We conclude that short sprint interval training (approximately 15 min of intense exercise over 2 wk) increased muscle oxidative potential and doubled endurance capacity during intense aerobic cycling in recreationally active individuals...
  23. ncbi request reprint Effect of short-term sprint interval training on human skeletal muscle carbohydrate metabolism during exercise and time-trial performance
    Kirsten A Burgomaster
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Appl Physiol 100:2041-7. 2006
    ..8+/-1.2 vs. pretraining: 18.9+/-1.2 min; P=0.74). We conclude that short-term SIT improved cycling TT performance and resulted in a closer matching of glycogenolytic flux and pyruvate oxidation during submaximal exercise...
  24. ncbi request reprint Effects of 7 wk of endurance training on human skeletal muscle metabolism during submaximal exercise
    Paul J Leblanc
    Department of Medicine, McMaster University Health Science Centre, Hamilton, ON, Canada L8N 3Z5
    J Appl Physiol 97:2148-53. 2004
    ..post-Tr: 28.6 +/- 5.6 mmol/kg dry wt). We have demonstrated for the first time that several signals act to coordinately regulate Phos and PDH, and thus carbohydrate metabolism, in human skeletal muscle after 7 wk of endurance training...
  25. doi request reprint Coingestion of protein with carbohydrate during recovery from endurance exercise stimulates skeletal muscle protein synthesis in humans
    Krista R Howarth
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Appl Physiol 106:1394-402. 2009
    ..However, adding protein or additional CHO to a feeding strategy that provided 1.2 g CHO x kg(-1) x h(-1) did not further enhance glycogen resynthesis during recovery...
  26. pmc An acute decrease in TCA cycle intermediates does not affect aerobic energy delivery in contracting rat skeletal muscle
    Kristen D Dawson
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON, Canada L8S 4K1
    J Physiol 565:637-43. 2005
    ..These data do not support the hypothesis that the total muscle concentration of TCAI is causally linked to the rate of mitochondrial respiration during contraction...
  27. doi request reprint Muscle metabolism during exercise with carbohydrate or protein-carbohydrate ingestion
    Naomi M Cermak
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Ontario, Canada
    Med Sci Sports Exerc 41:2158-64. 2009
    ....
  28. ncbi request reprint Exercise training increases branched-chain oxoacid dehydrogenase kinase content in human skeletal muscle
    Krista R Howarth
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 293:R1335-41. 2007
    ..Biochem Mol Biol Int 44: 1211-1216, 1998)...
  29. ncbi request reprint Resistance training with vascular occlusion: metabolic adaptations in human muscle
    Kirsten A Burgomaster
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Med Sci Sports Exerc 35:1203-8. 2003
    ..g., 22, 25). The OCC stress might be expected to induce metabolic alterations that are consistent with compromised oxygen delivery rather than an increase in strength per se, but this has not been studied...
  30. ncbi request reprint Neuromuscular adaptations in human muscle following low intensity resistance training with vascular occlusion
    Daniel R Moore
    Department of Kinesiology, Exercise and Metabolism Research Group, McMaster University, 1280 Main St W, Hamilton, Ontario, L8S 4K1, Canada
    Eur J Appl Physiol 92:399-406. 2004
    ....
  31. ncbi request reprint Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining
    Kirsten A Burgomaster
    Exercise Metabolism Research Group, Dept of Kinesiology, McMaster Univ, Hamilton, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 292:R1970-6. 2007
    ..05). We conclude that short-term SIT induces rapid increases in skeletal muscle oxidative capacity but has divergent effects on proteins associated with glucose, lactate, and fatty acid transport...
  32. ncbi request reprint Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans
    Jens Bangsbo
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 282:R273-80. 2002
    ..The present findings demonstrate that increasing PDH(a) does not alter muscle O2 uptake and anaerobic ATP provision during the initial phase of intense dynamic knee-extensor exercise in humans...
  33. pmc Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans
    Mark Rakobowchuk
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 295:R236-42. 2008
    ..However, alterations in central artery distensibility may require a longer training stimuli and/or greater initial vascular stiffness than observed in this group of healthy subjects...
  34. doi request reprint Effects of recovery method after exercise on performance, immune changes, and psychological outcomes
    Douglas L Stacey
    Fowler Kennedy Sports Medicine Clinic, London, ON, Canada
    J Orthop Sports Phys Ther 40:656-65. 2010
    ..Randomized controlled trial using a repeated-measures design...
  35. ncbi request reprint Failure of protein to improve time trial performance when added to a sports drink
    Martin van Essen
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Med Sci Sports Exerc 38:1476-83. 2006
    ..e., a race in which a fixed distance or set amount of work is performed as quickly as possible)...
  36. doi request reprint An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle
    Jonathan P Little
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 300:R1303-10. 2011
    ..These findings support the hypothesis that an acute bout of low-volume HIT activates mitochondrial biogenesis through a mechanism involving increased nuclear abundance of PGC-1α...
  37. ncbi request reprint Glycogen availability does not affect the TCA cycle or TAN pools during prolonged, fatiguing exercise
    Jacinta Baldwin
    Department of Physiology, University of Melbourne, Parkville 3010, Victoria, Australia
    J Appl Physiol 94:2181-7. 2003
    ..Therefore, our data do not support the concept that a decrease in muscle TCAI during prolonged exercise in humans compromises aerobic energy provision or is the cause of fatigue...
  38. ncbi request reprint Nutritional strategies to influence adaptations to training
    Lawrence L Spriet
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Sports Sci 22:127-41. 2004
    ..Research in these areas in the coming years will lead to strategies designed to improve the adaptive response to training...