Hertzel C Gerstein

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Clinical outcomes associated with the use of subcutaneous insulin-by-glucose sliding scales to manage hyperglycemia in hospitalized patients with pneumonia
    Taryn Becker
    Department of Medicine, McMaster University and Hamilton Health Sciences, c o Dr H C Gerstein, Room 3V38, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Diabetes Res Clin Pract 78:392-7. 2007
  2. doi request reprint Dysglycaemia, vasculopenia, and the chronic consequences of diabetes
    Hertzel C Gerstein
    Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada Electronic address
    Lancet Diabetes Endocrinol 1:71-8. 2013
  3. pmc Changes in trabecular bone microarchitecture in postmenopausal women with and without type 2 diabetes: a two year longitudinal study
    Janet M Pritchard
    Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    BMC Musculoskelet Disord 14:114. 2013
  4. pmc Diabetic retinopathy, its progression, and incident cardiovascular events in the ACCORD trial
    Hertzel C Gerstein
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 36:1266-71. 2013
  5. pmc Establishing a relationship between prolactin and altered fatty acid β-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells
    Katja Linher-Melville
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    BMC Cancer 11:56. 2011
  6. doi request reprint Dysglycaemia and the risk of acute myocardial infarction in multiple ethnic groups: an analysis of 15,780 patients from the INTERHEART study
    H C Gerstein
    The Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Diabetologia 53:2509-17. 2010
  7. ncbi request reprint Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies
    Hertzel C Gerstein
    Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Diabetes Res Clin Pract 78:305-12. 2007
  8. doi request reprint Effect of rosiglitazone on progression of coronary atherosclerosis in patients with type 2 diabetes mellitus and coronary artery disease: the assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cardiov
    Hertzel C Gerstein
    McMaster University and Hamilton Health Sciences, Department of Medicine, Hamilton, Ontario L8N 3Z5, Canada
    Circulation 121:1176-87. 2010
  9. ncbi request reprint Pre-prandial vs. post-prandial capillary glucose measurements as targets for repaglinide dose titration in people with diet-treated or metformin-treated Type 2 diabetes: a randomized controlled clinical trial
    H C Gerstein
    Division of Endocrinology and Metabolism, McMaster University and Hamilton Health Sciences, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Diabet Med 21:1200-3. 2004
  10. doi request reprint Is it possible to reduce cardiovascular risk with glucose-lowering approaches?
    Hertzel C Gerstein
    Department of Medicine and Population Health Research Institute, McMaster University and Hamilton Health Sciences, University, Room 3V38, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Nat Rev Endocrinol 5:270-5. 2009

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Clinical outcomes associated with the use of subcutaneous insulin-by-glucose sliding scales to manage hyperglycemia in hospitalized patients with pneumonia
    Taryn Becker
    Department of Medicine, McMaster University and Hamilton Health Sciences, c o Dr H C Gerstein, Room 3V38, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Diabetes Res Clin Pract 78:392-7. 2007
    ..Despite its ubiquitous use, the value of subcutaneous insulin-by-glucose sliding scales (SISS) for the management of in-patient hyperglycemia has not been carefully assessed...
  2. doi request reprint Dysglycaemia, vasculopenia, and the chronic consequences of diabetes
    Hertzel C Gerstein
    Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada Electronic address
    Lancet Diabetes Endocrinol 1:71-8. 2013
    ..If continuing research lends support to this theory, treatments that counteract the effect of glucose on capillaries such as those in the retina might ultimately also reduce other serious consequences of dysglycaemia. ..
  3. pmc Changes in trabecular bone microarchitecture in postmenopausal women with and without type 2 diabetes: a two year longitudinal study
    Janet M Pritchard
    Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    BMC Musculoskelet Disord 14:114. 2013
    ..The aim of this study was to compare two year changes in trabecular bone microarchitecture in women with and without type 2 diabetes...
  4. pmc Diabetic retinopathy, its progression, and incident cardiovascular events in the ACCORD trial
    Hertzel C Gerstein
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 36:1266-71. 2013
    ..Both the presence of diabetic retinopathy and its severity are significantly associated with future cardiovascular (CV) events. Whether its progression is also linked to incident CV outcomes hasn't been assessed...
  5. pmc Establishing a relationship between prolactin and altered fatty acid β-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells
    Katja Linher-Melville
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    BMC Cancer 11:56. 2011
    ..The effect of PRL on the adenosine 5'-monophosphate-activated protein kinase (AMPK) energy sensing pathway was also investigated...
  6. doi request reprint Dysglycaemia and the risk of acute myocardial infarction in multiple ethnic groups: an analysis of 15,780 patients from the INTERHEART study
    H C Gerstein
    The Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Diabetologia 53:2509-17. 2010
    ..Although diabetes is an established risk factor for myocardial infarction (MI), disease control may vary. HbA(1c) is a reliable index of ambient glucose levels and may provide more information on MI risk than diabetes status...
  7. ncbi request reprint Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies
    Hertzel C Gerstein
    Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Diabetes Res Clin Pract 78:305-12. 2007
    ..Several estimates of the risk of progression to diabetes in people with impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) have been reported...
  8. doi request reprint Effect of rosiglitazone on progression of coronary atherosclerosis in patients with type 2 diabetes mellitus and coronary artery disease: the assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cardiov
    Hertzel C Gerstein
    McMaster University and Hamilton Health Sciences, Department of Medicine, Hamilton, Ontario L8N 3Z5, Canada
    Circulation 121:1176-87. 2010
    ....
  9. ncbi request reprint Pre-prandial vs. post-prandial capillary glucose measurements as targets for repaglinide dose titration in people with diet-treated or metformin-treated Type 2 diabetes: a randomized controlled clinical trial
    H C Gerstein
    Division of Endocrinology and Metabolism, McMaster University and Hamilton Health Sciences, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Diabet Med 21:1200-3. 2004
    ..Targeting post-prandial glucose levels may lead to lower HbA(1c) levels and rates of hypoglycaemia than targeting pre-prandial glucose levels...
  10. doi request reprint Is it possible to reduce cardiovascular risk with glucose-lowering approaches?
    Hertzel C Gerstein
    Department of Medicine and Population Health Research Institute, McMaster University and Hamilton Health Sciences, University, Room 3V38, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Nat Rev Endocrinol 5:270-5. 2009
    ..Currently available evidence suggests that therapeutic efforts that target hyperglycemia early in the course of diabetes have a long-term cardiovascular benefit...
  11. ncbi request reprint The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis
    H C Gerstein
    McMaster University and Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 48:1749-55. 2005
    ....
  12. doi request reprint The hemoglobin A1c level as a progressive risk factor for cardiovascular death, hospitalization for heart failure, or death in patients with chronic heart failure: an analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and M
    Hertzel C Gerstein
    Department of Medicine and the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Arch Intern Med 168:1699-704. 2008
    ..To our knowledge, the nature of such a relationship in patients with symptomatic chronic heart failure (HF) has not been studied...
  13. ncbi request reprint Dysglycemia: a key cardiovascular risk factor
    Hertzel C Gerstein
    Department of Medicine and the Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada
    Semin Vasc Med 2:165-74. 2002
    ..The results of several large international trials of glucose lowering in dysglycemic individuals should clarify the cardiovascular benefits of such an approach within the next few years...
  14. ncbi request reprint Point: If it is important to prevent type 2 diabetes, it is important to consider all proven therapies within a comprehensive approach
    Hertzel C Gerstein
    Department of Medicine, Room 3V38, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Diabetes Care 30:432-4. 2007
  15. ncbi request reprint A randomized trial of adding insulin glargine vs. avoidance of insulin in people with Type 2 diabetes on either no oral glucose-lowering agents or submaximal doses of metformin and/or sulphonylureas. The Canadian INSIGHT (Implementing New Strategies with
    H C Gerstein
    Division of Endocrinology and Metabolism and the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada
    Diabet Med 23:736-42. 2006
    ..However, its potential advantages suggest that it could be added earlier to achieve glycaemic goals; this possibility was tested in a clinical trial...
  16. ncbi request reprint Glycemia treatment strategies in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    Hertzel C Gerstein
    Department of Medicine and the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Am J Cardiol 99:34i-43i. 2007
    ..It will also provide information on how to safely approach near-normal levels of glucose control in clinical practice and evidence to support future clinical guidelines for diabetes management in older adults...
  17. ncbi request reprint Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals
    H C Gerstein
    Department of Medicine, Room 3V38, 1200 Main St W, Hamilton, Ontario, L8N 3Z5
    JAMA 286:421-6. 2001
    ..Microalbuminuria is a risk factor for cardiovascular (CV) events. The relationship between the degree of albuminuria and CV risk is unclear...
  18. ncbi request reprint The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas--a randomized trial
    Hertzel C Gerstein
    Department of Medicine, McMaster University, Room 3V38, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Diabetes Res Clin Pract 55:209-19. 2002
    ..To assess the glucose-lowering efficacy, responsiveness, duration of action and impact on quality-of-life of hydroxychloroquine (HXCHL), when added as an antihyperglycemic agent to patients with sulfonylurea-refractory type 2 diabetes...
  19. ncbi request reprint Epidemiologic analyses of risk factors, risk indicators, risk markers, and causal factors. The example of albuminuria and the risk of cardiovascular disease in diabetes
    Hertzel C Gerstein
    Division of Endocrinology and Metabolism, Department of Medicine, Department of Clinical Epidemiology and Biostatistics, McMaster University, Room 3V38, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Endocrinol Metab Clin North Am 31:537-51. 2002
    ..Information regarding whether the risk factor causes the disease is highly desirable; however, it is often unavailable and is not required before making therapeutic decisions...
  20. ncbi request reprint Reduction of cardiovascular events and microvascular complications in diabetes with ACE inhibitor treatment: HOPE and MICRO-HOPE
    Hertzel C Gerstein
    McMaster University, Department of Medicine, Hamilton, Ontario, Canada
    Diabetes Metab Res Rev 18:S82-5. 2002
    ....
  21. ncbi request reprint The relationship between dysglycemia and atherosclerosis in South Asian, Chinese, and European individuals in Canada: a randomly sampled cross-sectional study
    Hertzel C Gerstein
    McMaster University and the Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetes Care 26:144-9. 2003
    ..The relationship between dysglycemia and atherosclerosis (AS) in the general population and in different ethnic groups remains controversial...
  22. ncbi request reprint Insulin therapy in people who have dysglycemia and type 2 diabetes mellitus: can it offer both cardiovascular protection and beta-cell preservation?
    Hertzel C Gerstein
    Division of Endocrinology and Metabolism and the Population Health Research Institute, Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, ON L8N 3Z5, Canada
    Endocrinol Metab Clin North Am 34:137-54. 2005
    ..Mounting evidence suggests that insulin therapy may reduce risk for CV events while preserving beta-cell function, and several continuing long-term CV trials are testing these hypotheses explicitly...
  23. ncbi request reprint Progression of renal insufficiency in type 2 diabetes with and without microalbuminuria: results of the Heart Outcomes and Prevention Evaluation (HOPE) randomized study
    Johannes F E Mann
    Department of Cardiology, McMaster University, Hamilton, Canada
    Am J Kidney Dis 42:936-42. 2003
    ..We studied changes in serum creatinine levels during 3.5 to 5.5 years in a large cohort of people with diabetes at high cardiovascular risk with microalbuminuria or normalbuminuria...
  24. pmc Maternal antioxidants prevent β-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure
    Jennifer E Bruin
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    J Diabetes 4:297-306. 2012
    ..The aim of the present study was to determine whether an antioxidant intervention could prevent nicotine-induced β-cell loss...
  25. pmc Prospective associations of vitamin D with β-cell function and glycemia: the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes 60:2947-53. 2011
    ..To examine the prospective associations of baseline vitamin D [25-hydroxyvitamin D; 25(OH)D] with insulin resistance (IR), β-cell function, and glucose homeostasis in subjects at risk for type 2 diabetes...
  26. ncbi request reprint Effect of ramipril on the incidence of diabetes
    Jackie Bosch
    McMaster University, Hamilton, Canada
    N Engl J Med 355:1551-62. 2006
    ..Previous studies have suggested that blockade of the renin-angiotensin system may prevent diabetes in people with cardiovascular disease or hypertension...
  27. doi request reprint Effect of ramipril and of rosiglitazone on carotid intima-media thickness in people with impaired glucose tolerance or impaired fasting glucose: STARR (STudy of Atherosclerosis with Ramipril and Rosiglitazone)
    Eva M Lonn
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 53:2028-35. 2009
    ....
  28. pmc Fetal and neonatal nicotine exposure in Wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 3:e3371. 2008
    ..These results clearly indicate that further investigation into the safety of NRT use during pregnancy is warranted...
  29. doi request reprint Glucose intolerance and diabetes as risk factors for cognitive impairment in people at high cardiovascular risk: results from the ONTARGET/TRANSCEND research programme
    Tali Cukierman-Yaffe
    Population Health Research Institute, McMaster University, Canada
    Diabetes Res Clin Pract 83:387-93. 2009
    ..To assess the cross-sectional associations of the measures of glycemia and cognitive function in subjects at high cardiovascular risk...
  30. doi request reprint Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 96:168-75. 2011
    ..However, evidence to date is limited and inconsistent, and few studies have examined associations with nontraditional MetS components...
  31. ncbi request reprint Transgenerational effects of fetal and neonatal exposure to nicotine
    Alison C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, RM HSC 3N52, 1200 Main Street West, Hamilton, ON, Canada
    Endocrine 31:254-9. 2007
    ..The offspring of nicotine-exposed mothers also had elevated blood pressure. These data demonstrate that adverse effects of fetal and neonatal exposure to nicotine can influence aspects of metabolic risk in subsequent generations...
  32. pmc Dysglycemia and a history of reproductive risk factors
    Sarah D McDonald
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, McMaster Universityand Hamilton Health Sciences, Hamilton, Ontario, Canada
    Diabetes Care 31:1635-8. 2008
    ..The purpose of this study was to identify reproductive risk factors associated with dysglycemia (diabetes, impaired glucose tolerance, and impaired fasting glucose) in a contemporary multiethnic population...
  33. ncbi request reprint Diagnostic strategies to detect glucose intolerance in a multiethnic population
    Sonia S Anand
    Department of Medicine, Division of Cardiology and Population Health Research Institute, McMaster University, Ontario, Canada
    Diabetes Care 26:290-6. 2003
    ....
  34. doi request reprint Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study
    Bernard Zinman
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada
    Lancet 376:103-11. 2010
    ..The CANOE (CAnadian Normoglycemia Outcomes Evaluation) trial investigated whether low-dose combination therapy would affect development of type 2 diabetes...
  35. pmc Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: the Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE)
    Sonia S Anand
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e22112. 2011
    ..We sought to determine if differences in the distribution and characteristics of adipose tissue between South Asians and white Caucasians account for differences in risk factors for cardiovascular disease...
  36. pmc Piloting a novel algorithm for glucose control in the coronary care unit: the RECREATE (REsearching Coronary REduction by Appropriately Targeting Euglycemia) trial
    Kara A Nerenberg
    Population Health Research Institute McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 35:19-24. 2012
    ..We developed a paper-based glucose-lowering algorithm and assessed its feasibility and safety in the setting of AMI...
  37. ncbi request reprint Effects of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure
    Salim Yusuf
    Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Canada
    Circulation 112:48-53. 2005
    ....
  38. doi request reprint Metabolic syndrome and risk of acute myocardial infarction a case-control study of 26,903 subjects from 52 countries
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 55:2390-8. 2010
    ..This study examines the risk of acute myocardial infarction (MI) conferred by the metabolic syndrome (MS) and its individual factors in multiple ethnic populations...
  39. doi request reprint Glucose levels compared with diabetes history in the risk assessment of patients with acute myocardial infarction
    Abhinav Goyal
    Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada
    Am Heart J 157:763-70. 2009
    ..Both a history of diabetes mellitus and elevated inhospital glucose levels predict death after acute myocardial infarction (AMI). However, only diabetes history (and not glucose levels) is routinely considered in AMI risk assessment...
  40. doi request reprint Rosiglitazone improves pancreatic mitochondrial function in an animal model of dysglycemia: role of the insulin-like growth factor axis
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Endocrine 37:303-11. 2010
    ..The underlying mechanism through which rosiglitazone targets the mitochondria remains to be determined, but does not appear to involve the IGF axis...
  41. ncbi request reprint Reevaluation by high-performance liquid chromatography: clinical significance of microalbuminuria in individuals at high risk of cardiovascular disease in the Heart Outcomes Prevention Evaluation (HOPE) Study
    Matthew J McQueen
    Hamilton Regional Laboratory Medicine Program, Department of Pathology, Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Am J Kidney Dis 48:889-96. 2006
    ..Conventional immunoassays may underestimate albuminuria by not detecting a mildly denatured unfragmented form of albumin, immunounreactive to conventional antibodies...
  42. doi request reprint Increased pancreatic beta-cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Toxicol Sci 103:362-70. 2008
    ..Taken together, these data suggest that beta-cell apoptosis following developmental nicotine exposure is mediated via the mitochondria...
  43. doi request reprint Effect of combining rosiglitazone with either metformin or insulin on β-cell mass and function in an animal model of Type 2 diabetes characterized by reduced β-cell mass at birth
    Alison C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    J Diabetes 3:74-81. 2011
    ..These effects may be mediated through changes in β-cell mass. In the present study, the effect of combining rosiglitazone with metformin and/or insulin on β-cell mass and glucose levels was examined in a rat model of Type 2 diabetes...
  44. doi request reprint Prospective association of 25(OH)D with metabolic syndrome
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 80:502-7. 2014
    ..Vitamin D may play a role in the aetiology of the metabolic syndrome (MetS), yet the majority of previous studies have been cross-sectional, and the limited number of prospective studies has yielded inconsistent results...
  45. doi request reprint Maternal nicotine exposure increases oxidative stress in the offspring
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Free Radic Biol Med 44:1919-25. 2008
    ..These data suggest that beta-cell apoptosis in the fetal and neonatal pancreas may be the result of a direct effect of nicotine via its receptor and that this effect may be mediated through increased oxidative stress...
  46. pmc Long-term consequences of fetal and neonatal nicotine exposure: a critical review
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Toxicol Sci 116:364-74. 2010
    ..This review will examine the long-term effects of fetal and neonatal nicotine exposure on postnatal health...
  47. ncbi request reprint Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy
    Eva Lonn
    Department of Medicine and Population Health Institute, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 25:1919-27. 2002
    ..However, data from randomized clinical trials are limited. Therefore, we evaluated the effects of vitamin E supplementation on major CV outcomes and on the development of nephropathy in people with diabetes...
  48. doi request reprint Estimation of the impact of diabetes-related complications on health utilities for patients with type 2 diabetes in Ontario, Canada
    Daria J O'Reilly
    Programs for Assessment of Technology in Health Research Institute, St Joseph s Healthcare, 25 Main Street West, Suite 2000, Hamilton, ON, L8P 1H1, Canada
    Qual Life Res 20:939-43. 2011
    ..The goal of this study was to analyze health-related quality of life (HRQL) data from a Canadian population with type 2 diabetes in order to estimate the disutility associated with experiencing a diabetes-related complication...
  49. ncbi request reprint Development of renal disease in people at high cardiovascular risk: results of the HOPE randomized study
    Johannes F E Mann
    Department of Cardiology and Population Health Research Institute, McMaster University, Hamilton, Canada
    J Am Soc Nephrol 14:641-7. 2003
    ..Microalbuminuria itself predicts clinical proteinuria in nondiabetic and in diabetic people. Ramipril prevents or delays the progression of albuminuria...
  50. pmc Impact of a computerized system for evidence-based diabetes care on completeness of records: a before-after study
    Pavel S Roshanov
    Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street, London, ON, Canada
    BMC Med Inform Decis Mak 12:63. 2012
    ....
  51. pmc Treatment gaps in the management of cardiovascular risk factors in patients with type 2 diabetes in Canada
    Manoela Braga
    Keenan Research Center, Li Ka Shing Knowledge Institute at St Michael s Hospital, University of Toronto, ON, Canada
    Can J Cardiol 26:297-302. 2010
    ..To evaluate vascular protection treatment patterns and attainment of the 2003 Canadian Diabetes Association's recommended targets in ambulatory patients with type 2 diabetes...
  52. ncbi request reprint Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review
    Cynthia M Balion
    Department of Laboratory Medicine, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Clin Chem Lab Med 45:1180-5. 2007
    ..We sought to determine what the reproducibility of these classifications was when repeat tests were performed by conducting a systematic review of the literature...
  53. pmc Effect of computer-generated tailored feedback on glycemic control in people with diabetes in the community: a randomized controlled trial
    Diana Sherifali
    School of Nursing, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 34:1794-8. 2011
    ..It is unknown whether computer-generated, patient-tailored feedback leads to improvements in glycemic control in people with type 2 diabetes...
  54. ncbi request reprint Preventing type 2 diabetes using combination therapy: design and methods of the CAnadian Normoglycaemia Outcomes Evaluation (CANOE) trial
    B Zinman
    Leadership Sinai Centre for Diabetes, Department of Medicine, Mount Sinai Hospital and the University of Toronto, Toronto, Ontario, Canada
    Diabetes Obes Metab 8:531-7. 2006
    ..In conclusion, the CANOE study will determine whether combination pharmacological therapy combined with a lifestyle intervention programme can significantly modify the development of diabetes in high-risk Canadians...
  55. ncbi request reprint Diabetes and cardiovascular disease: explaining the relationship
    Zubin Punthakee
    Division of Endocrinology and Metabolism, Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Rev Cardiovasc Med 8:145-53. 2007
    ..Whether glucose lowering can reduce the risk of cardiovascular disease is currently being studied in a number of large trials...
  56. pmc Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: post hoc epidemiologic analysis of the ACCORD trial
    Zubin Punthakee
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 35:787-93. 2012
    ..This study aimed to assess the effect of baseline cognitive function and cognitive decline on subsequent risk of severe hypoglycemia and to assess the effect of different glycemic strategies on these relationships...
  57. pmc Computerized clinical decision support systems for chronic disease management: a decision-maker-researcher partnership systematic review
    Pavel S Roshanov
    Health Research Methodology Program, McMaster University, 1280 Main Street West, Hamilton, ON, Canada
    Implement Sci 6:92. 2011
    ....
  58. doi request reprint Estimating modifiable coronary heart disease risk in multiple regions of the world: the INTERHEART Modifiable Risk Score
    Catherine McGorrian
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, David Braley Cardiovascular Stroke Research Institute, Hamilton, ON, Canada
    Eur Heart J 32:581-9. 2011
    ..We aimed to derive and validate a new score for myocardial infarction (MI) risk using modifiable risk factors, derived from the INTERHEART case-control study (n = 19 470)...
  59. ncbi request reprint A systematic review and meta-analysis of hypoglycemia and cardiovascular events: a comparison of glyburide with other secretagogues and with insulin
    Azim S Gangji
    Division of Nephrology, McMaster University and St Joseph s Healthcare, 708 25 Charlton Avenue East, Hamilton, Ontario L8P 3P7, Canada
    Diabetes Care 30:389-94. 2007
    ..Glyburide is the most widely used sulfonylurea but has unique pharmacodynamic properties that may increase harm. We hypothesized that glyburide causes more hypoglycemia and cardiovascular events than other secretagogues or insulin...
  60. pmc Does pioglitazone prevent macrovascular events in patients with type 2 diabetes?
    Rajesh Hiralal
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 174:1090-1. 2006
  61. ncbi request reprint Fetal and neonatal nicotine exposure and postnatal glucose homeostasis: identifying critical windows of exposure
    Jennifer E Bruin
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, RM HSC 3N52, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    J Endocrinol 194:171-8. 2007
    ..This model of type 2 diabetes requires that nicotine exposure occurs both in utero and during lactation...
  62. ncbi request reprint The HOPE (Heart Outcomes Prevention Evaluation) Study and its consequences
    M J McQueen
    Hamilton Regional Laboratory Medicine Program, Department of Laboratory Medicine, St Joseph s Hospital, Hamilton, Ontario
    Scand J Clin Lab Invest Suppl 240:143-56. 2005
    ..Sub-studies completed and on-going into the predictive role of natriuretic peptides, infectious and inflammatory markers, provide insight into possible mechanisms of action of Ramipril...
  63. doi request reprint Dual inhibition of the renin-angiotensin system in high-risk diabetes and risk for stroke and other outcomes: results of the ONTARGET trial
    Johannes F E Mann
    Munich General Hospitals, Munich and Friedrich Alexander University, Erlangen Nuremberg, Germany
    J Hypertens 31:414-21. 2013
    ....
  64. doi request reprint Glycemic index predicts individual glucose responses after self-selected breakfasts in free-living, abdominally obese adults
    Angela M Kochan
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Nutr 142:27-32. 2012
    ..In this study, GI was a more important determinant of glycemic response than carbohydrate intake...
  65. doi request reprint Effects of rosiglitazone on ovarian function and fertility in animals with reduced fertility following fetal and neonatal exposure to nicotine
    J J Petrik
    Department of Biomedical Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Endocrine 36:281-90. 2009
    ..Rosiglitazone may be an important treatment option for PCOS and the present study provides a potential mechanism by which rosiglitazone may have beneficial effects on fertility in these patients...
  66. doi request reprint Relationship of epicardial fat thickness and fasting glucose
    Gianluca Iacobellis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Int J Cardiol 128:424-6. 2008
    ..Echocardiographic epicardial fat measurement may be an additional tool for diabetes-related cardiac risk stratification...
  67. ncbi request reprint The effects of exercise training on insulin resistance in patients with coronary artery disease
    Neville G Suskin
    University of Western Ontario, London, ON, Canada
    Eur J Cardiovasc Prev Rehabil 14:803-8. 2007
    ..Moreover, patients with coronary artery disease (CAD) have not been studied...
  68. doi request reprint Kidney disease after preeclampsia: a systematic review and meta-analysis
    Sarah D McDonald
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Kidney Dis 55:1026-39. 2010
    ..Our objective is to undertake a systematic review and meta-analysis to determine whether women with a history of preeclampsia are at increased risk of subsequent kidney disease...
  69. pmc Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial
    Tali Cukierman-Yaffe
    Gertner Institute for Epidemiology and Health Policy Research, Endocrinology Institute Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Diabetes Care 32:221-6. 2009
    ..This was explored using baseline cognitive measures collected in the ongoing Memory in Diabetes (MIND) substudy of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial...
  70. ncbi request reprint Rosiglitazone prevents diabetes by increasing beta-cell mass in an animal model of type 2 diabetes characterized by reduced beta-cell mass at birth
    A C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Diabetes Obes Metab 10:763-71. 2008
    ..The effect of this drug on both glucose levels and beta-cell mass was studied in a rat model of diabetes, characterized by reduced beta-cell mass at birth with normoglycaemia, and progression to dysglycaemia with age...
  71. ncbi request reprint Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study
    H C Gerstein
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada
    J Am Coll Cardiol 33:612-9. 1999
    ..To assess the relationship between dysglycemia and myocardial infarction in nondiabetic individuals...
  72. ncbi request reprint Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview
    S E Capes
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Stroke 32:2426-32. 2001
    ..A systematic review and meta-analysis of the literature relating acute poststroke glucose levels to the subsequent course were done to summarize and quantify this relationship...
  73. ncbi request reprint Enalapril prevents clinical proteinuria in diabetic patients with low ejection fraction
    S E Capes
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:377-80. 2000
    ..The prevalence of clinical proteinuria, its correlates and predictive value, and the effect of ACE inhibitors in preventing clinical proteinuria in diabetic and nondiabetic patients with left ventricular (LV) dysfunction are unknown...
  74. ncbi request reprint Cognitive decline and dementia in diabetes--systematic overview of prospective observational studies
    T Cukierman
    Division of Endocrinology and Metabolism and Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    Diabetologia 48:2460-9. 2005
    ..We systematically reviewed and summarised prospective data relating diabetes status to changes in cognitive function over time...
  75. ncbi request reprint Prevalence and determinants of microalbuminuria in high-risk diabetic and nondiabetic patients in the Heart Outcomes Prevention Evaluation Study. The HOPE Study Investigators
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:B35-9. 2000
    ....
  76. ncbi request reprint A controlled evaluation of a national continuing medical education programme designed to improve family physicians' implementation of diabetes-specific clinical practice guidelines
    H C Gerstein
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabet Med 16:964-9. 1999
    ..This study assessed the short and long-term impact of a 7-h, small group workshop on family physicians' attitude, knowledge and self-reported practice patterns regarding diabetes mellitus...
  77. ncbi request reprint The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE Investigators
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario
    Can J Cardiol 14:1349-57. 1998
    ..The relationship between the conventional and emerging risk factors, and atherosclerosis, vascular disease and markers of end-organ damage will be evaluated between and within ethnic groups...
  78. ncbi request reprint Rationale, design and recruitment characteristics of a large, simple international trial of diabetes prevention: the DREAM trial
    H C Gerstein
    Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 47:1519-27. 2004
    ..This risk can be reduced by lifestyle changes and/or various drugs. Novel therapies to prevent diabetes, as well as new risk factors for diabetes, atherosclerosis and obesity require testing and identification...
  79. doi request reprint Anthropometric measures and glucose levels in a large multi-ethnic cohort of individuals at risk of developing type 2 diabetes
    L de Koning
    The Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Diabetologia 53:1322-30. 2010
    ..We also explored variation in anthropometric associations by sex and ethnicity...
  80. ncbi request reprint Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes
    A C Holloway
    Department of Obstetrics and Gynecology, McMaster University, Rm 3N52 HSC 1200 Main Street W, Hamilton, ON, Canada, L8N 3Z5
    Diabetologia 48:2661-6. 2005
    ..This study examines the effect of fetal and neonatal exposure to nicotine, the major addictive component of cigarettes, on postnatal growth, adiposity and glucose homeostasis...
  81. ncbi request reprint Dysglycemia in a community sample of people treated for schizophrenia: the Diabetes in Schizophrenia in Central-South Ontario (DiSCO) study
    L P Voruganti
    Department of Psychiatry and Behavioural Neurosciences, 100 West 5th Street, Hamilton, Ontario Canada L8N 3K7
    Schizophr Res 96:215-22. 2007
    ..Discerning the modifiable risk factors is crucial for developing diabetes prevention strategies in schizophrenia...
  82. ncbi request reprint Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes. The MICRO-HOPE Study. Microalbuminuria, cardiovascular, and renal outcomes. Heart Outcomes Preven
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 19:1225-8. 1996
    ....
  83. ncbi request reprint Dysglycaemia: a cardiovascular risk factor
    H C Gerstein
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, Ontario, Canada
    Diabetes Res Clin Pract 40:S9-14. 1998
    ..This relationship is similar to that of smoking, blood pressure and dyslipidaemia to cardiovascular risk. Whether glucose lowering in diabetic or non-diabetic individuals will prevent cardiovascular disease remains to be determined...
  84. ncbi request reprint Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview
    S E Capes
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Lancet 355:773-8. 2000
    ..We did a systematic review and meta-analysis to assess the risk of in-hospital mortality or congestive heart failure after myocardial infarction in patients with and without diabetes who had stress hyperglycaemia on admission...
  85. pmc Effect of insulin glargine and n-3FA on carotid intima-media thickness in people with dysglycemia at high risk for cardiovascular events: the glucose reduction and atherosclerosis continuing evaluation study (ORIGIN-GRACE)
    Eva M Lonn
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 36:2466-74. 2013
    ..To evaluate the effects of insulin glargine and n-3 polyunsaturated fatty acid (n-3FA) supplements on carotid intima-media thickness (CIMT)...
  86. pmc Can community retail pharmacist and diabetes expert support facilitate insulin initiation by family physicians? Results of the AIM@GP randomized controlled trial
    Stewart B Harris
    Centre for Studies in Family Medicine, Department of Family Medicine, Schulich School of Medicine and Dentistry, The University of Western Ontario, 245 100 Collip Circle, London, Ontario, N6G 4X8, Canada
    BMC Health Serv Res 13:71. 2013
    ..Limited evidence exists on the effectiveness of external diabetes support provided by diabetes specialists and community retail pharmacists to facilitate insulin-prescribing in family practice...
  87. pmc Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:1379-81. 2010
    ..To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes...
  88. doi request reprint Analysis of health utility data when some subjects attain the upper bound of 1: are Tobit and CLAD models appropriate?
    Eleanor M Pullenayegum
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Value Health 13:487-94. 2010
    ..We aimed to examine whether the Tobit and CLAD models yielded acceptable results when this censoring assumption was not appropriate...
  89. pmc Why don't pigs get diabetes? Explanations for variations in diabetes susceptibility in human populations living in a diabetogenic environment
    Hertzel C Gerstein
    Division of Endocrinology and Metabolism, Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ont
    CMAJ 174:25-6. 2006
  90. ncbi request reprint "I take what I think works for me": a qualitative study to explore patient perception of diabetes treatment benefits and risks
    Kalpana M Nair
    Centre for Evaluation of Medicines, St Joseph s Healthcare Hamilton, Hamilton, Canada
    Can J Clin Pharmacol 14:e251-9. 2007
    ..A key aspect of disease management is patient adherence to prescribed treatments. Treatment adherence is influenced by many factors, including the understanding of a treatment's benefits and risks...
  91. pmc The effect of oral antidiabetic agents on A1C levels: a systematic review and meta-analysis
    Diana Sherifali
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 33:1859-64. 2010
    ..Using predetermined methodological criteria, we evaluated the effect of OAD agents on A1C levels...
  92. ncbi request reprint Does a combination regimen of thyroxine (T4) and 3,5,3'-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial
    A M Sawka
    Department of Medicine and Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada
    J Clin Endocrinol Metab 88:4551-5. 2003
    ..05 for all indexes). In conclusion, the current data do not support the routine use of combined T(3) and T(4) therapy in hypothyroid patients with depressive symptoms...
  93. ncbi request reprint Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association
    John B Buse
    University of North Carolina, USA
    Circulation 115:114-26. 2007
    ..This statement will attempt to harmonize the recommendations of both organizations where possible but will recognize areas in which AHA and ADA recommendations differ...
  94. ncbi request reprint The burden of treatment failure in type 2 diabetes: response to Brown et al
    Denise G Simons-Morton
    Diabetes Care 28:761-2. 2005
  95. ncbi request reprint The effect of vitamin E supplementation on cardiovascular risk in diabetic individuals with different haptoglobin phenotypes
    Andrew P Levy
    Diabetes Care 27:2767. 2004
  96. ncbi request reprint Treatment satisfaction and quality of life using an early insulinization strategy with insulin glargine compared to an adjusted oral therapy in the management of Type 2 diabetes: the Canadian INSIGHT Study
    Robyn Houlden
    Division of Endocrinology, Queen s University, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, K7L 2V7 Canada
    Diabetes Res Clin Pract 78:254-8. 2007
    ..Improving glucose control by adding insulin glargine to OAD therapy had a positive impact on TS and general QoL without complaints related to hypoglycemia...
  97. ncbi request reprint Glycosylated hemoglobin: finally ready for prime time as a cardiovascular risk factor
    Hertzel C Gerstein
    Ann Intern Med 141:475-6. 2004
  98. ncbi request reprint Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial
    Jay S Skyler
    University of Miami, School of Medicine, Miami, FL 33136, USA
    Diabetes Care 28:1630-5. 2005
    ..We investigated whether a basal/bolus insulin regimen involving rapid-acting, dry powder, inhaled insulin could provide glycemic control comparable with a basal/bolus subcutaneous regimen...
  99. ncbi request reprint Effects of vitamin E on cardiovascular outcomes in people with mild-to-moderate renal insufficiency: results of the HOPE study
    Johannes F E Mann
    Department of Nephrology and Hypertension, Schwabing General Hospital, Munich, Germany
    Kidney Int 65:1375-80. 2004
    ..There are no data for renal insufficiency before the stage of terminal renal failure. We evaluated effects of vitamin E supplementation on cardiovascular and renal outcomes in 993 people with a serum creatinine > or =1.4 to 2.3 mg/dL...
  100. ncbi request reprint Cardiovascular risk in patients with early renal insufficiency: implications for the use of ACE inhibitors
    Johannes F E Mann
    Department of Nephrology and Hypertension, Schwabing General Hospital, Ludwig Maximilians University, Munich, Germany
    Am J Cardiovasc Drugs 2:157-62. 2002
    ..In addition, there is evidence that ACE inhibitors improve renal outcomes in renal insufficiency. Prospective studies should test the predictive power of ERI for cardiovascular disease and therapeutic options...
  101. ncbi request reprint Prevention of cardiovascular disease in persons with type 2 diabetes mellitus: current knowledge and rationale for the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    David C Goff
    Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Am J Cardiol 99:4i-20i. 2007
    ..The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial will test hypotheses to address these unanswered questions...