H C Gerstein

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes. The MICRO-HOPE Study. Microalbuminuria, cardiovascular, and renal outcomes. Heart Outcomes Preven
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 19:1225-8. 1996
  2. ncbi request reprint Dysglycaemia: a cardiovascular risk factor
    H C Gerstein
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, Ontario, Canada
    Diabetes Res Clin Pract 40:S9-14. 1998
  3. ncbi request reprint Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study
    H C Gerstein
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada
    J Am Coll Cardiol 33:612-9. 1999
  4. ncbi request reprint A controlled evaluation of a national continuing medical education programme designed to improve family physicians' implementation of diabetes-specific clinical practice guidelines
    H C Gerstein
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabet Med 16:964-9. 1999
  5. ncbi request reprint Prevalence and determinants of microalbuminuria in high-risk diabetic and nondiabetic patients in the Heart Outcomes Prevention Evaluation Study. The HOPE Study Investigators
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:B35-9. 2000
  6. doi request reprint Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study
    S S Anand
    Population Health Research Institute, Hamilton, Ontario, Canada
    Eur J Prev Cardiol 19:755-64. 2012
  7. ncbi request reprint Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals
    H C Gerstein
    Department of Medicine, Room 3V38, 1200 Main St W, Hamilton, Ontario, L8N 3Z5
    JAMA 286:421-6. 2001
  8. ncbi request reprint The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis
    H C Gerstein
    McMaster University and Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 48:1749-55. 2005
  9. doi request reprint Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia
    S D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Diabet Med 30:e1-7. 2013
  10. ncbi request reprint Rosiglitazone prevents diabetes by increasing beta-cell mass in an animal model of type 2 diabetes characterized by reduced beta-cell mass at birth
    A C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Diabetes Obes Metab 10:763-71. 2008

Detail Information

Publications34

  1. ncbi request reprint Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes. The MICRO-HOPE Study. Microalbuminuria, cardiovascular, and renal outcomes. Heart Outcomes Preven
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 19:1225-8. 1996
    ....
  2. ncbi request reprint Dysglycaemia: a cardiovascular risk factor
    H C Gerstein
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, Ontario, Canada
    Diabetes Res Clin Pract 40:S9-14. 1998
    ..This relationship is similar to that of smoking, blood pressure and dyslipidaemia to cardiovascular risk. Whether glucose lowering in diabetic or non-diabetic individuals will prevent cardiovascular disease remains to be determined...
  3. ncbi request reprint Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study
    H C Gerstein
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada
    J Am Coll Cardiol 33:612-9. 1999
    ..To assess the relationship between dysglycemia and myocardial infarction in nondiabetic individuals...
  4. ncbi request reprint A controlled evaluation of a national continuing medical education programme designed to improve family physicians' implementation of diabetes-specific clinical practice guidelines
    H C Gerstein
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabet Med 16:964-9. 1999
    ..This study assessed the short and long-term impact of a 7-h, small group workshop on family physicians' attitude, knowledge and self-reported practice patterns regarding diabetes mellitus...
  5. ncbi request reprint Prevalence and determinants of microalbuminuria in high-risk diabetic and nondiabetic patients in the Heart Outcomes Prevention Evaluation Study. The HOPE Study Investigators
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:B35-9. 2000
    ....
  6. doi request reprint Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study
    S S Anand
    Population Health Research Institute, Hamilton, Ontario, Canada
    Eur J Prev Cardiol 19:755-64. 2012
    ..In an international prospective cohort study we assessed the relationship between glucose levels and incident cardiovascular events and death...
  7. ncbi request reprint Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals
    H C Gerstein
    Department of Medicine, Room 3V38, 1200 Main St W, Hamilton, Ontario, L8N 3Z5
    JAMA 286:421-6. 2001
    ..Microalbuminuria is a risk factor for cardiovascular (CV) events. The relationship between the degree of albuminuria and CV risk is unclear...
  8. ncbi request reprint The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis
    H C Gerstein
    McMaster University and Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 48:1749-55. 2005
    ....
  9. doi request reprint Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia
    S D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Diabet Med 30:e1-7. 2013
    ..Our objective was to determine if the high risk of cardiovascular disease in women with pre-eclampsia is accounted for by known cardiovascular risk factors including albuminuria...
  10. ncbi request reprint Rosiglitazone prevents diabetes by increasing beta-cell mass in an animal model of type 2 diabetes characterized by reduced beta-cell mass at birth
    A C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Diabetes Obes Metab 10:763-71. 2008
    ..The effect of this drug on both glucose levels and beta-cell mass was studied in a rat model of diabetes, characterized by reduced beta-cell mass at birth with normoglycaemia, and progression to dysglycaemia with age...
  11. ncbi request reprint Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview
    S E Capes
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Lancet 355:773-8. 2000
    ..We did a systematic review and meta-analysis to assess the risk of in-hospital mortality or congestive heart failure after myocardial infarction in patients with and without diabetes who had stress hyperglycaemia on admission...
  12. ncbi request reprint The HOPE (Heart Outcomes Prevention Evaluation) Study and its consequences
    M J McQueen
    Hamilton Regional Laboratory Medicine Program, Department of Laboratory Medicine, St Joseph s Hospital, Hamilton, Ontario
    Scand J Clin Lab Invest Suppl 240:143-56. 2005
    ..Sub-studies completed and on-going into the predictive role of natriuretic peptides, infectious and inflammatory markers, provide insight into possible mechanisms of action of Ramipril...
  13. ncbi request reprint A randomized trial of adding insulin glargine vs. avoidance of insulin in people with Type 2 diabetes on either no oral glucose-lowering agents or submaximal doses of metformin and/or sulphonylureas. The Canadian INSIGHT (Implementing New Strategies with
    H C Gerstein
    Division of Endocrinology and Metabolism and the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada
    Diabet Med 23:736-42. 2006
    ..However, its potential advantages suggest that it could be added earlier to achieve glycaemic goals; this possibility was tested in a clinical trial...
  14. doi request reprint Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial
    Z Punthakee
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, ON, Canada, L8L 2X2
    Diabetologia 55:36-45. 2012
    ....
  15. doi request reprint Anthropometric measures and glucose levels in a large multi-ethnic cohort of individuals at risk of developing type 2 diabetes
    L de Koning
    The Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Diabetologia 53:1322-30. 2010
    ..We also explored variation in anthropometric associations by sex and ethnicity...
  16. ncbi request reprint Preventing type 2 diabetes using combination therapy: design and methods of the CAnadian Normoglycaemia Outcomes Evaluation (CANOE) trial
    B Zinman
    Leadership Sinai Centre for Diabetes, Department of Medicine, Mount Sinai Hospital and the University of Toronto, Toronto, Ontario, Canada
    Diabetes Obes Metab 8:531-7. 2006
    ..In conclusion, the CANOE study will determine whether combination pharmacological therapy combined with a lifestyle intervention programme can significantly modify the development of diabetes in high-risk Canadians...
  17. doi request reprint Poor achievement of guidelines-recommended targets in type 2 diabetes: findings from a contemporary prospective cohort study
    M F B Braga
    Department of Medicine, Division of Endocrinology and Metabolism, McMaster University, Hamilton, ON, Canada
    Int J Clin Pract 66:457-64. 2012
    ..5 mmol/l]...
  18. ncbi request reprint The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE Investigators
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario
    Can J Cardiol 14:1349-57. 1998
    ..The relationship between the conventional and emerging risk factors, and atherosclerosis, vascular disease and markers of end-organ damage will be evaluated between and within ethnic groups...
  19. doi request reprint Dysglycaemia and the risk of acute myocardial infarction in multiple ethnic groups: an analysis of 15,780 patients from the INTERHEART study
    H C Gerstein
    The Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Diabetologia 53:2509-17. 2010
    ..Although diabetes is an established risk factor for myocardial infarction (MI), disease control may vary. HbA(1c) is a reliable index of ambient glucose levels and may provide more information on MI risk than diabetes status...
  20. ncbi request reprint Rationale, design and recruitment characteristics of a large, simple international trial of diabetes prevention: the DREAM trial
    H C Gerstein
    Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 47:1519-27. 2004
    ..This risk can be reduced by lifestyle changes and/or various drugs. Novel therapies to prevent diabetes, as well as new risk factors for diabetes, atherosclerosis and obesity require testing and identification...
  21. ncbi request reprint Enalapril prevents clinical proteinuria in diabetic patients with low ejection fraction
    S E Capes
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:377-80. 2000
    ..The prevalence of clinical proteinuria, its correlates and predictive value, and the effect of ACE inhibitors in preventing clinical proteinuria in diabetic and nondiabetic patients with left ventricular (LV) dysfunction are unknown...
  22. ncbi request reprint Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes
    A C Holloway
    Department of Obstetrics and Gynecology, McMaster University, Rm 3N52 HSC 1200 Main Street W, Hamilton, ON, Canada, L8N 3Z5
    Diabetologia 48:2661-6. 2005
    ..This study examines the effect of fetal and neonatal exposure to nicotine, the major addictive component of cigarettes, on postnatal growth, adiposity and glucose homeostasis...
  23. ncbi request reprint Pre-prandial vs. post-prandial capillary glucose measurements as targets for repaglinide dose titration in people with diet-treated or metformin-treated Type 2 diabetes: a randomized controlled clinical trial
    H C Gerstein
    Division of Endocrinology and Metabolism, McMaster University and Hamilton Health Sciences, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Diabet Med 21:1200-3. 2004
    ..Targeting post-prandial glucose levels may lead to lower HbA(1c) levels and rates of hypoglycaemia than targeting pre-prandial glucose levels...
  24. ncbi request reprint Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview
    S E Capes
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Stroke 32:2426-32. 2001
    ..A systematic review and meta-analysis of the literature relating acute poststroke glucose levels to the subsequent course were done to summarize and quantify this relationship...
  25. doi request reprint Hyperglycaemia is associated with impaired vasa vasorum neovascularization and accelerated atherosclerosis in apolipoprotein-E deficient mice
    K J Veerman
    Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada
    Atherosclerosis 227:250-8. 2013
    ..The objective of this study is to investigate the effects of hyperglycaemia on the vasa vasorum and to examine correlations between these effects and the development of atherosclerosis in a mouse model...
  26. ncbi request reprint Cognitive decline and dementia in diabetes--systematic overview of prospective observational studies
    T Cukierman
    Division of Endocrinology and Metabolism and Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    Diabetologia 48:2460-9. 2005
    ..We systematically reviewed and summarised prospective data relating diabetes status to changes in cognitive function over time...
  27. doi request reprint Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial
    G R Dagenais
    Laval University Heart and Lung Institute, 2725 Chemin Ste Foy, Quebec, Quebec City, Canada
    Diabetes Care 31:1007-14. 2008
    ..We determined the effects of ramipril and rosiglitazone on combined and individual CVD and renal outcomes in people with IGT and/or IFG in the Diabetes REduction Assessment With ramipril and rosiglitazone Medication (DREAM) trial...
  28. doi request reprint Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ....
  29. ncbi request reprint Serum potassium, cardiovascular risk, and effects of an ACE inhibitor: results of the HOPE study
    J F E Mann
    Department of Nephrology, Schwabing General Hospital, Ludwig Maximilians University, Munich, Germany
    Clin Nephrol 63:181-7. 2005
    ..5 years in 9297 individuals at high cardiovascular risk, randomized to an ACE inhibitor or to placebo...
  30. ncbi request reprint Dysglycemia in a community sample of people treated for schizophrenia: the Diabetes in Schizophrenia in Central-South Ontario (DiSCO) study
    L P Voruganti
    Department of Psychiatry and Behavioural Neurosciences, 100 West 5th Street, Hamilton, Ontario Canada L8N 3K7
    Schizophr Res 96:215-22. 2007
    ..Discerning the modifiable risk factors is crucial for developing diabetes prevention strategies in schizophrenia...
  31. ncbi request reprint Glucose levels predict hospitalization for congestive heart failure in patients at high cardiovascular risk
    C Held
    Karolinska Institutet, Department of Medicine, Unit of Cardiology, Karolinska University Hospital, 17176 Stockholm, Sweden
    Circulation 115:1371-5. 2007
    ..Patients with diabetes mellitus (DM) are at high risk of developing congestive heart failure (CHF). However, the relationships between glucose levels and CHF in people with or without a history of DM have not been well characterized...
  32. ncbi request reprint Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial
    J F Mann
    Department of Nephrology and Hypertension, Schwabing General Hospital, LMU, Kolner Platz 1, D-80804 Munchen, Germany
    Ann Intern Med 134:629-36. 2001
    ..Ramipril reduced cardiovascular risk without increasing adverse effects...
  33. ncbi request reprint Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial
    H C Gerstein
    Lancet 368:1096-105. 2006
    ..The aim of this study was to assess prospectively the drug's ability to prevent type 2 diabetes in individuals at high risk of developing the condition...
  34. ncbi request reprint Does a combination regimen of thyroxine (T4) and 3,5,3'-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial
    A M Sawka
    Department of Medicine and Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada
    J Clin Endocrinol Metab 88:4551-5. 2003
    ..05 for all indexes). In conclusion, the current data do not support the routine use of combined T(3) and T(4) therapy in hypothyroid patients with depressive symptoms...