Research Topics
| Gail M GauvreauSummaryAffiliation: McMaster University Country: Canada Publications
| Collaborators
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Detail Information
Publications
Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthmaGail M Gauvreau
McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 183:1007-14. 2011..Extensive evidence in animal models supports a role for IL-13 in the pathobiology of asthma. IMA-638 and IMA-026 are fully humanized IgG(1) antibodies that bind to different epitopes and neutralize IL-13 bioactivity...- Dose-response effects of TPI ASM8 in asthmatics after allergenG M Gauvreau
McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
Allergy 66:1242-8. 2011..A previous study suggested that TPI ASM8 had broader effects than just inhibition of eosinophils in asthmatics... 
Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjectsGail M Gauvreau
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Respir Res 12:140. 2011..The objective of this study was to evaluate the effects of roflumilast on bronchoconstriction, airway hyperresponsiveness (AHR), and airway inflammation in mild asthmatic patients undergoing allergen inhalation challenge...- Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responsesGail M Gauvreau
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 177:952-8. 2008.... 
Allergen inhalation challenge: a human model of asthma exacerbationGail M Gauvreau
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Contrib Microbiol 14:21-32. 2007....- Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalationSandra C Dorman
Asthma Research Group, Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 169:565-72. 2004..We propose that after allergen inhalation, time-dependent changes in cytokine levels in the bone marrow control differentiation of eosinophil/basophil progenitors... - The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthmaKrishnan Parameswaran
Firestone Institute for Respiratory Health, St. Joseph's Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 169:915-20. 2004..We conclude that, the cysteinyl leukotriene receptor antagonist, pranlukast, attenuates allergen-induced increase in airway eosinophils by decreasing bone marrow eosinophilopoiesis and airway chemotactic and eosinophilopoietic cytokines... - Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting beta(2)-agonist, in patients with mild asthmaPaul M O'Byrne
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 124:1217-21. 2009..Long-acting ss(2)-agonists are an established controller medication in asthma. BI 1744 is a novel L\long-acting ss(2)-agonist with a preclinical profile that suggests 24-hour bronchodilation and bronchoprotection may be achieved... - Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthmaMargaret M Kelly
Firestone Institute for Respiratory Health, Department of Medicine, St Joseph s Healthcare and McMaster University Medical Center, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
J Allergy Clin Immunol 125:349-356.e13. 2010..However, there are limited data as to whether these beneficial effects are due to enhanced anti-inflammatory actions or whether such combination therapies affect airway remodeling in patients with asthma... - Modulation of beta1-integrins on hemopoietic progenitor cells after allergen challenge in asthmatic subjectsAdriana E Catalli
Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
J Allergy Clin Immunol 122:803-10. 2008..Understanding the mechanisms regulating progenitor cell mobilization and trafficking to the peripheral circulation might be important for the development of effective asthma therapies... - Effect of low-dose ciclesonide on allergen-induced responses in subjects with mild allergic asthmaGail M Gauvreau
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 116:285-91. 2005..025). CONCLUSION: With the exception of 24-hour postchallenge peripheral blood eosinophils, a low dose of ciclesonide, 80 microg, was effective in blocking all allergen-induced responses measured... - Protection by budesonide and fluticasone on allergen-induced airway responses after discontinuation of therapyPadmaja Subbarao
Firestone Institute for Respiratory Health, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 115:745-50. 2005..However, the duration of the protective effects of inhaled steroids after discontinuation of therapy has not been established... - Lung homing of endothelial progenitor cells in humans with asthma after allergen challengeHaruki Imaoka
Asthma Research Group, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 184:771-8. 2011..We have previously shown that inhibiting allergen (Ag)-induced recruitment of EPC in sensitized mice attenuated increased bronchial vascularity and development of airway hyperresponsiveness... - Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responsesGail M Gauvreau
McMaster University, Hamilton, ON, Canada
Am J Respir Crit Care Med 174:15-20. 2006..This suggests that induction of IFN and IFN-inducible genes alone is not sufficient to inhibit allergen-induced responses in asthmatic subjects... - Expression of functional cysteinyl leukotriene receptors by human basophilsGail M Gauvreau
Department of Medicine, McMaster University, Hamilton, MD, USA
J Allergy Clin Immunol 116:80-7. 2005..CONCLUSIONS: We have demonstrated that basophils express the cysLT receptors cysLT1 and cysLT2, and some functional responses to LTD 4 can be observed... - The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthmaGail M Gauvreau
Department of Medicine, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
J Allergy Clin Immunol 112:331-8. 2003..Larger studies are needed to confirm this... - Increased levels of airway neutrophils reduce the inhibitory effects of inhaled glucocorticosteroids on allergen-induced airway eosinophilsGail M Gauvreau
St Joseph's Hospital and the Department of Medicine, McMaster University, Hamilton, Canada
Can Respir J 9:26-32. 2002..CONCLUSIONS: Baseline airway neutrophils, not eosinophils, can be used to predict the efficacy of inhaled steroids on allergen-induced sputum eosinophils... - Myeloid and plasmacytoid dendritic cells in induced sputum after allergen inhalation in subjects with asthmaBenny Dua
Firestone Institute for Respiratory Health, St Joseph s Hospital and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 126:133-9. 2010..In animal models, the induction and maintenance of allergic airway inflammation is primarily a function of myeloid dendritic cells, whereas the tolerization to inhaled allergens is likely a function of plasmacytoid dendritic cells... - IL-10 production in circulating T cells differs between allergen-induced isolated early and dual asthmatic respondersKoichiro Matsumoto
Asthma Research Group, St Joseph's Healthcare and McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 109:281-6. 2002..CONCLUSIONS: These results suggest that the contrasting profiles of IL-10 production may be associated with the different time course of allergen-induced airway inflammation between allergen-induced early and dual responders... - Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthmaPaul M O'Byrne
Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
J Allergy Clin Immunol 124:397-403. 2009..Leukotriene receptor antagonists have an excellent safety profile... - The Effect of PPAR Agonists on the Migration of Mature and Immature EosinophilsSteven G Smith
Department of Medicine, McMaster University, Hamilton, ON, Canada L8S 4K1
PPAR Res 2012:235231. 2012..0042). The effect of rosiglitazone on eosinophil migration and chemokinesis appears to be through modification of calcium signaling, which alludes to a novel PPAR-mediated mechanism to modulate eosinophil function... - The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjectsFausto Braccioni
Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph's Healthcare, and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 110:96-101. 2002..The suppressive effect by montelukast demonstrates that this is a cysLT(1) receptor-mediated effect... - Eculizumab for treatment of asthmaSteven G Smith
McMaster University, Department of Medicine, Ontario, Canada
Expert Opin Biol Ther 12:529-37. 2012..Although this study provides some evidence that eculizumab may be effective to attenuate allergen-induced responses, the role of C5 in asthma remains to be clarified... - Reproducibility of sputum differential cell counts is not affected by squamous epithelial cellsZahra N Sohani
Department of Medicine, McMaster University, Hamilton, ON, Canada
J Asthma 48:952-6. 2011..The aim of this study is to evaluate the effect of SEC contamination and cell dispersion on the reproducibility of differential counts of sputum cells prepared on glass slides... - Comparison of changes in lung function measured by plethymography and IOS after bronchoprovocationNizar Naji
Cardiorespiratory Research Laboratory, Department of Medicine, McMaster University, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
Respir Med 107:503-10. 2013..We investigated the relative sensitivities of IOS, body plethysmography and spirometry in detecting allergen- and methacholine-induced bronchoconstriction... - IL-13 is a novel therapeutic target in allergic asthmaSteven G Smith
McMaster University, Asthma Research Group, Department of Medicine, Division of Respirology, HSC 3U24, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
Expert Rev Clin Immunol 3:671-5. 2007..Efficacy of anti-IL-13 in proof-of-concept human studies will be critical to evaluate the potential of this therapy for treatment of allergic asthma...