Gail M Gauvreau

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi Thymic stromal lymphopoietin: a central regulator of allergic asthma
    Brittany Watson
    McMaster University, Medicine, 1200 Main St West, Hamilton, Ontario, L8N 3Z5, Canada
    Expert Opin Ther Targets 18:771-85. 2014
  2. pmc The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils
    Steven G Smith
    Department of Medicine, McMaster University, Hamilton, ON, Canada L8S 4K1
    PPAR Res 2012:235231. 2012
  3. pmc Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge
    Masatsugu Yamamoto
    UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Room 166, Burrard Building, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    BMC Genomics 13:655. 2012
  4. doi Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 177:952-8. 2008
  5. doi Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
    Gail M Gauvreau
    McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 183:1007-14. 2011
  6. doi Dose-response effects of TPI ASM8 in asthmatics after allergen
    G M Gauvreau
    McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    Allergy 66:1242-8. 2011
  7. ncbi Allergen inhalation challenge: a human model of asthma exacerbation
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Contrib Microbiol 14:21-32. 2007
  8. pmc Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Respir Res 12:140. 2011
  9. ncbi Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalation
    Sandra C Dorman
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:565-72. 2004
  10. ncbi The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthma
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:915-20. 2004

Collaborators

Detail Information

Publications35

  1. ncbi Thymic stromal lymphopoietin: a central regulator of allergic asthma
    Brittany Watson
    McMaster University, Medicine, 1200 Main St West, Hamilton, Ontario, L8N 3Z5, Canada
    Expert Opin Ther Targets 18:771-85. 2014
    ..Clinical trials with TSLP blockade are underway and will unequivocally confirm whether TSLP is indeed a key driver of allergic inflammation in asthma. ..
  2. pmc The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils
    Steven G Smith
    Department of Medicine, McMaster University, Hamilton, ON, Canada L8S 4K1
    PPAR Res 2012:235231. 2012
    ..0042). The effect of rosiglitazone on eosinophil migration and chemokinesis appears to be through modification of calcium signaling, which alludes to a novel PPAR-mediated mechanism to modulate eosinophil function...
  3. pmc Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge
    Masatsugu Yamamoto
    UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Room 166, Burrard Building, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    BMC Genomics 13:655. 2012
    ..We aimed to evaluate changes in the microRNA profiles in the peripheral blood of asthmatic subjects undergoing allergen inhalation challenge...
  4. doi Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 177:952-8. 2008
    ....
  5. doi Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
    Gail M Gauvreau
    McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 183:1007-14. 2011
    ..Extensive evidence in animal models supports a role for IL-13 in the pathobiology of asthma. IMA-638 and IMA-026 are fully humanized IgG(1) antibodies that bind to different epitopes and neutralize IL-13 bioactivity...
  6. doi Dose-response effects of TPI ASM8 in asthmatics after allergen
    G M Gauvreau
    McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    Allergy 66:1242-8. 2011
    ..A previous study suggested that TPI ASM8 had broader effects than just inhibition of eosinophils in asthmatics...
  7. ncbi Allergen inhalation challenge: a human model of asthma exacerbation
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Contrib Microbiol 14:21-32. 2007
    ....
  8. pmc Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Respir Res 12:140. 2011
    ..The objective of this study was to evaluate the effects of roflumilast on bronchoconstriction, airway hyperresponsiveness (AHR), and airway inflammation in mild asthmatic patients undergoing allergen inhalation challenge...
  9. ncbi Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalation
    Sandra C Dorman
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:565-72. 2004
    ..We propose that after allergen inhalation, time-dependent changes in cytokine levels in the bone marrow control differentiation of eosinophil/basophil progenitors...
  10. ncbi The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthma
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:915-20. 2004
    ..We conclude that, the cysteinyl leukotriene receptor antagonist, pranlukast, attenuates allergen-induced increase in airway eosinophils by decreasing bone marrow eosinophilopoiesis and airway chemotactic and eosinophilopoietic cytokines...
  11. ncbi Effects of an anti-TSLP antibody on allergen-induced asthmatic responses
    Gail M Gauvreau
    From the Firestone Institute of Respiratory Health, Department of Medicine, McMaster University, Hamilton, ON G M G, P M O, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec City, QC L P B, Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, SK D C, B E D, Institute for Heart and Lung Health, University of British Columbia, Vancouver J M F, and Snyder Institute for Chronic Diseases, Faculty of Medicine, Calgary, AB R L all in Canada Amgen, Thousand Oaks, CA Y W, M B, C D, K S G, L S, E B, J R P and Amgen, Seattle J B, M R C
    N Engl J Med 370:2102-10. 2014
    ..AMG 157 is a human anti-TSLP monoclonal immunoglobulin G2λ that binds human TSLP and prevents receptor interaction...
  12. doi Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting beta(2)-agonist, in patients with mild asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 124:1217-21. 2009
    ..Long-acting ss(2)-agonists are an established controller medication in asthma. BI 1744 is a novel L\long-acting ss(2)-agonist with a preclinical profile that suggests 24-hour bronchodilation and bronchoprotection may be achieved...
  13. doi Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma
    Margaret M Kelly
    Firestone Institute for Respiratory Health, Department of Medicine, St Joseph s Healthcare and McMaster University Medical Center, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Allergy Clin Immunol 125:349-356.e13. 2010
    ..However, there are limited data as to whether these beneficial effects are due to enhanced anti-inflammatory actions or whether such combination therapies affect airway remodeling in patients with asthma...
  14. doi Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma
    Takashi Kinoshita
    Firestone Institute of Respiratory Health, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University, Fukuoka, Japan
    J Allergy Clin Immunol 133:696-703. 2014
    ..Natural regulatory T (Treg) cells are implicated in the regulation of the inflammatory response in patients with allergic asthma...
  15. doi Lung homing of endothelial progenitor cells in humans with asthma after allergen challenge
    Haruki Imaoka
    Asthma Research Group, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 184:771-8. 2011
    ..We have previously shown that inhibiting allergen (Ag)-induced recruitment of EPC in sensitized mice attenuated increased bronchial vascularity and development of airway hyperresponsiveness...
  16. ncbi The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma
    Gail M Gauvreau
    Department of Medicine, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
    J Allergy Clin Immunol 112:331-8. 2003
    ..Blocking of LFA-1/intercellular adhesion molecule interactions could inhibit asthmatic inflammation by blocking adhesion and activation of LFA-1-positive leukocytes...
  17. ncbi Protection by budesonide and fluticasone on allergen-induced airway responses after discontinuation of therapy
    Padmaja Subbarao
    Firestone Institute for Respiratory Health, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 115:745-50. 2005
    ..However, the duration of the protective effects of inhaled steroids after discontinuation of therapy has not been established...
  18. doi The effects of particle size on measurement of airway hyperresponsiveness to methacholine
    Nizar Naji
    Cardiorespiratory Research Laboratory, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Ann Allergy Asthma Immunol 110:359-63. 2013
    ..The effect of particle size on methacholine provocation concentration causing a decrease in forced expiratory volume of 1 second (FEV1) of 20% (PC20) is debatable...
  19. ncbi Effect of low-dose ciclesonide on allergen-induced responses in subjects with mild allergic asthma
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 116:285-91. 2005
    ..Ciclesonide, a nonhalogenated inhaled corticosteroid being developed for the treatment of persistent asthma, remains inactive until cleaved by esterases in the lung...
  20. doi Modulation of beta1-integrins on hemopoietic progenitor cells after allergen challenge in asthmatic subjects
    Adriana E Catalli
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 122:803-10. 2008
    ..Understanding the mechanisms regulating progenitor cell mobilization and trafficking to the peripheral circulation might be important for the development of effective asthma therapies...
  21. ncbi Increased levels of airway neutrophils reduce the inhibitory effects of inhaled glucocorticosteroids on allergen-induced airway eosinophils
    Gail M Gauvreau
    St Joseph s Hospital and the Department of Medicine, McMaster University, Hamilton, Canada
    Can Respir J 9:26-32. 2002
    ..Treatment with inhaled glucocorticosteroids attenuates allergen-induced airway inflammation but is less effective in people with asthma who have noneosinophilic airway inflammation...
  22. doi Comparison of changes in lung function measured by plethymography and IOS after bronchoprovocation
    Nizar Naji
    Cardiorespiratory Research Laboratory, Department of Medicine, McMaster University, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
    Respir Med 107:503-10. 2013
    ..We investigated the relative sensitivities of IOS, body plethysmography and spirometry in detecting allergen- and methacholine-induced bronchoconstriction...
  23. ncbi Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses
    Gail M Gauvreau
    McMaster University, Hamilton, ON, Canada
    Am J Respir Crit Care Med 174:15-20. 2006
    ..1018 ISS is a synthetic oligonucleotide containing immunostimulatory CpG motifs. In animal studies, 1018 ISS effectively inhibited Th2-mediated lung inflammation, including eosinophil infiltration, and airway hyperresponsiveness...
  24. ncbi Expression of functional cysteinyl leukotriene receptors by human basophils
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, MD, USA
    J Allergy Clin Immunol 116:80-7. 2005
    ..Receptors for cysLTs are expressed on a variety of peripheral blood leukocytes, but of interest, they are also expressed on cells that synthesize LTC 4 , such as eosinophils and mast cells...
  25. doi Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma
    Michelle L North
    Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Cell Mol Biol 48:694-702. 2013
    ..Thus, inhibition of polyamine production may represent a new therapeutic target to treat airway obstruction in allergic asthma...
  26. doi Myeloid and plasmacytoid dendritic cells in induced sputum after allergen inhalation in subjects with asthma
    Benny Dua
    Firestone Institute for Respiratory Health, St Joseph s Hospital and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 126:133-9. 2010
    ..In animal models, the induction and maintenance of allergic airway inflammation is primarily a function of myeloid dendritic cells, whereas the tolerization to inhaled allergens is likely a function of plasmacytoid dendritic cells...
  27. ncbi Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production
    Gail M Gauvreau
    McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Sci Transl Med 6:243ra85. 2014
    ..These studies indicate that targeting of membrane IgE-expressing cells with anti-M1 prime antibodies can prevent IgE production in humans. ..
  28. doi Reproducibility of sputum differential cell counts is not affected by squamous epithelial cells
    Zahra N Sohani
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    J Asthma 48:952-6. 2011
    ..The aim of this study is to evaluate the effect of SEC contamination and cell dispersion on the reproducibility of differential counts of sputum cells prepared on glass slides...
  29. pmc Evaluation of peroxisome proliferator-activated receptor agonists on interleukin-5-induced eosinophil differentiation
    Steven G Smith
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Immunology 142:484-91. 2014
    ..These findings indicate that the PPARγ agonist can attenuate tissue eosinophilia by interfering with local differentiative responses. ..
  30. ncbi The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects
    Fausto Braccioni
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 110:96-101. 2002
    ..However, the effect of cysLTs on peripheral blood and bone marrow eosinophil pro-genitor cells in allergic subjects is not known...
  31. doi Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 124:397-403. 2009
    ..Leukotriene receptor antagonists have an excellent safety profile...
  32. ncbi IL-10 production in circulating T cells differs between allergen-induced isolated early and dual asthmatic responders
    Koichiro Matsumoto
    Asthma Research Group, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 109:281-6. 2002
    ..Allergen inhalation by atopic asthmatic subjects results in 2 bronchoconstrictor phenotypes: isolated early response and dual response. Persistence of allergen-induced airway inflammation is a feature of dual responders...
  33. doi Eculizumab for treatment of asthma
    Steven G Smith
    McMaster University, Department of Medicine, Ontario, Canada
    Expert Opin Biol Ther 12:529-37. 2012
    ..Asthma continues to be a profound public health problem due to asthma exacerbation in a low proportion of patients in need of more effective medications...
  34. pmc IL-4 and IL-13 Differentially Regulate TLR-Induced Eosinophil-Basophil Differentiation of Cord Blood CD34+ Progenitor Cells
    Pia Reece
    Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 9:e100734. 2014
    ..This may have implications for in utero interactions between placental-derived pro-allergic cytokines and neonatal progenitor cells influencing Eo/B-mediated inflammatory responses in early life. ..
  35. ncbi IL-13 is a novel therapeutic target in allergic asthma
    Steven G Smith
    McMaster University, Asthma Research Group, Department of Medicine, Division of Respirology, HSC 3U24, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Expert Rev Clin Immunol 3:671-5. 2007
    ..Efficacy of anti-IL-13 in proof-of-concept human studies will be critical to evaluate the potential of this therapy for treatment of allergic asthma...