Jack Gauldie

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-β1
    Thomas Rodt
    Department of Radiology, Hannover Medical School, Hannover, Germany
    Respir Res 11:181. 2010
  2. pmc Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice
    Claudia Raja Gabaglia
    Division of Immune Regulation, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    J Transl Med 8:98. 2010
  3. ncbi request reprint Inflammation and the aging process: devil or angel
    Jack Gauldie
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Nutr Rev 65:S167-9. 2007
  4. pmc A new direction in the pathogenesis of idiopathic pulmonary fibrosis?
    Jack Gauldie
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Respir Res 3:1. 2002
  5. ncbi request reprint Adenoviral gene transfer of connective tissue growth factor in the lung induces transient fibrosis
    Philippe Bonniaud
    Department of Pathology and Molecular Medicine, Room 2N16, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
    Am J Respir Crit Care Med 168:770-8. 2003
  6. pmc Smad3 signaling involved in pulmonary fibrosis and emphysema
    Jack Gauldie
    Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street, W MDCL 4016, Hamilton, ON, Canada L8N 3Z5
    Proc Am Thorac Soc 3:696-702. 2006
  7. pmc Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia
    Jack Gauldie
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    Am J Pathol 163:2575-84. 2003
  8. ncbi request reprint TGF-beta, Smad3 and the process of progressive fibrosis
    J Gauldie
    Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
    Biochem Soc Trans 35:661-4. 2007
  9. ncbi request reprint Connective tissue growth factor is crucial to inducing a profibrotic environment in "fibrosis-resistant" BALB/c mouse lungs
    Philippe Bonniaud
    Departments of Medicine, Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 31:510-6. 2004
  10. ncbi request reprint TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis
    Philippe Bonniaud
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 175:5390-5. 2005

Detail Information

Publications115 found, 100 shown here

  1. pmc Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-β1
    Thomas Rodt
    Department of Radiology, Hannover Medical School, Hannover, Germany
    Respir Res 11:181. 2010
    ..Its value for assessing progressive lung fibrosis in mice has not been reported so far. Here we examined the importance of in vivo micro-CT as non-invasive tool to assess progression of pulmonary fibrosis in mice over time...
  2. pmc Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice
    Claudia Raja Gabaglia
    Division of Immune Regulation, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    J Transl Med 8:98. 2010
    ..Here, we assessed whether treatment with RU486 in conjunction with an intratumor injection of Ad5IL-12 vector (a recombinant adenovirus expressing IL-12) could impact the TSLN microenvironment and prostate cancer progression...
  3. ncbi request reprint Inflammation and the aging process: devil or angel
    Jack Gauldie
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Nutr Rev 65:S167-9. 2007
    ..It is more appropriate to target the underlying initiating conditions than the inflammatory process that ensues and treat the basic mechanisms of disease rather than interfere in a very important protective mechanism of the host...
  4. pmc A new direction in the pathogenesis of idiopathic pulmonary fibrosis?
    Jack Gauldie
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Respir Res 3:1. 2002
    ..Altered microenvironment and involvement of epithelial cell/mesenchymal cell interaction are the most likely contributors to the pathogenesis of this chronic progressive disorder...
  5. ncbi request reprint Adenoviral gene transfer of connective tissue growth factor in the lung induces transient fibrosis
    Philippe Bonniaud
    Department of Pathology and Molecular Medicine, Room 2N16, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
    Am J Respir Crit Care Med 168:770-8. 2003
    ....
  6. pmc Smad3 signaling involved in pulmonary fibrosis and emphysema
    Jack Gauldie
    Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street, W MDCL 4016, Hamilton, ON, Canada L8N 3Z5
    Proc Am Thorac Soc 3:696-702. 2006
    ..A common element is tissue damage and repair, with TGF-beta and the Smad signaling pathway playing prominent molecular roles. Both changes can be followed in experimental models with noninvasive imaging and physiologic measurements...
  7. pmc Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia
    Jack Gauldie
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    Am J Pathol 163:2575-84. 2003
    ....
  8. ncbi request reprint TGF-beta, Smad3 and the process of progressive fibrosis
    J Gauldie
    Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
    Biochem Soc Trans 35:661-4. 2007
    ..These results suggest that mechanisms of progressive fibrosis involve factors presented within the context of the matrix that define the microenvironment for progressive matrix deposition...
  9. ncbi request reprint Connective tissue growth factor is crucial to inducing a profibrotic environment in "fibrosis-resistant" BALB/c mouse lungs
    Philippe Bonniaud
    Departments of Medicine, Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 31:510-6. 2004
    ..CTGF should be considered as a novel drug target and as a potential marker for identifying individuals at risk...
  10. ncbi request reprint TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis
    Philippe Bonniaud
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 175:5390-5. 2005
    ..KO and WT animals demonstrated a similar inflammatory response to overexpression of IL-1beta indicating that inflammation must link to the Smad3 pathway, likely through TGF-beta, to induce progressive fibrosis...
  11. ncbi request reprint Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis
    Philippe Bonniaud
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Canada
    J Immunol 173:2099-108. 2004
    ..The Smad3 pathway is involved in pathogenic mechanisms mediating tissue destruction (lack of repair) and fibrogenesis (excessive repair)...
  12. ncbi request reprint Epithelial expression of profibrotic mediators in a model of allergen-induced airway remodeling
    Margaret M Kelly
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, MDCL 4017, McMaster University, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Am J Respir Cell Mol Biol 32:99-107. 2005
    ..These data suggest that transforming growth factor-beta1 and other profibrotic mediators produced by airway wall, and specifically, airway epithelium, play an important role in the pathophysiology of airway remodeling...
  13. ncbi request reprint Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains
    Martin Kolb
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 27:141-50. 2002
    ....
  14. doi request reprint Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice
    Laszlo Farkas
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 301:L391-401. 2011
    ....
  15. doi request reprint Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats
    Jennifer V Robertson
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Invest Ophthalmol Vis Sci 51:308-18. 2010
    ..Gene transfer of TGF-beta can, therefore, be used to induce anatomic changes in the anterior segment in a rodent model that result in ocular hypertension...
  16. pmc Immunization with a bivalent adenovirus-vectored tuberculosis vaccine provides markedly improved protection over its monovalent counterpart against pulmonary tuberculosis
    Jingyu Mu
    Centre for Gene Therapeutics, M G DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Mol Ther 17:1093-100. 2009
    ..Our results indicate a unique advantage of multivalent viral-vectored TB vaccines for immunization against pulmonary TB...
  17. pmc Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum
    Peter J Margetts
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 160:2285-94. 2002
    ..IL-1 beta exposure, however, led to a different response with sustained vascularization and fibrosis. IL-1 beta inhibition may be a therapeutic goal in acute peritonitis to prevent peritoneal damage...
  18. pmc Adenoviral gene transfer of bioactive TGFbeta1 to the rodent eye as a novel model for anterior subcapsular cataract
    Jennifer V Robertson
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, ON, Canada
    Mol Vis 13:457-69. 2007
    ..Establishment of this model will be important for further investigations of TGFbeta-induced signaling cascades in ASC...
  19. pmc Comparison between conventional and "clinical" assessment of experimental lung fibrosis
    Kjetil Ask
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Transl Med 6:16. 2008
    ..We used a model of experimental PF in rats and compare parameters obtained in living animals with conventional assessment tools that require removal of the lungs...
  20. ncbi request reprint Enhanced antitumor immunity elicited by dendritic cell vaccines is a result of their ability to engage both CTL and IFN gamma-producing NK cells
    Khalil Karimi
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Mol Ther 16:411-8. 2008
    ....
  21. pmc VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats
    Laszlo Farkas
    Department of Medicine, McMaster University, Firestone Institute for Respiratory Health and St Joseph s Healthcare, Hamilton, Ontario, Canada
    J Clin Invest 119:1298-311. 2009
    ..As administration of VEGF ameliorated the PH in this model but concomitantly aggravated the fibrogenic process, VEGF-based therapies should be used with caution...
  22. pmc Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs
    Laszlo Farkas
    Departments of Medicine, Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 44:870-8. 2011
    ..Increased Gremlin expression in human IPF tissue may be an expression of continuing epithelial injury, and Gremlin may be part of activated repair mechanisms...
  23. pmc Influence of the tissue microenvironment on Toll-like receptor expression by CD11c+ antigen-presenting cells isolated from mucosal tissues
    Shunsuke Takenaka
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Vaccine Immunol 16:1615-23. 2009
    ..Thus, unique tissue microenvironments have a significant influence on determining TLR expression by CD11c+ cells that migrate to and reside in each mucosal tissue and are likely to modulate their functional activities...
  24. ncbi request reprint Mucosally delivered dendritic cells activate T cells independently of IL-12 and endogenous APCs
    Sarah McCormick
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, and M G DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
    J Immunol 181:2356-67. 2008
    ..Our observations indicate that mucosal delivery of vaccine DCs represents an effective approach to enhance mucosal T cell immunity, which may operate independent of vaccine IL-12 and endogenous DCs...
  25. doi request reprint Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma
    Margaret M Kelly
    Firestone Institute for Respiratory Health, Department of Medicine, St Joseph s Healthcare and McMaster University Medical Center, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Allergy Clin Immunol 125:349-356.e13. 2010
    ..However, there are limited data as to whether these beneficial effects are due to enhanced anti-inflammatory actions or whether such combination therapies affect airway remodeling in patients with asthma...
  26. doi request reprint Fibrocytes in chronic lung disease--facts and controversies
    Shyam S Maharaj
    McMaster University, Departments of Medicine, Pathology and Molecular Medicine, Canada
    Pulm Pharmacol Ther 25:263-7. 2012
    ..This review will briefly summarize the current knowledge about fibrocytes in human lung disease and in animal disease models and highlight areas of consensus as well as issues that remain controversial to date...
  27. pmc Negative regulation of lung inflammation and immunopathology by TNF-α during acute influenza infection
    Daniela Damjanovic
    Department of Pathology and Molecular Medicine and McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 179:2963-76. 2011
    ..Thus, TNF-α is dispensable for influenza clearance; however, different from the traditional belief, this cytokine is critically required for negatively regulating the extent of lung immunopathology during acute influenza infection...
  28. pmc Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis
    Cory M Yamashita
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Am J Pathol 179:1733-45. 2011
    ..These observations support a novel role for MMP-3 in the pathogenesis of IPF, through activation of β-catenin signaling and induction of epithelial-mesenchymal transition...
  29. ncbi request reprint Critical negative regulation of type 1 T cell immunity and immunopathology by signaling adaptor DAP12 during intracellular infection
    Maziar Divangahi
    Infectious Diseases Division, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 179:4015-26. 2007
    ..Our study thus identifies DAP12 as an important novel immune regulatory molecule that acts, via APC, to control the level of antimicrobial type 1 T cell activation and immunopathology...
  30. ncbi request reprint Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL
    Lea Luketic
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 179:5024-32. 2007
    ..Furthermore, our study reinforces the application of exosomes as a vaccination platform and suggests that exosome-based vaccines may be advantageous for booster immunizations due to their resistance to CTL...
  31. ncbi request reprint Targeting genes for treatment in idiopathic pulmonary fibrosis: challenges and opportunities, promises and pitfalls
    Kjetil Ask
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Proc Am Thorac Soc 3:389-93. 2006
    ..Regardless, gene targeted therapy has numerous pitfalls that have to be addressed before we see a real therapeutic advance...
  32. doi request reprint Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis
    Antje Moeller
    Department of Medicine, McMaster University, and Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, ON, L8N 4A6 Canada
    Am J Respir Crit Care Med 179:588-94. 2009
    ..Fibrocytes are circulating mesenchymal cell progenitors that are involved in tissue repair and fibrosis...
  33. doi request reprint Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling
    Ramzi Fattouh
    Department of Pathology and Molecular Medicine, Head, Division of Respiratory Diseases and Allergy, MDCL 4013, McMaster University, 1200 Main Street West, Hamilton, ON, Canada
    Am J Respir Crit Care Med 177:593-603. 2008
    ..Transforming growth factor (TGF)-beta is a powerful regulator of both the tissue repair and inflammatory responses, and numerous experimental and clinical studies suggest that it may play an integral role in the pathogenesis of asthma...
  34. ncbi request reprint Gene therapy for pulmonary diseases
    Martin Kolb
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St W, Hamilton, ON, Canada L8N 3Z5
    Chest 130:879-84. 2006
    ..This review summarizes the recent advances in the development of more efficient gene transfer systems and highlights areas of clinical application of gene therapy...
  35. pmc Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3
    Kjetil Ask
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Int J Biochem Cell Biol 40:484-95. 2008
    ..TGF-beta3 is important in "normal wound healing", but is outbalanced by TGF-beta1 in "fibrotic wound healing" in the lung...
  36. ncbi request reprint Cell-based cancer gene therapy: breaking tolerance or inducing autoimmunity?
    Juan Carlos Rodriguez-Lecompte
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Anim Health Res Rev 5:227-34. 2004
    ..The viability and feasibility of expansion of canine dendritic cells from bone marrow and peripheral blood ex vivo for the treatment of spontaneous cancers in dogs is also discussed...
  37. doi request reprint Have advanced research technologies made real impact on respiratory medicine?
    Kjetil Ask
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, McMaster University, Hamilton, Ontario, Canada
    Respirology 15:876-80. 2010
    ....
  38. ncbi request reprint Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor
    Philippe Bonniaud
    Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Room 2N16, Hamilton, ON, Canada
    Am J Respir Crit Care Med 171:889-98. 2005
    ..These data show promise of the development of an effective therapeutic intervention for IPF and that inhibition of chronic progressive fibrosis may be achieved by blocking TGF-beta receptor activation...
  39. ncbi request reprint Cell-specific gene expression in patients with usual interstitial pneumonia
    Margaret M Kelly
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Am J Respir Crit Care Med 174:557-65. 2006
    ..Usual interstitial pneumonia (UIP) is characterized by extracellular matrix deposition and the development of pulmonary fibrosis. Fibroblastic foci found in the lung are believed to represent an early stage in the evolution of this disease...
  40. pmc Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3
    Alice Banh
    School of Optometry, University of Waterloo, Ontario, Canada
    Invest Ophthalmol Vis Sci 47:3450-60. 2006
    ..In this study, the role of Smad3 in anterior subcapsular cataract (ASC) formation was investigated in a transgenic TGF-beta/Smad3 knockout mouse model...
  41. ncbi request reprint Re-evaluation of fibrogenic cytokines in lung fibrosis
    Margaret Kelly
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Canada
    Curr Pharm Des 9:39-49. 2003
    ..A growth factor 'downstream' from the pro-fibrotic effects of TGF-beta, CTGF, is a likely critical mediator. However, over-expression of CTGF produces only mild and reversible fibrosis...
  42. pmc Therapeutic effect of angiostatin gene transfer in a murine model of endometriosis
    Charlotta Dabrosin
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 161:909-18. 2002
    ..However, local or targeted delivery of the gene must be considered to avoid prolonged systemic effects and impaired ovarian function...
  43. pmc The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
    Antje Moeller
    Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada
    Int J Biochem Cell Biol 40:362-82. 2008
    ..The use of alternative and more robust animal models, which better reflect human IPF, is warranted...
  44. ncbi request reprint Generation of in vitro B-CLL specific HLA class I restricted CTL responses using autologous dendritic cells pulsed with necrotic tumor lysate
    Kalathil Suresh
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5
    Leuk Lymphoma 47:297-306. 2006
    ..The specificity of the CTL response was confirmed by blocking HLA class I molecules and cold target inhibition assays...
  45. ncbi request reprint Eosinophilia is induced in the colon of Th2-sensitized mice upon exposure to locally expressed antigen
    Qing Zhu
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 293:G383-90. 2007
    ..Thus the model established here may provide a useful tool to study GI and, in particular, colonic inflammation with respect to underlying mechanisms involved in the recruitment and the immediate function of eosinophils...
  46. doi request reprint Pulmonary hypertension and idiopathic pulmonary fibrosis: a tale of angiogenesis, apoptosis, and growth factors
    Laszlo Farkas
    Departments of Medicine, Pathology and Molecular Medicine, McMaster University, Firestone Institute for Respiratory Health, 50 Charlton Avenue East, Room T2121, Hamilton, ON L8N 4A6, Canada
    Am J Respir Cell Mol Biol 45:1-15. 2011
    ..This report summarizes currently available therapeutic options, and also translates experimental research to discuss potential novel biomarkers and therapeutic strategies derived from new concepts in pathogenesis...
  47. ncbi request reprint Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung
    M Kolb
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, 1200 Main St, West Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol Lung Cell Mol Physiol 280:L1327-34. 2001
    ....
  48. pmc Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia
    J Wang
    Immunology and Infection Program, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Clin Invest 102:1132-41. 1998
    ..These findings also provide the rationale for developing strategies to target circulating IL-5 and/or its receptors in bone marrow to effectively control asthmatic airways eosinophilia...
  49. ncbi request reprint Budesonide enhances repeated gene transfer and expression in the lung with adenoviral vectors
    M Kolb
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 164:866-72. 2001
    ..001, serum p = 0.04). We conclude that budesonide can be valuable in gene therapy of the lung where repeated transient gene transfer is necessary...
  50. ncbi request reprint Montelukast treatment attenuates the increase in myofibroblasts following low-dose allergen challenge
    Margaret M Kelly
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 130:741-53. 2006
    ..In the present study, we evaluated the effect of montelukast on airway myofibroblasts following low-dose allergen challenge (LDAC)...
  51. ncbi request reprint Dendritic cells derived from murine colonic mucosa have unique functional and phenotypic characteristics
    Shunsuke Takenaka
    Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    J Immunol 178:7984-93. 2007
    ..We speculate that colonic DCs have unique reactivities differing from DCs residing in other lymphoid tissues and are adapted for the unique microenvironment of the colonic mucosa and that these cells react uniquely to their environment...
  52. ncbi request reprint The human SCGB2A2 (mammaglobin-1) promoter/enhancer in a helper-dependent adenovirus vector directs high levels of transgene expression in mammary carcinoma cells but not in normal nonmammary cells
    Chang Xin Shi
    Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
    Mol Ther 10:758-67. 2004
    ..We suggest that the SCGB2A2 promoter/enhancer should be particularly advantageous for gene therapy protocols involving oncolytic viruses or toxic gene transfer via adenovectors to mammary tumors...
  53. pmc Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1
    Y Motomura
    Intestinal Diseases Research Programme, McMaster University, Hamilton, Ontario, Canada
    Gut 55:662-70. 2006
    ..We investigated the fibrotic potential of MCP-1 in the gut by overexpressing this chemokine in the mouse colorectal wall...
  54. ncbi request reprint Proinflammatory properties of IL-4 in the intestinal microenvironment
    C Van Kampen
    Intestinal Disease Research Program, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 288:G111-7. 2005
    ....
  55. pmc Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis
    M Kolb
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 107:1529-36. 2001
    ..IL-1beta should be considered a valid target for therapeutic intervention in diseases associated with fibrosis and tissue remodeling...
  56. ncbi request reprint Bone marrow-derived dendritic cell vaccination of dogs with naturally occurring melanoma by using human gp100 antigen
    Steve Gyorffy
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Vet Intern Med 19:56-63. 2005
    ..However, another dog, which was CTL negative, relapsed 22 months after vaccination. Ex vivo DC expansion is feasible for immunotherapy of spontaneous cancers in outbred dogs...
  57. pmc IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
    Z Xing
    Immunology and Infection Program, Department of Pathology, McMaster University, Hamilton, Ontario, L8N 3Z5 Canada
    J Clin Invest 101:311-20. 1998
    ....
  58. ncbi request reprint Cytokines and pulmonary inflammatory and immune diseases
    Z Xing
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Histol Histopathol 14:185-201. 1999
    ....
  59. ncbi request reprint Adenoviral-mediated gene transfer of interleukin-6 in rat lung enhances antiviral immunoglobulin A and G responses in distinct tissue compartments
    Z Xing
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    Biochem Biophys Res Commun 258:332-5. 1999
    ....
  60. ncbi request reprint A randomized controlled trial on the effect of inhaled corticosteroids on airways inflammation in adult cigarette smokers
    G Cox
    Firestone Regional Chest and Allergy Unit, St Joseph s Hospital, Hamilton, Ontario, Canada
    Chest 115:1271-7. 1999
    ..To determine whether inhaled corticosteroid treatment can reduce airways inflammation in adult cigarette smokers...
  61. ncbi request reprint Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin
    M Kolb
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 163:770-7. 2001
    ..05 microg/mg; p = 0.0005). These results suggest that a single administration of AdDec was able to generate a local pulmonary environment that effectively blocked the fibrogenic response to bleomycin by inhibition of TGF-beta...
  62. ncbi request reprint Gene vectors for cytokine expression in vivo
    M M Hitt
    McMaster University, Department of Pathology and Molecular Medicine, HSC 4H30C, Hamilton, Ontario, L8N 3Z5, Canada
    Curr Pharm Des 6:613-32. 2000
    ..The implementations of cytokine-encoding gene therapy vectors for analyzing immune responses and for the therapy of inflammatory disorders, immune disease, infections and cancer are reviewed...
  63. ncbi request reprint The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-beta type II receptor gene transfer
    Y Motomura
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 288:G143-50. 2005
    ..These observations indicate that sFlt-1 gene transfer might be of therapeutic benefit in peritoneal fibrosis...
  64. ncbi request reprint Recent advances in immunotherapy of B-CLL using ex vivo modified dendritic cells
    Kalathil Suresh
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ont, Canada, L8N 3Z5 2
    Hematology 10:189-203. 2005
    ..After a brief survey of general properties of DCs, this review focuses on the different approaches exploiting monocyte-derived DCs in CLL, which may help to design novel strategies for phase-I clinical trials...
  65. pmc Adenoviral vector expressing murine angiostatin inhibits a model of breast cancer metastatic growth in the lungs of mice
    S Gyorffy
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 159:1137-47. 2001
    ..This study has demonstrated that the specific targeting of tumors to inhibit angiogenesis using an adenovirus expressing angiostatin, may deliver localized concentrations of protein having a greater impact on inhibition of tumor growth...
  66. ncbi request reprint Effects of adenoviral-mediated gene transfer of interleukin-10, interleukin-4, and transforming growth factor-beta on the survival of axotomized retinal ganglion cells
    P D Koeberle
    Department of Pathology and Molecular Medicine, McMaster University, Anatomy, HSC 1R1, 1200 Main Street West, Hamilton, Canada
    Neuroscience 125:903-20. 2004
    ..Our results suggest that interleukin-10 and interleukin-4 may help prevent neurodegeneration caused by the activation of glial cells after CNS injury...
  67. doi request reprint A human type 5 adenovirus-based tuberculosis vaccine induces robust T cell responses in humans despite preexisting anti-adenovirus immunity
    Fiona Smaill
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Sci Transl Med 5:205ra134. 2013
    ..It also suggests that the widely perceived negative effect of preexisting anti-AdHu5 immunity may not be universally applied to all AdHu5-based vaccines against different types of human pathogens. ..
  68. doi request reprint New treatment and markers of prognosis for idiopathic pulmonary fibrosis: lessons learned from translational research
    Eva Baroke
    Department of Medicine, McMaster University, ON, Canada, L8S4L8 and Department of Pathology and Molecular Medicine, McMaster University, Ontario ON, Canada, L8S4L8
    Expert Rev Respir Med 7:465-78. 2013
    ..This review provides an up to date summary of the most relevant clinical trials, novel therapeutic drug targets and outlines a spectrum of potential prognostic biomarkers for IPF. ..
  69. ncbi request reprint Estradiol promotes growth and angiogenesis in polyoma middle T transgenic mouse mammary tumor explants
    Charlotta Dabrosin
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Breast Cancer Res Treat 78:1-6. 2003
    ..This immune-competent animal model offers the opportunity to study molecular events in estrogen dependent breast cancer...
  70. ncbi request reprint Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation
    Richard Leigh
    Firestone Institute for Respiratory Health, Department of Medicine and Center for Gene Therapeutics, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 27:526-35. 2002
    ....
  71. ncbi request reprint TGF-beta effects on epithelial ion transport and barrier: reduced Cl- secretion blocked by a p38 MAPK inhibitor
    Kathryn Howe
    Intestinal Disease Research Program, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol Cell Physiol 283:C1667-74. 2002
    ....
  72. doi request reprint Cytokine elevations in acute coronary syndrome and ovarian cancer: a mechanism for the up-regulation of the acute phase proteins in these different disease etiologies
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Clin Biochem 41:607-10. 2008
    ..To identify if a common set of cytokines is elevated in both ovarian cancer and acute coronary syndrome (ACS)...
  73. ncbi request reprint Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity
    K Palmer
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    Gene Ther 8:282-90. 2001
    ..These results suggest augmenting the antitumor immune response and inhibiting tumor angiogenesis with adenoviral vectors expressing IP-10 in combination with IL-12 is a novel way to enhance tumor regression...
  74. ncbi request reprint A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice
    V A Wallace
    Amgen Institute, Department of Immunology, University of Toronto, Ontario, Canada
    Eur J Immunol 24:1463-6. 1994
    ..These data show that only some of the pathological effects of the Tsk mutation are T cell dependent and that different T cell subsets affect different parameters in this multi-organ model of fibrotic disease...
  75. pmc Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease
    C M Hogaboam
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 100:2766-76. 1997
    ..Thus, IL-4, introduced by Ad5, is therapeutic during acute inflammation in the rat colon. The therapeutic effect of IL-4 was associated with an inhibition of inducible nitric oxide expression and a reduction in nitric oxide synthesis...
  76. doi request reprint Immunization with adenovirus at the large intestinal mucosa as an effective vaccination strategy against sexually transmitted viral infection
    Q Zhu
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Mucosal Immunol 1:78-88. 2008
    ..Therefore, large intestine mucosal immunization using Ad represents an effective vaccination strategy against virus infection at both rectal and vaginal mucosal tissue sites...
  77. pmc Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells
    J Gauldie
    Department of Pathology, McMaster University, Hamilton, ON, Canada
    Proc Natl Acad Sci U S A 84:7251-5. 1987
    ....
  78. ncbi request reprint Disruption of CD40-CD40 ligand pathway inhibits the development of intestinal muscle hypercontractility and protective immunity in nematode infection
    W I Khan
    Intestinal Disease Research Program, Department of Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 288:G15-22. 2005
    ..The present data suggest that the early events leading to the generation of Th2 response include CD40-CD40 ligand interaction, which subsequently influences the production of Th2 cytokines, most likely via upregulation of MCP-1...
  79. ncbi request reprint A chronic inflammatory infusion model of peritoneal dialysis in rats
    P J Margetts
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Perit Dial Int 21:S368-72. 2001
    ..The present animal model mimics changes seen in humans on peritoneal dialysis and may be valuable for evaluating short-term interventions to prevent membrane damage...
  80. ncbi request reprint Behavioral effects of infection with IL-6 adenovector
    B Sakic
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Brain Behav Immun 15:25-42. 2001
    ..The inability of circulating IL-6 to alter other aspects of behavior supports the hypothesis that multiple immuno-neuroendocrine mechanisms contribute to the pathogenesis of AABS...
  81. ncbi request reprint Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function
    P J Margetts
    Division of Nephrology, McMaster University, 1200 Main Street W, Hamilton, Ontario, Canada L8N 3Z5
    J Am Soc Nephrol 12:2029-39. 2001
    ..This model should allow further delineation of the relative contributions of profibrotic and angiogenic cytokines to changes in peritoneal function and may lead to potential new interventions for peritoneal membrane failure...
  82. ncbi request reprint Intratumoral administration of an adenovirus expressing a kinase dead form of ErbB-2 inhibits tumor growth
    K Palmer
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Gene Ther 9:898-905. 2002
    ..The results suggest both immune and non-immune mechanisms contribute to the antitumor efficacy of this vector...
  83. doi request reprint Extracellular matrix microenvironment contributes actively to pulmonary fibrosis
    Chiko Shimbori
    Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, Hamilton, Ontario, Canada
    Curr Opin Pulm Med 19:446-52. 2013
    ..The purpose of this review is to describe the contribution of an altered, profibrotic extracellular matrix (ECM) microenvironment to pulmonary fibrosis and how it changes cell behaviour and actively drives disease progression...
  84. ncbi request reprint Antiangiogenic and antifibrotic gene therapy in a chronic infusion model of peritoneal dialysis in rats
    Peter J Margetts
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine and Division of Nephrology, McMaster University, Hamilton, Canada
    J Am Soc Nephrol 13:721-8. 2002
    ..Improvement in the function of the peritoneum as a dialysis membrane after treatment with angiostatin has implications for treatment of peritoneal membrane dysfunction seen in patients on long-term dialysis...
  85. ncbi request reprint IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice
    W I Khan
    Intestinal Disease Research Program, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 281:G102-10. 2001
    ..These findings strongly indicate that worm expulsion, muscle hypercontractility, and goblet cell hyperplasia share a common immunologic basis and may be causally linked...
  86. ncbi request reprint Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12
    Y Chen
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Gene Ther 8:316-23. 2001
    ..These studies support DC vaccines as a therapeutic strategy for human breast cancer, while emphasizing the importance of optimizing an immune response by combining tumor antigen presentation with immunostimulatory cytokines...
  87. pmc Oestradiol enhances tumour regression induced by B7-1/IL-2 adenoviral gene transfer in a murine model of breast cancer
    C Dabrosin
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Br J Cancer 89:385-90. 2003
    ..This may be one mechanism explaining the higher response rate of tumours in oestradiol-replenished mice...
  88. ncbi request reprint Three-dimensional computed tomography imaging in an animal model of emphysema
    A R Froese
    Dept of Pathology and Molecular Medicine, McMaster University, Hamilton L8N 4A6, ON, Canada
    Eur Respir J 30:1082-9. 2007
    ..It adds significant information to conventional assessment...
  89. ncbi request reprint Combined treatment of a murine breast cancer model with type 5 adenovirus vectors expressing murine angiostatin and IL-12: a role for combined anti-angiogenesis and immunotherapy
    S Gyorffy
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 166:6212-7. 2001
    ..The rationale for this therapy is to limit the tumor size by attacking the vasculature with angiostatin, thereby allowing IL-12 to mount a T cell-specific response against the tumor AG:..
  90. ncbi request reprint Adenovector engineered interleukin-2 expressing autologous plasma cell vaccination after high-dose chemotherapy for multiple myeloma--a phase 1 study
    S Trudel
    Division of Hematology-Oncology, The Princess Margaret Hospital, Toronto, Ontario, Canada
    Leukemia 15:846-54. 2001
    ..These results demonstrate that the generation of adenovector modified plasma cell vaccines is technically feasible and can be safely administered post-transplant. Further studies of immunlogic and clinical efficacy are required...
  91. ncbi request reprint Pro: Inflammatory mechanisms are a minor component of the pathogenesis of idiopathic pulmonary fibrosis
    Jack Gauldie
    Am J Respir Crit Care Med 165:1205-6. 2002
  92. ncbi request reprint Life-long systemic protection in mice vaccinated with L. major and adenovirus IL-12 vector requires active infection, macrophages and intact lymph nodes
    Claudia Raja Gabaglia
    Division of Immune Regulation, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Vaccine 23:247-57. 2004
    ..These results have important implications for vaccine design against leishmanial and mycobacterial infections and diseases caused by intracellular pathogens...
  93. ncbi request reprint IL-4 gene transfer to the small bowel serosa leads to intestinal inflammation and smooth muscle hyperresponsiveness
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, ACB, Rm K4 188, 4480 Oak St, Vancouver, BC, Canada V6H 3V4
    Am J Physiol Gastrointest Liver Physiol 292:G385-94. 2007
    ..These results highlight an important causal role for IL-4 in the pathological regulation of enteric smooth muscle function and identify a novel strategy for gene transfer to the intestine...
  94. ncbi request reprint Overexpression of tumor necrosis factor-alpha diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-beta
    Masaki Fujita
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 29:669-76. 2003
    ..Endogenous TNF-alpha may be important in the development of fibrosis as indicated in other reports, but overexpression of TNF-alpha or exogenous TNF-alpha limits pulmonary fibrosis in mice...
  95. pmc Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile
    Haitao Wen
    Department of Pathology, University of Michigan Medical School, M5214 Med Sci I, 1301 Catherine St, Ann Arbor, MI 48109 0602, USA
    Am J Pathol 168:1940-50. 2006
    ..Our data indicate that severe sepsis shifts the pulmonary cytokine environment, presumably via effects on pulmonary dendritic cells, which in turn alters the lung cell-mediated immune response...
  96. ncbi request reprint TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada
    Am J Physiol Gastrointest Liver Physiol 289:G116-28. 2005
    ..Through adenoviral gene transfer technology, we describe a novel mouse model of colitis and implicate TGF-beta1 in the pathogenesis of obstructive intestinal fibrosis...
  97. ncbi request reprint Pulmonary fibrosis: searching for model answers
    Felix Chua
    Centre for Respiratory Research, Royal Free and University College London School of Medicine, London, UK
    Am J Respir Cell Mol Biol 33:9-13. 2005
    ..A brief review of the exacting requirements of such research will place the strengths of this particular model in perspective...
  98. ncbi request reprint Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin
    Charles C Reed
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, PA 19107, USA
    Oncogene 21:3688-95. 2002
    ..Thus, decorin gene therapy helps in retarding the growth of human tumors in immunocompromised animals and could represent a new independent or adjunctive therapeutic modality against cancer...
  99. ncbi request reprint Adenoviral-mediated gene transfer of lymphotactin to the lungs of mice and rats results in infiltration and direct accumulation of CD4+, CD8+, and NK cells
    Peter C R Emtage
    Division of Hematology Oncology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Interferon Cytokine Res 22:573-82. 2002
    ..These findings extend the previous in vitro findings on the activity of lymphotactin and provide a model for studying the local effects of overexpressing chemokines in various tissues in vivo...
  100. ncbi request reprint TGF-beta1 induces progressive pleural scarring and subpleural fibrosis
    Nathalie Decologne
    Faculty of Medicine and Pharmacy, Institut National de la Sante et de la Recherche Medicale INSERM, Unité Mixte de Recherche UMR 866, Dijon, France
    J Immunol 179:6043-51. 2007
    ..This new model of pleural fibrosis will allow us to better understand the mechanisms of progressive fibrogenesis, and to explore novel antifibrotic therapies in the pleural cavity...
  101. ncbi request reprint Animal models of pulmonary fibrosis: how far from effective reality?
    Jack Gauldie
    Am J Physiol Lung Cell Mol Physiol 294:L151. 2008