M J Farquharson
Affiliation: McMaster University
- Zinc presence in invasive ductal carcinoma of the breast and its correlation with oestrogen receptor statusM J Farquharson
Department of Medical Physics and Applied Radiation Sciences, McMaster University, Ontario, Canada Department of Radiography, City Community and Health Sciences, City University, London, UK
Phys Med Biol 54:4213-23. 2009..When comparing the increase in zinc in the tumour regions expressed as a percentage of the surrounding non-tumour tissue zinc level in the same sample, a significant difference between the ER+ve and ER-ve samples was found (P < 0.01)...
- The distribution of trace elements Ca, Fe, Cu and Zn and the determination of copper oxidation state in breast tumour tissue using muSRXRF and muXANESM J Farquharson
Department of Radiography, City Community and Health Sciences, City University, London, EC1V 0HB, UK
Phys Med Biol 53:3023-37. 2008..However, the shape of the spectra does not exclude the presence of Cu+. Tumour regions were found to have a higher fraction of Cu+ compared to the normal samples...
- The evaluation of biologically important trace metals in liver, kidney and breast tissueA Al-Ebraheem
Department of Radiography, Institute of Community and Health Sciences, City University, Northampton Square, London EC1V 0HB, UK
Appl Radiat Isot 67:470-4. 2009..The distributions were compared to reference images and higher concentrations of metals correlated with areas of cancer cells. The average increase of Ca, Fe, Cu and Zn concentrations in areas of malignancy were 70%, 43%, 53% and 87%...
- X-ray fluorescence and energy dispersive x-ray diffraction for the quantification of elemental concentrations in breast tissueK Geraki
Department of Radiography, City University, Rutland Place, Charterhouse Square, London EC1M 6PA, UK
Phys Med Biol 49:99-110. 2004..The measurement precision was between 1% and 9% while the calculated uncertainties on the final elemental concentrations ranged between 10% and 16%...
- The localisation and micro-mapping of copper and other trace elements in breast tumours using a synchrotron micro-XRF systemM J Farquharson
Department of Radiography, School of Allied Health Sciences, City University, London EC1V 0HB, UK
Appl Radiat Isot 65:183-8. 2007..Correlation of these distributions with the concentrations of cancer cells was achieved in some samples...
- Human soft tissue analysis using x-ray or gamma-ray techniquesC Theodorakou
City Community and Health Sciences, City University, Northampton Sq, London, EC1V 0HB, UK
Phys Med Biol 53:R111-49. 2008..The soft tissues that have been classified using x-rays or gamma rays include brain, breast, colon, fat, kidney, liver, lung, muscle, prostate, skin, thyroid and uterus...
- Effect of sample preparation techniques on the concentrations and distributions of elements in biological tissues using µSRXRF: a comparative studyA Al-Ebraheem
Department of Medical Physics and Applied Radiation Sciences, McMaster University, 1280 Main St West, Hamilton, ON, Canada
Physiol Meas 36:N51-60. 2015..01). It can be concluded that studies involving Ca, Cu and Zn might show similar results using both sample preparation techniques, however studies involving Fe would need more special attention. ..
- Concentrations of Fe, Cu and Zn in breast tissue: a synchrotron XRF studyK Geraki
Department of Radiography, City University, London, UK
Phys Med Biol 47:2327-39. 2002..6 for the paired samples and 2.7 for the non-paired samples. The ratios describing copper content were 3.1 for paired and 3.6 for non-paired samples while for zinc they were 2.4 and 4.4 respectively...
- Influence of zinc and zinc chelator on HT-29 colorectal cell lineK S Gurusamy
University Department of Surgery, Royal Free Campus, UCL Medical School, London, UK
Biometals 24:143-51. 2011..HT-29 cells are not able to counteract the effect of intracellular chelation of zinc by altering zinc transport. Further research into the mechanisms of these findings is necessary and may lead to novel therapeutic options...