Margaret Fahnestock

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease
    Bernadeta Michalski
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ont, Canada L8N 3Z5
    Brain Res Mol Brain Res 111:148-54. 2003
  2. ncbi request reprint Neurotrophic activity of proNGF in vivo
    Holly Buttigieg
    Department of Biology, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    Exp Neurol 204:832-5. 2007
  3. pmc BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog
    Margaret Fahnestock
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON L8N 3Z5, Canada
    Neurobiol Aging 33:546-54. 2012
  4. ncbi request reprint The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor
    Margaret Fahnestock
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 89:581-92. 2004
  5. ncbi request reprint ProNGF: a neurotrophic or an apoptotic molecule?
    Margaret Fahnestock
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Prog Brain Res 146:101-10. 2004
  6. ncbi request reprint Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease
    Shiyong Peng
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 93:1412-21. 2005
  7. pmc Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease
    Shiyong Peng
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Neurosci 29:9321-9. 2009
  8. ncbi request reprint Differential actions of nerve growth factor receptors TrkA and p75NTR in a rat model of epileptogenesis
    Songlin Li
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
    Mol Cell Neurosci 29:162-72. 2005
  9. doi request reprint Electrical muscle stimulation after immediate nerve repair reduces muscle atrophy without affecting reinnervation
    Michael P Willand
    School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    Muscle Nerve 48:219-25. 2013
  10. pmc Sensory protection of rat muscle spindles following peripheral nerve injury and reinnervation
    Amal Elsohemy
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Plast Reconstr Surg 124:1860-8. 2009

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease
    Bernadeta Michalski
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ont, Canada L8N 3Z5
    Brain Res Mol Brain Res 111:148-54. 2003
    ..Although the biological activity of proBDNF is unknown, reduced proBDNF may have functional consequences for the selective neuronal degeneration in Alzheimer's disease brain...
  2. ncbi request reprint Neurotrophic activity of proNGF in vivo
    Holly Buttigieg
    Department of Biology, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    Exp Neurol 204:832-5. 2007
    ..Together with the robust axonal growth and lack of neuronal death in the ganglia in these animals, our results are clearly consistent with proNGF exhibiting neurotrophic activity in vivo...
  3. pmc BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog
    Margaret Fahnestock
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON L8N 3Z5, Canada
    Neurobiol Aging 33:546-54. 2012
    ..This is the first demonstration in a higher animal that nonpharmacological changes in lifestyle in advanced age can upregulate BDNF to levels approaching those in the young brain...
  4. ncbi request reprint The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor
    Margaret Fahnestock
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 89:581-92. 2004
    ..These data, coupled with our previous report that proNGF is the major form of NGF in the CNS, suggest that proNGF could be responsible for much of the biological activity normally attributed to mature NGF in vivo...
  5. ncbi request reprint ProNGF: a neurotrophic or an apoptotic molecule?
    Margaret Fahnestock
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Prog Brain Res 146:101-10. 2004
    ..This chapter will review the structure and processing of NGF and what is known about the biological activity of proNGF. Possible reasons for the discrepancies in recent reports are discussed...
  6. ncbi request reprint Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease
    Shiyong Peng
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 93:1412-21. 2005
    ....
  7. pmc Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease
    Shiyong Peng
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Neurosci 29:9321-9. 2009
    ..These findings also suggest that the effect of A beta on decreased BDNF expression is specific to the aggregation state of A beta and is dependent on large oligomers...
  8. ncbi request reprint Differential actions of nerve growth factor receptors TrkA and p75NTR in a rat model of epileptogenesis
    Songlin Li
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
    Mol Cell Neurosci 29:162-72. 2005
    ....
  9. doi request reprint Electrical muscle stimulation after immediate nerve repair reduces muscle atrophy without affecting reinnervation
    Michael P Willand
    School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    Muscle Nerve 48:219-25. 2013
    ..Electrical stimulation of denervated muscle has been shown to minimize atrophy and fibrosis and increase force in animal and human models. However, electrical stimulation after nerve repair is controversial due to questions of efficacy...
  10. pmc Sensory protection of rat muscle spindles following peripheral nerve injury and reinnervation
    Amal Elsohemy
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Plast Reconstr Surg 124:1860-8. 2009
    ..The purpose of this study was to determine whether temporary sensory innervation also protects muscle spindles from degeneration...
  11. pmc Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors
    Raheleh Masoudi
    Department of Biology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Biol Chem 284:18424-33. 2009
    ..We conclude that the relative level of proNGF receptors determines whether this precursor exhibits neurotrophic or apoptotic activity...
  12. ncbi request reprint NGF, BDNF, NT-3, and GDNF mRNA expression in rat skeletal muscle following denervation and sensory protection
    Chunnian Zhao
    Department of Psychiatry, McMaster University, Ontario, Canada
    J Neurotrauma 21:1468-78. 2004
    ..Our study suggests that sensory protection provides a modified trophic environment by modulating neurotrophic factor synthesis in muscle...
  13. pmc Altered balance of proteolytic isoforms of pro-brain-derived neurotrophic factor in autism
    Kristine L P Garcia
    Departments of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neuropathol Exp Neurol 71:289-97. 2012
    ..Thus, imbalance in proteolytic isoforms is a possible new mechanism for altered synaptic plasticity leading to autism...
  14. ncbi request reprint Differential expression of nerve growth factor transcripts in glia and neurons and their regulation by transforming growth factor-beta1
    Guanhua Yu
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Brain Res Mol Brain Res 105:115-25. 2002
    ..These results have implications for the use of mice versus rats as models for the study of NGF regulation following CNS injury...
  15. pmc Clinical application of sensory protection of denervated muscle
    James R Bain
    Department of Surgery, Division of Plastic Surgery, McMaster University, Hamilton, Ontario, Canada
    J Neurosurg 109:955-61. 2008
    ..The patient reported clinically significant functional improvements in activities of daily living. The authors hypothesize that the presence of a sensory nerve during muscle denervation can improve functional motor recovery...
  16. ncbi request reprint Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease
    Shiyong Peng
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neuropathol Exp Neurol 63:641-9. 2004
    ..These findings demonstrate that proNGF levels increase during the preclinical stage of AD and may reflect an early biological marker for the onset of AD...
  17. pmc Determining the effects of electrical stimulation on functional recovery of denervated rat gastrocnemius muscle using motor unit number estimation
    Michael P Willand
    School of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4K1, Canada
    Conf Proc IEEE Eng Med Biol Soc 2011:1977-80. 2011
    ..These results provide evidence that electrical stimulation prior to delayed nerve repair increases muscle receptivity to regenerating axons and may be a worthwhile treatment for peripheral nerve injuries...
  18. doi request reprint The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-β oligomer toxicity
    Valeriy G Ostapchenko
    Robarts Research Institute, Departments of Physiology and Pharmacology, Anatomy and Cell Biology, and Biochemistry, The University of Western Ontario, London, Ontario, Canada N6A 5K8, Department of Molecular and Cell Biology, International Research Center, A C Camargo Cancer Center and National Institute for Translational Neuroscience, Sao Paulo, Sao Paulo, Brazil, 01508 010, Chemistry Department and Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada L8S 4K1, Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil, 21941 590
    J Neurosci 33:16552-64. 2013
    ..Our findings reveal a previously unrecognized role of the PrP(C) ligand STI1 in protecting neurons in AD and suggest a novel pathway that may help to offset AβO-induced toxicity. ..
  19. ncbi request reprint Time-dependent effect of kainate-induced seizures on glutamate receptor GluR5, GluR6, and GluR7 mRNA and Protein Expression in rat hippocampus
    Gautam Ullal
    Department of Psychology, McMaster University, Hamilton, Ontario, Canada
    Epilepsia 46:616-23. 2005
    ..We studied the messenger ribonucleic acid (mRNA) and protein expression of GluR5, GluR6, and GluR7 in rat hippocampus 72 h, 90 days, and 180 days after KA-induced SE...
  20. doi request reprint Increased pro-nerve growth factor and decreased brain-derived neurotrophic factor in non-Alzheimer's disease tauopathies
    Jillian C Belrose
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Neurobiol Aging 35:926-33. 2014
    ..These findings implicate tau pathology in neurotrophin dysregulation, which may represent a mechanism through which tau confers toxicity in Alzheimer's disease and related non-Alzheimer's dementias. ..
  21. ncbi request reprint Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells
    Diego J Garzon
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Neurosci 27:2628-35. 2007
    ..Thus, oligomeric Abeta(1-42) could compromise neuronal function, causing memory loss and cognitive dysfunction by downregulation of BDNF in AD...
  22. ncbi request reprint Differential gene expression profiling of short and long term denervated muscle
    Jane Batt
    Clinical Sciences Division, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    FASEB J 20:115-7. 2006
    ..Understanding of the timing and type of pathological processes that are triggered by denervation may allow the design of interventions that delay or protect muscle from loss of nerve function...
  23. ncbi request reprint Glial cell line-derived neurotrophic factor modulates kindling and activation-induced sprouting in hippocampus of adult rats
    Songlin Li
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Exp Neurol 178:49-58. 2002
    ..Our results raise the possibility that glial cell line-derived neurotrophic factor plays a role in kindling and activation-induced neural growth via mechanisms distinct from those of the neurotrophins...
  24. ncbi request reprint A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex
    Diego Garzon
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 82:1058-64. 2002
    ..This could lead to specific down-regulation of the brain-derived neurotrophic factor transcripts shown here...
  25. ncbi request reprint Contribution of the distal nerve sheath to nerve and muscle preservation following denervation and sensory protection
    Karen Veltri
    Department of Medical Sciences, Division of Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Reconstr Microsurg 21:57-70; discussion 71-4. 2005
    ..The authors conclude that sensory protection of muscle does not require the distal nerve sheath, but that preservation of the distal sheath may contribute to enhanced nerve regeneration...
  26. ncbi request reprint Neural growth, neural damage and neurotrophins in the kindling model of epilepsy
    Ronald J Racine
    Department of Psychology, McMaster University, Hamilton, Ontario, Canada
    Adv Exp Med Biol 497:149-70. 2002
    ..Dr. Racine, one of the pioneers in the kindling field, describes the basic phenomena of kindling, and discusses the possible roles of cell growth and cell death in this model...
  27. ncbi request reprint Cholinotrophic molecular substrates of mild cognitive impairment in the elderly
    Elliott J Mufson
    Department of Neurological Sciences, Rush University Medical School, Chicago, IL 60612, USA
    Curr Alzheimer Res 4:340-50. 2007
    ..These findings support the concept that from a neurotrophic pathobiologic perspective, MCI is already early AD...
  28. pmc Proteasome inhibition by fellutamide B induces nerve growth factor synthesis
    John Hines
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Chem Biol 15:501-12. 2008
    ..These results demonstrate an unrecognized connection between proteasome inhibition and NGF production, suggesting a possible new strategy in the development of neurotrophic agents...