Research Topics
| J A DenburgSummaryAffiliation: McMaster University Country: Canada Publications
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Detail Information
Publications
Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthmaMarie Claire Rousseau
Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, QC, Canada
Allergy Asthma Clin Immunol 7:8. 2011..abstract:..- Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopyJudah A Denburg
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Pediatr Res 57:276-81. 2005..Dietary n-3 PUFA supplementation during pregnancy in atopic mothers alters infant cord blood hemopoietic progenitor phenotype. This may have an impact on development of atopic disease... - Eosinophil progenitors in airway diseases: clinical implicationsJudah A Denburg
Division of Clinical Immunology and Allergy, McMaster University, Hamilton, ON, Canada
Chest 134:1037-43. 2008.... - Regulation of IL-5 receptor on eosinophil progenitors in allergic inflammation: role of retinoic acidJ A Denburg
Department of Medicine, McMaster University, Hamilton, Ont, Canada
Int Arch Allergy Immunol 124:246-8. 2001..ATRA may be of therapeutic benefit in allergic inflammatory disorders in which eosinophil differentiation and membrane-bound IL-5R are upregulated... - Systemic aspects of chronic rhinosinusitisJudah A Denburg
Division of Clinical Immunology and Allergy, Department of Medicine, HSC 3V46, McMaster University, 120 Main Street West, Hamilton, ON, L8N 3Z5, Canada
Immunol Allergy Clin North Am 24:87-102. 2004 - Bone marrow contribution to eosinophilic inflammationJ A Denburg
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Mem Inst Oswaldo Cruz 92:33-5. 1997..The possibility that there is constitutive marrow upregulation of eosinophilopoiesis in allergic airways disease is also an area for future investigation... - Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in miceM D Inman
Asthma Research Group, McMaster University, Hamilton, Ontario, Canada
Am J Respir Cell Mol Biol 21:473-9. 1999..These findings support the use of this model to explore the mechanisms of increased eosinopoiesis observed in human asthma... - Bone marrow progenitors in allergic airways diseases: studies in canine and human modelsJ A Denburg
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Int Arch Allergy Immunol 113:181-3. 1997..Further studies to characterize the serum hematopoietic factor(s) and to determine the nature of any atopy-related progenitor profile are in progress... - Distinct phenotypic adhesion molecule expression on human cord blood progenitors during early Eosinophilic commitment: upregulation of beta(7) integrinsJ Lundahl
Department of Medicine, Division of Clinical Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden
Scand J Immunol 56:161-7. 2002..These data indicate a sequential alteration of disparate members of the integrin family during eosinophilic-basophilic differentiation, which may attribute to specific adhesion requirements at distinct stages of cell maturation... - Haemopoietic processes in allergic disease: eosinophil/basophil developmentG M Gauvreau
McMaster University, Hamilton, ON, Canada
Clin Exp Allergy 39:1297-306. 2009.... - Allergen-induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhinitisH Saito
Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada
Immunology 104:226-34. 2001..Understanding these events and their regulation could provide new therapeutic targets for rhinitis and asthma... - Haemopoietic mechanisms in murine allergic upper and lower airway inflammationJing Li
Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada
Immunology 114:386-96. 2005..These data support the concept that the systemic mechanisms linking rhinitis to asthma depend on the location and extent of airway allergen exposure... - Systemic aspects of allergic disease: the role of the bone marrowM M Cyr
Department of Medicine, HSC-3V46, McMaster University, 1200 Main Street West, Ontario L8N 3Z5, Hamilton, Canada
Curr Opin Immunol 13:727-32. 2001.... - Hemopoietic mechanisms in allergic airway inflammationJ A Denburg
Department of Medicine, McMaster University, Hamilton, Ont, Canada
Int Arch Allergy Immunol 117:155-9. 1998..Understanding the signalling between the tissue and the bone marrow at the molecular level may well open up new avenues of therapy for allergic inflammation... - Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthmaLorna J Wood
Asthma Research Group, Firestone Institute for Respiratory Health, St. Joseph's Hospital and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 166:883-9. 2002.... - Sputum CD34+IL-5Ralpha+ cells increase after allergen: evidence for in situ eosinophilopoiesisSandra C Dorman
Firestone Institute of Respiratory Health, Asthma Research Group, St. Joseph's Healthcare, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 169:573-7. 2004..These results indicate that eosinophil progenitors can migrate to the airways and may differentiate toward an eosinophilic phenotype... - Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiencyHiroko Saito
Asthma Research Group, Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Immunol 168:3017-23. 2002.... - Basophils and mast cells in airway inflammation and asthmaJ A Denburg
McMaster University, Hamilton, Canada
Can Respir J 5:41A-4A. 1998..The relative contributions of basophils, mast cells, eosinophils and T cells to the inflammatory process and production of proinflammatory and hemopoietic cytokines within inflamed airway tissues remain subjects of active investigation... - Hemopoietic progenitor cells and hemopoietic factors: potential targets for treatment of allergic inflammatory diseasesR Sehmi
Department of Medicine, HSC 3V46, McMaster University, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
Curr Drug Targets Inflamm Allergy 2:271-8. 2003..In addition, we will address the potential role that small molecular weight chemokine receptor antagonists may play in modulating progenitor cell trafficking to tissue sites of inflammation... - Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalationSandra C Dorman
Asthma Research Group, Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 169:565-72. 2004..We propose that after allergen inhalation, time-dependent changes in cytokine levels in the bone marrow control differentiation of eosinophil/basophil progenitors... - Cord blood hemopoietic progenitor profiles predict acute respiratory symptoms in infancyRochelle Fernandes
Division of Allergy and Clinical Immunology, McMaster University, Hamilton, ON, Canada
Pediatr Allergy Immunol 19:239-47. 2008..The elevation of IL-3/GM-CSF-responsive Eo/B progenitors in high-risk infants in relation to ARI outcomes suggests a mechanism for the increased severity of inflammatory responses in these subjects following viral infection... - Regulation of IL-5 and IL-5 receptor expression in the bone marrow of allergic asthmaticsJ A Denburg
Asthma Research Group, Division of Clinical Immunology and Allergy, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Int Arch Allergy Immunol 118:101-3. 1999.... - Behavioral effects of infection with IL-6 adenovectorB Sakic
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
Brain Behav Immun 15:25-42. 2001..The inability of circulating IL-6 to alter other aspects of behavior supports the hypothesis that multiple immuno-neuroendocrine mechanisms contribute to the pathogenesis of AABS... - Immunosuppression prevents neuronal atrophy in lupus-prone mice: evidence for brain damage induced by autoimmune disease?B Sakic
Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
J Neuroimmunol 111:93-101. 2000.... - Increased TUNEL staining in brains of autoimmune Fas-deficient miceB Sakic
Department of Psychiatry and Behavioural Neurosciences, McMaster University, HSC 4N77A, 1200 Main Street, Hamilton, Ontario, Canada
J Neuroimmunol 104:147-54. 2000.... - Progressive atrophy of pyramidal neuron dendrites in autoimmune MRL-lpr miceB Sakic
Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada
J Neuroimmunol 87:162-70. 1998..Reduced dendritic complexity may represent, at least in part, a structural basis for the altered behavioral profile of MRL-lpr mice... - Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunctionB Sakic
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
J Neuroimmunol 96:80-91. 1999..Furthermore, they support the parallel between chronic stress and chronic autoimmunity/inflammation, and suggest common central mechanisms relevant to endocrine function and behavior... - The effects of montelukast on tissue inflammatory and bone marrow responses in murine experimental allergic rhinitis: interaction with interleukin-5 deficiencyJohanna Roa
Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada
Immunology 122:438-44. 2007..The addition of cysLT1R blockade to IL-5 deficiency more fully attenuates symptoms and upper airway inflammation than either factor alone, providing evidence of systemic, BM mechanisms in allergic rhinitis... - Altered neurotransmission in brains of autoimmune mice: pharmacological and neurochemical evidenceBoris Sakic
The Brain Body Institute, McMaster University, Rm H305, Father Sean O Sullivan Research Center, St Joseph s Healthcare, 50 Charlton Avenue East, L8N 4A6, Hamilton, Ontario, Canada
J Neuroimmunol 129:84-96. 2002..These results are consistent with the hypothesis that imbalanced neurotransmitter regulation of the hypothalamus-pituitary axis plays an important role in the etiology of behavioral dysfunction induced by systemic autoimmune disease... - Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammationRoma Sehmi
Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Divisions of Clinical Immunology, McMaster University, Hamilton, Ontario, Canada
Immunology 109:536-46. 2003.... - Cognition and mood in systemic lupus erythematosus. Evaluation and pathogenesisS D Denburg
Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada
Ann N Y Acad Sci 823:44-59. 1997..Such studies could also lead to more specific therapeutic interventions to ameliorate or reverse brain compromise in SLE... - Anti-allergic therapies: effects on eosinophil progenitorsAdrian J Baatjes
Asthma Research Group, Department of Medicine, Division of Allergy and Clinical Immunology, HSC 3V46, Canada
Pharmacol Ther 95:63-72. 2002..Therefore, targeting the systemic hematopoietic response may provide additional, more beneficial, therapeutic effects... - Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitisHiroko Saito
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Immunology 113:246-52. 2004..The anti-allergic effects of cysLT1-R antagonists are consistent with the concept that cysLTs and IL-5 act together in the recruitment of eosinophils and eosinophil progenitors from the marrow during upper airway allergic inflammation... - Functional heterogeneity of mast cells isolated from different microenvironments within nasal polyp tissueS Finotto
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Clin Exp Immunol 95:343-50. 1994..The failure of release of epithelial mast cell mediators from an immunologic stimulus may have implications concerning acute effects of antigen exposure in nasal polyposis... - Cognitive dysfunction and antiphospholipid antibodies in systemic lupus erythematosusS D Denburg
McMaster University, Hamilton, ON, Canada
Lupus 12:883-90. 2003..To date, the most robust findings have emerged in relation to antiphospholipid antibodies, which carry with them important therapeutic implications... - Rapid response of circulating myeloid dendritic cells to inhaled allergen in asthmatic subjectsJ W Upham
Department of Medicine, University of Western Australia, Perth, Australia, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Clin Exp Allergy 32:818-23. 2002.... - Immunosuppressive treatment prevents behavioral deficit in autoimmune MRL-lpr miceB Sakic
Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Physiol Behav 58:797-802. 1995..The effect of cyclophosphamide in the MRL-lpr group is believed to reflect the suppression of pathogenic immune factor(s) that alter behavior during the onset of autoimmune disease... - The effect of desloratadine on eosinophil/basophil progenitors and other inflammatory markers in seasonal allergic rhinitis: a placebo-controlled randomized studyMichael M Cyr
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Int Arch Allergy Immunol 138:209-16. 2005..Eo/B CFU were not affected by varying in vitro concentrations of DL. Conclusion: These results suggest that DL can modulate aspects of allergic inflammation in vivo through mechanisms other than simple blockade of H1 histamine receptors... - Proliferating brain cells are a target of neurotoxic CSF in systemic autoimmune diseaseBoris Sakic
Department of Psychiatry and Behavioural Neurosciences, HSC Rm 4N81, McMaster University, 1200 Main St. West, Hamilton, Ontario, Canada L8N 3Z5
J Neuroimmunol 169:68-85. 2005..Antibody-mediated lesions of germinal layers may impair the regenerative capacity of the brain in NP-SLE and possibly, brain development and function in some forms of CNS disorders in which autoimmune phenomena have been documented... - Systemic lupus erythematosus presenting as subacute delirium in an 82-year-old womanG A Heckman
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Am Geriatr Soc 49:458-61. 2001..CONCLUSION: Neuropsychiatric symptoms can be prominent in older people, presenting features of SLE. This case illustrates the lowest dose of corticosteroids shown to be effective in an older patient with delirium due to SLE... - Spatial learning during the course of autoimmune disease in MRL miceB Sakic
Department of Biomedical Sciences, McMaster University, Hamilton, Ont, Canada
Behav Brain Res 54:57-66. 1993.... - The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjectsFausto Braccioni
Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph's Healthcare, and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Allergy Clin Immunol 110:96-101. 2002..The suppressive effect by montelukast demonstrates that this is a cysLT(1) receptor-mediated effect... - Ibuprofen fails to prevent brain pathology in a model of neuropsychiatric lupusDavid A Ballok
Department of Psychiatry and Behavioral Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
J Rheumatol 33:2199-213. 2006..Reduced brain mass, increased microglial activation, and condensation of cytoplasm point to a metabolic perturbation (e.g., excitotoxic damage) that compromises function and survival of central neurons during lupus-like disease... - Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cellsJohn W Upham
Department of Medicine, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 109:307-13. 2002..Currently, little is known concerning regulation of IL-5Ralpha expression in the context of commitment of hemopoietic progenitor cells to the eosinophil and basophil lineages...