J A Denburg

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc In vitro effects of budesonide on eosinophil-basophil lineage commitment
    Michael M Cyr
    Division of Clinical Immunology and Allergy, McMaster University, Hamilton, ON, Canada
    Open Respir Med J 2:60-6. 2008
  2. pmc Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma
    Marie Claire Rousseau
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, QC, Canada
    Allergy Asthma Clin Immunol 7:8. 2011
  3. ncbi request reprint Regulation of IL-5 receptor on eosinophil progenitors in allergic inflammation: role of retinoic acid
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    Int Arch Allergy Immunol 124:246-8. 2001
  4. doi request reprint Eosinophil progenitors in airway diseases: clinical implications
    Judah A Denburg
    Division of Clinical Immunology and Allergy, McMaster University, Hamilton, ON, Canada
    Chest 134:1037-43. 2008
  5. ncbi request reprint Systemic aspects of chronic rhinosinusitis
    Judah A Denburg
    Division of Clinical Immunology and Allergy, Department of Medicine, HSC 3V46, McMaster University, 120 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    Immunol Allergy Clin North Am 24:87-102. 2004
  6. ncbi request reprint Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopy
    Judah A Denburg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Pediatr Res 57:276-81. 2005
  7. ncbi request reprint Bone marrow contribution to eosinophilic inflammation
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Mem Inst Oswaldo Cruz 92:33-5. 1997
  8. ncbi request reprint Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice
    M D Inman
    Asthma Research Group, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 21:473-9. 1999
  9. ncbi request reprint Distinct phenotypic adhesion molecule expression on human cord blood progenitors during early Eosinophilic commitment: upregulation of beta(7) integrins
    J Lundahl
    Department of Medicine, Division of Clinical Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden
    Scand J Immunol 56:161-7. 2002
  10. ncbi request reprint Bone marrow progenitors in allergic airways diseases: studies in canine and human models
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Int Arch Allergy Immunol 113:181-3. 1997

Collaborators

Detail Information

Publications46

  1. pmc In vitro effects of budesonide on eosinophil-basophil lineage commitment
    Michael M Cyr
    Division of Clinical Immunology and Allergy, McMaster University, Hamilton, ON, Canada
    Open Respir Med J 2:60-6. 2008
    ..A potential transcriptional pathway has been identified which may mediate the effects of budesonide on eosinophil/basophil lineage commitment...
  2. pmc Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma
    Marie Claire Rousseau
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, QC, Canada
    Allergy Asthma Clin Immunol 7:8. 2011
    ..abstract:..
  3. ncbi request reprint Regulation of IL-5 receptor on eosinophil progenitors in allergic inflammation: role of retinoic acid
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    Int Arch Allergy Immunol 124:246-8. 2001
    ..ATRA may be of therapeutic benefit in allergic inflammatory disorders in which eosinophil differentiation and membrane-bound IL-5R are upregulated...
  4. doi request reprint Eosinophil progenitors in airway diseases: clinical implications
    Judah A Denburg
    Division of Clinical Immunology and Allergy, McMaster University, Hamilton, ON, Canada
    Chest 134:1037-43. 2008
    ....
  5. ncbi request reprint Systemic aspects of chronic rhinosinusitis
    Judah A Denburg
    Division of Clinical Immunology and Allergy, Department of Medicine, HSC 3V46, McMaster University, 120 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    Immunol Allergy Clin North Am 24:87-102. 2004
  6. ncbi request reprint Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopy
    Judah A Denburg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Pediatr Res 57:276-81. 2005
    ..Dietary n-3 PUFA supplementation during pregnancy in atopic mothers alters infant cord blood hemopoietic progenitor phenotype. This may have an impact on development of atopic disease...
  7. ncbi request reprint Bone marrow contribution to eosinophilic inflammation
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Mem Inst Oswaldo Cruz 92:33-5. 1997
    ..The possibility that there is constitutive marrow upregulation of eosinophilopoiesis in allergic airways disease is also an area for future investigation...
  8. ncbi request reprint Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice
    M D Inman
    Asthma Research Group, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 21:473-9. 1999
    ..These findings support the use of this model to explore the mechanisms of increased eosinopoiesis observed in human asthma...
  9. ncbi request reprint Distinct phenotypic adhesion molecule expression on human cord blood progenitors during early Eosinophilic commitment: upregulation of beta(7) integrins
    J Lundahl
    Department of Medicine, Division of Clinical Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden
    Scand J Immunol 56:161-7. 2002
    ..These data indicate a sequential alteration of disparate members of the integrin family during eosinophilic-basophilic differentiation, which may attribute to specific adhesion requirements at distinct stages of cell maturation...
  10. ncbi request reprint Bone marrow progenitors in allergic airways diseases: studies in canine and human models
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Int Arch Allergy Immunol 113:181-3. 1997
    ..Further studies to characterize the serum hematopoietic factor(s) and to determine the nature of any atopy-related progenitor profile are in progress...
  11. pmc Use of induced sputum cell counts to investigate airway inflammation in asthma
    I Pin
    Department of Medicine, St Joseph s Hospital, Hamilton, Ontario, Canada
    Thorax 47:25-9. 1992
    ..Less invasive methods of obtaining sputum from patients unable to produce it spontaneously should provide a useful investigational tool in asthma...
  12. pmc Allergen-induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhinitis
    H Saito
    Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada
    Immunology 104:226-34. 2001
    ..Understanding these events and their regulation could provide new therapeutic targets for rhinitis and asthma...
  13. doi request reprint Haemopoietic processes in allergic disease: eosinophil/basophil development
    G M Gauvreau
    McMaster University, Hamilton, ON, Canada
    Clin Exp Allergy 39:1297-306. 2009
    ....
  14. pmc Haemopoietic mechanisms in murine allergic upper and lower airway inflammation
    Jing Li
    Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada
    Immunology 114:386-96. 2005
    ..These data support the concept that the systemic mechanisms linking rhinitis to asthma depend on the location and extent of airway allergen exposure...
  15. ncbi request reprint Hemopoietic mechanisms in allergic airway inflammation
    J A Denburg
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    Int Arch Allergy Immunol 117:155-9. 1998
    ..Understanding the signalling between the tissue and the bone marrow at the molecular level may well open up new avenues of therapy for allergic inflammation...
  16. ncbi request reprint Systemic aspects of allergic disease: the role of the bone marrow
    M M Cyr
    Department of Medicine, HSC-3V46, McMaster University, 1200 Main Street West, Ontario L8N 3Z5, Hamilton, Canada
    Curr Opin Immunol 13:727-32. 2001
    ....
  17. ncbi request reprint Sputum CD34+IL-5Ralpha+ cells increase after allergen: evidence for in situ eosinophilopoiesis
    Sandra C Dorman
    Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:573-7. 2004
    ..These results indicate that eosinophil progenitors can migrate to the airways and may differentiate toward an eosinophilic phenotype...
  18. ncbi request reprint Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthma
    Lorna J Wood
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 166:883-9. 2002
    ....
  19. ncbi request reprint Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency
    Hiroko Saito
    Asthma Research Group, Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 168:3017-23. 2002
    ....
  20. ncbi request reprint Basophils and mast cells in airway inflammation and asthma
    J A Denburg
    McMaster University, Hamilton, Canada
    Can Respir J 5:41A-4A. 1998
    ..The relative contributions of basophils, mast cells, eosinophils and T cells to the inflammatory process and production of proinflammatory and hemopoietic cytokines within inflamed airway tissues remain subjects of active investigation...
  21. ncbi request reprint Hemopoietic progenitor cells and hemopoietic factors: potential targets for treatment of allergic inflammatory diseases
    R Sehmi
    Department of Medicine, HSC 3V46, McMaster University, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
    Curr Drug Targets Inflamm Allergy 2:271-8. 2003
    ..In addition, we will address the potential role that small molecular weight chemokine receptor antagonists may play in modulating progenitor cell trafficking to tissue sites of inflammation...
  22. ncbi request reprint Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalation
    Sandra C Dorman
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:565-72. 2004
    ..We propose that after allergen inhalation, time-dependent changes in cytokine levels in the bone marrow control differentiation of eosinophil/basophil progenitors...
  23. doi request reprint Cord blood hemopoietic progenitor profiles predict acute respiratory symptoms in infancy
    Rochelle Fernandes
    Division of Allergy and Clinical Immunology, McMaster University, Hamilton, ON, Canada
    Pediatr Allergy Immunol 19:239-47. 2008
    ..The elevation of IL-3/GM-CSF-responsive Eo/B progenitors in high-risk infants in relation to ARI outcomes suggests a mechanism for the increased severity of inflammatory responses in these subjects following viral infection...
  24. ncbi request reprint Regulation of IL-5 and IL-5 receptor expression in the bone marrow of allergic asthmatics
    J A Denburg
    Asthma Research Group, Division of Clinical Immunology and Allergy, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Int Arch Allergy Immunol 118:101-3. 1999
    ....
  25. ncbi request reprint Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunction
    B Sakic
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neuroimmunol 96:80-91. 1999
    ..Furthermore, they support the parallel between chronic stress and chronic autoimmunity/inflammation, and suggest common central mechanisms relevant to endocrine function and behavior...
  26. ncbi request reprint Progressive atrophy of pyramidal neuron dendrites in autoimmune MRL-lpr mice
    B Sakic
    Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada
    J Neuroimmunol 87:162-70. 1998
    ..Reduced dendritic complexity may represent, at least in part, a structural basis for the altered behavioral profile of MRL-lpr mice...
  27. ncbi request reprint Increased TUNEL staining in brains of autoimmune Fas-deficient mice
    B Sakic
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, HSC 4N77A, 1200 Main Street, Hamilton, Ontario, Canada
    J Neuroimmunol 104:147-54. 2000
    ....
  28. ncbi request reprint Immunosuppression prevents neuronal atrophy in lupus-prone mice: evidence for brain damage induced by autoimmune disease?
    B Sakic
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada
    J Neuroimmunol 111:93-101. 2000
    ....
  29. ncbi request reprint Behavioral effects of infection with IL-6 adenovector
    B Sakic
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Brain Behav Immun 15:25-42. 2001
    ..The inability of circulating IL-6 to alter other aspects of behavior supports the hypothesis that multiple immuno-neuroendocrine mechanisms contribute to the pathogenesis of AABS...
  30. pmc Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation
    Roma Sehmi
    Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Divisions of Clinical Immunology, McMaster University, Hamilton, Ontario, Canada
    Immunology 109:536-46. 2003
    ....
  31. pmc The effects of montelukast on tissue inflammatory and bone marrow responses in murine experimental allergic rhinitis: interaction with interleukin-5 deficiency
    Johanna Roa
    Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada
    Immunology 122:438-44. 2007
    ..The addition of cysLT1R blockade to IL-5 deficiency more fully attenuates symptoms and upper airway inflammation than either factor alone, providing evidence of systemic, BM mechanisms in allergic rhinitis...
  32. ncbi request reprint Altered neurotransmission in brains of autoimmune mice: pharmacological and neurochemical evidence
    Boris Sakic
    The Brain Body Institute, McMaster University, Rm H305, Father Sean O Sullivan Research Center, St Joseph s Healthcare, 50 Charlton Avenue East, L8N 4A6, Hamilton, Ontario, Canada
    J Neuroimmunol 129:84-96. 2002
    ..These results are consistent with the hypothesis that imbalanced neurotransmitter regulation of the hypothalamus-pituitary axis plays an important role in the etiology of behavioral dysfunction induced by systemic autoimmune disease...
  33. ncbi request reprint Cognition and mood in systemic lupus erythematosus. Evaluation and pathogenesis
    S D Denburg
    Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada
    Ann N Y Acad Sci 823:44-59. 1997
    ..Such studies could also lead to more specific therapeutic interventions to ameliorate or reverse brain compromise in SLE...
  34. pmc Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis
    Hiroko Saito
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Immunology 113:246-52. 2004
    ..The anti-allergic effects of cysLT1-R antagonists are consistent with the concept that cysLTs and IL-5 act together in the recruitment of eosinophils and eosinophil progenitors from the marrow during upper airway allergic inflammation...
  35. ncbi request reprint Anti-allergic therapies: effects on eosinophil progenitors
    Adrian J Baatjes
    Asthma Research Group, Department of Medicine, Division of Allergy and Clinical Immunology, HSC 3V46, Canada
    Pharmacol Ther 95:63-72. 2002
    ..Therefore, targeting the systemic hematopoietic response may provide additional, more beneficial, therapeutic effects...
  36. pmc Functional heterogeneity of mast cells isolated from different microenvironments within nasal polyp tissue
    S Finotto
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Immunol 95:343-50. 1994
    ..The failure of release of epithelial mast cell mediators from an immunologic stimulus may have implications concerning acute effects of antigen exposure in nasal polyposis...
  37. ncbi request reprint Rapid response of circulating myeloid dendritic cells to inhaled allergen in asthmatic subjects
    J W Upham
    Department of Medicine, University of Western Australia, Perth, Australia, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Allergy 32:818-23. 2002
    ..While the density of DC within the bronchial mucosa is increased in stable asthma, there is little information currently available concerning the effects of allergen inhalation on DC in subjects with asthma...
  38. ncbi request reprint Cognitive dysfunction and antiphospholipid antibodies in systemic lupus erythematosus
    S D Denburg
    McMaster University, Hamilton, ON, Canada
    Lupus 12:883-90. 2003
    ..To date, the most robust findings have emerged in relation to antiphospholipid antibodies, which carry with them important therapeutic implications...
  39. ncbi request reprint Immunosuppressive treatment prevents behavioral deficit in autoimmune MRL-lpr mice
    B Sakic
    Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
    Physiol Behav 58:797-802. 1995
    ..The effect of cyclophosphamide in the MRL-lpr group is believed to reflect the suppression of pathogenic immune factor(s) that alter behavior during the onset of autoimmune disease...
  40. ncbi request reprint The effect of desloratadine on eosinophil/basophil progenitors and other inflammatory markers in seasonal allergic rhinitis: a placebo-controlled randomized study
    Michael M Cyr
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Int Arch Allergy Immunol 138:209-16. 2005
    ..Our objective was to evaluate whether the antihistamine desloratadine (DL) can modulate peripheral blood Eo/B progenitors or other markers of allergic inflammation...
  41. pmc Proliferating brain cells are a target of neurotoxic CSF in systemic autoimmune disease
    Boris Sakic
    Department of Psychiatry and Behavioural Neurosciences, HSC Rm 4N81, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada L8N 3Z5
    J Neuroimmunol 169:68-85. 2005
    ..Antibody-mediated lesions of germinal layers may impair the regenerative capacity of the brain in NP-SLE and possibly, brain development and function in some forms of CNS disorders in which autoimmune phenomena have been documented...
  42. ncbi request reprint Systemic lupus erythematosus presenting as subacute delirium in an 82-year-old woman
    G A Heckman
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Am Geriatr Soc 49:458-61. 2001
    ..CONCLUSION: Neuropsychiatric symptoms can be prominent in older people, presenting features of SLE. This case illustrates the lowest dose of corticosteroids shown to be effective in an older patient with delirium due to SLE...
  43. ncbi request reprint Spatial learning during the course of autoimmune disease in MRL mice
    B Sakic
    Department of Biomedical Sciences, McMaster University, Hamilton, Ont, Canada
    Behav Brain Res 54:57-66. 1993
    ....
  44. pmc Ibuprofen fails to prevent brain pathology in a model of neuropsychiatric lupus
    David A Ballok
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    J Rheumatol 33:2199-213. 2006
    ..We examined inflammatory and ultrastructural aspects of central nervous system (CNS) involvement using a nonselective cyclooxygenase-2 (COX-2) inhibitor and measuring effects on behavior, microglial activation, and neuronal morphology...
  45. ncbi request reprint The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects
    Fausto Braccioni
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 110:96-101. 2002
    ..However, the effect of cysLTs on peripheral blood and bone marrow eosinophil pro-genitor cells in allergic subjects is not known...
  46. ncbi request reprint Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells
    John W Upham
    Department of Medicine, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 109:307-13. 2002
    ..Currently, little is known concerning regulation of IL-5Ralpha expression in the context of commitment of hemopoietic progenitor cells to the eosinophil and basophil lineages...