Mark A Crowther

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
  2. pmc Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings
    Wendy Lim
    Department of Medicine, McMaster University, Canada
    Crit Care 12:R36. 2008
  3. pmc Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors
    Deborah Cook
    Department of Medicine, 1200 Main Street, McMaster University, Hamilton, Canada
    Crit Care 12:R32. 2008
  4. doi request reprint Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents
    Mark A Crowther
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, USA
    Blood 111:4871-9. 2008
  5. pmc Measuring the anticoagulant effect of low molecular weight heparins in the critically ill
    Mark Crowther
    St Joseph s Hospital, Hamilton, Ontario, Canada
    Crit Care 10:150. 2006
  6. doi request reprint Preventing and managing bleeding complications in anticoagulated patients: a case based approach
    Mark Crowther
    Division of Hematology, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 4A6
    Thromb Res 123:S42-5. 2008
  7. ncbi request reprint Low molecular weight heparin and bleeding in patients with chronic renal failure
    Mark Crowther
    St Joseph s Hospital, Hamilton, Ontario, Canada
    Curr Opin Pulm Med 13:409-13. 2007
  8. ncbi request reprint Inferior vena cava filters in the management of venous thromboembolism
    Mark A Crowther
    Division of Hematology, McMaster University, Hamilton, Ontario, Canada
    Am J Med 120:S13-7. 2007
  9. ncbi request reprint Evidence based treatment of the antiphospholipid syndrome II. Optimal anticoagulant therapy for thrombosis
    Mark A Crowther
    Department of Medicine, McMaster University, Room L208 St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Thromb Res 115:3-8. 2005
  10. doi request reprint Managing bleeding in anticoagulated patients with a focus on novel therapeutic agents
    M A Crowther
    Division of Hematology, Department of Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 7:107-10. 2009

Detail Information

Publications137 found, 100 shown here

  1. pmc Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
    ..The objective of this study was to determine if RBC transfusions or RBC storage age predicts incident DVT in medical or surgical intensive care unit (ICU) patients...
  2. pmc Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings
    Wendy Lim
    Department of Medicine, McMaster University, Canada
    Crit Care 12:R36. 2008
    ..This is a prospective screening study...
  3. pmc Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors
    Deborah Cook
    Department of Medicine, 1200 Main Street, McMaster University, Hamilton, Canada
    Crit Care 12:R32. 2008
    ..The objective of the present study was to evaluate the prevalence, incidence and predictors of DVT and the incidence of bleeding in intensive care unit (ICU) patients with estimated creatinine clearance <30 ml/min...
  4. doi request reprint Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents
    Mark A Crowther
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, USA
    Blood 111:4871-9. 2008
    ..Available data on the efficacy and safety of current and experimental agents for anticoagulant reversal are reviewed, and a plan for management of anticoagulant-induced bleeding is presented...
  5. pmc Measuring the anticoagulant effect of low molecular weight heparins in the critically ill
    Mark Crowther
    St Joseph s Hospital, Hamilton, Ontario, Canada
    Crit Care 10:150. 2006
    ..These findings provide reassurance that subcutaneously administered medications may be used in critically ill patients with edema...
  6. doi request reprint Preventing and managing bleeding complications in anticoagulated patients: a case based approach
    Mark Crowther
    Division of Hematology, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 4A6
    Thromb Res 123:S42-5. 2008
    ..The paper is "case based" and narrative since there is little evidence to guide practice in this area...
  7. ncbi request reprint Low molecular weight heparin and bleeding in patients with chronic renal failure
    Mark Crowther
    St Joseph s Hospital, Hamilton, Ontario, Canada
    Curr Opin Pulm Med 13:409-13. 2007
    ..Consequently, care should be employed when LMWH is administered to patients with impaired renal function as reduced clearance and bioaccumulation may cause bleeding...
  8. ncbi request reprint Inferior vena cava filters in the management of venous thromboembolism
    Mark A Crowther
    Division of Hematology, McMaster University, Hamilton, Ontario, Canada
    Am J Med 120:S13-7. 2007
    ..Current evidence-based guidelines recommend IVC filter insertion only in patients with proven venous thromboembolism and an absolute contraindication for anticoagulation...
  9. ncbi request reprint Evidence based treatment of the antiphospholipid syndrome II. Optimal anticoagulant therapy for thrombosis
    Mark A Crowther
    Department of Medicine, McMaster University, Room L208 St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Thromb Res 115:3-8. 2005
    ..0 to 3.0. These recommendations have been called into question by three recently reported studies...
  10. doi request reprint Managing bleeding in anticoagulated patients with a focus on novel therapeutic agents
    M A Crowther
    Division of Hematology, Department of Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 7:107-10. 2009
    ..However, these new agents have one general limitation--a lack of a widely available antidote. We focus on the management of bleeding in anticoagulated patients, with particular regard to novel anticoagulants...
  11. ncbi request reprint Vitamin K for the treatment of asymptomatic coagulopathy associated with oral anticoagulant therapy
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Thromb Thrombolysis 16:69-72. 2003
    ..Subcutaneous vitamin K is relatively ineffective, and its use may be associated with over-correction of the INR...
  12. ncbi request reprint A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 349:1133-8. 2003
    ..0. However, there are no prospective data to support this approach to thromboprophylaxis...
  13. ncbi request reprint Vitamin K deficiency and D-dimer levels in the intensive care unit: a prospective cohort study
    M A Crowther
    Department of Medicine, McMaster University, St Joseph s Hospital, Hamilton, Ontario, Canada
    Blood Coagul Fibrinolysis 13:49-52. 2002
    ....
  14. doi request reprint Preventing venous thromboembolism in critically ill patients
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Thromb Hemost 34:469-74. 2008
    ..Large, well-designed randomized trials, powered to detect differences in clinically relevant end points, are required to advance the care of this highly vulnerable patient population...
  15. doi request reprint Oral vitamin K effectively treats international normalised ratio (INR) values in excess of 10. Results of a prospective cohort study
    Mark A Crowther
    Division of Hematology and Thromboembolism, McMaster University Faculty of Health Sciences, St Joseph s Hospital, 50 Charlton Ave East, Hamilton, Ontario, Canada
    Thromb Haemost 104:118-21. 2010
    ..Based on our low rate of observed major bleeding we conclude that 2.5 mg of oral vitamin K is a reasonable treatment for patients with INR values of more than 10 who are not actively bleeding...
  16. ncbi request reprint Oral vitamin K lowers the international normalized ratio more rapidly than subcutaneous vitamin K in the treatment of warfarin-associated coagulopathy. A randomized, controlled trial
    Mark A Crowther
    St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    Ann Intern Med 137:251-4. 2002
    ..Excessive anticoagulation due to warfarin use is associated with hemorrhage. Subcutaneously administered vitamin K has not been evaluated for the treatment of warfarin-associated coagulopathy, yet it is widely used...
  17. doi request reprint Systematic review and meta-analysis methodology
    Mark Crowther
    Department of Haematology, Worcestershire Royal Hospital, Worcester, United Kingdom
    Blood 116:3140-6. 2010
    ..This article aims to provide the reader with a practical overview of systematic review and meta-analysis methodology, with a focus on the process of performing a review and the related issues at each step...
  18. doi request reprint The 4Ts scoring system for heparin-induced thrombocytopenia in medical-surgical intensive care unit patients
    Mark Andrew Crowther
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 25:287-93. 2010
    ..The 4Ts score (Thrombocytopenia, Timing of thrombocytopenia, Thrombosis, and oTher reason) might identify individual patients at risk of having this disorder...
  19. ncbi request reprint Anticoagulant therapy for the thrombotic complications of the antiphospholipid antibody syndrome
    Mark A Crowther
    St Joseph s Hospital, Room L208, 50 Charlton Ave East, Hamilton, ON, L8N 4A6, Canada
    Thromb Res 114:443-6. 2004
    ..Because of this increased risk of recurrent TE, after anticoagulants are discontinued, most "experts" recommend extended duration therapeutic dose warfarin for such patients. This paper will briefly review this evidence...
  20. ncbi request reprint Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial
    Mark A Crowther
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 150:293-300. 2009
    ..Low-dose oral vitamin K decreases the international normalized ratio (INR) in overanticoagulated patients who receive warfarin therapy. Its effects on bleeding events are uncertain...
  21. doi request reprint Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial
    Clive Kearon
    McMaster University, Hamilton, ON
    Blood 112:4432-6. 2008
    ..7; 95% CI, 0.2-2.3) or more than one (HR, 0.7; 95% CI, 0.2-3.4) defect. We conclude that single or multiple thrombophilic defects are not associated with a higher risk of recurrent VTE during warfarin therapy...
  22. doi request reprint The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trial
    Nancy M Heddle
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Transfusion 52:1203-12. 2012
    ..The objective was to determine feasibility of a comparative effectiveness trial to evaluate duration of storage of blood before transfusion on in-hospital mortality...
  23. doi request reprint A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopenia
    Donald M Arnold
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Blood 119:1356-62. 2012
    ..No difference in the frequency of the composite outcome was observed in this pilot trial (registered at www.clinicaltrials.gov NCT00372892)...
  24. doi request reprint Acute management of bleeding in patients on novel oral anticoagulants
    Deborah M Siegal
    Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Eur Heart J 34:489-498b. 2013
    ..We provide an approach to the management of patients with bleeding complications with evidence for various interventions for reversal, where available...
  25. ncbi request reprint Meta-analysis: anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients
    Francesco Dentali
    McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Ann Intern Med 146:278-88. 2007
    ..Underutilization of anticoagulant prophylaxis may be due to lack of evidence that prophylaxis prevents clinically important outcomes in hospitalized medical patients at risk for venous thromboembolism...
  26. ncbi request reprint An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trial
    Clive Kearon
    McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada
    Ann Intern Med 144:812-21. 2006
    ..It may be safe to omit additional diagnostic testing in selected patients with suspected pulmonary embolism (PE) who have a negative D-dimer test, but this approach has never been evaluated in a randomized, controlled trial...
  27. ncbi request reprint Elevated cardiac troponin levels in critically ill patients: prevalence, incidence, and outcomes
    Wendy Lim
    The Department of Medicine, McMaster University, Hamilton, Ontario, CA
    Am J Crit Care 15:280-8; quiz 289. 2006
    ..Levels of cardiac troponin, a sensitive and specific marker of myocardial injury, are often elevated in critically ill patients...
  28. ncbi request reprint Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism
    Clive Kearon
    McMaster University, Hamilton, Ont
    N Engl J Med 349:631-9. 2003
    ..After three months of conventional warfarin therapy, a lower dose of anticoagulant medication may result in less bleeding and still prevent recurrent venous thromboembolism...
  29. ncbi request reprint Elevated cardiac troponin measurements in critically ill patients
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 166:2446-54. 2006
    ..We reviewed the frequency of cTn elevation and its association with mortality and length of ICU stay in these patients...
  30. ncbi request reprint Reliability of electrocardiogram interpretation in critically ill patients
    Wendy Lim
    Medicine and Clinical Epidemiology, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 34:1338-43. 2006
    ..To assess the intrarater and interrater reliability of electrocardiogram (ECG) interpretation in critically ill patients and to assess the effect of knowledge of cardiac troponin values on these reliability estimates...
  31. doi request reprint The effect of pre-operative aspirin on bleeding, transfusion, myocardial infarction, and mortality in coronary artery bypass surgery: a systematic review of randomized and observational studies
    Jack C J Sun
    Division of Cardiac Surgery, Hamilton General Hospital, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada L8L 2X2
    Eur Heart J 29:1057-71. 2008
    ..To obtain estimates of the efficacy and safety of pre-operative aspirin in patients undergoing coronary artery bypass grafting (CABG)...
  32. ncbi request reprint Thrombocytopenia in medical-surgical critically ill patients: prevalence, incidence, and risk factors
    Mark A Crowther
    Department of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:348-53. 2005
    ....
  33. pmc Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis
    Adam Cuker
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Blood 120:4160-7. 2012
    ..14 (0.09-0.22) and 0.64 (0.40-0.82), respectively. A low probability 4Ts score appears to be a robust means of excluding HIT. Patients with intermediate and high probability scores require further evaluation...
  34. ncbi request reprint Bridging anticoagulation with low-molecular-weight heparin after interruption of warfarin therapy is associated with a residual anticoagulant effect prior to surgery
    James D Douketis
    Department of Medicine and St Joseph s Heathcare, McMaster University, Hamilton, Canada
    Thromb Haemost 94:528-31. 2005
    ..In patients who require bridging anticoagulation with LMWH, a residual anticoagulant effect from LMWH is detected in 1 of 6 patients, and receiving therapeutic-dose LMWH is the strongest predictor of such an effect...
  35. ncbi request reprint Dalteparin thromboprophylaxis for critically ill medical-surgical patients with renal insufficiency
    Christian G Rabbat
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:357-63. 2005
    ....
  36. ncbi request reprint Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responses
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 46:1286-91. 2006
    ..A description of current platelet (PLT) transfusion practice in the intensive care unit (ICU) is needed...
  37. doi request reprint A multifaceted strategy to reduce inappropriate use of frozen plasma transfusions in the intensive care unit
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 26:636.e7-636.e13. 2011
    ..The purpose of this study is to determine the effect of a multifaceted behavior-change strategy on inappropriate use of frozen plasma (FP) transfusions in the intensive care unit (ICU)...
  38. doi request reprint The relationship between fibrinogen levels after cardiopulmonary bypass and large volume red cell transfusion in cardiac surgery: an observational study
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, 3EN, Toronto, ON, M5G 2C4, Canada
    Anesth Analg 117:14-22. 2013
    ..We explored the relationship between post-CPB fibrinogen levels and large volume red cell transfusion...
  39. ncbi request reprint Reversing anticoagulant therapy
    Shari Ghanny
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, L301 50 Charlton Ave East Hamilton, Ontario L8N 4A6, Canada
    Curr Drug Discov Technol 9:143-9. 2012
    ..The increasing use of novel anticoagulants will require physicians to have an understanding of rational approaches to "reverse" their anticoagulant effects when true antidotes do not exist...
  40. pmc A team-based approach to warfarin management in long term care: a feasibility study of the MEDeINR electronic decision support system
    Alexandra Papaioannou
    Department of Medicine, McMaster University, 1280 Main Street West, Hamilton L8N 3Z5, Canada
    BMC Geriatr 10:38. 2010
    ..We evaluated the MEDeINR system in a pre-post implementation design by examining the impact on INR control, testing frequency, and experiences of staff in using the system...
  41. ncbi request reprint Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura
    Donald M Arnold
    McMaster University and Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Ann Intern Med 146:25-33. 2007
    ..Rituximab, a monoclonal anti-CD20 antibody, is increasingly used to treat idiopathic thrombocytopenic purpura (ITP)...
  42. ncbi request reprint Deep venous thrombosis: clinically silent in the intensive care unit
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:334-40. 2005
    ....
  43. doi request reprint Selective D-dimer testing for diagnosis of a first suspected episode of deep venous thrombosis: a randomized trial
    Lori Ann Linkins
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 158:93-100. 2013
    ..Changing the use of testing and the threshold level for a positive test result on the basis of risk for DVT might improve the tradeoff between sensitivity and specificity and reduce the need for testing...
  44. pmc Elevated troponin and myocardial infarction in the intensive care unit: a prospective study
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 9:R636-44. 2005
    ....
  45. ncbi request reprint Low-dose oral vitamin K to normalize the international normalized ratio prior to surgery in patients who require temporary interruption of warfarin
    Karen Woods
    Department of Medicine, McMaster University and St Joseph s Healthcare, Room F 544, 50 Charlton Ave East, Hamilton, ON, Canada L8N 4A6
    J Thromb Thrombolysis 24:93-7. 2007
    ..In patients who require warfarin interruption before surgery and have an elevated international normalized ratio (INR) before surgery, low-dose vitamin K may normalize the INR in time for surgery...
  46. ncbi request reprint Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency
    Wendy Lim
    McMaster University and Hamilton General Hospital, Hamilton, Ontario, Canada
    Ann Intern Med 144:673-84. 2006
    ....
  47. ncbi request reprint Research agenda: venous thromboembolism in medical-surgical critically ill patients
    Deborah J Cook
    Deparment of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:330-3. 2005
  48. ncbi request reprint Patient preferences for capillary vs. venous INR determination in an anticoagulation clinic: a randomized controlled trial
    Karen Woods
    Department of Medicine, McMaster University, Room F 541, 50 Charlton Avenue East, Hamilton, ON, Canada L8N 4A6
    Thromb Res 114:161-5. 2004
    ..Although previous studies suggest that capillary blood monitoring of the international normalize ratio (INR) is rapid and reliable, patient preferences for the method of blood drawing have not been investigated...
  49. ncbi request reprint Warfarin cessation before cardiopulmonary bypass: lessons learned from a randomized controlled trial of oral vitamin K
    Richard P Whitlock
    Division of Cardiac Surgery, HHSC, McMaster University, Hamilton, Ontario, Canada
    Ann Thorac Surg 84:103-8. 2007
    ..Administration of preoperative oral vitamin K was investigated in a randomized, placebo-controlled trial. A post hoc analysis examined residual anti-Xa activity of enoxaparin bridging...
  50. doi request reprint Thromboprophylaxis in the intensive care unit: focus on medical-surgical patients
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 38:S76-82. 2010
    ..Furthermore, because thromboprophylaxis is a common error of omission in hospitalized patients, redoubled efforts are needed to ensure that it is used in practice...
  51. pmc Low-intensity adjusted-dose warfarin for the prevention of hemodialysis catheter failure: a randomized, controlled trial
    Trevor J Wilkieson
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin J Am Soc Nephrol 6:1018-24. 2011
    ..To determine whether warfarin prolongs the time to first mechanical-catheter failure...
  52. ncbi request reprint Anticoagulant prophylaxis in special populations with an indwelling epidural catheter or renal insufficiency
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    J Crit Care 20:324-9. 2005
    ..This review focuses on anticoagulant prophylaxis in such patients, including reasonable approaches for using low-molecular-weight heparins as thromboprophylaxis...
  53. ncbi request reprint Acute reversal of anticoagulant-induced bleeding complications
    Mark A Crowther
    McMaster University, Canada
    Clin Adv Hematol Oncol 2:578-82. 2004
  54. pmc Low-dose oral vitamin K therapy for the management of asymptomatic patients with elevated international normalized ratios: a brief review
    Sarah E Wilson
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    CMAJ 170:821-4. 2004
    ..5 and 10. The fear of over-correction of the INR has limited the widespread use of vitamin K; however, our review suggests that this occurs infrequently when small doses are administered orally...
  55. doi request reprint The effect of prothrombotic blood abnormalities on risk of deep vein thrombosis in users of hormone replacement therapy: a prospective case-control study
    Jim D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    Clin Appl Thromb Hemost 17:E106-13. 2011
    ..Few studies have assessed the effect of prothrombotic blood abnormalities on the risk of deep vein thrombosis (DVT) with hormone replacement therapy (HRT)...
  56. doi request reprint Newer anticoagulants in critically ill patients
    Anita Rajasekhar
    Department of Medicine, University of Florida, College of Medicine, Gainesville, FL 32610 0278, USA
    Crit Care Clin 28:427-51, vii. 2012
    ..Well-designed clinical trials are needed to improve our understanding of the safety and efficacy of these newer agents in critically ill patients...
  57. pmc Quality of anticoagulation and use of warfarin-interacting medications in long-term care: a chart review
    Madeleine Verhovsek
    McMaster University, Hamilton, Ontario, Canada
    BMC Geriatr 8:13. 2008
    ....
  58. doi request reprint A multicenter trial of the effectiveness of zeta-globin enzyme-linked immunosorbent assay and hemoglobin H inclusion body screening for the detection of alpha0-thalassemia trait
    John D Lafferty
    McMaster University, Hamilton Regional Laboratory Medicine Program, Toronto, Canada
    Am J Clin Pathol 129:309-15. 2008
    ....
  59. doi request reprint Transfusion premedication to prevent acute transfusion reactions: a retrospective observational study to assess current practices
    Jessica L Fry
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Transfusion 50:1722-30. 2010
    ....
  60. ncbi request reprint Paper-based dosing algorithms for maintenance of warfarin anticoagulation
    Sarah E Wilson
    PGY1, Internal Medicine, University of Toronto, Toronto, ON, Canada, M5R 2N9
    J Thromb Thrombolysis 23:195-8. 2007
    ..We conclude that the performance, minimal cost, and ease-of-use of these algorithms make them well-suited for patient management within primary-care and research settings...
  61. ncbi request reprint Are brand-name and generic warfarin interchangeable? Multiple n-of-1 randomized, crossover trials
    Jennifer A Pereira
    Centre for Evaluation of Medicines, St Joseph s Healthcare, Hamilton, Ontario, Canada
    Ann Pharmacother 39:1188-93. 2005
    ..Warfarin is a commonly used anticoagulant in North America. Several generic formulations have been approved, raising concern over the safety and efficacy of these products compared with brand-name Coumadin...
  62. ncbi request reprint Management of antiphospholipid antibody syndrome: a systematic review
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 295:1050-7. 2006
    ..Patients with APS may be at increased risk of recurrent arterial or venous thrombosis or pregnancy loss...
  63. doi request reprint Misleading hepatitis B test results due to intravenous immunoglobulin administration: implications for a clinical trial of rituximab in immune thrombocytopenia
    Donald M Arnold
    Department of Medicine, Michael deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 50:2577-81. 2010
    ..A high seroprevalence of anti-HBc observed among patients screened for the trial prompted this substudy to investigate for an association between anti-HBc seropositivity and exposure to intravenous immunoglobulin (IVIG)...
  64. ncbi request reprint Thromboprophylaxis in medical-surgical intensive care unit patients
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:320-3. 2005
  65. doi request reprint Bleeding and venous thromboembolism in the critically ill with emphasis on patients with renal insufficiency
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Pulm Med 15:455-62. 2009
    ....
  66. ncbi request reprint A randomized trial of diagnostic strategies after normal proximal vein ultrasonography for suspected deep venous thrombosis: D-dimer testing compared with repeated ultrasonography
    Clive Kearon
    McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada
    Ann Intern Med 142:490-6. 2005
    ..With suspected deep venous thrombosis and normal results on proximal vein ultrasonography, a negative d-dimer result may exclude thrombosis and a positive D-dimer result may be an indication for venography...
  67. doi request reprint How I treat with anticoagulants in 2012: new and old anticoagulants, and when and how to switch
    Sam Schulman
    Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
    Blood 119:3016-23. 2012
    ..Unfortunately, there is a limited evidence base to inform decisions around management of these agents. We present our practice in these settings supported, where available, with literature evidence...
  68. pmc Venous thromboembolism and bleeding in a community setting. The Worcester Venous Thromboembolism Study
    Frederick A Spencer
    McMaster University, Medical Centre, 1200 Main Street West, HSC 3X28, Hamilton, Ontario L8N 3Z5, Canada
    Thromb Haemost 101:878-85. 2009
    ..Future study of antithrombotic strategies for VTE should be informed by this finding. Advances that result in decreased bleeding rates may paradoxically decrease the risk of VTE recurrence...
  69. doi request reprint Thromboprophylaxis in medical-surgical critically ill patients
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Crit Care 14:520-3. 2008
    ....
  70. ncbi request reprint Prevalence, incidence, and risk factors for venous thromboembolism in medical-surgical intensive care unit patients
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:309-13. 2005
  71. doi request reprint Intensity of warfarin coagulation in the antiphospholipid syndrome
    Mark Crowther
    Division of Hematology and Thromboembolism, McMaster University, St Joseph s Hospital, 50 Charlton Ave, East Hamilton, Ontario, Canada
    Curr Rheumatol Rep 12:64-9. 2010
    ..Care must be taken with all anticoagulants because of the increased risk of bleeding. Several other strategies are available if warfarin fails, including the addition of aspirin, increasing the warfarin target range, and use of heparin...
  72. ncbi request reprint Low-intensity warfarin is ineffective for the prevention of PTFE graft failure in patients on hemodialysis: a randomized controlled trial
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Am Soc Nephrol 13:2331-7. 2002
    ..Furthermore, low-intensity, monitored-dose warfarin does not appear to prolong PTFE graft survival...
  73. ncbi request reprint Safety and efficacy of low molecular weight heparins for hemodialysis in patients with end-stage renal failure: a meta-analysis of randomized trials
    Wendy Lim
    Department of Medicine, McMaster University, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    J Am Soc Nephrol 15:3192-206. 2004
    ..However, inferences from these trials assessing anticoagulation for patients who undergo hemodialysis will continue to be weak until larger, more rigorous randomized trials are conducted...
  74. ncbi request reprint The diagnosis of deep venous thrombosis and pulmonary embolism in medical-surgical intensive care unit patients
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    J Crit Care 20:314-9. 2005
  75. ncbi request reprint Deep venous thrombosis in medical-surgical critically ill patients: prevalence, incidence, and risk factors
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 33:1565-71. 2005
    ..The objective was to determine the prevalence, incidence, and risk factors for proximal lower extremity deep venous thrombosis among critically ill medical-surgical patients...
  76. ncbi request reprint Natural history of cerebral vein thrombosis: a systematic review
    Francesco Dentali
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Blood 108:1129-34. 2006
    ..8% (range, 0%-11.7%) had objectively confirmed recurrence. We conclude that patients with CVT have a low risk of death and that most patients have a good long-term prognosis...
  77. ncbi request reprint Antiphospholipid antibody syndrome: recent findings on managing this challenging condition
    Mark A Crowther
    Division of Hematology, McMaster University, St Joseph s Hospital, Hamilton, Ontario, Canada
    Cleve Clin J Med 72:245-9. 2005
    ..Recent research has demonstrated that high-intensity anticoagulation is not superior to standard therapy. Basic questions about the nature and treatment of this syndrome remain unanswered...
  78. ncbi request reprint Malignancy-associated venous thrombosis with concurrent warfarin-induced skin necrosis, venous limb gangrene and thrombotic microangiopathy
    Heng Joo Ng
    St Joseph s Hospital, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    Thromb Haemost 95:1038-9. 2006
  79. doi request reprint Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials
    Yoan K Kagoma
    Applied Science and Engineering, University of Toronto, Toronto, Ontario, Canada
    Thromb Res 123:687-96. 2009
    ..To address this issue we performed a systematic review of randomized trials describing the use of tranexamic acid, epsilon aminocaproic acid, or aprotinin administration in the perioperative setting...
  80. ncbi request reprint Antiphospholipid antibiodies: a critical review of the literature
    Wendy Lim
    St Joseph s Hospital, Hamilton, Ontario, Canada
    Curr Opin Hematol 14:494-9. 2007
    ..Antithrombotic therapies are the mainstay of treatment to reduce the risk of recurrent thromboembolism that characterizes this condition...
  81. doi request reprint Low-molecular-weight heparin thromboprophylaxis in medical-surgical critically ill patients: a systematic review
    Christine Ribic
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:197-205. 2009
    ..The study aimed to systematically review the effect of low-molecular-weight heparin (LMWH) thromboprophylaxis in medical-surgical critically ill patients in the intensive care unit...
  82. ncbi request reprint Short-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of prospective studies investigating symptomatic outcomes
    James D Douketis
    Department of Medicine, McMaster University, and St Joseph s Hospital, Hamilton, Ontario, Canada L8N 4A6
    Arch Intern Med 162:1465-71. 2002
    ....
  83. ncbi request reprint Anticoagulant effect at the time of epidural catheter removal in patients receiving twice-daily or once-daily low-molecular-weight heparin and continuous epidural analgesia after orthopedic surgery
    James D Douketis
    Department of Medicine, McMaster University and St Joseph s Hospital, Hamilton, Canada
    Thromb Haemost 88:37-40. 2002
    ....
  84. ncbi request reprint Thrombotic thrombocytopenic purpura: 2008 update
    Mark A Crowther
    Division of Hematology, McMaster University, Hamilton, Ontario, Canada
    Cleve Clin J Med 75:369-75. 2008
    ..Unless TTP is recognized promptly and treated aggressively, most patients die of it...
  85. ncbi request reprint Should aspirin be discontinued before coronary artery bypass surgery?
    Jack C J Sun
    Division of Cardiac Surgery, McMaster University, Hamilton, Canada
    Circulation 112:e85-90. 2005
  86. pmc Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review
    Donald M Arnold
    1Michael G DeGroote School of Medicine, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Haematologica 94:850-6. 2009
    ..pylori infection and immune thrombocytopenia in some patients. Randomized trials are needed to determine the applicability of H. pylori eradication therapy across diverse geographical regions...
  87. ncbi request reprint Elevated cardiac troponin levels in patients with submassive pulmonary embolism
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    Arch Intern Med 162:79-81. 2002
    ..We performed a prospective cohort study to determine the prevalence of elevated cardiac troponin I (cTnI) levels in patients with submassive pulmonary embolism...
  88. doi request reprint Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:168-75. 2009
    ....
  89. doi request reprint Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics: the DIRECT study
    James Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 168:1805-12. 2008
    ..To challenge this premise, we evaluated if deep vein thrombosis (DVT) prophylaxis with dalteparin sodium confers an excessive anticoagulant effect in critically ill patients with severe renal insufficiency...
  90. ncbi request reprint Thromboembolism in children with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute protocols: effect of age and risk stratification of disease
    Uma H Athale
    Division of Hematology Oncology, Department of Pediatrics, McMaster University, Hamilton, ON, Canada
    Br J Haematol 129:803-10. 2005
    ..Age-related risk may partly reflect the effect of ALL-risk stratification. Higher dose steroids combined with ASP may lead to an increased risk of TE in HR patients...
  91. ncbi request reprint Warfarin maintenance dosing patterns in clinical practice: implications for safer anticoagulation in the elderly population
    David Garcia
    Department of Medicine, Division of General Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA
    Chest 127:2049-56. 2005
    ....
  92. ncbi request reprint Effect of chronic kidney disease on red blood cell rheology
    K Scott Brimble
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Clin Hemorheol Microcirc 34:411-20. 2006
    ..This study measured blood viscosity over a range of shear rates in erythropoietin-treated patients on hemodialysis (HD), and compared the findings to matched patients with chronic renal insufficiency (CRI) and healthy controls...
  93. doi request reprint A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopenia
    Nancy M Heddle
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Blood 113:1564-73. 2009
    ..Whether this finding was due to chance or represents a real difference requires further investigation. These clinical studies are registered on (http://www.clinicaltrials.gov) as NCT00420914...
  94. pmc Clinically important deep vein thrombosis in the intensive care unit: a survey of intensivists
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 8:R145-52. 2004
    ..The objective of the present survey is to identify the patient factors and radiologic features of lower limb DVT that intensivists consider more or less likely to make a DVT clinically important in ICU patients...
  95. ncbi request reprint Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:364-72. 2005
    ..Its additional goals were to evaluate the suitability of the exclusion criteria and to document the range of research activities that precede accrual of patients into a trial to plan multisite management...
  96. ncbi request reprint Systematic overview of warfarin and its drug and food interactions
    Anne M Holbrook
    Centre for Evaluation of Medicines, St Joseph s Healthcare, Hamilton, Ontario
    Arch Intern Med 165:1095-106. 2005
    ..Drug and food interactions are frequently cited as causes of adverse events with warfarin. We provide an updated systematic overview of the quality, clinical effect, and importance of these reported interactions...
  97. ncbi request reprint A diagnostic strategy involving a quantitative latex D-dimer assay reliably excludes deep venous thrombosis
    Shannon M Bates
    McMaster University Medical Centre, HSC 3W11, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Ann Intern Med 138:787-94. 2003
    ..Because clinical diagnosis is inaccurate, objective testing is usually considered necessary when patients present with suspected deep venous thrombosis (DVT)...
  98. ncbi request reprint Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials
    Francesco Dentali
    Department of Medicine, McMaster University, and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Arch Intern Med 167:117-24. 2007
    ..We performed a systematic review and meta-analysis of randomized controlled trials comparing these 2 treatment strategies (combined aspirin-OAC therapy vs OAC therapy alone) to assess the therapeutic benefits and risks...
  99. doi request reprint The diagnosis of myocardial infarction in critically ill patients: an agreement study
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:447-52. 2009
    ..The aim of the study was to assess agreement among 4 intensivists in diagnosing myocardial infarction (MI) in critically ill patients based on screening electrocardiograms (ECGs) and cardiac troponin (cTn) levels...
  100. ncbi request reprint Bleeding in cardiac surgery: its prevention and treatment--an evidence-based review
    Richard Whitlock
    Department of Medicine, McMaster University, Room L208, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    Crit Care Clin 21:589-610. 2005
    ..A thorough understanding of these factors is necessary to reduce bleeding. This is a desirable clinical goal, because excessive bleeding is associated with adverse outcomes...
  101. ncbi request reprint Azathioprine and inhibition of the anticoagulant effect of warfarin: evidence from a case report and a literature review
    Heng Joo Ng
    St Joseph s Hospital, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    Am J Geriatr Pharmacother 4:75-7. 2006
    ..However, a potential interaction between the 2 drugs, resulting in an increased warfarin requirement, may be overlooked in clinical practice...