Deborah J Cook

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Thromboprophylaxis in medical-surgical intensive care unit patients
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:320-3. 2005
  2. ncbi request reprint Barriers and facilitators of thromboprophylaxis for medical-surgical intensive care unit patients: A multicenter survey
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada Electronic address
    J Crit Care 29:471.e1-9. 2014
  3. ncbi request reprint End of life care in Canada: a report from the canadian academy of health sciences forum
    Deborah Cook
    Clin Invest Med 36:E112. 2013
  4. pmc Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
  5. pmc LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, Buffalo, USA
    Trials 10:40. 2009
  6. pmc Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
  7. pmc Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
    Simon Finfer
    Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
    Crit Care 14:R185. 2010
  8. pmc Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis
    Mark Duffett
    Department of Critical Care, McMaster Children s Hospital, 1200 Main St, W, Hamilton, Ontario L8S 4J9, Canada
    Crit Care 11:R66. 2007
  9. pmc A survey of Canadian intensivists' resuscitation practices in early septic shock
    Lauralyn A McIntyre
    University of Ottawa Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit of the Ottawa Hospital, Ottawa Health Research Institute, 501 Smyth Rd Ottawa, Ontario, Canada K1H 8L6
    Crit Care 11:R74. 2007
  10. pmc Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings
    Wendy Lim
    Department of Medicine, McMaster University, Canada
    Crit Care 12:R36. 2008

Detail Information

Publications139 found, 100 shown here

  1. ncbi request reprint Thromboprophylaxis in medical-surgical intensive care unit patients
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:320-3. 2005
  2. ncbi request reprint Barriers and facilitators of thromboprophylaxis for medical-surgical intensive care unit patients: A multicenter survey
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada Electronic address
    J Crit Care 29:471.e1-9. 2014
    ..The objective of this study was to identify the self-reported barriers to and facilitators of prescribing low-molecular-weight heparin (LMWH) thromboprophylaxis in the intensive care unit (ICU)...
  3. ncbi request reprint End of life care in Canada: a report from the canadian academy of health sciences forum
    Deborah Cook
    Clin Invest Med 36:E112. 2013
    ..Three articles in this issue of Clinical Investigative Medicine build on presentations from that day...
  4. pmc Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
    ..The objective of this study was to determine if RBC transfusions or RBC storage age predicts incident DVT in medical or surgical intensive care unit (ICU) patients...
  5. pmc LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, Buffalo, USA
    Trials 10:40. 2009
    ..The secondary objectives are to describe, for published RCTs, (1) the reporting of loss to follow-up information, (2) the analytic methods used for handling loss to follow-up information, and (3) the extent of reported loss to follow-up...
  6. pmc Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
    ..The aim of STOPIT-2 is to determine the magnitude and determinants of possible bias introduced by stopping RCTs early for benefit...
  7. pmc Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
    Simon Finfer
    Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
    Crit Care 14:R185. 2010
    ..Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients...
  8. pmc Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis
    Mark Duffett
    Department of Critical Care, McMaster Children s Hospital, 1200 Main St, W, Hamilton, Ontario L8S 4J9, Canada
    Crit Care 11:R66. 2007
    ..The objective of the present systematic review is to assess the effect of exogenous pulmonary surfactant on all-cause mortality in children mechanically ventilated for acute respiratory failure...
  9. pmc A survey of Canadian intensivists' resuscitation practices in early septic shock
    Lauralyn A McIntyre
    University of Ottawa Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit of the Ottawa Hospital, Ottawa Health Research Institute, 501 Smyth Rd Ottawa, Ontario, Canada K1H 8L6
    Crit Care 11:R74. 2007
    ..The objective of this survey was to characterize reported resuscitation practices of Canadian physicians caring for adult critically ill patients with early septic shock...
  10. pmc Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings
    Wendy Lim
    Department of Medicine, McMaster University, Canada
    Crit Care 12:R36. 2008
    ..This is a prospective screening study...
  11. ncbi request reprint Moving toward evidence-based practice
    Deborah J Cook
    Division of Critical Care Medicine, Department of Medicine, St Joseph s Hospital, Hamilton, Ontario, Canada
    Respir Care 48:859-68. 2003
    ..We should always ask whether the right provider is doing the right thing for the right patient at the right time in the right setting with the right resources...
  12. ncbi request reprint Research agenda: venous thromboembolism in medical-surgical critically ill patients
    Deborah J Cook
    Deparment of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:330-3. 2005
  13. doi request reprint Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:168-75. 2009
    ....
  14. doi request reprint Thromboprophylaxis for hospitalized medical patients: a multicenter qualitative study
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Hosp Med 4:269-75. 2009
    ..Observational studies have documented that medical patients infrequently receive venous thromboembolism (VTE) prevention...
  15. ncbi request reprint Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:364-72. 2005
    ..Its additional goals were to evaluate the suitability of the exclusion criteria and to document the range of research activities that precede accrual of patients into a trial to plan multisite management...
  16. ncbi request reprint Dying in the ICU: strategies that may improve end-of-life care
    Deborah Cook
    Departments of Medicine, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Can J Anaesth 51:266-72. 2004
    ..The purpose of this article is to suggest some strategies to consider to improve the care of patients dying in the ICU...
  17. ncbi request reprint Improving patients' safety locally: changing clinician behaviour
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Lancet 363:1224-30. 2004
    ..The steps are to: do an environmental scan; understand current behaviour, target behaviour for change (why, what, when, where, and who); adopt effective strategies to change behaviour; and synergise...
  18. pmc Clinically important deep vein thrombosis in the intensive care unit: a survey of intensivists
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 8:R145-52. 2004
    ..The objective of the present survey is to identify the patient factors and radiologic features of lower limb DVT that intensivists consider more or less likely to make a DVT clinically important in ICU patients...
  19. pmc Serious adverse events in academic critical care research
    Deborah Cook
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont
    CMAJ 178:1181-4. 2008
  20. pmc Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors
    Deborah Cook
    Department of Medicine, 1200 Main Street, McMaster University, Hamilton, Canada
    Crit Care 12:R32. 2008
    ..The objective of the present study was to evaluate the prevalence, incidence and predictors of DVT and the incidence of bleeding in intensive care unit (ICU) patients with estimated creatinine clearance <30 ml/min...
  21. doi request reprint Randomized trials in vulnerable populations
    Deborah Cook
    Department of Medicine, McMaster University Health Sciences Center, Hamilton, Ontario, Canada
    Clin Trials 5:61-9. 2008
    ....
  22. doi request reprint Enrollment of intensive care unit patients into clinical studies: a trinational survey of researchers' experiences, beliefs, and practices
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Crit Care Med 36:2100-5. 2008
    ..As critical care practice increases in scope, size, and complexity, enrollment of critically ill patients into clinical studies is increasing...
  23. doi request reprint Bleeding and venous thromboembolism in the critically ill with emphasis on patients with renal insufficiency
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Pulm Med 15:455-62. 2009
    ....
  24. pmc Prevention and diagnosis of venous thromboembolism in critically ill patients: a Canadian survey
    D Cook
    Department of Medicine, McMaster University, Hamilton, Canada
    Crit Care 5:336-42. 2001
    ..The objective of this study was to understand current approaches to the prevention and diagnosis of deep venous thrombosis (DVT) and pulmonary embolism (PE) among patients in the intensive care unit (ICU)...
  25. ncbi request reprint Trials of miscellaneous interventions to wean from mechanical ventilation
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:438S-44S. 2001
    ..Multidisciplinary, patient-centered, holistic, and non-pulmonary approaches to weaning may provide additional safe, effective adjunctive methods of hastening liberation from mechanical ventilation...
  26. ncbi request reprint Qualitative studies on the patient's experience of weaning from mechanical ventilation
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:469S-73S. 2001
    ....
  27. ncbi request reprint Cardiopulmonary resuscitation directives on admission to intensive-care unit: an international observational study
    D J Cook
    Department of Medicine, McMaster University, Ontario, Hamilton, Canada
    Lancet 358:1941-5. 2001
    ..Our objective was to ascertain prevalence, predictors, and procurement pattern of cardiopulmonary resuscitation directives within 24 h of admission to the intensive-care unit (ICU)...
  28. doi request reprint PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 26:223.e1-9. 2011
    ....
  29. doi request reprint Pulmonary embolism in medical-surgical critically ill patients
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Hematol Oncol Clin North Am 24:677-82, vii. 2010
    ....
  30. doi request reprint Thromboprophylaxis in the intensive care unit: focus on medical-surgical patients
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 38:S76-82. 2010
    ..Furthermore, because thromboprophylaxis is a common error of omission in hospitalized patients, redoubled efforts are needed to ensure that it is used in practice...
  31. doi request reprint Clinical research ethics for critically ill patients: a pandemic proposal
    Deborah Cook
    International Forum for Acute Care Trialists InFACT Ethics Committee, Department of Medicine, McMaster University, Hamilton, Canada
    Crit Care Med 38:e138-42. 2010
    ..We also propose strategies such as expedited and centralized research ethics committee reviews and alternate consent models...
  32. pmc The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 5:368-75. 2001
    ..To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically ventilated critically ill patients...
  33. doi request reprint The development and validation of a novel questionnaire to measure patient and family satisfaction with end-of-life care: the Canadian Health Care Evaluation Project (CANHELP) Questionnaire
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, Ontario, Canada
    Palliat Med 24:682-95. 2010
    ..We conclude that the CANHELP Questionnaire is a valid and internally consistent instrument to measure satisfaction with end-of-life care...
  34. doi request reprint Adjudication of bleeding outcomes in an international thromboprophylaxis trial in critical illness
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada Canadian Blood Services, Hamilton, Ontario, Canada
    Thromb Res 131:204-9. 2013
    ..Measuring bleeding in critical care trials is challenging. We determined the reliability of adjudicated bleeding assessments in a large thromboprophylaxis trial in the intensive care unit (ICU)...
  35. doi request reprint The 4Ts scoring system for heparin-induced thrombocytopenia in medical-surgical intensive care unit patients
    Mark Andrew Crowther
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 25:287-93. 2010
    ..The 4Ts score (Thrombocytopenia, Timing of thrombocytopenia, Thrombosis, and oTher reason) might identify individual patients at risk of having this disorder...
  36. ncbi request reprint Bilevel noninvasive positive pressure ventilation for acute respiratory failure: survey of Ontario practice
    Karen E A Burns
    Division of Critical Care Medicine, University of Western Ontario, London, Ontario, Canada
    Crit Care Med 33:1477-83. 2005
    ..To determine physicians' stated practices regarding the use of bilevel noninvasive ventilation (NIV) for acute respiratory failure and the predictors of practice variation...
  37. ncbi request reprint DNR directives are established early in mechanically ventilated intensive care unit patients
    Tasnim Sinuff
    Department of Medicine, McMaster University Health Sciences Center, Room 2C11, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Can J Anaesth 51:1034-41. 2004
    ..Our objective was to study the rate of establishing do-not-resuscitate (DNR) directives, determinants, and outcomes of those directives for mechanically ventilated patients...
  38. pmc Elevated troponin and myocardial infarction in the intensive care unit: a prospective study
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 9:R636-44. 2005
    ....
  39. doi request reprint Corticosteroid use in the intensive care unit: a survey of intensivists
    Francois Lamontagne
    Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Can J Anaesth 60:652-9. 2013
    ..The efficacy of systemic corticosteroids in many critical illnesses remains uncertain. Our primary objective was to survey intensivists in North America about their perceived use of corticosteroids in clinical practice...
  40. doi request reprint Integrating mortality and morbidity outcomes: using quality-adjusted life years in critical care trials
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, The University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 187:256-61. 2013
    ..Outcome measures that integrate mortality and morbidity, like quality-adjusted life years (QALYs), have been proposed for critical care clinical trials...
  41. doi request reprint The PRECISE RCT: evolution of an early septic shock fluid resuscitation trial
    Lauralyn McIntyre
    The Clinical Epidemiology Program, Ottawa Hospital Research Institute OHRI, The Ottawa Hospital, Ottawa, Ontario, Canada
    Transfus Med Rev 26:333-41. 2012
    ....
  42. ncbi request reprint Elevated cardiac troponin levels in critically ill patients: prevalence, incidence, and outcomes
    Wendy Lim
    The Department of Medicine, McMaster University, Hamilton, Ontario, CA
    Am J Crit Care 15:280-8; quiz 289. 2006
    ..Levels of cardiac troponin, a sensitive and specific marker of myocardial injury, are often elevated in critically ill patients...
  43. ncbi request reprint Thrombocytopenia in medical-surgical critically ill patients: prevalence, incidence, and risk factors
    Mark A Crowther
    Department of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:348-53. 2005
    ....
  44. ncbi request reprint Decision-making in the ICU: perspectives of the substitute decision-maker
    Daren K Heyland
    Department of Medicine, Angada 3, Kingston General Hospital, Ontario, Canada
    Intensive Care Med 29:75-82. 2003
    ..To describe the substitute decision-makers' perspectives related to decision-making in the intensive care unit (ICU) and to determine those variables associated with their overall satisfaction with decision-making...
  45. ncbi request reprint Survey of interventions for the prevention and treatment of acute respiratory distress syndrome
    Maureen O Meade
    Clinical Epidemiology and Biostatistics, and Medicine, McMaster University Health Sciences Centre, Hamilton, ON, Canada
    Crit Care Med 32:946-54. 2004
    ..To determine physicians' opinions and practices related to the management of patients with acute respiratory distress syndrome...
  46. ncbi request reprint Mortality predictions in the intensive care unit: comparing physicians with scoring systems
    Tasnim Sinuff
    Department of Critical Care Medicine, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Crit Care Med 34:878-85. 2006
    ..Our systematic review compared the accuracy of ICU physicians' and scoring system predictions of ICU or hospital mortality of critically ill adults...
  47. ncbi request reprint Surrogate decision makers' attitudes towards research decision making for critically ill patients
    Kali A Barrett
    Internal Medicine Programme, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Intensive Care Med 38:1616-23. 2012
    ..To examine the attitudes and preferences of surrogate decision makers (SDMs) regarding their involvement in the consent to research process for ICU patients...
  48. doi request reprint Consent in critical care trials: a survey of Canadian research ethics boards and critical care researchers
    Mark Duffett
    McMaster Children s Hospital, Hamilton, Ontario, Canada
    J Crit Care 26:533.e11-22. 2011
    ..We compared the attitudes and beliefs of Canadian research ethics boards (REBs) and intensive care unit researchers toward the use of various consent models for a low-risk randomized controlled trial...
  49. doi request reprint Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trial
    Lauralyn A McIntyre
    University of Ottawa Centre for Transfusion and Critical Care Research, Ottawa Hospital, Ottawa, Ontario, Canada
    Can J Anaesth 55:819-26. 2008
    ..This randomized controlled trial determined the feasibility of conducting a large trial testing resuscitation with pentastarch vs normal saline in early septic shock, powered for a difference in mortality...
  50. doi request reprint A randomized trial of daily awakening in critically ill patients managed with a sedation protocol: a pilot trial
    Sangeeta Mehta
    Inter Departmental Division of Critical Care Medicine, Mount Sinai Hospital, University Health Network, and University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 36:2092-9. 2008
    ..Our objective was to determine the safety and feasibility of a randomized trial to determine whether adults managed with both PS + DI have a shorter duration of MV than patients managed with PS alone...
  51. ncbi request reprint Elevated cardiac troponin measurements in critically ill patients
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 166:2446-54. 2006
    ..We reviewed the frequency of cTn elevation and its association with mortality and length of ICU stay in these patients...
  52. ncbi request reprint Reliability of electrocardiogram interpretation in critically ill patients
    Wendy Lim
    Medicine and Clinical Epidemiology, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 34:1338-43. 2006
    ..To assess the intrarater and interrater reliability of electrocardiogram (ECG) interpretation in critically ill patients and to assess the effect of knowledge of cardiac troponin values on these reliability estimates...
  53. ncbi request reprint Bleeding during critical illness: a prospective cohort study using a new measurement tool
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Invest Med 30:E93-102. 2007
    ..To estimate the incidence, severity, duration and consequences of bleeding during critical illness, and to test the performance characteristics of a new bleeding assessment tool...
  54. ncbi request reprint Most critically ill patients are perceived to die in comfort during withdrawal of life support: a Canadian multicentre study
    Graeme M Rocker
    Department of Medicine, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    Can J Anaesth 51:623-30. 2004
    ..Most deaths in intensive care units (ICUs) follow a withdrawal of life support (LS). Evaluation of this process including the related perspectives of grieving family members is integral to improvement of palliation in the ICU...
  55. doi request reprint Knowledge translation interventions for critically ill patients: a systematic review*
    Tasnim Sinuff
    1Department of Critical Care Medicine, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 2Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada 3Department of Medicine, Queen s University, Kingston, ON, Canada 4Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, ON, Canada 5Department of Critical Care Medicine, University of Calgary and Alberta Health Services, Calgary, AB, Canada 6Department of Medicine, University of Calgary and Alberta Health Services, Calgary, AB, Canada 7Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada 8Institute of Public Health, University of Calgary, Calgary, AB, Canada 9Center for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada 10Department of Medicine, Providence Health Care and University of British Columbia, Vancouver, BC, Canada 11Department of Medicine, McMaster University, Hamilton, ON, Canada 12Department of Clinical Epidemiology and Biostatistics, Japan
    Crit Care Med 41:2627-40. 2013
    ..We systematically reviewed ICU-based knowledge translation studies to assess the impact of knowledge translation interventions on processes and outcomes of care...
  56. pmc Strategies to enhance venous thromboprophylaxis in hospitalized medical patients (SENTRY): a pilot cluster randomized trial
    Menaka Pai
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Implement Sci 8:1. 2013
    ..Knowledge-translation strategies are needed to bridge this gap...
  57. doi request reprint High-frequency oscillation in early acute respiratory distress syndrome
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada
    N Engl J Med 368:795-805. 2013
    ....
  58. pmc A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial
    Karen E A Burns
    Interdepartmental Division of Critical Care Medicine and Departments of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Trials 12:70. 2011
    ....
  59. ncbi request reprint Deep venous thrombosis: clinically silent in the intensive care unit
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:334-40. 2005
    ....
  60. pmc Defining priorities for improving end-of-life care in Canada
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, Ont
    CMAJ 182:E747-52. 2010
    ..The objective of this study was to identify aspects of end-of-life care that are high in priority as targets for improvement using feedback elicited from patients and their families...
  61. ncbi request reprint Resuscitating patients with early severe sepsis: a Canadian multicentre observational study
    Lauralyn A McIntyre
    Department of Medicine critical care, The Ottawa Hospital, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 54:790-8. 2007
    ..We sought to examine associations of the quantity and type of fluid administered in the first six hours after identification of severe sepsis and hospital mortality, intensive care unit (ICU) mortality, and organ failure...
  62. doi request reprint Research recruitment practices and critically ill patients. A multicenter, cross-sectional study (the Consent Study)
    Karen E A Burns
    Division of Critical Care Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 187:1212-8. 2013
    ..Limited cross-sectional data exist to characterize the challenges of enrolling critically ill patients into research studies...
  63. doi request reprint A multifaceted strategy to reduce inappropriate use of frozen plasma transfusions in the intensive care unit
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 26:636.e7-636.e13. 2011
    ..The purpose of this study is to determine the effect of a multifaceted behavior-change strategy on inappropriate use of frozen plasma (FP) transfusions in the intensive care unit (ICU)...
  64. doi request reprint Quality of reporting of surveys in critical care journals: a methodologic review
    Mark Duffett
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 40:441-9. 2012
    ..Adequate reporting is needed to judge methodologic quality and assess the risk of bias of surveys. The objective of this study is to describe the methodology and quality of reporting of surveys published in five critical care journals...
  65. pmc Payments for care at private for-profit and private not-for-profit hospitals: a systematic review and meta-analysis
    P J Devereaux
    Department of Medicine, McMaster University, Hamilton
    CMAJ 170:1817-24. 2004
    ....
  66. doi request reprint Biomarkers of sepsis
    John C Marshall
    Li Ka Shing Knowledge Institute, The Keenan Research Centre, Toronto, Ontario, Canada
    Crit Care Med 37:2290-8. 2009
    ..Validated biomarkers of sepsis may improve diagnosis and therapeutic decision making for these high-risk patients...
  67. ncbi request reprint Prevention of ventilator-associated pneumonia: current practice in Canadian intensive care units
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Crit Care 17:161-7. 2002
    ..To evaluate the current use of strategies to prevent ventilator-associated pneumonia (VAP) and to identify interventions to target for quality-improvement initiatives...
  68. doi request reprint Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis
    Dirk Bassler
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA 303:1180-7. 2010
    ..Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping...
  69. ncbi request reprint A framework for resolving disagreement during end of life care in the critical care unit
    Karen Choong
    Department of Pediatrics and Critical Care, McMaster Children s Hospital, McMaster University, Hamilton, Ontario
    Clin Invest Med 33:E240-53. 2010
    ..Such disagreements can cause tension and moral distress among families and clinicians...
  70. ncbi request reprint Dalteparin thromboprophylaxis for critically ill medical-surgical patients with renal insufficiency
    Christian G Rabbat
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:357-63. 2005
    ....
  71. ncbi request reprint How qualitative research can contribute to research in the intensive care unit
    Tasnim Sinuff
    Department of Critical Care, Sunnybrook Health Sciences Centre, and Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
    J Crit Care 22:104-11. 2007
    ..To illustrate how our understanding of social phenomena such as patient safety and behavior change has been enhanced we use recent qualitative studies in acute care medicine...
  72. doi request reprint Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock: a pilot randomized, controlled trial
    Lauralyn A McIntyre
    Department of Medicine Division of Critical Care, Ottawa Hospital Research Institute OHRI, University of Ottawa, Ottawa, Ontario, Canada
    J Crit Care 27:317.e1-6. 2012
    ..We describe the Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock (PRECISE) pilot trial study design and report feasibility of patient recruitment...
  73. ncbi request reprint Practice guidelines as multipurpose tools: a qualitative study of noninvasive ventilation
    Tasnim Sinuff
    Department of Critical Care, Sunnybrook Health Sciences Centre, Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
    Crit Care Med 35:776-82. 2007
    ..The objective was to understand the knowledge about and attitudes toward an NIV guideline for patients with ARF and potential barriers to its use...
  74. doi request reprint The climate of patient safety in a Canadian intensive care unit
    Michelle E Kho
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:469.e7-13. 2009
    ..We assessed multidisciplinary team members' perspectives of patient safety climate in a 15-bed, closed medical-surgical intensive care unit through a self-administered questionnaire...
  75. doi request reprint Quality of professional society guidelines and consensus conference statements in critical care
    Tasnim Sinuff
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 36:1049-58. 2008
    ..To examine the quality of professional society critical care guidelines and consensus statements...
  76. doi request reprint Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial
    Maureen O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 299:637-45. 2008
    ..Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality...
  77. pmc Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Susan R Kahn
    Department of Medicine, McGill University, Montreal, QC, Canada
    Chest 141:e195S-226S. 2012
    ..This guideline addressed VTE prevention in hospitalized medical patients, outpatients with cancer, the chronically immobilized, long-distance travelers, and those with asymptomatic thrombophilia...
  78. pmc A retrospective cohort pilot study to evaluate a triage tool for use in a pandemic
    Michael D Christian
    Department of National Defence, Canadian Forces, Mount Sinai Hospital Toronto University Health Network, University of Toronto, 600 University Avenue, Toronto, ON, Canada
    Crit Care 13:R170. 2009
    ....
  79. ncbi request reprint Dying in the ICU: perspectives of family members
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, ON, Canada
    Chest 124:392-7. 2003
    ..To describe the perspectives of family members to the care provided to critically ill patients who died in the ICU...
  80. doi request reprint Patient and healthcare professional factors influencing end-of-life decision-making during critical illness: a systematic review
    David W Frost
    Division of General Internal Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 39:1174-89. 2011
    ..DATA SOURCES, SELECTION, AND ABSTRACTION: We conducted a structured search of Ovid Medline for interventional and observational research articles incorporating critical care and end-of-life decision-making terms...
  81. ncbi request reprint A study of the physiologic responses to a lung recruitment maneuver in acute lung injury and acute respiratory distress syndrome
    Maureen O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Respir Care 53:1441-9. 2008
    ..To determine the magnitude, duration, and consistency of the effects of lung recruitment maneuvers (RMs) on oxygenation, lung mechanics, and comfort in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)...
  82. ncbi request reprint Systematic reviewers neglect bias that results from trials stopped early for benefit
    Dirk Bassler
    The Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Clin Epidemiol 60:869-73. 2007
    ....
  83. doi request reprint Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis
    Daniel R Ricciuto
    McLaughlin Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, The University of Toronto, Ontario, Canada
    Crit Care Med 39:702-10. 2011
    ..To determine the utility of angiopoietin-1 and angiopoietin-2 as potentially novel biomarkers of morbidity and mortality in patients with severe sepsis...
  84. ncbi request reprint Abstract reporting in randomized clinical trials of acute lung injury: an audit and assessment of a quality of reporting score
    Karen E A Burns
    Graduate Program in Health Research Methodology, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 33:1937-45. 2005
    ..To evaluate the quality of reporting among abstracts of randomized controlled trials (RCTs) in acute lung injury and to highlight important trial information for abstract inclusion...
  85. doi request reprint Noninvasive ventilation for acute respiratory failure near the end of life
    Tasnim Sinuff
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 36:789-94. 2008
    ....
  86. ncbi request reprint Prevention of venous thromboembolism in critically ill surgery patients: a cross-sectional study
    D Cook
    Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 16:161-6. 2001
    ..3, P =.001). CONCLUSIONS: VTE prevention for surgical ICU patients within the first postoperative week appear to be individualized, and influenced by current and future risks of thrombosis and bleeding...
  87. ncbi request reprint Safety and efficacy of low molecular weight heparins for hemodialysis in patients with end-stage renal failure: a meta-analysis of randomized trials
    Wendy Lim
    Department of Medicine, McMaster University, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    J Am Soc Nephrol 15:3192-206. 2004
    ..However, inferences from these trials assessing anticoagulation for patients who undergo hemodialysis will continue to be weak until larger, more rigorous randomized trials are conducted...
  88. pmc Written informed consent and selection bias in observational studies using medical records: systematic review
    Michelle E Kho
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L8
    BMJ 338:b866. 2009
    ..To determine whether informed consent introduces selection bias in prospective observational studies using data from medical records, and consent rates for such studies...
  89. pmc A systematic review and meta-analysis of studies comparing mortality rates of private for-profit and private not-for-profit hospitals
    P J Devereaux
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 166:1399-406. 2002
    ..To inform this debate, we undertook a systematic review and meta-analysis of studies comparing the mortality rates of private for-profit hospitals and those of private not-for-profit hospitals...
  90. ncbi request reprint Heparin, low molecular weight heparin, and heparin-induced thrombocytopenia in the ICU
    Theodore E Warkentin
    Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    Crit Care Clin 21:513-29. 2005
    ..This article describes clinical features of HIT and interpretation of laboratory tests for HIT antibodies from the perspective of the intensive care unit...
  91. ncbi request reprint Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responses
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 46:1286-91. 2006
    ..A description of current platelet (PLT) transfusion practice in the intensive care unit (ICU) is needed...
  92. ncbi request reprint Evaluation of a practice guideline for noninvasive positive-pressure ventilation for acute respiratory failure
    Tasnim Sinuff
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 123:2062-73. 2003
    ....
  93. ncbi request reprint Health technology assessment in the ICU: noninvasive positive pressure ventilation for acute respiratory failure
    Tasnim Sinuff
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 18:59-67. 2003
    ..Careful evaluation of health technologies in the ICU should be an ongoing priority...
  94. ncbi request reprint Comparison of mortality between private for-profit and private not-for-profit hemodialysis centers: a systematic review and meta-analysis
    P J Devereaux
    Depatment of Medicine, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada L8N 3Z5
    JAMA 288:2449-57. 2002
    ..There has been extensive debate about whether the profit status of these facilities influences patient mortality...
  95. pmc Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk
    P J Devereaux
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ont
    CMAJ 173:627-34. 2005
    ....
  96. doi request reprint Thromboprophylaxis in medical-surgical critically ill patients
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Crit Care 14:520-3. 2008
    ....
  97. doi request reprint Preventing venous thromboembolism in critically ill patients
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Thromb Hemost 34:469-74. 2008
    ..Large, well-designed randomized trials, powered to detect differences in clinically relevant end points, are required to advance the care of this highly vulnerable patient population...
  98. doi request reprint Grades of recommendation for antithrombotic agents: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Gordon H Guyatt
    Health Sciences Centre, McMaster University, Hamilton, Ontario, Canada
    Chest 133:123S-131S. 2008
    ..Weak (Grade 2) suggestions require more judicious application, particularly considering patient values and preferences and, when resource limitations play an important role, issues of cost...
  99. ncbi request reprint Interrater reliability of APACHE II scores for medical-surgical intensive care patients: a prospective blinded study
    Michelle E Kho
    Health Research Methodology Program, at McMaster University, Hamilton, Ontario, Canada
    Am J Crit Care 16:378-83. 2007
    ..Despite widespread use of the Acute Physiology and Chronic Health Evaluation II (APACHE II), its interrater reliability has not been well studied...
  100. ncbi request reprint Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study
    John C Marshall
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 190:527-34. 2004
    ..Stepwise logistic regression analysis showed that elevated Acute Physiology and Chronic Health Evaluation II score, gram-negative infection, and emergency admission status were independent predictors of EA...
  101. pmc Need for expertise based randomised controlled trials
    P J Devereaux
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street, West Hamilton ON, Canada L8N 3Z5
    BMJ 330:88. 2005