Deborah J Cook

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
  2. ncbi LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, Buffalo, USA
    Trials 10:40. 2009
  3. ncbi Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
  4. ncbi Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
    Simon Finfer
    Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
    Crit Care 14:R185. 2010
  5. ncbi Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis
    Mark Duffett
    Department of Critical Care, McMaster Children s Hospital, 1200 Main St, W, Hamilton, Ontario L8S 4J9, Canada
    Crit Care 11:R66. 2007
  6. ncbi A survey of Canadian intensivists' resuscitation practices in early septic shock
    Lauralyn A McIntyre
    University of Ottawa Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit of the Ottawa Hospital, Ottawa Health Research Institute, 501 Smyth Rd Ottawa, Ontario, Canada K1H 8L6
    Crit Care 11:R74. 2007
  7. ncbi Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings
    Wendy Lim
    Department of Medicine, McMaster University, Canada
    Crit Care 12:R36. 2008
  8. ncbi Moving toward evidence-based practice
    Deborah J Cook
    Division of Critical Care Medicine, Department of Medicine, St Joseph s Hospital, Hamilton, Ontario, Canada
    Respir Care 48:859-68. 2003
  9. ncbi Pulmonary embolism in medical-surgical critically ill patients
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Hematol Oncol Clin North Am 24:677-82, vii. 2010
  10. ncbi Thromboprophylaxis in medical-surgical intensive care unit patients
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:320-3. 2005

Detail Information

Publications128 found, 100 shown here

  1. ncbi Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
    ..The objective of this study was to determine if RBC transfusions or RBC storage age predicts incident DVT in medical or surgical intensive care unit (ICU) patients...
  2. ncbi LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, Buffalo, USA
    Trials 10:40. 2009
    ..The secondary objectives are to describe, for published RCTs, (1) the reporting of loss to follow-up information, (2) the analytic methods used for handling loss to follow-up information, and (3) the extent of reported loss to follow-up...
  3. ncbi Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
    ..The aim of STOPIT-2 is to determine the magnitude and determinants of possible bias introduced by stopping RCTs early for benefit...
  4. ncbi Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
    Simon Finfer
    Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
    Crit Care 14:R185. 2010
    ..Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients...
  5. ncbi Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis
    Mark Duffett
    Department of Critical Care, McMaster Children s Hospital, 1200 Main St, W, Hamilton, Ontario L8S 4J9, Canada
    Crit Care 11:R66. 2007
    ..The objective of the present systematic review is to assess the effect of exogenous pulmonary surfactant on all-cause mortality in children mechanically ventilated for acute respiratory failure...
  6. ncbi A survey of Canadian intensivists' resuscitation practices in early septic shock
    Lauralyn A McIntyre
    University of Ottawa Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit of the Ottawa Hospital, Ottawa Health Research Institute, 501 Smyth Rd Ottawa, Ontario, Canada K1H 8L6
    Crit Care 11:R74. 2007
    ..The objective of this survey was to characterize reported resuscitation practices of Canadian physicians caring for adult critically ill patients with early septic shock...
  7. ncbi Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings
    Wendy Lim
    Department of Medicine, McMaster University, Canada
    Crit Care 12:R36. 2008
    ..This is a prospective screening study...
  8. ncbi Moving toward evidence-based practice
    Deborah J Cook
    Division of Critical Care Medicine, Department of Medicine, St Joseph s Hospital, Hamilton, Ontario, Canada
    Respir Care 48:859-68. 2003
    ..We should always ask whether the right provider is doing the right thing for the right patient at the right time in the right setting with the right resources...
  9. ncbi Pulmonary embolism in medical-surgical critically ill patients
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Hematol Oncol Clin North Am 24:677-82, vii. 2010
    ....
  10. ncbi Thromboprophylaxis in medical-surgical intensive care unit patients
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:320-3. 2005
  11. ncbi Clinically important deep vein thrombosis in the intensive care unit: a survey of intensivists
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 8:R145-52. 2004
    ..The objective of the present survey is to identify the patient factors and radiologic features of lower limb DVT that intensivists consider more or less likely to make a DVT clinically important in ICU patients...
  12. ncbi Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:168-75. 2009
    ....
  13. ncbi Dying in the ICU: strategies that may improve end-of-life care
    Deborah Cook
    Departments of Medicine, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Can J Anaesth 51:266-72. 2004
    ..The purpose of this article is to suggest some strategies to consider to improve the care of patients dying in the ICU...
  14. ncbi Improving patients' safety locally: changing clinician behaviour
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Lancet 363:1224-30. 2004
    ..The steps are to: do an environmental scan; understand current behaviour, target behaviour for change (why, what, when, where, and who); adopt effective strategies to change behaviour; and synergise...
  15. ncbi Thromboprophylaxis in the intensive care unit: focus on medical-surgical patients
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 38:S76-82. 2010
    ..Furthermore, because thromboprophylaxis is a common error of omission in hospitalized patients, redoubled efforts are needed to ensure that it is used in practice...
  16. ncbi Thromboprophylaxis for hospitalized medical patients: a multicenter qualitative study
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Hosp Med 4:269-75. 2009
    ..Observational studies have documented that medical patients infrequently receive venous thromboembolism (VTE) prevention...
  17. ncbi Clinical research ethics for critically ill patients: a pandemic proposal
    Deborah Cook
    International Forum for Acute Care Trialists InFACT Ethics Committee, Department of Medicine, McMaster University, Hamilton, Canada
    Crit Care Med 38:e138-42. 2010
    ..We also propose strategies such as expedited and centralized research ethics committee reviews and alternate consent models...
  18. ncbi Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:364-72. 2005
    ..Its additional goals were to evaluate the suitability of the exclusion criteria and to document the range of research activities that precede accrual of patients into a trial to plan multisite management...
  19. ncbi Research agenda: venous thromboembolism in medical-surgical critically ill patients
    Deborah J Cook
    Deparment of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:330-3. 2005
  20. ncbi Randomized trials in vulnerable populations
    Deborah Cook
    Department of Medicine, McMaster University Health Sciences Center, Hamilton, Ontario, Canada
    Clin Trials 5:61-9. 2008
    ....
  21. ncbi PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 26:223.e1-9. 2011
    ....
  22. ncbi Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors
    Deborah Cook
    Department of Medicine, 1200 Main Street, McMaster University, Hamilton, Canada
    Crit Care 12:R32. 2008
    ..The objective of the present study was to evaluate the prevalence, incidence and predictors of DVT and the incidence of bleeding in intensive care unit (ICU) patients with estimated creatinine clearance <30 ml/min...
  23. ncbi Prevention and diagnosis of venous thromboembolism in critically ill patients: a Canadian survey
    D Cook
    Department of Medicine, McMaster University, Hamilton, Canada
    Crit Care 5:336-42. 2001
    ..The objective of this study was to understand current approaches to the prevention and diagnosis of deep venous thrombosis (DVT) and pulmonary embolism (PE) among patients in the intensive care unit (ICU)...
  24. ncbi The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 5:368-75. 2001
    ..To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically ventilated critically ill patients...
  25. ncbi Trials of miscellaneous interventions to wean from mechanical ventilation
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:438S-44S. 2001
    ..Multidisciplinary, patient-centered, holistic, and non-pulmonary approaches to weaning may provide additional safe, effective adjunctive methods of hastening liberation from mechanical ventilation...
  26. ncbi Qualitative studies on the patient's experience of weaning from mechanical ventilation
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:469S-73S. 2001
    ....
  27. ncbi Cardiopulmonary resuscitation directives on admission to intensive-care unit: an international observational study
    D J Cook
    Department of Medicine, McMaster University, Ontario, Hamilton, Canada
    Lancet 358:1941-5. 2001
    ..Our objective was to ascertain prevalence, predictors, and procurement pattern of cardiopulmonary resuscitation directives within 24 h of admission to the intensive-care unit (ICU)...
  28. ncbi Bleeding and venous thromboembolism in the critically ill with emphasis on patients with renal insufficiency
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Pulm Med 15:455-62. 2009
    ....
  29. ncbi Serious adverse events in academic critical care research
    Deborah Cook
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont
    CMAJ 178:1181-4. 2008
  30. ncbi Enrollment of intensive care unit patients into clinical studies: a trinational survey of researchers' experiences, beliefs, and practices
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Crit Care Med 36:2100-5. 2008
    ..As critical care practice increases in scope, size, and complexity, enrollment of critically ill patients into clinical studies is increasing...
  31. ncbi The development and validation of a novel questionnaire to measure patient and family satisfaction with end-of-life care: the Canadian Health Care Evaluation Project (CANHELP) Questionnaire
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, Ontario, Canada
    Palliat Med 24:682-95. 2010
    ..We conclude that the CANHELP Questionnaire is a valid and internally consistent instrument to measure satisfaction with end-of-life care...
  32. ncbi The 4Ts scoring system for heparin-induced thrombocytopenia in medical-surgical intensive care unit patients
    Mark Andrew Crowther
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 25:287-93. 2010
    ..The 4Ts score (Thrombocytopenia, Timing of thrombocytopenia, Thrombosis, and oTher reason) might identify individual patients at risk of having this disorder...
  33. ncbi DNR directives are established early in mechanically ventilated intensive care unit patients
    Tasnim Sinuff
    Department of Medicine, McMaster University Health Sciences Center, Room 2C11, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Can J Anaesth 51:1034-41. 2004
    ..The strongest predictors of DNR directives were physician prediction of low probability of survival, physician perception of patient preference to limit life support, organ dysfunction, medical diagnosis and age...
  34. ncbi Elevated troponin and myocardial infarction in the intensive care unit: a prospective study
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 9:R636-44. 2005
    ....
  35. ncbi Elevated cardiac troponin levels in critically ill patients: prevalence, incidence, and outcomes
    Wendy Lim
    The Department of Medicine, McMaster University, Hamilton, Ontario, CA
    Am J Crit Care 15:280-8; quiz 289. 2006
    ..CONCLUSIONS: Elevated levels of cardiac troponin I in critically ill patients do not always indicate myocardial infarction or an adverse prognosis...
  36. ncbi Thrombocytopenia in medical-surgical critically ill patients: prevalence, incidence, and risk factors
    Mark A Crowther
    Department of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:348-53. 2005
    ..Heparin-induced thrombocytopenia was frequently suspected but did not develop in these critically ill patients...
  37. ncbi Decision-making in the ICU: perspectives of the substitute decision-maker
    Daren K Heyland
    Department of Medicine, Angada 3, Kingston General Hospital, Ontario, Canada
    Intensive Care Med 29:75-82. 2003
    ..To describe the substitute decision-makers' perspectives related to decision-making in the intensive care unit (ICU) and to determine those variables associated with their overall satisfaction with decision-making...
  38. ncbi Bilevel noninvasive positive pressure ventilation for acute respiratory failure: survey of Ontario practice
    Karen E A Burns
    Division of Critical Care Medicine, University of Western Ontario, London, Ontario, Canada
    Crit Care Med 33:1477-83. 2005
    ..Some factors associated with variation in NIV use may be suitable targets for utilization improvement interventions...
  39. ncbi Consent in critical care trials: a survey of Canadian research ethics boards and critical care researchers
    Mark Duffett
    McMaster Children s Hospital, Hamilton, Ontario, Canada
    J Crit Care 26:533.e11-22. 2011
    ..We compared the attitudes and beliefs of Canadian research ethics boards (REBs) and intensive care unit researchers toward the use of various consent models for a low-risk randomized controlled trial...
  40. ncbi A randomized trial of daily awakening in critically ill patients managed with a sedation protocol: a pilot trial
    Sangeeta Mehta
    Inter Departmental Division of Critical Care Medicine, Mount Sinai Hospital, University Health Network, and University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 36:2092-9. 2008
    ..Our objective was to determine the safety and feasibility of a randomized trial to determine whether adults managed with both PS + DI have a shorter duration of MV than patients managed with PS alone...
  41. ncbi Most critically ill patients are perceived to die in comfort during withdrawal of life support: a Canadian multicentre study
    Graeme M Rocker
    Department of Medicine, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    Can J Anaesth 51:623-30. 2004
    ..Most deaths in intensive care units (ICUs) follow a withdrawal of life support (LS). Evaluation of this process including the related perspectives of grieving family members is integral to improvement of palliation in the ICU...
  42. ncbi Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trial
    Lauralyn A McIntyre
    University of Ottawa Centre for Transfusion and Critical Care Research, Ottawa Hospital, Ottawa, Ontario, Canada
    Can J Anaesth 55:819-26. 2008
    ..This randomized controlled trial determined the feasibility of conducting a large trial testing resuscitation with pentastarch vs normal saline in early septic shock, powered for a difference in mortality...
  43. ncbi Reliability of electrocardiogram interpretation in critically ill patients
    Wendy Lim
    Medicine and Clinical Epidemiology, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 34:1338-43. 2006
    ..Additional studies assessing the appropriate methods of diagnosing myocardial ischemia and infarction and assessing the reliability of these diagnostic tests in critically ill patients are required...
  44. ncbi Bleeding during critical illness: a prospective cohort study using a new measurement tool
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Invest Med 30:E93-102. 2007
    ..To estimate the incidence, severity, duration and consequences of bleeding during critical illness, and to test the performance characteristics of a new bleeding assessment tool...
  45. ncbi Elevated cardiac troponin measurements in critically ill patients
    Wendy Lim
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 166:2446-54. 2006
    ..Research is needed to clarify the underlying causes of elevated cTn in this population and to examine their clinical significance...
  46. ncbi A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial
    Karen E A Burns
    Interdepartmental Division of Critical Care Medicine and Departments of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Trials 12:70. 2011
    ....
  47. ncbi Mortality predictions in the intensive care unit: comparing physicians with scoring systems
    Tasnim Sinuff
    Department of Critical Care Medicine, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
    Crit Care Med 34:878-85. 2006
    ..The overall accuracy of both predictions of patient mortality was moderate, implying limited usefulness of outcome prediction in the first 24 hrs for clinical decision making...
  48. ncbi Deep venous thrombosis: clinically silent in the intensive care unit
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:334-40. 2005
    ..42-0.75, P = .02). An AUC of 1.0 indicates an ideal test, and AUC of 0.50 indicates a test with no diagnostic utility. CONCLUSIONS: The history and physical examination for DVT are not useful in detecting lower limb DVT in the ICU...
  49. ncbi Defining priorities for improving end-of-life care in Canada
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, Ont
    CMAJ 182:E747-52. 2010
    ..The objective of this study was to identify aspects of end-of-life care that are high in priority as targets for improvement using feedback elicited from patients and their families...
  50. ncbi Survey of interventions for the prevention and treatment of acute respiratory distress syndrome
    Maureen O Meade
    Clinical Epidemiology and Biostatistics, and Medicine, McMaster University Health Sciences Centre, Hamilton, ON, Canada
    Crit Care Med 32:946-54. 2004
    ....
  51. ncbi A multifaceted strategy to reduce inappropriate use of frozen plasma transfusions in the intensive care unit
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 26:636.e7-636.e13. 2011
    ..The purpose of this study is to determine the effect of a multifaceted behavior-change strategy on inappropriate use of frozen plasma (FP) transfusions in the intensive care unit (ICU)...
  52. ncbi Quality of reporting of surveys in critical care journals: a methodologic review
    Mark Duffett
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 40:441-9. 2012
    ..Adequate reporting is needed to judge methodologic quality and assess the risk of bias of surveys. The objective of this study is to describe the methodology and quality of reporting of surveys published in five critical care journals...
  53. ncbi Dalteparin thromboprophylaxis for critically ill medical-surgical patients with renal insufficiency
    Christian G Rabbat
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:357-63. 2005
    ..If dalteparin does not bioaccumulate, it may be an attractive alternative agent for thromboprophylaxis...
  54. ncbi Prevention of ventilator-associated pneumonia: current practice in Canadian intensive care units
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Crit Care 17:161-7. 2002
    ..To evaluate the current use of strategies to prevent ventilator-associated pneumonia (VAP) and to identify interventions to target for quality-improvement initiatives...
  55. ncbi Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis
    Dirk Bassler
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA 303:1180-7. 2010
    ..Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping...
  56. ncbi A framework for resolving disagreement during end of life care in the critical care unit
    Karen Choong
    Department of Pediatrics and Critical Care, McMaster Children s Hospital, McMaster University, Hamilton, Ontario
    Clin Invest Med 33:E240-53. 2010
    ..Such disagreements can cause tension and moral distress among families and clinicians...
  57. ncbi Payments for care at private for-profit and private not-for-profit hospitals: a systematic review and meta-analysis
    P J Devereaux
    Department of Medicine, McMaster University, Hamilton
    CMAJ 170:1817-24. 2004
    ....
  58. ncbi Biomarkers of sepsis
    John C Marshall
    Li Ka Shing Knowledge Institute, The Keenan Research Centre, Toronto, Ontario, Canada
    Crit Care Med 37:2290-8. 2009
    ..Validated biomarkers of sepsis may improve diagnosis and therapeutic decision making for these high-risk patients...
  59. ncbi Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock: a pilot randomized, controlled trial
    Lauralyn A McIntyre
    Department of Medicine Division of Critical Care, Ottawa Hospital Research Institute OHRI, University of Ottawa, Ottawa, Ontario, Canada
    J Crit Care 27:317.e1-6. 2012
    ..We describe the Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock (PRECISE) pilot trial study design and report feasibility of patient recruitment...
  60. ncbi The climate of patient safety in a Canadian intensive care unit
    Michelle E Kho
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:469.e7-13. 2009
    ..We assessed multidisciplinary team members' perspectives of patient safety climate in a 15-bed, closed medical-surgical intensive care unit through a self-administered questionnaire...
  61. ncbi Quality of professional society guidelines and consensus conference statements in critical care
    Tasnim Sinuff
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 36:1049-58. 2008
    ..To examine the quality of professional society critical care guidelines and consensus statements...
  62. ncbi Practice guidelines as multipurpose tools: a qualitative study of noninvasive ventilation
    Tasnim Sinuff
    Department of Critical Care, Sunnybrook Health Sciences Centre, Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
    Crit Care Med 35:776-82. 2007
    ..The objective was to understand the knowledge about and attitudes toward an NIV guideline for patients with ARF and potential barriers to its use...
  63. ncbi Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial
    Maureen O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 299:637-45. 2008
    ..Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality...
  64. ncbi Resuscitating patients with early severe sepsis: a Canadian multicentre observational study
    Lauralyn A McIntyre
    Department of Medicine critical care, The Ottawa Hospital, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 54:790-8. 2007
    ..We sought to examine associations of the quantity and type of fluid administered in the first six hours after identification of severe sepsis and hospital mortality, intensive care unit (ICU) mortality, and organ failure...
  65. ncbi Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Susan R Kahn
    Department of Medicine, McGill University, Montreal, QC, Canada
    Chest 141:e195S-226S. 2012
    ..This guideline addressed VTE prevention in hospitalized medical patients, outpatients with cancer, the chronically immobilized, long-distance travelers, and those with asymptomatic thrombophilia...
  66. ncbi A retrospective cohort pilot study to evaluate a triage tool for use in a pandemic
    Michael D Christian
    Department of National Defence, Canadian Forces, Mount Sinai Hospital Toronto University Health Network, University of Toronto, 600 University Avenue, Toronto, ON, Canada
    Crit Care 13:R170. 2009
    ....
  67. ncbi Patient and healthcare professional factors influencing end-of-life decision-making during critical illness: a systematic review
    David W Frost
    Division of General Internal Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 39:1174-89. 2011
    ..DATA SOURCES, SELECTION, AND ABSTRACTION: We conducted a structured search of Ovid Medline for interventional and observational research articles incorporating critical care and end-of-life decision-making terms...
  68. ncbi Systematic reviewers neglect bias that results from trials stopped early for benefit
    Dirk Bassler
    The Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Clin Epidemiol 60:869-73. 2007
    ....
  69. ncbi Abstract reporting in randomized clinical trials of acute lung injury: an audit and assessment of a quality of reporting score
    Karen E A Burns
    Graduate Program in Health Research Methodology, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 33:1937-45. 2005
    ..Checklists may aid authors and editors in prioritizing important criteria for inclusion in RCT abstracts...
  70. ncbi Noninvasive ventilation for acute respiratory failure near the end of life
    Tasnim Sinuff
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 36:789-94. 2008
    ....
  71. ncbi How qualitative research can contribute to research in the intensive care unit
    Tasnim Sinuff
    Department of Critical Care, Sunnybrook Health Sciences Centre, and Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
    J Crit Care 22:104-11. 2007
    ..To illustrate how our understanding of social phenomena such as patient safety and behavior change has been enhanced we use recent qualitative studies in acute care medicine...
  72. ncbi Dying in the ICU: perspectives of family members
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, ON, Canada
    Chest 124:392-7. 2003
    ..To describe the perspectives of family members to the care provided to critically ill patients who died in the ICU...
  73. ncbi A study of the physiologic responses to a lung recruitment maneuver in acute lung injury and acute respiratory distress syndrome
    Maureen O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Respir Care 53:1441-9. 2008
    ..To determine the magnitude, duration, and consistency of the effects of lung recruitment maneuvers (RMs) on oxygenation, lung mechanics, and comfort in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)...
  74. ncbi Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis
    Daniel R Ricciuto
    McLaughlin Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, The University of Toronto, Ontario, Canada
    Crit Care Med 39:702-10. 2011
    ..To determine the utility of angiopoietin-1 and angiopoietin-2 as potentially novel biomarkers of morbidity and mortality in patients with severe sepsis...
  75. ncbi Prevention of venous thromboembolism in critically ill surgery patients: a cross-sectional study
    D Cook
    Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 16:161-6. 2001
    ..3, P =.001). CONCLUSIONS: VTE prevention for surgical ICU patients within the first postoperative week appear to be individualized, and influenced by current and future risks of thrombosis and bleeding...
  76. ncbi Grades of recommendation for antithrombotic agents: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Gordon H Guyatt
    Health Sciences Centre, McMaster University, Hamilton, Ontario, Canada
    Chest 133:123S-131S. 2008
    ..Weak (Grade 2) suggestions require more judicious application, particularly considering patient values and preferences and, when resource limitations play an important role, issues of cost...
  77. ncbi Preventing venous thromboembolism in critically ill patients
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Thromb Hemost 34:469-74. 2008
    ..Large, well-designed randomized trials, powered to detect differences in clinically relevant end points, are required to advance the care of this highly vulnerable patient population...
  78. ncbi Written informed consent and selection bias in observational studies using medical records: systematic review
    Michelle E Kho
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L8
    BMJ 338:b866. 2009
    ..To determine whether informed consent introduces selection bias in prospective observational studies using data from medical records, and consent rates for such studies...
  79. ncbi A systematic review and meta-analysis of studies comparing mortality rates of private for-profit and private not-for-profit hospitals
    P J Devereaux
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 166:1399-406. 2002
    ..To inform this debate, we undertook a systematic review and meta-analysis of studies comparing the mortality rates of private for-profit hospitals and those of private not-for-profit hospitals...
  80. ncbi Thromboprophylaxis in medical-surgical critically ill patients
    Mark A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Crit Care 14:520-3. 2008
    ....
  81. ncbi Health technology assessment in the ICU: noninvasive positive pressure ventilation for acute respiratory failure
    Tasnim Sinuff
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 18:59-67. 2003
    ..Careful evaluation of health technologies in the ICU should be an ongoing priority...
  82. ncbi Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk
    P J Devereaux
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ont
    CMAJ 173:627-34. 2005
    ....
  83. ncbi Heparin, low molecular weight heparin, and heparin-induced thrombocytopenia in the ICU
    Theodore E Warkentin
    Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    Crit Care Clin 21:513-29. 2005
    ..This article describes clinical features of HIT and interpretation of laboratory tests for HIT antibodies from the perspective of the intensive care unit...
  84. ncbi Need for expertise based randomised controlled trials
    P J Devereaux
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street, West Hamilton ON, Canada L8N 3Z5
    BMJ 330:88. 2005
  85. ncbi Comparison of mortality between private for-profit and private not-for-profit hemodialysis centers: a systematic review and meta-analysis
    P J Devereaux
    Depatment of Medicine, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada L8N 3Z5
    JAMA 288:2449-57. 2002
    ..There has been extensive debate about whether the profit status of these facilities influences patient mortality...
  86. ncbi Safety and efficacy of low molecular weight heparins for hemodialysis in patients with end-stage renal failure: a meta-analysis of randomized trials
    Wendy Lim
    Department of Medicine, McMaster University, St. Joseph's Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    J Am Soc Nephrol 15:3192-206. 2004
    ..However, inferences from these trials assessing anticoagulation for patients who undergo hemodialysis will continue to be weak until larger, more rigorous randomized trials are conducted...
  87. ncbi Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responses
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 46:1286-91. 2006
    ..A description of current platelet (PLT) transfusion practice in the intensive care unit (ICU) is needed...
  88. ncbi Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study
    John C Marshall
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 190:527-34. 2004
    ..Stepwise logistic regression analysis showed that elevated Acute Physiology and Chronic Health Evaluation II score, gram-negative infection, and emergency admission status were independent predictors of EA...
  89. ncbi Prognostic value of myocardial perfusion studies in patients with end-stage renal disease assessed for kidney or kidney-pancreas transplantation: a meta-analysis
    Christian G Rabbat
    Department of Medicine, Division of Nephrology, McMaster University, Hamilton, Ontario, Canada
    J Am Soc Nephrol 14:431-9. 2003
    ..It is concluded that positive MPS are useful in identifying patients with significantly increased risk of future MI and CD in both diabetic and nondiabetic ESRD patients...
  90. ncbi Interrater reliability of APACHE II scores for medical-surgical intensive care patients: a prospective blinded study
    Michelle E Kho
    Health Research Methodology Program, at McMaster University, Hamilton, Ontario, Canada
    Am J Crit Care 16:378-83. 2007
    ..Despite widespread use of the Acute Physiology and Chronic Health Evaluation II (APACHE II), its interrater reliability has not been well studied...
  91. ncbi Evaluation of a practice guideline for noninvasive positive-pressure ventilation for acute respiratory failure
    Tasnim Sinuff
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 123:2062-73. 2003
    ....
  92. ncbi Vitamin K deficiency and D-dimer levels in the intensive care unit: a prospective cohort study
    M A Crowther
    Department of Medicine, McMaster University, St Joseph s Hospital, Hamilton, Ontario, Canada
    Blood Coagul Fibrinolysis 13:49-52. 2002
    ....
  93. ncbi Minimizing errors of omission: behavioural reenforcement of heparin to avert venous emboli: the BEHAVE study
    J McMullin
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Crit Care Med 34:694-9. 2006
    ..Guideline adherence was maintained 1 yr later. Further research is needed on which are the most effective strategies to implement patient safety initiatives in the intensive care unit...
  94. ncbi Regular versus as-needed short-acting inhaled beta-agonist therapy for chronic obstructive pulmonary disease
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 163:85-90. 2001
    ..02 (95% CI: -0.20 to 0.24). We found that in patients with COPD, use of regular short-acting inhaled beta-agonists resulted in twice as much beta-agonist use without physiologic or clinical benefit as did use on an as-needed basis...
  95. ncbi Withholding and withdrawing life support in critical care settings: ethical issues concerning consent
    E Gedge
    Department of Philosophy, University Hall 310, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    J Med Ethics 33:215-8. 2007
    ..Both the bioethics and critical care communities should investigate the possibilities and limits of growing pressure for doctors to disclose their reasoning or seek patient consent when decisions to withhold life support are made...
  96. ncbi Does this patient have deep vein thrombosis?
    S S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 279:1094-9. 1998
    ..To review the validity of the clinical assessment and diagnostic tests in patients with suspected deep vein thrombosis (DVT)...
  97. ncbi Ventilator associated pneumonia: perspectives on the burden of illness
    D Cook
    Department of Medicine, St Joseph s Hospital, Hamilton, Ontario, Canada
    Intensive Care Med 26:S31-7. 2000
    ..The objective of this narrative review is to summarize selected current concepts and clinical evidence regarding the burden of illness of VAP, including its epidemiology, diagnosis, attributable mortality and risk factors...
  98. ncbi Influence of airway management on ventilator-associated pneumonia: evidence from randomized trials
    D Cook
    Department of Medicine, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
    JAMA 279:781-7. 1998
    ..Many interventions have been studied to reduce the risk of VAP. We systematically reviewed the influence of airway management on VAP in critically ill patients...
  99. ncbi Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial
    P J Devereaux
    McMaster University, Faculty of Health Sciences, Clinical Epidemiology and Biostatistics, Room 2C8, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    Lancet 371:1839-47. 2008
    ..This randomised controlled trial, done in 190 hospitals in 23 countries, was designed to investigate the effects of perioperative beta blockers...
  100. ncbi Prevalence, incidence, and risk factors for venous thromboembolism in medical-surgical intensive care unit patients
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:309-13. 2005
  101. ncbi Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia
    Aaron P Hong
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Blood 101:3049-51. 2003
    ..0; P =.011). We conclude that a localizing vascular injury (CVC use) and a systemic hypercoagulability disorder (HIT) interact to explain upper-extremity DVT complicating HIT...