D J Cook

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Influence of airway management on ventilator-associated pneumonia: evidence from randomized trials
    D Cook
    Department of Medicine, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
    JAMA 279:781-7. 1998
  2. ncbi request reprint Regular versus as-needed short-acting inhaled beta-agonist therapy for chronic obstructive pulmonary disease
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 163:85-90. 2001
  3. ncbi request reprint Ventilator associated pneumonia: perspectives on the burden of illness
    D Cook
    Department of Medicine, St Joseph s Hospital, Hamilton, Ontario, Canada
    Intensive Care Med 26:S31-7. 2000
  4. pmc Life support in the intensive care unit: a qualitative investigation of technological purposes. Canadian Critical Care Trials Group
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 161:1109-13. 1999
  5. ncbi request reprint Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients
    D J Cook
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 129:433-40. 1998
  6. pmc The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 5:368-75. 2001
  7. ncbi request reprint The effect of acidified enteral feeds on gastric colonization in critically ill patients: results of a multicenter randomized trial. Canadian Critical Care Trials Group
    D K Heyland
    Department of Medicine, Queen s University, Kingston, ON, Canada
    Crit Care Med 27:2399-406. 1999
  8. ncbi request reprint The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia. Canadian Critical Care Trials Group
    D K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Chest 115:1076-84. 1999
  9. ncbi request reprint The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. The Canadian Critical Trials Group
    D K Heyland
    Department of Medicine, Queen s University, Kingston, ON, Canada
    Am J Respir Crit Care Med 159:1249-56. 1999
  10. ncbi request reprint Discrimination and abuse in internal medicine residency. The Internal Medicine Program Directors of Canada
    C H vanIneveld
    Geriatrics Residency Program, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    J Gen Intern Med 11:401-5. 1996

Detail Information

Publications51

  1. ncbi request reprint Influence of airway management on ventilator-associated pneumonia: evidence from randomized trials
    D Cook
    Department of Medicine, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
    JAMA 279:781-7. 1998
    ..Many interventions have been studied to reduce the risk of VAP. We systematically reviewed the influence of airway management on VAP in critically ill patients...
  2. ncbi request reprint Regular versus as-needed short-acting inhaled beta-agonist therapy for chronic obstructive pulmonary disease
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 163:85-90. 2001
    ..02 (95% CI: -0.20 to 0.24). We found that in patients with COPD, use of regular short-acting inhaled beta-agonists resulted in twice as much beta-agonist use without physiologic or clinical benefit as did use on an as-needed basis...
  3. ncbi request reprint Ventilator associated pneumonia: perspectives on the burden of illness
    D Cook
    Department of Medicine, St Joseph s Hospital, Hamilton, Ontario, Canada
    Intensive Care Med 26:S31-7. 2000
    ..The objective of this narrative review is to summarize selected current concepts and clinical evidence regarding the burden of illness of VAP, including its epidemiology, diagnosis, attributable mortality and risk factors...
  4. pmc Life support in the intensive care unit: a qualitative investigation of technological purposes. Canadian Critical Care Trials Group
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 161:1109-13. 1999
    ..The objective of this study was to understand the purposes for which advanced life support is withheld, provided, continued or withdrawn in the ICU...
  5. ncbi request reprint Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients
    D J Cook
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 129:433-40. 1998
    ..Understanding the risk factors for ventilator-associated pneumonia can help to assess prognosis and devise and test preventive strategies...
  6. pmc The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 5:368-75. 2001
    ..To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically ventilated critically ill patients...
  7. ncbi request reprint The effect of acidified enteral feeds on gastric colonization in critically ill patients: results of a multicenter randomized trial. Canadian Critical Care Trials Group
    D K Heyland
    Department of Medicine, Queen s University, Kingston, ON, Canada
    Crit Care Med 27:2399-406. 1999
    ..To evaluate the effect of acidified enteral feeds on gastric colonization in critically ill patients compared with a standard feeding formula...
  8. ncbi request reprint The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia. Canadian Critical Care Trials Group
    D K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Chest 115:1076-84. 1999
    ..To evaluate the clinical utility of bronchoscopy with protected brush catheter (PBC) and BAL for patients with ventilator-associated pneumonia (VAP)...
  9. ncbi request reprint The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. The Canadian Critical Trials Group
    D K Heyland
    Department of Medicine, Queen s University, Kingston, ON, Canada
    Am J Respir Crit Care Med 159:1249-56. 1999
    ..We conclude that VAP prolongs ICU length of stay and may increase the risk of death in critically ill patients. The attributable risk of VAP appears to vary with patient population and infecting organism...
  10. ncbi request reprint Discrimination and abuse in internal medicine residency. The Internal Medicine Program Directors of Canada
    C H vanIneveld
    Geriatrics Residency Program, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    J Gen Intern Med 11:401-5. 1996
    ..Housestaff, medical educators, allied health workers, and the public need to work together to address these problems in the training environment...
  11. ncbi request reprint Prevention of venous thromboembolism in critically ill surgery patients: a cross-sectional study
    D Cook
    Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 16:161-6. 2001
    ..3, P =.001). CONCLUSIONS: VTE prevention for surgical ICU patients within the first postoperative week appear to be individualized, and influenced by current and future risks of thrombosis and bleeding...
  12. ncbi request reprint Cardiopulmonary resuscitation directives on admission to intensive-care unit: an international observational study
    D J Cook
    Department of Medicine, McMaster University, Ontario, Hamilton, Canada
    Lancet 358:1941-5. 2001
    ..Our objective was to ascertain prevalence, predictors, and procurement pattern of cardiopulmonary resuscitation directives within 24 h of admission to the intensive-care unit (ICU)...
  13. ncbi request reprint Agreement between alternative classifications of acute respiratory distress syndrome
    M O Meade
    Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 163:490-3. 2001
    ..These discordant classifications had no prognostic importance...
  14. ncbi request reprint Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses
    D Moher
    University of Ottawa, Thomas C Chalmers Centre for Systematic Reviews, Ontario, Canada
    Lancet 354:1896-900. 1999
    ..The Quality of Reporting of Meta-analyses (QUOROM) conference was convened to address standards for improving the quality of reporting of meta-analyses of clinical randomised controlled trials (RCTs)...
  15. ncbi request reprint Deep vein thrombosis and its prevention in critically ill adults
    J Attia
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 161:1268-79. 2001
    ..More potent prophylactic regimens other than unfractionated or low-molecular-weight heparins alone may be needed with higher-risk groups...
  16. ncbi request reprint When should an effective treatment be used? Derivation of the threshold number needed to treat and the minimum event rate for treatment
    J C Sinclair
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Room 3N11F, 1200 Main Street West, Hamilton, L8N 3Z5, Ontario, Canada
    J Clin Epidemiol 54:253-62. 2001
    ..Quantification of the determinants of the threshold NNT and of the minimum event rate to justify treatment can assist clinicians and patients in the explicit use of underlying values when making treatment decisions...
  17. ncbi request reprint Trials of corticosteroids to prevent postextubation airway complications
    M O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:464S-8S. 2001
    ..However, the effect of corticosteroids in children and adults to reduce postextubation complications such as reintubation is uncertain...
  18. ncbi request reprint Discrimination and abuse experienced by general internists in Canada
    D J Cook
    Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    J Gen Intern Med 10:565-72. 1995
    ..CONCLUSIONS: Abuse, discrimination, and homophobia are prevalent in the internal medicine workplace. A direct, progressive, multidisciplinary approach is necessary to label and address these problems...
  19. doi request reprint Enrollment of intensive care unit patients into clinical studies: a trinational survey of researchers' experiences, beliefs, and practices
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Crit Care Med 36:2100-5. 2008
    ..As critical care practice increases in scope, size, and complexity, enrollment of critically ill patients into clinical studies is increasing...
  20. pmc A guide to interpreting discordant systematic reviews
    A R Jadad
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont
    CMAJ 156:1411-6. 1997
    ..The authors provide an adjunct decision tool--a decision algorithm--to help decision-makers select from among discordant reviews...
  21. ncbi request reprint Weaning from mechanical ventilation: the evidence from clinical research
    M O Meade
    Department of Medicine and the Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Respir Care 46:1408-15; discussion 1415-7. 2001
    ....
  22. ncbi request reprint Qualitative studies on the patient's experience of weaning from mechanical ventilation
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:469S-73S. 2001
    ....
  23. ncbi request reprint The use of glycopyrrolate in a case of intermediate syndrome following acute organophosphate poisoning
    P T Choi
    Department of Anaesthesia, McMaster University, Ontario, Canada
    Can J Anaesth 45:337-40. 1998
    ....
  24. ncbi request reprint Trials of miscellaneous interventions to wean from mechanical ventilation
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:438S-44S. 2001
    ..Multidisciplinary, patient-centered, holistic, and non-pulmonary approaches to weaning may provide additional safe, effective adjunctive methods of hastening liberation from mechanical ventilation...
  25. doi request reprint Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial
    P J Devereaux
    McMaster University, Faculty of Health Sciences, Clinical Epidemiology and Biostatistics, Room 2C8, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    Lancet 371:1839-47. 2008
    ..This randomised controlled trial, done in 190 hospitals in 23 countries, was designed to investigate the effects of perioperative beta blockers...
  26. pmc Withholding and withdrawing life support in critical care settings: ethical issues concerning consent
    E Gedge
    Department of Philosophy, University Hall 310, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    J Med Ethics 33:215-8. 2007
    ..Both the bioethics and critical care communities should investigate the possibilities and limits of growing pressure for doctors to disclose their reasoning or seek patient consent when decisions to withhold life support are made...
  27. ncbi request reprint Vitamin K deficiency and D-dimer levels in the intensive care unit: a prospective cohort study
    M A Crowther
    Department of Medicine, McMaster University, St Joseph s Hospital, Hamilton, Ontario, Canada
    Blood Coagul Fibrinolysis 13:49-52. 2002
    ....
  28. ncbi request reprint Minimizing errors of omission: behavioural reenforcement of heparin to avert venous emboli: the BEHAVE study
    J McMullin
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Crit Care Med 34:694-9. 2006
    ..To improve patient safety by increasing heparin thromboprophylaxis for medical-surgical intensive care unit patients using a multiple-method approach to evidence-based guideline development and implementation...
  29. pmc Prevention and diagnosis of venous thromboembolism in critically ill patients: a Canadian survey
    D Cook
    Department of Medicine, McMaster University, Hamilton, Canada
    Crit Care 5:336-42. 2001
    ..The objective of this study was to understand current approaches to the prevention and diagnosis of deep venous thrombosis (DVT) and pulmonary embolism (PE) among patients in the intensive care unit (ICU)...
  30. ncbi request reprint Does this patient have deep vein thrombosis?
    S S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 279:1094-9. 1998
    ..To review the validity of the clinical assessment and diagnostic tests in patients with suspected deep vein thrombosis (DVT)...
  31. doi request reprint Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:168-75. 2009
    ....
  32. ncbi request reprint Trials comparing alternative weaning modes and discontinuation assessments
    M Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Chest 120:425S-37S. 2001
    ..Other RCTs suggest that early extubation with the back-up institution of noninvasive positive-pressure ventilation as needed may be a useful strategy in selected patients...
  33. ncbi request reprint Neither baseline tests of molecular hypercoagulability nor D-dimer levels predict deep venous thrombosis in critically ill medical-surgical patients
    M A Crowther
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Intensive Care Med 31:48-55. 2005
    ..Tests that might be useful for these applications include markers of hypercoagulability (predicting patients at risk of DVT) and D-dimer (predicting which patients may have acute DVT)...
  34. ncbi request reprint Improving patients' safety locally: changing clinician behaviour
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Lancet 363:1224-30. 2004
    ..The steps are to: do an environmental scan; understand current behaviour, target behaviour for change (why, what, when, where, and who); adopt effective strategies to change behaviour; and synergise...
  35. ncbi request reprint The influence of dietary and nondietary calcium supplementation on blood pressure: an updated metaanalysis of randomized controlled trials
    L E Griffith
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Am J Hypertens 12:84-92. 1999
    ..We conclude that calcium supplementation leads to a small reduction in systolic and diastolic blood pressure. The effect of supplemental calcium in the diet is at least as great as nondietary supplementation...
  36. pmc Safety Climate Survey: reliability of results from a multicenter ICU survey
    M E Kho
    McMaster University, Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Qual Saf Health Care 14:273-8. 2005
    ..It is important to understand the clinical properties of instruments used to measure patient safety before they are used in the setting of an intensive care unit (ICU)...
  37. ncbi request reprint Guidelines in the intensive care unit
    Tasnim Sinuff
    Department of Medicine, McMaster University, Room 3W10, 1200 Main Street West, Hamilton, ON L9H 6Z6, Canada
    Clin Chest Med 24:739-49, viii. 2003
    ..The quality of the growing number of practice guidelines in critical care is important to assess and several useful instruments are available for this purpose...
  38. ncbi request reprint Clinical estimation of trunk position among mechanically ventilated patients
    J P McMullin
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Intensive Care Med 28:304-9. 2002
    ..The objectives of this study were to determine the accuracy of trunk flexion estimates compared to a reference standard measurement, and to determine agreement about trunk flexion among ICU clinicians...
  39. ncbi request reprint Inadequacy of intravenous heparin therapy in the initial management of venous thromboembolism
    H N Lee
    Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    J Gen Intern Med 10:342-5. 1995
    ..05). A heparin nomogram is likely to achieve consistently higher rates of adequate heparinization...
  40. ncbi request reprint Multiple organ dysfunction: baseline and serial component scores
    R Cook
    Department of Statistics and Actuarial Statistics, Waterloo, Ontario, Canada
    Crit Care Med 29:2046-50. 2001
    ..4 [1.0-2.0]). CONCLUSIONS: Organ dysfunction scores describe physiology at ICU admission and during ICU stay. Although patterns vary by system, daily MODS component scores provide additional prognostic value over baseline MODS...
  41. ncbi request reprint Patient autonomy versus parentalism
    D Cook
    Department of Medicine of Clinical Epidemiology, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada
    Crit Care Med 29:N24-5. 2001
    ..Analysis of human relationships and communication with critically ill patients and their families require transdisciplinary, multicultural, and multidisciplinary interpretation...
  42. ncbi request reprint Decision tools for life support: a review and policy analysis
    M Giacomini
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 34:864-70. 2006
    ..To identify, describe, and compare published documents intended to guide decisions about the administration, withholding, or withdrawal of life support in critical care...
  43. ncbi request reprint Systematic reviews: synthesis of best evidence for clinical decisions
    D J Cook
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 126:376-80. 1997
    ..Used increasingly to inform medical decision making, plan future research agendas, and establish clinical policy, systematic reviews may strengthen the link between best research evidence and optimal health care...
  44. pmc Guidelines as rationing tools: a qualitative analysis of psychosocial patient selection criteria for cardiac procedures
    M K Giacomini
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont
    CMAJ 164:634-40. 2001
    ..The aim of this study was to investigate the terms and justifications for and the meanings of psychosocial patient characteristics used in cardiac procedure guidelines...
  45. ncbi request reprint Methodology and reports of systematic reviews and meta-analyses: a comparison of Cochrane reviews with articles published in paper-based journals
    A R Jadad
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA 280:278-80. 1998
    ..Ideally, reviews should include strategies to minimize bias and to maximize precision and be reported so explicitly that any interested reader would be able to replicate them...
  46. ncbi request reprint Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. QUOROM Group
    D Moher
    University of Ottawa, Thomas C Chalmers Centre for Systematic Reviews, Ontario, Canada
    Br J Surg 87:1448-54. 2000
    ..The Quality of Reporting of Meta-analyses (QUOROM) conference was convened to address standards for improving the quality of reporting of meta-analyses of clinical randomised controlled trials (RCTs)...
  47. ncbi request reprint Predicting success in weaning from mechanical ventilation
    M Meade
    Department of Medicine, McMaster University, Hamilton, Canada
    Chest 120:400S-24S. 2001
    ..Why do most of these tests perform so poorly? The likely explanation is that clinicians have already considered the results when they choose patients for trials of weaning...
  48. ncbi request reprint Effect of smoking cessation on mortality after myocardial infarction: meta-analysis of cohort studies
    K Wilson
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 160:939-44. 2000
    ..To determine the effect of smoking cessation on mortality after myocardial infarction...
  49. ncbi request reprint Does treatment with L-thyroxine influence health status in middle-aged and older adults with subclinical hypothyroidism?
    R Jaeschke
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Gen Intern Med 11:744-9. 1996
    ....