S J Connolly

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Pacemaker therapy for prevention of syncope in patients with recurrent severe vasovagal syncope: Second Vasovagal Pacemaker Study (VPS II): a randomized trial
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario
    JAMA 289:2224-9. 2003
  2. ncbi request reprint Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events
    S Connolly
    Population Health Research Institute, Hamilton, Ontario, Canada
    Am Heart J 151:1187-93. 2006
  3. ncbi request reprint Comparison of beta-blockers, amiodarone plus beta-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: the OPTIC Study: a randomized trial
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario
    JAMA 295:165-71. 2006
  4. ncbi request reprint Preventing stroke in patients with atrial fibrillation: current treatments and new concepts
    Stuart J Connolly
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 145:418-23. 2003
  5. ncbi request reprint Therapies for the prevention of stroke and other vascular events in atrial fibrillation and atrial flutter
    Stuart J Connolly
    McMaster University, Hamilton, Ontario
    Can J Cardiol 21:71B-73B. 2005
  6. ncbi request reprint Double-blind, placebo-controlled, randomized trial of prophylactic metoprolol for reduction of hospital length of stay after heart surgery: the beta-Blocker Length Of Stay (BLOS) study
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 145:226-32. 2003
  7. ncbi request reprint Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. Canadian Trial of Physiologic Pacing Investigators
    S J Connolly
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 342:1385-91. 2000
  8. doi request reprint Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
  9. ncbi request reprint Canadian implantable defibrillator study (CIDS) : a randomized trial of the implantable cardioverter defibrillator against amiodarone
    S J Connolly
    Departments of Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 101:1297-302. 2000
  10. doi request reprint Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011

Detail Information

Publications75

  1. ncbi request reprint Pacemaker therapy for prevention of syncope in patients with recurrent severe vasovagal syncope: Second Vasovagal Pacemaker Study (VPS II): a randomized trial
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario
    JAMA 289:2224-9. 2003
    ..However, because these trials were not double blind, they may have been biased in their assessment of outcomes and had a placebo effect of surgery...
  2. ncbi request reprint Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events
    S Connolly
    Population Health Research Institute, Hamilton, Ontario, Canada
    Am Heart J 151:1187-93. 2006
    ..Irbesartan is an angiotensin receptor-blocking agent that reduces blood pressure and has other vascular protective effects...
  3. ncbi request reprint Comparison of beta-blockers, amiodarone plus beta-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: the OPTIC Study: a randomized trial
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario
    JAMA 295:165-71. 2006
    ..Implantable cardioverter defibrillator (ICD) therapy is effective but is associated with high-voltage shocks that are painful...
  4. ncbi request reprint Preventing stroke in patients with atrial fibrillation: current treatments and new concepts
    Stuart J Connolly
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 145:418-23. 2003
    ..A direct thrombin inhibitor, ximelagatran, has been shown to have an excellent pharmacokinetic profile and is being developed as an oral agent for stroke prevention in AF, and it will not need regular monitoring...
  5. ncbi request reprint Therapies for the prevention of stroke and other vascular events in atrial fibrillation and atrial flutter
    Stuart J Connolly
    McMaster University, Hamilton, Ontario
    Can J Cardiol 21:71B-73B. 2005
    ..Acetylsalicylic acid is less effective than oral anticoagulants but better tolerated. Anticoagulants are recommended for AF patients with risk factors for stroke...
  6. ncbi request reprint Double-blind, placebo-controlled, randomized trial of prophylactic metoprolol for reduction of hospital length of stay after heart surgery: the beta-Blocker Length Of Stay (BLOS) study
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 145:226-32. 2003
    ..No previous trials have been primarily directed at demonstrating that the use of drugs that prevent AF would shorten length of stay and reduce the costs of postoperative care...
  7. ncbi request reprint Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. Canadian Trial of Physiologic Pacing Investigators
    S J Connolly
    Department of Medicine, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 342:1385-91. 2000
    ..These benefits have not been evaluated in a large, randomized, controlled trial...
  8. doi request reprint Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
    ..The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk...
  9. ncbi request reprint Canadian implantable defibrillator study (CIDS) : a randomized trial of the implantable cardioverter defibrillator against amiodarone
    S J Connolly
    Departments of Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 101:1297-302. 2000
    ..The implantable cardioverter defibrillator (ICD) terminates VT or VF, but it is not known whether this device prolongs life in these patients compared with medical therapy with amiodarone...
  10. doi request reprint Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011
    ..Apixaban, a novel factor Xa inhibitor, may be an alternative treatment for such patients...
  11. ncbi request reprint The North American Vasovagal Pacemaker Study (VPS). A randomized trial of permanent cardiac pacing for the prevention of vasovagal syncope
    S J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 33:16-20. 1999
    ..This study was done to evaluate pacemaker therapy for severe recurrent vasovagal syncope...
  12. doi request reprint Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    ..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
  13. doi request reprint Effect of a simple two-step warfarin dosing algorithm on anticoagulant control as measured by time in therapeutic range: a pilot study
    Y K Kim
    Department of Medicine, McMaster University, and Population Health Research Institute, Hamilton, ON, Canada
    J Thromb Haemost 8:101-6. 2010
    ....
  14. pmc Effects of magnesium on atrial fibrillation after cardiac surgery: a meta-analysis
    S Miller
    Arrhythmia Services, Schulich Heart Centre, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Heart 91:618-23. 2005
    ..To assess the efficacy of the administration of magnesium as a method for the prevention of postoperative atrial fibrillation (AF) and to evaluate its influence on hospital length of stay (LOS) and mortality...
  15. ncbi request reprint Appropriate outcome measures in trials evaluating treatment of atrial fibrillation
    S J Connolly
    McMaster University, Hamilton, Canada
    Am Heart J 139:752-60. 2000
    ..Atrial fibrillation (AF) is a widespread disease that has only recently received the focused attention of arrhythmia specialists despite being the most frequently occurring significant cardiac arrhythmia...
  16. ncbi request reprint Cost-effectiveness of the implantable cardioverter-defibrillator: results from the Canadian Implantable Defibrillator Study (CIDS)
    S J Connolly
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Circulation 103:1416-21. 2001
    ..Further research is warranted to identify the indications and patient subgroups for whom ICDs are a cost-effective use of resources...
  17. ncbi request reprint Dose-response relations of azimilide in the management of symptomatic, recurrent, atrial fibrillation
    S J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 88:974-9. 2001
    ..9% of patients receiving either of the 2 effective doses. Thus, doses of azimilide <100 mg/day are not effective for control of AF, whereas doses of 100 and 125 mg/day are effective with an acceptable risk of serious toxicity...
  18. doi request reprint Randomised comparison of a simple warfarin dosing algorithm versus a computerised anticoagulation management system for control of warfarin maintenance therapy
    Robby Nieuwlaat
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Thromb Haemost 108:1228-35. 2012
    ..4% to 4.1%]; p-value for non-inferiority=0.002; p-value for superiority=0.34). In conclusion, similar maintenance control of the INR was achieved with a simple one-step dosing algorithm and a commercial computerised management system...
  19. doi request reprint Defibrillation testing at the time of ICD insertion: an analysis from the Ontario ICD Registry
    J S Healey
    Population Health Research Institute and McMaster University, Hamilton, Canada
    J Cardiovasc Electrophysiol 21:1344-8. 2010
    ..increasingly, ICD implantation is performed without defibrillation testing (DT)...
  20. ncbi request reprint ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial (ASSERT)
    Stefan H Hohnloser
    Division of Electrophysiology, Department of Cardiology, J W Goethe University, Frankfurt, Germany
    Am Heart J 152:442-7. 2006
    ..This substudy will determine if atrial electrical remodeling is detectable in pacemaker patients and if it is associated with the development of AF...
  21. ncbi request reprint Efficacy of azimilide for the maintenance of sinus rhythm in patients with paroxysmal atrial fibrillation in the presence and absence of structural heart disease
    Charles R Kerr
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Cardiol 98:215-8. 2006
    ..56, p=0.11), and overall group (hazard ratio 1.22, 95% confidence interval 1.00 to 1.49, p=0.053). No patient died. In conclusion, azimilide showed a nonsignificant trend toward efficacy in maintaining sinus rhythm in patients with AF...
  22. ncbi request reprint Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial
    Stefan H Hohnloser
    Department of Medicine, Division of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circulation 114:104-9. 2006
    ..The effects of these drugs on defibrillation energy requirements have not been previously assessed in a randomized controlled trial...
  23. ncbi request reprint Cardiovascular outcomes with atrial-based pacing compared with ventricular pacing: meta-analysis of randomized trials, using individual patient data
    Jeffrey S Healey
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada, L8L 2X2
    Circulation 114:11-7. 2006
    ..No trial has shown a mortality reduction, and only 1 small trial suggested a reduction in stroke. The goal of this review was to determine whether atrial-based pacing prevents major cardiovascular events...
  24. pmc Stroke prevention in patients with atrial fibrillation: the diagnosis and management of hypertension by specialists
    Jeff S Healey
    McMaster University, Hamilton, Ontario
    Can J Cardiol 22:485-8. 2006
    ..Hypertension is common in patients with atrial fibrillation (AF) and is an important cause of stroke...
  25. ncbi request reprint Left Atrial Appendage Occlusion Study (LAAOS): results of a randomized controlled pilot study of left atrial appendage occlusion during coronary bypass surgery in patients at risk for stroke
    Jeff S Healey
    McMaster University, Hamilton, Ontario, Canada
    Am Heart J 150:288-93. 2005
    ..This pilot study assessed the safety and efficacy of left atrial appendage (LAA) occlusion, performed at the time of coronary artery bypass grafting (CABG)...
  26. ncbi request reprint Risks and benefits of combining aspirin with anticoagulant therapy in patients with atrial fibrillation: an exploratory analysis of stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials
    Greg C Flaker
    Department of Medicine, University of Missouri Columbia, Columbia, MO, USA
    Am Heart J 152:967-73. 2006
    ..Aspirin is used in combination with anticoagulant therapy in patients with atrial fibrillation (AF), but evidence of additional efficacy is not available...
  27. ncbi request reprint Role of the implantable defibrillator among elderly patients with a history of life-threatening ventricular arrhythmias
    Jeffrey S Healey
    Population Health Research Institute, Hamilton Health Sciences General Site, McMaster University, Ontario, Hamilton, Canada
    Eur Heart J 28:1746-9. 2007
    ..However, its effectiveness in elderly patients is uncertain, given their competing risk of non-arrhythmic death...
  28. ncbi request reprint Challenges of establishing new antithrombotic therapies in atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Circulation 116:449-55. 2007
  29. doi request reprint Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)
    Jose Antonio Marin-Neto
    Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Am Heart J 156:37-43. 2008
    ..However, the efficacy of trypanocidal therapy in preventing clinical complications in patients with preexisting cardiac disease is unknown...
  30. doi request reprint Rhythm control versus rate control for atrial fibrillation and heart failure
    Denis Roy
    Montreal Heart Institute and the Université de Montréal, Montreal, QC H1T 1C8, Canada
    N Engl J Med 358:2667-77. 2008
    ..However, the benefits and risks of this approach have not been adequately studied...
  31. doi request reprint Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W)
    Jeff S Healey
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada
    Stroke 39:1482-6. 2008
    ..However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify patients for whom the absolute benefits of OAC exceed its risks...
  32. ncbi request reprint Incidence of stroke in paroxysmal versus sustained atrial fibrillation in patients taking oral anticoagulation or combined antiplatelet therapy: an ACTIVE W Substudy
    Stefan H Hohnloser
    Department of Cardiology, Division of Electrophysiology, J W Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 50:2156-61. 2007
    ..Our goal was to determine the risk of stroke or non-cerebral embolism associated with paroxysmal compared with sustained atrial fibrillation (AF)...
  33. ncbi request reprint Rationale and design of ATHENA: A placebo-controlled, double-blind, parallel arm Trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular Hospitalization or death from any cause in patiENts with Atrial fibrillation/atria
    Stefan H Hohnloser
    J W Goethe University, Department of Cardiology, Frankfurt, Germany
    J Cardiovasc Electrophysiol 19:69-73. 2008
    ..There is a continued need for new antiarrhythmic drugs to treat the ever-increasing number of patients with this arrhythmia. Dronedarone is a new antiarrhythmic compound currently being developed for treatment of AF...
  34. ncbi request reprint Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter
    Bramah N Singh
    Cardiology Division, Veterans Affairs Greater Los Angeles Healthcare System and the David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    N Engl J Med 357:987-99. 2007
    ..Dronedarone is a new antiarrhythmic agent pharmacologically related to amiodarone but developed to reduce the risk of side effects...
  35. ncbi request reprint The effect of atrial-based pacing on exercise capacity as measured by the 6-minute walk test: a substudy of the Canadian Trial of Physiological Pacing (CTOPP)
    Adrian Baranchuk
    Queen s University, Kingston, Ontario, Canada
    Heart Rhythm 4:1024-8. 2007
    ....
  36. ncbi request reprint Omega-3 fatty acids and sudden arrhythmic death
    Stuart J Connolly
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Herz 31:59-64. 2006
    ..However, the most conservative estimates suggest that no less than 25% of deaths in patients with a diagnosis of ischemic heart disease are due to ventricular fibrillation...
  37. ncbi request reprint Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis
    Jeff S Healey
    Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Am Coll Cardiol 45:1832-9. 2005
    ....
  38. doi request reprint Antithrombotic drug development for atrial fibrillation: proceedings, Washington, DC, July 25-27, 2005
    Kevin Jackson
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 155:829-40. 2008
    ..With this summary document, we hope to provide a helpful resource for future drug development for AF...
  39. ncbi request reprint Atrial fibrillation after cardiac surgery: update on the evidence on the available prophylactic interventions
    Eugene Crystal
    Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Card Electrophysiol Rev 7:189-92. 2003
    ..Amiodarone and bi-atrial pacing may decrease the length of hospital stay...
  40. ncbi request reprint Combined antiplatelet therapy in atrial fibrillation: review of the literature and future avenues
    Stefan H Hohnloser
    Department of Medicine, J W Goethe University Hospital, Frankfurt, Germany
    J Cardiovasc Electrophysiol 14:S60-3. 2003
    ..The ACTIVE program began patient enrollment in spring 2003...
  41. ncbi request reprint Prevention of vascular events in patients with atrial fibrillation: evidence, guidelines, and practice
    Stuart J Connolly
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Cardiovasc Electrophysiol 14:S52-5. 2003
    ..Many patients do not receive anticoagulation therapy despite its proven benefits...
  42. ncbi request reprint Symptoms at the time of arrhythmia recurrence in patients receiving azimilide for control of atrial fibrillation or flutter: results from randomized trials
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 146:489-93. 2003
    ..This paper examines the data collected during those studies regarding the symptoms reported by patients at the time of AF recurrence..
  43. ncbi request reprint Atrial fibrillation: hypertension as a causative agent, risk factor for complications, and potential therapeutic target
    Jeff S Healey
    McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 91:9G-14G. 2003
    ..Specific pharmacotherapy could potentially play a major role in the primary and secondary prevention of atrial fibrillation and its complications...
  44. ncbi request reprint Quality of life improves with treatment in the Canadian Trial of Atrial Fibrillation
    Paul Dorian
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 143:984-90. 2002
    ..The impact of atrial fibrillation (AF) and its treatment on health-related quality of life (QOL) is not well understood. We assessed QOL in patients with symptomatic AF participating in the Canadian Trial of Atrial Fibrillation...
  45. ncbi request reprint Effect of pacing mode on health-related quality of life in the Canadian Trial of Physiologic Pacing
    David Newman
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 145:430-7. 2003
    ..The QOL studies within the Canadian Trial of Physiologic Pacing were performed to assess whether QOL differences exist in patients randomized to these 2 pacing modes...
  46. ncbi request reprint Long-term amiodarone therapy and the risk of complications after cardiac surgery: results from the Canadian Amiodarone Myocardial Infarction Arrhythmia Trial (CAMIAT)
    Eugene Crystal
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Thorac Cardiovasc Surg 125:633-7. 2003
    ....
  47. ncbi request reprint Asymptomatic or "silent" atrial fibrillation: frequency in untreated patients and patients receiving azimilide
    Richard L Page
    Cardiovascular Division, Clinical Cardiac Electrophysiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, USA
    Circulation 107:1141-5. 2003
    ....
  48. ncbi request reprint Left Atrial Appendage Occlusion Study (LAAOS): a randomized clinical trial of left atrial appendage occlusion during routine coronary artery bypass graft surgery for long-term stroke prevention
    Eugene Crystal
    McMaster University, Hamilton, Ontario, Canada
    Am Heart J 145:174-8. 2003
    ..The left atrial appendage (LAA) is a main source of thrombus coming from the left atrium. LAA occlusion should be tested as a means to reduce future cerebral ischemic events in these patients...
  49. ncbi request reprint Quality of life in the Canadian Implantable Defibrillator Study (CIDS)
    Jane Irvine
    Department of Psychology, York University, University of Toronto, Ontario, Canada
    Am Heart J 144:282-9. 2002
    ..A secondary aim was to evaluate the effects on quality-of-life outcomes of receiving shocks from the device...
  50. ncbi request reprint Interventions on prevention of postoperative atrial fibrillation in patients undergoing heart surgery: a meta-analysis
    Eugene Crystal
    Division of Cardiology, Faculty of Health Sciences, McMaster University, Ontario, Hamilton, Canada
    Circulation 106:75-80. 2002
    ..To better understand the role of various prophylactic therapies against postoperative AF, a systematic review of evidence from randomized trials was performed...
  51. ncbi request reprint Effects of azimilide on heart rate and ECG conduction intervals during sinus rhythm in patients with a history of atrial fibrillation
    Edward L C Pritchett
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Clin Pharmacol 42:388-94. 2002
    ..It was concluded that in patients with a history of atrial fibrillation or flutter, azimilide was associated with statistically significant increases in RR, QT, QTc(Bazett), and QTc(Fridericia) when patients were in sinus rhythm...
  52. ncbi request reprint Canadian Trial of Physiological Pacing: Effects of physiological pacing during long-term follow-up
    Charles R Kerr
    Room 344, Division of Cardiology, St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada, V6Z 1Y6
    Circulation 109:357-62. 2004
    ..However, the occurrence of atrial fibrillation was significantly less frequent with physiological pacemakers. To assess a potential delayed benefit of physiological pacing, follow-up of patients in this study was extended to 6 years...
  53. ncbi request reprint Antiarrhythmic effects of azimilide in paroxysmal supraventricular tachycardia: efficacy and dose-response
    Richard L Page
    Department of Medicine, Cardiovascular Division, University of Texas Southwestern Medical Center, Parkland Memorial Hospital, Dallas, Tex 75390 9047, USA
    Am Heart J 143:643-9. 2002
    ..Its effect on paroxysmal supraventricular tachycardia (PSVT) has not been reported...
  54. ncbi request reprint Progression to chronic atrial fibrillation after the initial diagnosis of paroxysmal atrial fibrillation: results from the Canadian Registry of Atrial Fibrillation
    Charles R Kerr
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Am Heart J 149:489-96. 2005
    ..After its initial diagnosis, atrial fibrillation (AF) may progress from paroxysmal to chronic AF (CAF). The rate of progression and risk factors for progression are not clearly defined...
  55. ncbi request reprint Cost-effectiveness of physiologic pacing: results of the Canadian Health Economic Assessment of Physiologic Pacing
    Bernie J O'Brien
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Heart Rhythm 2:270-5. 2005
    ..The purpose of this study was to determine the cost-effectiveness of physiologic pacemakers...
  56. ncbi request reprint Role of the renin-angiotensin-aldosterone system in atrial fibrillation and cardiac remodeling
    Jeff S Healey
    McMaster University, Hamilton, Ontario, Canada
    Curr Opin Cardiol 20:31-7. 2005
    ..It then explores the possible mechanisms for this effect based on current animal models and limited human study...
  57. ncbi request reprint Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction
    Stefan H Hohnloser
    Department of Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    N Engl J Med 351:2481-8. 2004
    ..Whether benefit occurs in patients early after myocardial infarction is unknown...
  58. ncbi request reprint The association of left atrial size and occurrence of atrial fibrillation: a prospective cohort study from the Canadian Registry of Atrial Fibrillation
    Ratika Parkash
    University of Ottawa, Ottawa, Ontario, Canada
    Am Heart J 148:649-54. 2004
    ..We evaluated the effect of LA dimension on the occurrence of AF using 2- and 4-year echocardiographic data in a large cohort of patients with new onset AF...
  59. pmc Role of oral anticoagulation in management of atrial fibrillation
    Eugene Crystal
    Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Heart 90:813-7. 2004
  60. ncbi request reprint The Defibrillator in Acute Myocardial Infarction Trial (DINAMIT): rationale, design and specific aims
    Gerian Grönefeld
    Department of Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    Card Electrophysiol Rev 7:447-51. 2003
    ..This paper summarizes the rationale, design and specific contributions of the Defibrillator in Myocardial infarction trial (DINAMIT) in comparison to other relevant studies on primary prevention of sudden cardiac death...
  61. ncbi request reprint Prognostic differences between atrial fibrillation and atrial flutter
    Paul Lelorier
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am J Cardiol 93:647-9. 2004
    ..We also evaluated warfarin use over time and compared left atrial dimensions in patients with atrial flutter with those with atrial fibrillation...
  62. ncbi request reprint Potential demographic and baselines variables for risk stratification of high-risk post-myocardial infarction patients in the era of implantable cardioverter-defibrillator--a prognostic indicator
    Yee Guan Yap
    Department of Cardiological Sciences, St George s Hospital Medical School, London, United Kingdom
    Int J Cardiol 126:101-7. 2008
    ..Risk stratification after myocardial infarction (MI) remains expensive and disappointing. We designed a prognostic indicator using demographic information to select patients at risk of dying after MI...
  63. ncbi request reprint Evolution of the implantable cardioverter defibrillator
    Eugene Crystal
    Division of Cardiology, McMaster University, Ontario L8L 2X2, Hamilton, Canada
    Lancet 359:1362-3. 2002
  64. ncbi request reprint Prognostic value of blood pressure measured during hospitalization after acute myocardial infarction: an insight from survival trials
    Yee Guan Yap
    Department of Cardiological Sciences, St George s Hospital Medical School, London, UK
    J Hypertens 25:307-13. 2007
    ..The prognostic value of blood pressure measured during hospitalization after acute myocardial infarction (MI) has not been investigated, particularly with regard to arrhythmic death...
  65. ncbi request reprint Prognostic impact of demographic factors and clinical features on the mode of death in high-risk patients after myocardial infarction--a combined analysis from multicenter trials
    Yee Guan Yap
    Department of Cardiological Sciences, St George s Hospital Medical School, London, UK
    Clin Cardiol 28:471-8. 2005
    ..Contemporary information is lacking on the effect of demographic features and clinical features on the specific mode of mortality after myocardial infarction (MI) in the thrombolytic era...
  66. ncbi request reprint Age of first faint in patients with vasovagal syncope
    Robert S Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 17:49-54. 2006
    ..Accordingly, we determined the age of the first syncopal spell in adult patients who sought care for syncope...
  67. ncbi request reprint Use and misuse of surrogate outcomes in arrhythmia trials
    Stuart J Connolly
    Circulation 113:764-6. 2006
  68. ncbi request reprint Atrial deformation: the key to maintenance of sinus rhythm in patients with atrial fibrillation?
    Hisham Dokainish
    Eur Heart J 29:1483-4. 2008
  69. ncbi request reprint Temporal trends on the risk of arrhythmic vs. non-arrhythmic deaths in high-risk patients after myocardial infarction: a combined analysis from multicentre trials
    Yee Guan Yap
    Department of Cardiological Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Eur Heart J 26:1385-93. 2005
    ..However, contemporary data on such information is lacking...
  70. ncbi request reprint Worsening of symptoms before presentation with vasovagal syncope
    Robert S Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada
    J Cardiovasc Electrophysiol 18:954-9. 2007
    ..Much of the natural history of vasovagal syncope is unknown. We determined whether patients presenting for care have had a recently worsened syncope frequency...
  71. ncbi request reprint Diminishing proportional risk of sudden death with advancing age: implications for prevention of sudden death
    Andrew D Krahn
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 147:837-40. 2004
    ..We sought to determine the effect of advancing age on the mode of death in the Amiodarone Trialists Metanalysis...
  72. pmc Should patients with cardiovascular disease take fish oil?
    Girish M Nair
    Division of Cardiology, McMaster University and Hamilton Health Sciences, Hamilton, Ont
    CMAJ 178:181-2. 2008
  73. ncbi request reprint The management of patients with carotid sinus syndrome: is pacing the answer?
    Jeff Healey
    Dept of Medicine, Cardiology Division, Arrhythmia Service, Population Health Research Institute, McMaster University, Hamilton ON, Canada
    Clin Auton Res 14:80-6. 2004
    ..The present paper critically reviews the latest insights in the pathophysiology, diagnosis and management of CSS...
  74. ncbi request reprint Atrial fibrillation: guiding lessons from epidemiology
    Eugene Crystal
    University of Toronto, Schulich Heart Centre, Sunnybrook and Women s College Health Science Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Cardiol Clin 22:1-8. 2004
    ..Hypertension may be the most common primary etiology of AF, and the possibility of effective primary prevention of AF by strict control of hypertension needs to be evaluated adequately...