S Collins

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Putative therapeutic targets in the treatment of visceral hyperalgesia
    S Collins
    Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Gut 53:ii19-21. 2004
  2. doi request reprint Altered colonic function and microbiota profile in a mouse model of chronic depression
    A J Park
    Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada
    Neurogastroenterol Motil 25:733-e575. 2013
  3. doi request reprint The interplay between the intestinal microbiota and the brain
    Stephen M Collins
    Farncombe Family Digestive Health Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton L8N 3Z5, Ontario, Canada
    Nat Rev Microbiol 10:735-42. 2012
  4. doi request reprint The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications
    Stephen M Collins
    Farncombe Family Digestive Health Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Microbiol 16:240-5. 2013
  5. ncbi request reprint Peripheral mechanisms of symptom generation in irritable bowel syndrome
    S M Collins
    Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Can J Gastroenterol 15:14B-16B. 2001
  6. doi request reprint The role of pathogenic microbes and commensal bacteria in irritable bowel syndrome
    Stephen Collins
    The Farncombe Family Digestive Health Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ont, Canada
    Dig Dis 27:85-9. 2009
  7. doi request reprint The putative role of the intestinal microbiota in the irritable bowel syndrome
    S M Collins
    The Farncombe Digestive Health Research Institute, The Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Dig Liver Dis 41:850-3. 2009
  8. doi request reprint The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease
    Stephen M Collins
    The Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 136:2003-14. 2009
  9. ncbi request reprint The establishment of a national tissue bank for inflammatory bowel disease research in Canada
    Stephen M Collins
    Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Can J Gastroenterol 17:107-9. 2003
  10. ncbi request reprint Translating symptoms into mechanisms: functional GI disorders
    Stephen M Collins
    Intestinal Diseases Research Program, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Adv Physiol Educ 31:329-31. 2007

Collaborators

Detail Information

Publications78

  1. pmc Putative therapeutic targets in the treatment of visceral hyperalgesia
    S Collins
    Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Gut 53:ii19-21. 2004
    ..This review addresses novel insights into peripheral mechanisms underlying visceral hyperalgesia and their applicability to the development of novel therapeutic approaches to the treatment of chronic abdominal pain...
  2. doi request reprint Altered colonic function and microbiota profile in a mouse model of chronic depression
    A J Park
    Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada
    Neurogastroenterol Motil 25:733-e575. 2013
    ..The aim of this study was to determine whether the induction of chronic depression results in changes in the colonic function and in its microbial community, and to explore underlying mechanisms...
  3. doi request reprint The interplay between the intestinal microbiota and the brain
    Stephen M Collins
    Farncombe Family Digestive Health Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton L8N 3Z5, Ontario, Canada
    Nat Rev Microbiol 10:735-42. 2012
    ..We also review how this extended communication system might influence a broad spectrum of diseases, including irritable bowel syndrome, psychiatric disorders and demyelinating conditions such as multiple sclerosis...
  4. doi request reprint The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications
    Stephen M Collins
    Farncombe Family Digestive Health Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Microbiol 16:240-5. 2013
    ....
  5. ncbi request reprint Peripheral mechanisms of symptom generation in irritable bowel syndrome
    S M Collins
    Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Can J Gastroenterol 15:14B-16B. 2001
    ..Substances that mediate these changes are not fully understood, but there is growing recognition of the role of serotonin as a sensitizing agent...
  6. doi request reprint The role of pathogenic microbes and commensal bacteria in irritable bowel syndrome
    Stephen Collins
    The Farncombe Family Digestive Health Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ont, Canada
    Dig Dis 27:85-9. 2009
    ..We propose that pathogenic bacteria act as triggers and that disturbances of commensal bacteria maintain low-grade inflammation, that in turn leads to dysfunction in the gut or brain...
  7. doi request reprint The putative role of the intestinal microbiota in the irritable bowel syndrome
    S M Collins
    The Farncombe Digestive Health Research Institute, The Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Dig Liver Dis 41:850-3. 2009
    ..This hypothesis states that dysbiosis exists in at least a subset of IBS patients, as a result of infection, dietary change or drugs and contributes to gut inflammatory and functional change in addition to psychiatric co-morbidity...
  8. doi request reprint The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease
    Stephen M Collins
    The Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 136:2003-14. 2009
    ..Gaining a better understanding of the relationship between behavior and the microbiota could provide insight into the pathogenesis of functional and inflammatory bowel disorders...
  9. ncbi request reprint The establishment of a national tissue bank for inflammatory bowel disease research in Canada
    Stephen M Collins
    Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Can J Gastroenterol 17:107-9. 2003
    ..In the future, criteria for the submission of tissue will be tailored to specific research questions. This bank is believed to be the first national bank of its kind dedicated to research in Crohn's disease and ulcerative colitis..
  10. ncbi request reprint Translating symptoms into mechanisms: functional GI disorders
    Stephen M Collins
    Intestinal Diseases Research Program, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Adv Physiol Educ 31:329-31. 2007
    ..Mechanisms underlying these symptoms include alterations in gastrointestinal motility, visceral perception, altered epithelial function, and disturbances in fermentation activity by gut commensal bacteria...
  11. pmc Intestinal nematode infection ameliorates experimental colitis in mice
    W I Khan
    Intestinal Disease Research Program, McMaster University, Hamilton, Ontario, Canada
    Infect Immun 70:5931-7. 2002
    ..These results indicate a protective role of nematode infection in Th1 cell-driven inflammation and prompt consideration of a novel therapeutic strategy in IBD based on immunological distraction...
  12. ncbi request reprint Role of immunologic factors and cyclooxygenase 2 in persistent postinfective enteric muscle dysfunction in mice
    G Barbara
    Intestinal Disease Research Program and Division of Gastroenterology, Health Sciences Center, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 120:1729-36. 2001
    ..CONCLUSIONS: These findings show that COX-2 activation in resident cells of the muscularis externa contributes to the muscle hypercontractility that persists after infection...
  13. pmc Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse
    G Barbara
    Intestinal Disease Research Program and Gastrointestinal Division, Health Sciences Center, McMaster University, Hamilton, Ontario, Canada
    Gut 52:1457-64. 2003
    ..We hypothesised that diminished expression of NEP would exacerbate T spiralis induced enteritis...
  14. pmc Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P
    S Sturiale
    Intestinal Diseases Research Program, Gastrointestinal Division, Health Sciences Center, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Proc Natl Acad Sci U S A 96:11653-8. 1999
    ..Because we have previously shown that intestinal inflammation results in down-regulation of NEP and diminished degradation of SP, our present results suggest that defects in NEP expression contribute to uncontrolled inflammation...
  15. ncbi request reprint Disruption of CD40-CD40 ligand pathway inhibits the development of intestinal muscle hypercontractility and protective immunity in nematode infection
    W I Khan
    Intestinal Disease Research Program, Department of Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 288:G15-22. 2005
    ..The present data suggest that the early events leading to the generation of Th2 response include CD40-CD40 ligand interaction, which subsequently influences the production of Th2 cytokines, most likely via upregulation of MCP-1...
  16. ncbi request reprint Proinflammatory properties of IL-4 in the intestinal microenvironment
    C Van Kampen
    Intestinal Disease Research Program, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 288:G111-7. 2005
    ....
  17. ncbi request reprint Neural change in Trichinella-infected mice is MHC II independent and involves M-CSF-derived macrophages
    F Galeazzi
    Intestinal Diseases Research Program, Health Sciences Center, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 281:G151-8. 2001
    ..Thus M-CSF plays a critical role in this model by recruiting a subset of macrophages that selectively suppresses enteric neural function...
  18. ncbi request reprint IL-5 contributes to worm expulsion and muscle hypercontractility in a primary T. spiralis infection
    B A Vallance
    Intestinal Diseases Research Program, Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol 277:G400-8. 1999
    ..IL-5 also appears to play a minor role in expelling a primary T. spiralis infection from the gut...
  19. ncbi request reprint Stat6 dependent goblet cell hyperplasia during intestinal nematode infection
    W I Khan
    Intestinal Disease Research Program, McMaster University, Hamilton, Ontario, Canada
    Parasite Immunol 23:39-42. 2001
    ....
  20. ncbi request reprint IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice
    W I Khan
    Intestinal Disease Research Program, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 281:G102-10. 2001
    ..These findings strongly indicate that worm expulsion, muscle hypercontractility, and goblet cell hyperplasia share a common immunologic basis and may be causally linked...
  21. pmc The putative role of endogenous and exogenous opiates in inflammatory bowel disease
    S Collins
    Intestinal Diseases Program, McMaster University, Ontario, Canada
    Gut 55:756-7. 2006
  22. ncbi request reprint Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system
    J D Huizinga
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 120:561-7. 2001
    ..However, a normal musculature, including a network of ICC-AP, allowed for generation of rhythmic, propagating contractile activity, suggesting the presence of functional motor activity...
  23. doi request reprint Vagal dysfunction in irritable bowel syndrome assessed by rectal distension and baroreceptor sensitivity
    R Spaziani
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Neurogastroenterol Motil 20:336-42. 2008
    ..4 +/- 0.3; P < 0.05) at rest and throughout rectal distension. Greater systolic blood pressure response to rectal distension and associated diminished BRS suggests a compromise of the autonomic nervous system in IBS patients...
  24. pmc East meets West: infection, nerves, and mast cells in the irritable bowel syndrome
    S M Collins
    Intestinal Diseases Research Program, Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Gut 53:1068-9. 2004
  25. pmc Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
    E F Verdu
    Intestinal Disease Research Program, McMaster University, 1200 Main S West, Hamilton, Ontario, Canada
    Gut 55:182-90. 2006
    ..These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivity...
  26. pmc Gut motor function: immunological control in enteric infection and inflammation
    W I Khan
    Intestinal Diseases Research Program, Division of Gastroenterology, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5 Canada
    Clin Exp Immunol 143:389-97. 2006
    ....
  27. ncbi request reprint Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario
    J K Marshall
    Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Aliment Pharmacol Ther 20:1317-22. 2004
    ..Post-infectious irritable bowel syndrome is a common clinical phenomenon of uncertain aetiology...
  28. ncbi request reprint A comparison of autonomic function in patients with inflammatory bowel disease and in healthy controls
    S C Ganguli
    Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, ON, Canada
    Neurogastroenterol Motil 19:961-7. 2007
    ..UC patients have an increased sympathetic ANS activity which is independent of symptom severity. In these patients symptom severity is strongly associated with measures of personality related (but not current) anxiety...
  29. ncbi request reprint Immune-mediated alteration in gut physiology and its role in host defence in nematode infection
    W I Khan
    Intestinal Disease Research Program, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Parasite Immunol 26:319-26. 2004
    ....
  30. ncbi request reprint Cytokine modulation of T-lymphocyte activation by intestinal smooth muscle cells
    C M Hogaboam
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 112:1986-95. 1997
    ..We investigated whether IL-1beta and TNF-alpha modulate T-cell activation by murine intestinal smooth muscle cells (ISMCs)...
  31. ncbi request reprint Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections
    B A Vallance
    Intestinal Diseases Research Programme, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Parasite Immunol 22:487-92. 2000
    ..Thus, unlike in a primary infection, IL-5 is not only essential for the onset of intestinal eosinophilia, but also makes a significant contribution to enteric host defence during challenge T. spiralis infections...
  32. pmc Modulation of intestinal muscle contraction by interleukin-9 (IL-9) or IL-9 neutralization: correlation with worm expulsion in murine nematode infections
    W I Khan
    Intestinal Disease Research Program, McMaster University, Hamilton, Ontario, Canada
    Infect Immun 71:2430-8. 2003
    ..These findings suggest that IL-9 contributes to intestinal muscle function and to host protective immunity and that its importance and contribution may differ depending on the type of nematode infection...
  33. ncbi request reprint Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells
    W I Khan
    Intestinal Disease Research Program, Department of Medicine, McMaster University, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 291:G803-11. 2006
    ..These results provide evidence for a critical role of MCP-1 in the development of colonic inflammation in this model in the context of immune and enteric endocrine cells...
  34. ncbi request reprint Stress and the Gastrointestinal Tract IV. Modulation of intestinal inflammation by stress: basic mechanisms and clinical relevance
    S M Collins
    McMaster University Medical Centre, Hamilton, Ontario L8N 3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 280:G315-8. 2001
    ..Together, these experimental observations provide insights into the expression of inflammatory disorders in humans, including inflammatory bowel disease and postinfective irritable bowel syndrome...
  35. ncbi request reprint Mast cell-independent impairment of host defense and muscle contraction in T. spiralis-infected W/W(V) mice
    B A Vallance
    Intestinal Diseases Research Program, Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 280:G640-8. 2001
    ..These abnormalities were also present in BMR-W/W(V) mice. These results indicate that mast cells mediate tissue damage and contribute to the timely expulsion of nematodes from the gut during primary infection...
  36. doi request reprint Heightened central affective response to visceral sensations of pain and discomfort in IBS
    G B C Hall
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Neurogastroenterol Motil 22:276-e80. 2010
    ..CONCLUSION&INFERENCES This work points to alterations in the central response to visceral pain and discomfort in IBS, highlighting diminished modulation and heightened internalization of affective reactions...
  37. ncbi request reprint Neuromuscular regulation of T-cell activation
    C M Hogaboam
    Intestinal Disease Research Program, McMaster University, Hamilton, ON, USA
    J Neuroimmunol 75:123-34. 1997
    ....
  38. pmc Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1
    Y Motomura
    Intestinal Diseases Research Programme, McMaster University, Hamilton, Ontario, Canada
    Gut 55:662-70. 2006
    ..We investigated the fibrotic potential of MCP-1 in the gut by overexpressing this chemokine in the mouse colorectal wall...
  39. pmc Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease
    C M Hogaboam
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 100:2766-76. 1997
    ..Thus, IL-4, introduced by Ad5, is therapeutic during acute inflammation in the rat colon. The therapeutic effect of IL-4 was associated with an inhibition of inducible nitric oxide expression and a reduction in nitric oxide synthesis...
  40. ncbi request reprint Fourth isoform of preprotachykinin messenger RNA encoding for substance P in the rat intestine
    I Khan
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Biochem Biophys Res Commun 202:796-802. 1994
    ..This was not detected in the kidney or uterus. The level of this PPT mRNA was enhanced significantly by 60% during colitis in rat induced by trinitro benzene sulphonic acid...
  41. ncbi request reprint T cell-mediated exocrine pancreatic damage in major histocompatibility complex class II-deficient mice
    B A Vallance
    Intestinal Diseases Research Programme, Health Science Centre, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 115:978-87. 1998
    ..The purpose of this study was to characterize this model of immune-based pancreatic injury...
  42. pmc 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: psycho-neuroimmunology and the intestinal microbiota: clinical observations and basic mechanisms
    J Bienenstock
    Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Clin Exp Immunol 160:85-91. 2010
    ..We then focus upon emerging data that will contribute to the generation of a new conceptual framework about the microbiota-gut-brain axis. In the final section we anticipate future directions of this field...
  43. doi request reprint Immunization with adenovirus at the large intestinal mucosa as an effective vaccination strategy against sexually transmitted viral infection
    Q Zhu
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Mucosal Immunol 1:78-88. 2008
    ..Therefore, large intestine mucosal immunization using Ad represents an effective vaccination strategy against virus infection at both rectal and vaginal mucosal tissue sites...
  44. ncbi request reprint The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-beta type II receptor gene transfer
    Y Motomura
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 288:G143-50. 2005
    ..These observations indicate that sFlt-1 gene transfer might be of therapeutic benefit in peritoneal fibrosis...
  45. ncbi request reprint Cytokine modulation of muscarinic receptors in the murine intestine
    Hirotada Akiho
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Gastrointest Liver Physiol 293:G250-5. 2007
    ..These findings explain the basis for altered muscle contractility observed in Th1 and Th2 models of inflammation, as well as in the post-nematode-infected state...
  46. ncbi request reprint The protective effect of the vagus nerve in a murine model of chronic relapsing colitis
    Jean Eric Ghia
    Intestinal Diseases Research Programme, Health Science Center, McMaster Univ Medical Center, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 293:G711-8. 2007
    ..Identification of the molecular mechanisms underlying the protective role of parasympathetic nerves opens a new therapeutic avenue for the treatment of acute relapses of chronic inflammatory bowel disease...
  47. ncbi request reprint Vagus nerve integrity and experimental colitis
    Jean Eric Ghia
    McMaster University Medical Center, 1200 Main St West, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 293:G560-7. 2007
    ..These findings indicate that although vagal integrity is an important protective factor, other counterinflammatory mechanisms come into play if vagal integrity is compromised beyond 2 wk...
  48. ncbi request reprint Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation
    Francois Pierre J Martin
    Biological Chemistry, Biomedical Sciences Division, Faculty of Natural Sciences, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    J Proteome Res 5:2185-93. 2006
    ..The work presented here suggests that probiotics may be beneficial in patients with IBS...
  49. ncbi request reprint Lymphocyte-mediated regulation of beta-endorphin in the myenteric plexus
    Monica Verma-Gandhu
    Intestinal Disease Research Programme, McMaster Univ, 1200 Main St, HSC Bldg, Rm 3N5C, Hamilton, ON, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 292:G344-8. 2007
    ..Thus, we propose that the mechanism underlying lymphocyte modulation of visceral pain involves T cell modulation of opioid expression in the enteric nervous system...
  50. pmc Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse
    Monica Verma-Gandhu
    Intestinal Disease Research Programme, McMaster University, Health Sciences Bldg, Hamilton, ON, Canada
    Gut 56:358-64. 2007
    ..This suggests that the nature of the inflammatory infiltrate influences visceral perception...
  51. pmc Recommendations on chronic constipation (including constipation associated with irritable bowel syndrome) treatment
    P Pare
    Université Laval and CHAUQ Hôpital St Sacrement, Quebec City, Canada
    Can J Gastroenterol 21:3B-22B. 2007
    ..The myriad of treatment options available to Canadian physicians can be confusing; thus, the main aim of the recommendations and treatment algorithm is to optimize the approach in clinical care based on available evidence...
  52. ncbi request reprint Eosinophilia is induced in the colon of Th2-sensitized mice upon exposure to locally expressed antigen
    Qing Zhu
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 293:G383-90. 2007
    ..Thus the model established here may provide a useful tool to study GI and, in particular, colonic inflammation with respect to underlying mechanisms involved in the recruitment and the immediate function of eosinophils...
  53. pmc Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression
    Jean Eric Ghia
    Intestinal Diseases Research Programme, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 118:2209-18. 2008
    ....
  54. ncbi request reprint Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery
    John K Marshall
    Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 131:445-50; quiz 660. 2006
    ..To better define its incidence and epidemiology, a large cohort study was initiated after the contamination of a municipal water supply led to a large outbreak of acute Escherichia coli 0157:H7 and Campylobacter jejuni gastroenteritis...
  55. ncbi request reprint The incidence of irritable bowel syndrome among community subjects with previous acute enteric infection
    Mark R Borgaonkar
    Department of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Dig Dis Sci 51:1026-32. 2006
    ..96; P = .02). The incidence of postinfectious IBS in community subjects is 3.7%. Fever during the AEI may be an important risk factor for this condition...
  56. ncbi request reprint Interleukin-4- and -13-induced hypercontractility of human intestinal muscle cells-implication for motility changes in Crohn's disease
    Hirotada Akiho
    Dept of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu Univ, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Gastrointest Liver Physiol 288:G609-15. 2005
    ..05). IL-4 and IL-13 mediate the hypercontractility of intestinal muscle via a STAT6 pathway at the level of the smooth muscle cell. The STAT6 pathway may contribute to the hypercontractility of intestinal muscle in Crohn's disease...
  57. ncbi request reprint Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction
    Elena F Verdu
    McMaster University, 1200 Main Street West, HSC 3N5C, Hamilton, Ontario, Canada
    Gastroenterology 127:826-37. 2004
    ..We tested whether probiotics influence persistent muscle hypercontractility in mice after recovery from infection with Trichinella spiralis and analyzed the underlying mechanisms...
  58. ncbi request reprint Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction
    Premysl Bercik
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 127:179-87. 2004
    ..The present study determined whether gut dysfunction in this model involves motor and sensory changes reminiscent of changes found in patients with postinfective irritable bowel syndrome (PI-IBS) and investigated underlying mechanisms...
  59. ncbi request reprint Microbial-gut interactions in health and disease. Irritable bowel syndrome
    Elena F Verdu
    Intestinal Research Programme, McMaster University, Hamilton, Ont, Canada
    Best Pract Res Clin Gastroenterol 18:315-21. 2004
    ..This chapter concentrates on the experimental evidence for a role of intestinal microbiota and the potential therapeutic value of probiotics in functional diseases such as irritable bowel syndrome...
  60. ncbi request reprint Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    Giovanni Barbara
    Departmentof Internal Medicine and Gastroenterology, and CRBA, University of Bologna, Italy
    Gastroenterology 126:693-702. 2004
    ..We assessed colonic mast cell infiltration, mediator release, and spatial interactions with mucosal innervation and their correlation with abdominal pain in IBS patients...
  61. ncbi request reprint Immune-mediated neural dysfunction in a murine model of chronic Helicobacter pylori infection
    Premysl Bercik
    Intestinal Diseases Research Programme, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 123:1205-15. 2002
    ..Neuromuscular changes producing dysmotility and hyperalgesia may underlie symptom generation in functional gastrointestinal disorders. We investigated whether chronic Helicobacter pylori-induced gastritis causes neuromuscular dysfunction...
  62. pmc Pathology of interstitial cells of Cajal in relation to inflammation revealed by ultrastructure but not immunohistochemistry
    Xuan Yu Wang
    Intestinal Disease Research Program and Department ofMedicine, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 160:1529-40. 2002
    ..From day 23 onward, immune cells withdrew from the musculature except macrophages, resulting in a markedly increased population of macrophages in the AP area at day 60 after infection...
  63. ncbi request reprint Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells
    Hirotada Akiho
    Intestinal Diseases Research Program, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 282:G226-32. 2002
    ..02). These results indicate both IL-4 and IL-13 induce hypercontractility of muscle cells via the STAT6 pathway, and this is the basis for hypercontractility observed in T. spiralis-infected mice...
  64. ncbi request reprint Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, Vancouver, British Columbia, V6H 3V4
    Am J Physiol Gastrointest Liver Physiol 287:G865-74. 2004
    ..These results identify a protective role for both iNOS and eNOS during colitis, with eNOS deficiency resulting in impaired intestinal defense against lumenal bacteria and increased susceptibility to colitis...
  65. ncbi request reprint TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada
    Am J Physiol Gastrointest Liver Physiol 289:G116-28. 2005
    ..Through adenoviral gene transfer technology, we describe a novel mouse model of colitis and implicate TGF-beta1 in the pathogenesis of obstructive intestinal fibrosis...
  66. ncbi request reprint Is irritable bowel syndrome a low-grade inflammatory bowel disease?
    Premysl Bercik
    Intestinal Disease Research Program and Division of Gastroenterology, McMaster University, 1200 Main Street West, HSC 3N49C, Hamilton, Ontario L8N 3Z5, Canada
    Gastroenterol Clin North Am 34:235-45, vi-vii. 2005
    ..This article examines these relation-ships using immune activation and inflammation as a common pathogenic process to IBD and a subset of IBS patients...
  67. ncbi request reprint Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction
    Hirotada Akiho
    Intestinal Diseases Research Program, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 129:131-41. 2005
    ..Here, we investigate the mechanisms underlying the maintenance of this hypercontractility in the postinfective (PI) state...
  68. ncbi request reprint Antidepressants attenuate increased susceptibility to colitis in a murine model of depression
    Ashwin K Varghese
    Intestinal Diseases Research Program, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 130:1743-53. 2006
    ..We also examined whether antidepressant therapy attenuates the increased susceptibility to colitis...
  69. ncbi request reprint CD4+ T-cell modulation of visceral nociception in mice
    Monica Verma-Gandhu
    Intestinal Disease Research Programme, McMaster University Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 130:1721-8. 2006
    ..We hypothesized that a component of the immune system exerts an antinociceptive influence, thus enabling the gut to function in the absence of undue pain or discomfort...
  70. ncbi request reprint Fundamentals of neurogastroenterology: basic science
    David Grundy
    Department of Biomedical Sciences, University of Sheffield, Sheffield, England
    Gastroenterology 130:1391-411. 2006
    ..Continued focus on neurogastroenterologic factors that underlie the development of symptoms will lead to mechanistic understanding that is expected to directly benefit the large contingent of patients and care-givers who deal with FGIDs...
  71. ncbi request reprint Evolving pathophysiologic models of functional gastrointestinal disorders
    Emeran A Mayer
    CURE Neuroenteric Disease Program, UCLA Division of Digestive Diseases and Brain Research Institute, Los Angeles, California 90073, USA
    Gastroenterology 122:2032-48. 2002
    ..Future development of existing and novel models involves the use of transgenic and knockout animals, as well as the demonstration of predictive validity in terms of responsiveness to candidate drugs...
  72. ncbi request reprint A case for an immunological basis for irritable bowel syndrome
    Stephen M Collins
    Gastroenterology 122:2078-80. 2002
  73. ncbi request reprint Modulatory effects of estrogen in two murine models of experimental colitis
    Elena F Verdu
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 283:G27-36. 2002
    ..The net modulatory effect most likely reflects a combination of estrogen receptor-mediated effects and antioxidant activity and may explain, in part, conflicting results from clinical trials...
  74. ncbi request reprint [Role of enteric infections and inflammation in functional bowel disorders]
    Thierry Piche
    Fédération des Maladies de l Appareil Digestif, CHU de Nice, France
    Gastroenterol Clin Biol 26:624-9. 2002
  75. ncbi request reprint The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model
    Jean Eric Ghia
    Intestinal Diseases Research Programme, Health Science Center, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Gastroenterology 131:1122-30. 2006
    ..The purpose of this study was to determine whether a similar vagus/macrophage axis modulates the inflammatory responses in the colon in mice...
  76. ncbi request reprint Dysregulation of peripheral cytokine production in irritable bowel syndrome
    Stephen M Collins
    Am J Gastroenterol 100:2517-8. 2005
  77. ncbi request reprint Irritable bowel syndrome and probiotics: from rationale to clinical use
    Elena F Verdu
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Gastroenterol 21:697-701. 2005
    ..An understanding that probiotics are heterogeneous, with multiple targets and mechanisms of action, is fundamental to the development of clinical trials...
  78. ncbi request reprint IL-4 gene transfer to the small bowel serosa leads to intestinal inflammation and smooth muscle hyperresponsiveness
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, ACB, Rm K4 188, 4480 Oak St, Vancouver, BC, Canada V6H 3V4
    Am J Physiol Gastrointest Liver Physiol 292:G385-94. 2007
    ..These results highlight an important causal role for IL-4 in the pathological regulation of enteric smooth muscle function and identify a novel strategy for gene transfer to the intestine...