D A Clark

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi The use and misuse of animal analog models of human pregnancy disorders
    David A Clark
    McMaster University Department of Medicine, Health Sciences Center, Room 3H1E, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1 Department of Immunology, Faculty of Medicine, and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Toronto General Research Institute, Canada Electronic address
    J Reprod Immunol 103:1-8. 2014
  2. doi Seminal plasma peptides may determine maternal immune response that alters success or failure of pregnancy in the abortion-prone CBAxDBA/2 model
    David A Clark
    Department of Medicine, Molecular Medicine and Pathology, Ob Gyn, McMaster University, Health Sciences Centre, Room 3H1E, Hamilton, Ontario, Canada L8S 4K1 Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Electronic address
    J Reprod Immunol 99:46-53. 2013
  3. doi Aspirin and heparin to improve live birth rate in IVF for unexplained implantation failure?
    David A Clark
    Department of Medicine, Molecular Medicine and Pathology, Obstetrics and Gynecology, McMaster University, Health Sciences Centre, 1280 Main St West, Hamilton, Ontario, Canada
    Reprod Biomed Online 26:538-41. 2013
  4. doi Regulatory T cells and reproduction: how do they do it?
    David A Clark
    Departments of Medicine, Molecular Medicine and Pathology, Obstetrics and Gynecology, McMaster University, Health Sciences Centre Rm 3H1E, Hamilton, Ontario, Canada L8S 4K1
    J Reprod Immunol 96:1-7. 2012
  5. doi The end of evidence-based medicine?
    David A Clark
    Department of Medicine, Molecular Medicine and Pathology, Ob Gyn, Faculty of Graduate Studies, McMaster University, Health Sciences Centre, West, Hamilton, ON L8S 4K1, Canada
    Inflammopharmacology 20:187-93. 2012
  6. doi The power of observation
    David A Clark
    Departments of Medicine, Molecular Medicine and Pathology, and Ob Gyn, McMaster University, 1200 Main Street West, Hamilton, ON, Canada
    Am J Reprod Immunol 66:71-5. 2011
  7. doi How should data on murine spontaneous abortion rates be expressed and analyzed?
    David A Clark
    McMaster University Rm 3V39, Hamilton, ON, Canada
    Am J Reprod Immunol 60:192-6. 2008
  8. ncbi The fgl2 prothrombinase/fibroleukin gene is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction
    David A Clark
    Department of Medicine, McMaster University Medical Center, Hamilton, Ontario, Canada
    Mol Hum Reprod 10:99-108. 2004
  9. doi Anti-TNFalpha therapy in immune-mediated subfertility: state of the art
    David A Clark
    McMaster University Room 3V39, 1200 Main St West, Hamilton, Ontario L8N 3Z5, Canada
    J Reprod Immunol 85:15-24. 2010
  10. doi Cell-surface CD200 may predict efficacy of paternal mononuclear leukocyte immunotherapy in treatment of human recurrent pregnancy loss
    David A Clark
    Department of Medicine, Molecular Medicine and Pathology, Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Am J Reprod Immunol 61:75-84. 2009

Collaborators

Detail Information

Publications66

  1. ncbi The use and misuse of animal analog models of human pregnancy disorders
    David A Clark
    McMaster University Department of Medicine, Health Sciences Center, Room 3H1E, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1 Department of Immunology, Faculty of Medicine, and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Toronto General Research Institute, Canada Electronic address
    J Reprod Immunol 103:1-8. 2014
    ....
  2. doi Seminal plasma peptides may determine maternal immune response that alters success or failure of pregnancy in the abortion-prone CBAxDBA/2 model
    David A Clark
    Department of Medicine, Molecular Medicine and Pathology, Ob Gyn, McMaster University, Health Sciences Centre, Room 3H1E, Hamilton, Ontario, Canada L8S 4K1 Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Electronic address
    J Reprod Immunol 99:46-53. 2013
    ..Direct antigen presentation of paternal H-2(d)-restricted paternal peptides (600-1800 D) may prevent the rejection of the CBAxDBA/2 embryos, and larger sized peptides may bind to immunizing splenocytes and augment abortion mechanisms...
  3. doi Aspirin and heparin to improve live birth rate in IVF for unexplained implantation failure?
    David A Clark
    Department of Medicine, Molecular Medicine and Pathology, Obstetrics and Gynecology, McMaster University, Health Sciences Centre, 1280 Main St West, Hamilton, Ontario, Canada
    Reprod Biomed Online 26:538-41. 2013
    ..The data concerning use of aspirin and/or heparin in IVF failure patients is reviewed. A number of methodological and biological problems are identified. A strategy to achieve reliable conclusions is explained...
  4. doi Regulatory T cells and reproduction: how do they do it?
    David A Clark
    Departments of Medicine, Molecular Medicine and Pathology, Obstetrics and Gynecology, McMaster University, Health Sciences Centre Rm 3H1E, Hamilton, Ontario, Canada L8S 4K1
    J Reprod Immunol 96:1-7. 2012
    ..The relevance of findings in mice to human pregnancy problems is also discussed...
  5. doi The end of evidence-based medicine?
    David A Clark
    Department of Medicine, Molecular Medicine and Pathology, Ob Gyn, Faculty of Graduate Studies, McMaster University, Health Sciences Centre, West, Hamilton, ON L8S 4K1, Canada
    Inflammopharmacology 20:187-93. 2012
    ..Advantages of observational studies are outlined, and the importance of assessing one's actual results when applying a treatment based on controlled trial evidence is set out...
  6. doi The power of observation
    David A Clark
    Departments of Medicine, Molecular Medicine and Pathology, and Ob Gyn, McMaster University, 1200 Main Street West, Hamilton, ON, Canada
    Am J Reprod Immunol 66:71-5. 2011
    ..In the golden age of evidence-based medicine, how should one view the cohort-controlled study of IVIG + anti-TNF-α (Humira) in recurrent in vitro fertilization (IVF) failure patients with an elevated Th1/Th2 cytokine production ratio...
  7. doi How should data on murine spontaneous abortion rates be expressed and analyzed?
    David A Clark
    McMaster University Rm 3V39, Hamilton, ON, Canada
    Am J Reprod Immunol 60:192-6. 2008
    ..Recently, it has been argued that medians with box plots should replace the accepted standard, but this deprives readers of data needed to verify P-values, and leads to inferences incompatible with biological and statistical reality...
  8. ncbi The fgl2 prothrombinase/fibroleukin gene is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction
    David A Clark
    Department of Medicine, McMaster University Medical Center, Hamilton, Ontario, Canada
    Mol Hum Reprod 10:99-108. 2004
    ..Physiological expression of fgl2 in fetal trophoblast may prevent occult loss in early pregnancy, along with other coagulation factors, but fgl2 expression is required for LPS to induce abortion pathology...
  9. doi Anti-TNFalpha therapy in immune-mediated subfertility: state of the art
    David A Clark
    McMaster University Room 3V39, 1200 Main St West, Hamilton, Ontario L8N 3Z5, Canada
    J Reprod Immunol 85:15-24. 2010
    ..Potential side effects and key issues in informed consent are set out. Anti-TNFalpha drugs may offer a new safe and effective approach to treating patients with Th1-cytokine-dependent infertility and recurrent miscarriages...
  10. doi Cell-surface CD200 may predict efficacy of paternal mononuclear leukocyte immunotherapy in treatment of human recurrent pregnancy loss
    David A Clark
    Department of Medicine, Molecular Medicine and Pathology, Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Am J Reprod Immunol 61:75-84. 2009
    ..Recent data emphasize an important role of expression of the CD200 tolerance-signaling molecule on cells used to prevent abortions both in mice and humans...
  11. ncbi Placental trophoblast from successful human pregnancies expresses the tolerance signaling molecule, CD200 (OX-2)
    David A Clark
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Reprod Immunol 50:187-95. 2003
    ..Abortions could be prevented by administration of a soluble CD200. Is CD200 expressed on trophoblast in successful human pregnancy?..
  12. doi Ecology of danger-dependent cytokine-boosted spontaneous abortion in the CBA x DBA/2 mouse model: II. Fecal LPS levels in colonies with different basal abortion rates
    David A Clark
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Am J Reprod Immunol 60:529-33. 2008
    ..It was predicted that intestinal availability of LPS was a major factor in the endogenous and cytokine-boosted resorption rates...
  13. ncbi Shall we properly re-examine the status of allogeneic lymphocyte therapy for recurrent early pregnancy failure?
    David A Clark
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Reprod Immunol 51:7-15. 2004
    ..How to evaluate immunological therapy advocated for recurrent spontaneous abortion and implantation failure. I was invited to comment on the opinion article of Chaouat (AJRI December 2003)...
  14. ncbi MD-1 is a critical part of the mechanism causing Th1-cytokine-triggered murine fetal loss syndrome
    David A Clark
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Reprod Immunol 49:297-307. 2003
    ..5 depends on endogenous rate of loss, and appears to depend on microbial flora. Is cytokine-triggered abortion dependent upon a third signaling pathway that senses 'danger'?..
  15. doi Prevention of spontaneous abortion in the CBA x DBA/2 mouse model by intravaginal TGF-beta and local recruitment of CD4+8+ FOXP3+ cells
    David A Clark
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Am J Reprod Immunol 59:525-34. 2008
    ..Seminal plasma contains many factors besides TGF-beta, and a critical test of the hypothesis was required. The purpose of the present study was to directly test the effect of pure TGF-beta...
  16. ncbi Loss of surface CD200 on stored allogeneic leukocytes may impair anti-abortive effect in vivo
    David A Clark
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Reprod Immunol 53:13-20. 2005
    ..The mechanism and generality of the phenomenon has not been elucidated...
  17. doi Immunological factors in pregnancy wastage: fact or fiction
    David A Clark
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Reprod Immunol 59:277-300. 2008
    ..In order to select patients most likely to benefit from known treatments, more extensive immunological testing is required. It is also important to determine the karyotype of all failing embryos...
  18. ncbi Tolerance signaling molecules
    David A Clark
    McMaster University, Hamilton, Ont, Canada
    Chem Immunol Allergy 89:36-48. 2005
    ..This chapter will critically review current data concerning the mechanisms and relevance of the various proposed mechanisms...
  19. ncbi Reduced uterine indoleamine 2,3-dioxygenase versus increased Th1/Th2 cytokine ratios as a basis for occult and clinical pregnancy failure in mice and humans
    David A Clark
    Biomedical Research Center, Charite, University Medicine of Berlin, Berlin, Germany
    Am J Reprod Immunol 54:203-16. 2005
    ..Could stress act by reducing IDO expression?..
  20. pmc Is intravenous immunoglobulins (IVIG) efficacious in early pregnancy failure? A critical review and meta-analysis for patients who fail in vitro fertilization and embryo transfer (IVF)
    David A Clark
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Assist Reprod Genet 23:1-13. 2006
    ..Systematic reviews generating inconclusive results have focused on methodological rigor to the exclusion of biological plausibility...
  21. doi Tolerance mechanisms in pregnancy: a reappraisal of the role of class I paternal MHC antigens
    David A Clark
    Department of Medicine, McMaster University Rm 3V39, Hamilton, ON, Canada
    Am J Reprod Immunol 63:93-103. 2010
    ..The alphabeta T-cell receptor recognizes peptide bound to the groove in Class I MHC, and peptides have profound effects on the interaction of KIR receptors on T and NK cells with Class I MHC...
  22. pmc CD200-dependent and nonCD200-dependent pathways of NK cell suppression by human IVIG
    David A Clark
    Department of Medicine, McMaster University, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
    J Assist Reprod Genet 25:67-72. 2008
    ..CD200 acts by binding to CD200 receptors (C200R). The objective of this study was to determine if CD200-dependent NK suppression by IVIG involved direct binding of IVIG-associated CD200 molecules to CD200R on NK cells...
  23. ncbi TH1/TH2,3 imbalance due to cytokine-producing NK, gammadelta T and NK-gammadelta T cells in murine pregnancy decidua in success or failure of pregnancy
    D A Clark
    Department of Molecular Medicine and Pathology, Obstetrics Gynecology, McMaster University, Hamilton, Ont, Canada
    Am J Reprod Immunol 45:257-65. 2001
    ..However, TGF-beta2-producing cells are present in the decidua of pregnant severe combined immune deficient (SCID) mice, which lack gammadelta T cells...
  24. ncbi Procoagulants in fetus rejection: the role of the OX-2 (CD200) tolerance signal
    D A Clark
    Departments of Medicine, Molecular Medicine and Pathology, Obstetrics and Gynecology, Mucosal Immunology Group, Immunology and Inflammation Program, McMaster University, Rm 3V39, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Semin Immunol 13:255-63. 2001
    ..Similarities and differences between findings in the mouse and human, and the potential evolutionary significance of mechanisms affecting reproductive success are reviewed...
  25. pmc Introduction to special issue on implantation
    David A Clark
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Assist Reprod Genet 24:282-3. 2007
  26. ncbi Fgl2 prothrombinase expression in mouse trophoblast and decidua triggers abortion but may be countered by OX-2
    D A Clark
    Department of Medicine, Pathology and Molecular Medicine, and Department of Obstetrics and Gynecology, McMaster University, 1200 Main St West, Room 3V39, Hamilton, Ontario, Canada L8N 3Z5
    Mol Hum Reprod 7:185-94. 2001
    ..Fgl2 prothrombinase may provide a mechanism explaining pregnancy loss, and conversely, successful pregnancy may be due in part to OX-2-dependent activation of maternal tolerance mechanisms at the feto-maternal interface...
  27. pmc Defining the roles of perforin, Fas/FasL, and tumour necrosis factor alpha in T cell induced mucosal damage in the mouse intestine
    M Merger
    Intestinal Disease Research Program, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Gut 51:155-63. 2002
    ..We describe the histological features of this enteropathy and define the effector mechanisms involved in T cell induced mucosal injury in this in vivo model...
  28. ncbi Activation of the novel prothrombinase, fg12, as a basis for the pregnancy complications spontaneous abortion and pre-eclampsia
    M Knackstedt
    Toronto General Hospital Research Institute, University of Toronto, Ontario, Canada
    Am J Reprod Immunol 46:196-210. 2001
    ..CONCLUSIONS: Activation of fg12 prothrombinase by Th1-type cytokines in pregnancy may lead to spontaneous abortion, or in ongoing pregnancy, to pre-eclampsia and/or IUGR...
  29. ncbi Regulation of gene expression of murine MD-1 regulates subsequent T cell activation and cytokine production
    R M Gorczynski
    Medical Research Council Group on Organ Injury, Transplant Research Division, The Toronto Hospital, Toronto, Canada
    J Immunol 165:1925-32. 2000
    ..MD-1 is linked to CD14, a "danger receptor complex," and activation of this complex can regulate cell surface expression of CD80/CD86, which signal T cells...
  30. ncbi Cytokine-dependent abortion in CBA x DBA/2 mice is mediated by the procoagulant fgl2 prothrombinase [correction of prothombinase]
    D A Clark
    McMaster University, Hamilton, Ontario, Canada
    J Immunol 160:545-9. 1998
    ..Cytokine-triggered thrombotic/inflammatory processes in maternal uteroplacental blood vessels causes abortion...
  31. ncbi Stress triggered abortions are associated with alterations of granulated cells into the decidua
    U R Markert
    McMaster University, Hamilton, Ontario, Canada
    Am J Reprod Immunol 37:94-100. 1997
    ..Substance P release by nerves in endometrium/decidua has been found to be the key neurotransmitter in this pathway. It is still unclear which cells are stimulated by substance P to produce the increased TNF-alpha level...
  32. ncbi Decidua-associated suppressor cells in abortion-prone DBA/2-mated CBA/J mice that release bioactive transforming growth factor beta2-related immunosuppressive molecules express a bone marrow-derived natural suppressor cell marker and gamma delta T-cell re
    D A Clark
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Biol Reprod 56:1351-60. 1997
    ....
  33. ncbi Th1 cytokines and the prothrombinase fgl2 in stress-triggered and inflammatory abortion
    M K Knackstedt
    Department of Internal Medicine, Charite, Charite, Humboldt University, Berlin, Germany
    Am J Reprod Immunol 49:210-20. 2003
    ..This study further investigates the Th1 cytokine up-regulation of fgl2 expression in a pathophysiological, stress induced abortion model, and an inflammatory, interleukin-12 (IL-12) triggered abortion model...
  34. ncbi Unexplained sporadic and recurrent miscarrage in the new millennium: a critical analysis of immune mechanisms and treatments
    D A Clark
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Hum Reprod Update 7:501-11. 2001
    ....
  35. ncbi The same immunoregulatory molecules contribute to successful pregnancy and transplantation
    Reginald M Gorczynski
    Transplant Research Division, The Toronto Hospital, Ontario, Canada
    Am J Reprod Immunol 48:18-26. 2002
    ....
  36. doi The prothrombinase activity of FGL2 contributes to the pathogenesis of experimental arthritis
    M C Melnyk
    Multi Organ Transplant Program, University of Toronto and Toronto General Hospital, Toronto, ON, Canada
    Scand J Rheumatol 40:269-78. 2011
    ..We hypothesized that expression of mFGL2 in inflamed synovium contributes to the fibrin deposition and subsequent inflammation in arthritis...
  37. ncbi A novel suppressor cell develops in uterine decidua in response to fetal trophoblast-type cells
    R M Slapsys
    Molecular Virology and Immunology Program, McMaster University, Hamilton, Ontario, Canada
    Reg Immunol 1:182-9. 1988
    ..Possible mechanisms of this induction and the importance of trophoblast-decidual interaction in generating localized immunosuppressive buffer zone (chemical barrier) about the implanted conceptus are discussed...
  38. ncbi Critical analysis of intravenous immunoglobulin therapy for recurrent miscarriage
    S Daya
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Hum Reprod Update 5:475-82. 1999
    ..The collective evidence thus far indicates that IVIG does not have a therapeutic effect that is clinically meaningful...
  39. ncbi LPS-induced occult loss in mice requires FGL2
    Katharina Foerster
    Toronto General Research Institute and CIHR Group on Cellular and Molecular Mechanisms of Organ Injury, Toronto Hospital, Toronto, ON, Canada
    Am J Reprod Immunol 58:524-9. 2007
    ..However, the frequency of such losses appears to vary among breeding periods and between laboratories...
  40. doi LPS-induced murine abortions require C5 but not C3, and are prevented by upregulating expression of the CD200 tolerance signaling molecule
    Gary Yu
    Toronto General Research Institute and CIHR Group on Cellular and Molecular Mechanisms of Organ Injury, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
    Am J Reprod Immunol 60:135-40. 2008
    ..CD200Fc can prevent abortions in the CBA x DBA/2 model, but an action through Fc could not be excluded...
  41. ncbi Thinking outside the box: mechanisms of environmental selective pressures on the outcome of the materno-fetal relationship
    David A Clark
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Reprod Immunol 47:275-82. 2002
    ..Furthermore, there is a poor correlation between Th1/Th2.3 cytokine ratios and abortion rates. Could there be a third factor involved, and if so, what might this mean?..
  42. ncbi Ecology of danger-dependent cytokine-boosted spontaneous abortion in the CBA x DBA/2 mouse model. I. Synergistic effect of LPS and (TNF-alpha + IFN-gamma) on pregnancy loss
    David A Clark
    Department of Medicine, McMaster University, 1200 Main Street West, Room 3V39, Hamilton, Ontario, Canada L8N 3Z5
    Am J Reprod Immunol 52:370-8. 2004
    ..A specific role for LPS has been postulated to determine both the endogenous and cytokine-boosted losses...
  43. ncbi Cytokine-induced hepatic apoptosis is dependent on FGL2/fibroleukin: the role of Sp1/Sp3 and STAT1/PU.1 composite cis elements
    Mingfeng Liu
    Multi Organ Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Immunol 176:7028-38. 2006
    ..Overall, this study demonstrates that IFN-gamma and TNF-alpha induce hepatocyte apoptosis in vivo, which is dependent on induction of fgl2, and defines the molecular basis of transcription of fgl2 in vitro...
  44. ncbi Transforming growth factor-beta 2-related-decidual suppressor factor is not related to TJ6 protein
    F S Merali
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Reprod Immunol 35:342-7. 1996
    ..TJ6 has only a 30% gene sequence homology and a 13% amino acid homology to TGF-beta 2. TJ6 and TGF-beta 2-related DSF appear to be different immunosuppressive proteins in decidua...
  45. doi The FGL2-FcgammaRIIB pathway: a novel mechanism leading to immunosuppression
    Hao Liu
    Multi Organ Transplant Program, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada
    Eur J Immunol 38:3114-26. 2008
    ..The identification of specific receptor binding has important implications for the pathogenesis of immune-mediated disease and suggests a potential for targeted FGL2 therapy...
  46. doi The novel CD4+CD25+ regulatory T cell effector molecule fibrinogen-like protein 2 contributes to the outcome of murine fulminant viral hepatitis
    Itay Shalev
    Multi Organ Transplant Program, University of Toronto, Toronto, Ontario, Canada
    Hepatology 49:387-97. 2009
    ..The results further suggest that targeting FGL2 may lead to the development of novel treatment approaches for acute viral hepatitis infection...
  47. pmc Is there any evidence for immunologically mediated or immunologically modifiable early pregnancy failure?
    David A Clark
    Department of Medicine, 3V39 McMaster Universitty Medical Center, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    J Assist Reprod Genet 20:63-72. 2003
    ..Genetic abnormalities can explain much of the wastage, but can it explain all of the failures? As embryos bear paternal and embryonic antigens foreign to the maternal immune system, could some otherwise normal embryos be "rejected"?..
  48. ncbi Decline in number of elevated blood CD3(+) CD56(+) NKT cells in response to intravenous immunoglobulin treatment correlates with successful pregnancy
    Marianne J van den Heuvel
    Department of Pediatrics, University of Western Ontario, London, ON, Canada
    Am J Reprod Immunol 58:447-59. 2007
    ..In mouse models of pregnant failure, NKT cells appear to be important. However, a mouse model may only be pertinent to a subset of patients, as recurrent pregnancy failure is a heterogenous group...
  49. ncbi Transforming growth factor-beta (TGF-beta)
    D A Clark
    Department of Medicine, Pathology, Obstetrics and Gynecology, McMaster University, Hamilton, Ont, Canada
    Int J Biochem Cell Biol 30:293-8. 1998
    ..The role of TGF-beta in homeostatic and pathogenic processes suggests numerous applications in the diagnosis and treatment of various diseases characterised by inflammation and fibrosis...
  50. pmc Human ovarian carcinoma: evidence for patient-related differences in susceptibility to cytotoxic effectors that attack different cellular subpopulations within a tumour
    D A Clark
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Br J Cancer 58:415-8. 1988
    ..Apparent heterogeneity between patients and stem cell susceptibility to effector cells may be important determinants of the efficacy of treatment of patients with biologic response modifiers such as interferon and interleukin 2...
  51. ncbi Fgl2 deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice
    Junwu Mu
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Physiol Genomics 31:53-62. 2007
    ....
  52. doi Transfusion-related immunomodulation due to peripheral blood dendritic cells expressing the CD200 tolerance signaling molecule and alloantigen
    David A Clark
    Department of Medicine, Immunology and Inflammation Program, McMaster University, Hamilton, Ontario, Canada
    Transfusion 48:814-21. 2008
    ....
  53. pmc The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis
    Philip A Marsden
    CIHR Group on Cellular and Molecular Mechanisms of Organ Injury, Toronto, Ontario, Canada
    J Clin Invest 112:58-66. 2003
    ..Fibrin deposition was strongly associated with Fgl2/fibroleukin expression. Collectively, these data indicate a critical role for Fgl2/fibroleukin in the pathophysiology of experimental and human viral hepatitis...
  54. ncbi Characterization of murine pregnancy decidua transforming growth factor beta. I. Transforming growth factor beta 2-like molecules of unusual molecular size released in bioactive form
    D A Clark
    Molecular Virology Immunology Program, McMaster University, Hamilton, Ontario, Canada
    Biol Reprod 52:1380-8. 1995
    ..abstract truncated at 250 words)..
  55. ncbi CD56+ cells are recruited to the uterus in two waves: at ovulation and during the first 2 weeks after missed menses
    Marianne J van den Heuvel
    Department of Pediatrics, Children s Health Research Institute, University of Western Ontario, London, ON, Canada
    Am J Reprod Immunol 59:90-8. 2008
    ..To support a hypothesis that precursors of uNK cells are recruited from blood, adhesive function of blood CD56+ subsets were assessed during one cycle and during pregnancy...
  56. ncbi Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis
    Itay Shalev
    Multi Organ Transplant Program, Department of Immunology, University of Toronto, Ontario, Canada
    J Immunol 180:249-60. 2008
    ..Collectively, these data suggest that FGL2 contributes to Treg cell activity and inhibits the development of autoimmune disease...
  57. ncbi Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface
    Reginald M Gorczynski
    Transplant Research Division, The Toronto Hospital, Ontario, Canada
    Am J Reprod Immunol 52:147-63. 2004
    ..CD200 is expressed on a subpopulation of uterine decidua cells and on trophoblast, both in the mouse and human. The receptor(s) for CD200, CD200R(s), was not previously well-characterized...
  58. ncbi Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3
    Mingfeng Liu
    Multi Organ Transplant Program, Toronto General Hospital and the University of Toronto, Canada
    Eur J Biochem 270:2274-86. 2003
    ....
  59. ncbi Assessing human alloimmunization as a strategy for inducing HIV type 1 neutralizing anti-HLA responses
    Jonathan G Leith
    Department of Immunology, University of Toronto, Toronto, Canada
    AIDS Res Hum Retroviruses 19:957-65. 2003
    ....
  60. ncbi Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity
    Camie W Y Chan
    Multi Organ Transplant Program, Toronto General Hospital and University of Toronto, 621 University Avenue 10th Floor, Room 116, Toronto, Ontario M5G 2C4, Canada
    J Immunol 168:5170-7. 2002
    ..In this work we provide direct evidence that fgl2 cleaves prothrombin to thrombin consistent with serine protease activity and requires calcium, phospholipids, and factor Va for its full activity...
  61. ncbi Combined donor leucocyte administration and immunosuppressive drug treatment for survival of rat heart allografts
    Marcel den Dulk
    AW Morrow Liver Immunobiology Laboratory, Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Locked Bag 6, Newtown, Sydney NSW 2042, Australia
    Transpl Immunol 13:177-84. 2004
    ..They appear to induce early activation, altered patterns of infiltration and death of recipient alloreactive T cells. The ability of immunosuppressive drugs to combine with DL administration was examined in a rat heart transplant model...
  62. ncbi Recognizing the clinical features of Trisomy 13 syndrome
    Angel Rios
    Department of Pediatrics, The Children s Hospital at Albany Medical Center, Albany, NY 12208, USA
    Adv Neonatal Care 4:332-43. 2004
    ..The diagnosis of Trisomy 13 is confirmed antenatally or after delivery with genetic testing. Prognosis of infants with Trisomy 13 and implications for the infants development are described...
  63. ncbi Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
    Peter Terness
    Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Reprod Immunol 58:238-54. 2007
    ..Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid?..
  64. ncbi The Ronald McDonald House as an alternative to antepartum hospitalization
    Scott C Dexter
    Department of Obstetrics and Gynecology, Albany Medical College, Albany, NY, USA
    J Perinatol 24:623-5. 2004
    ..We sought to evaluate the use of the Ronald McDonald House (RMH) for selected high-risk pregnant women...
  65. ncbi ANCA-positive vasculitis of the breast
    Ibrahim M Zardawi
    Pathology 36:370-3. 2004
  66. ncbi Fine needle aspiration cytology of a primary amyloid tumor of the breast
    Ibrahim M Zardawi
    Acta Cytol 48:286-8. 2004