Affiliation: McMaster University
- Long-term effects of ramipril on cardiovascular events and on diabetes: results of the HOPE study extensionJackie Bosch
Division of Cardiology, Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Circulation 112:1339-46. 2005..6 years of follow-up and (2) observed in subgroups based on risk and ancillary treatments...
- Use of ramipril in preventing stroke: double blind randomised trialJackie Bosch
Canadian Cardiovascular Collaboration, McMaster University, 237 Barton St E, Hamilton, ON, Canada L8L 2X2
BMJ 324:699-702. 2002..To determine the effect of the angiotensin converting enzyme inhibitor ramipril on the secondary prevention of stroke...
- Cognitive impairment and risk of cardiovascular events and mortalityMartin O'Donnell
Population Health Research Institute, McMaster University, DBCVS Research Institute, Hamilton, Ontario, Canada
Eur Heart J 33:1777-86. 2012....
- Effects of ramipril on left ventricular mass and function in cardiovascular patients with controlled blood pressure and with preserved left ventricular ejection fraction: a substudy of the Heart Outcomes Prevention Evaluation (HOPE) TrialEva Lonn
Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Am Coll Cardiol 43:2200-6. 2004..The purpose of this study was to assess the effects of ramipril on left ventricular mass (LVM) and function in vascular disease patients with controlled blood pressure (BP) and with preserved left ventricular ejection fraction (LVEF)...
- Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trialEva Lonn
Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario
JAMA 293:1338-47. 2005..Experimental and epidemiological data suggest that vitamin E supplementation may prevent cancer and cardiovascular events. Clinical trials have generally failed to confirm benefits, possibly due to their relatively short duration...
- Effect of ramipril on the incidence of diabetesJackie Bosch
McMaster University, Hamilton, Canada
N Engl J Med 355:1551-62. 2006..Previous studies have suggested that blockade of the renin-angiotensin system may prevent diabetes in people with cardiovascular disease or hypertension...
- Effect of ramipril and of rosiglitazone on carotid intima-media thickness in people with impaired glucose tolerance or impaired fasting glucose: STARR (STudy of Atherosclerosis with Ramipril and Rosiglitazone)Eva M Lonn
Department of Medicine, McMaster University, Hamilton, Ontario, Canada Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
J Am Coll Cardiol 53:2028-35. 2009....
- Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudyEva Lonn
Department of Medicine and Population Health Institute, McMaster University, Hamilton, Ontario, Canada
Diabetes Care 25:1919-27. 2002..However, data from randomized clinical trials are limited. Therefore, we evaluated the effects of vitamin E supplementation on major CV outcomes and on the development of nephropathy in people with diabetes...
- Effect of ramipril in reducing sudden deaths and nonfatal cardiac arrests in high-risk individuals without heart failure or left ventricular dysfunctionKoon K Teo
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Circulation 110:1413-7. 2004....
- Relationship of electrocardiographic left ventricular hypertrophy to mortality and cardiovascular morbidity in high-risk patientsEva Lonn
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Eur J Cardiovasc Prev Rehabil 10:420-8. 2003..The prognostic significance of left ventricular hypertrophy (LVH) identified by simple electrocardiographic (ECG) criteria in high-risk patients with established cardiovascular (CV) diseases is not clearly understood...
- Effect of long-term therapy with ramipril in high-risk womenEva Lonn
Department of Medicine, Division of Cardiology and Population Health Institute, McMaster University, Hamilton, Ontario, Canada
J Am Coll Cardiol 40:693-702. 2002..We evaluated the effects of long-term therapy with the angiotensin-converting enzyme (ACE) inhibitor ramipril on major cardiovascular (CV) outcomes in high-risk women...
- The fluid study protocol: a randomized controlled study on the effects of bioimpedance analysis and vitamin D on left ventricular mass in peritoneal dialysis patientsWinnie S Su
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Perit Dial Int 31:529-36. 2011....
- Setting the record straight on TIDE: a lost opportunity for patients with diabetesZubin Punthakee
Population Health Research Institute, McMaster University, 1280 Main Street West, HSC 3V51, Hamilton, ON, Canada, L8S 4K1
Diabetologia 56:1884-7. 2013..As such, we deemed it appropriate to clarify TIDE's objectives, research questions and design and the clinical equipoise regarding its research questions. ..
- Increased risk of cognitive and functional decline in patients with atrial fibrillation: results of the ONTARGET and TRANSCEND studiesIrene Marzona
Population Health Research Institute, McMaster University, Hamilton, Ont
CMAJ 184:E329-36. 2012..We sought to determine the association of atrial fibrillation with cognitive and physical impairment in a large group of patients at high cardiovascular risk...
- Home and community occupational therapy for children and youth: a before and after studyMary Law
School of Rehabilitation Science, McMaster University, Institute for Applied Health Science, Hamilton, ON
Can J Occup Ther 72:289-97. 2005..There has been an increased focus on home care service provision in recent years, yet there are few data available about the provision of home and community occupational therapy for children and youth...
- Independent design and conduct of clinical trialsSalim Yusuf
Department of Medicine, Division of Cardiology, McMaster University, Hamilton, Ontario, Canada, Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Clin Trials 3:503-7. 2006..The most frequent type of RCT are those evaluating therapies, and much of this commentary will be focused on issues relevant to such trials, although the principles apply generally...
- Sensible guidelines for the conduct of large randomized trialsSalim Yusuf
Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
Clin Trials 5:38-9. 2008
- Prevention of Heart Failure in Patients in the Heart Outcomes Prevention Evaluation (HOPE) StudyJ Malcolm O Arnold
London Health Sciences Centre, London, Canada
Circulation 107:1284-90. 2003..We assessed an angiotensin-converting enzyme (ACE) inhibitor, ramipril, to prevent the development of heart failure in high-risk patients without known low ejection fraction or heart failure...
- Effects of vitamin E on cardiovascular outcomes in people with mild-to-moderate renal insufficiency: results of the HOPE studyJohannes F E Mann
Department of Nephrology and Hypertension, Schwabing General Hospital, Munich, Germany
Kidney Int 65:1375-80. 2004..There are no data for renal insufficiency before the stage of terminal renal failure. We evaluated effects of vitamin E supplementation on cardiovascular and renal outcomes in 993 people with a serum creatinine > or =1.4 to 2.3 mg/dL...
- Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: the ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention)Hertzel Gerstein
Am Heart J 155:26-32, 32.e1-6. 2008..Thus, targeting normal fasting glucose levels with insulin may reduce CV events. Previous studies suggest that omega-3 fatty acid supplements may reduce CV death; however, their effect in high-risk dysglycemic individuals is not known...
- Effect of long-term ACE-inhibitor therapy in elderly vascular disease patientsMonica Gianni
Department of Medicine, University of Insubria, Varese, Italy
Eur Heart J 28:1382-8. 2007..Cardiovascular (CV) disease is the leading cause of death in the elderly. The use of ACE-inhibitors in elderly patients with chronic stable vascular disease has not been previously reported...
- Preventing stroke with ramipril--authors' replySalim Yusuf
BMJ 326:52. 2003
- Prognostic impact of body weight and abdominal obesity in women and men with cardiovascular diseaseGilles R Dagenais
Department of Cardiology, Laval University Heart and Lung Institute, Ste Foy, Quebec, Canada
Am Heart J 149:54-60. 2005..Increased body mass index (BMI) and abdominal adiposity increase the risk of cardiovascular disease (CVD) in persons free of these diseases, but their independent prognostic impact in persons with CVD has not been well defined...