Premysl Bercik

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint The effects of inflammation, infection and antibiotics on the microbiota-gut-brain axis
    Premysl Bercik
    Department of Medicine, McMaster University, 1200 Main Street West, HSC 2E16, Hamilton, ON, Canada, L8S 4K1
    Adv Exp Med Biol 817:279-89. 2014
  2. ncbi request reprint The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice
    Premysl Bercik
    The Farncombe Family Digestive Health Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 141:599-609, 609.e1-3. 2011
  3. doi request reprint Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice
    Premysl Bercik
    Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 139:2102-2112.e1. 2010
  4. ncbi request reprint Role of gut-brain axis in persistent abnormal feeding behavior in mice following eradication of Helicobacter pylori infection
    Premysl Bercik
    Intestinal Diseases Research Program, McMaster Univ, MUMC 4W8, Hamilton, Ontario L8N 3Z5
    Am J Physiol Regul Integr Comp Physiol 296:R587-94. 2009
  5. ncbi request reprint Is irritable bowel syndrome a low-grade inflammatory bowel disease?
    Premysl Bercik
    Intestinal Disease Research Program and Division of Gastroenterology, McMaster University, 1200 Main Street West, HSC 3N49C, Hamilton, Ontario L8N 3Z5, Canada
    Gastroenterol Clin North Am 34:235-45, vi-vii. 2005
  6. ncbi request reprint Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction
    Elena F Verdu
    McMaster University, 1200 Main Street West, HSC 3N5C, Hamilton, Ontario, Canada
    Gastroenterology 127:826-37. 2004
  7. ncbi request reprint Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction
    Premysl Bercik
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 127:179-87. 2004
  8. ncbi request reprint Immune-mediated neural dysfunction in a murine model of chronic Helicobacter pylori infection
    Premysl Bercik
    Intestinal Diseases Research Programme, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 123:1205-15. 2002
  9. ncbi request reprint Microbial-gut interactions in health and disease. Irritable bowel syndrome
    Elena F Verdu
    Intestinal Research Programme, McMaster University, Hamilton, Ont, Canada
    Best Pract Res Clin Gastroenterol 18:315-21. 2004
  10. doi request reprint The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infection
    Elena F Verdu
    McMaster Univ HSC 3N49C, 1200 Main St West, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 295:G664-70. 2008

Collaborators

Detail Information

Publications27

  1. ncbi request reprint The effects of inflammation, infection and antibiotics on the microbiota-gut-brain axis
    Premysl Bercik
    Department of Medicine, McMaster University, 1200 Main Street West, HSC 2E16, Hamilton, ON, Canada, L8S 4K1
    Adv Exp Med Biol 817:279-89. 2014
    ....
  2. ncbi request reprint The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice
    Premysl Bercik
    The Farncombe Family Digestive Health Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 141:599-609, 609.e1-3. 2011
    ..We examined whether the intestinal microbiota affects behavior and brain biochemistry in mice...
  3. doi request reprint Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice
    Premysl Bercik
    Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 139:2102-2112.e1. 2010
    ..Clinical and preclinical studies have associated gastrointestinal inflammation and infection with altered behavior. We investigated whether chronic gut inflammation alters behavior and brain biochemistry and examined underlying mechanisms...
  4. ncbi request reprint Role of gut-brain axis in persistent abnormal feeding behavior in mice following eradication of Helicobacter pylori infection
    Premysl Bercik
    Intestinal Diseases Research Program, McMaster Univ, MUMC 4W8, Hamilton, Ontario L8N 3Z5
    Am J Physiol Regul Integr Comp Physiol 296:R587-94. 2009
    ..pylori eradication and is accompanied by increased TNF-alpha in the brain. The results support a role for altered gut-brain pathways in the maintenance of postinfective gut dysfunction...
  5. ncbi request reprint Is irritable bowel syndrome a low-grade inflammatory bowel disease?
    Premysl Bercik
    Intestinal Disease Research Program and Division of Gastroenterology, McMaster University, 1200 Main Street West, HSC 3N49C, Hamilton, Ontario L8N 3Z5, Canada
    Gastroenterol Clin North Am 34:235-45, vi-vii. 2005
    ..This article examines these relation-ships using immune activation and inflammation as a common pathogenic process to IBD and a subset of IBS patients...
  6. ncbi request reprint Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction
    Elena F Verdu
    McMaster University, 1200 Main Street West, HSC 3N5C, Hamilton, Ontario, Canada
    Gastroenterology 127:826-37. 2004
    ..We tested whether probiotics influence persistent muscle hypercontractility in mice after recovery from infection with Trichinella spiralis and analyzed the underlying mechanisms...
  7. ncbi request reprint Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction
    Premysl Bercik
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 127:179-87. 2004
    ..The present study determined whether gut dysfunction in this model involves motor and sensory changes reminiscent of changes found in patients with postinfective irritable bowel syndrome (PI-IBS) and investigated underlying mechanisms...
  8. ncbi request reprint Immune-mediated neural dysfunction in a murine model of chronic Helicobacter pylori infection
    Premysl Bercik
    Intestinal Diseases Research Programme, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 123:1205-15. 2002
    ..Neuromuscular changes producing dysmotility and hyperalgesia may underlie symptom generation in functional gastrointestinal disorders. We investigated whether chronic Helicobacter pylori-induced gastritis causes neuromuscular dysfunction...
  9. ncbi request reprint Microbial-gut interactions in health and disease. Irritable bowel syndrome
    Elena F Verdu
    Intestinal Research Programme, McMaster University, Hamilton, Ont, Canada
    Best Pract Res Clin Gastroenterol 18:315-21. 2004
    ..This chapter concentrates on the experimental evidence for a role of intestinal microbiota and the potential therapeutic value of probiotics in functional diseases such as irritable bowel syndrome...
  10. doi request reprint The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infection
    Elena F Verdu
    McMaster Univ HSC 3N49C, 1200 Main St West, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 295:G664-70. 2008
    ..These changes do not seem to occur in association with modulation of intestinal permeability...
  11. ncbi request reprint Antidepressants attenuate increased susceptibility to colitis in a murine model of depression
    Ashwin K Varghese
    Intestinal Diseases Research Program, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 130:1743-53. 2006
    ..We also examined whether antidepressant therapy attenuates the increased susceptibility to colitis...
  12. pmc Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse
    Monica Verma-Gandhu
    Intestinal Disease Research Programme, McMaster University, Health Sciences Bldg, Hamilton, ON, Canada
    Gut 56:358-64. 2007
    ..This suggests that the nature of the inflammatory infiltrate influences visceral perception...
  13. ncbi request reprint CD4+ T-cell modulation of visceral nociception in mice
    Monica Verma-Gandhu
    Intestinal Disease Research Programme, McMaster University Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 130:1721-8. 2006
    ..We hypothesized that a component of the immune system exerts an antinociceptive influence, thus enabling the gut to function in the absence of undue pain or discomfort...
  14. doi request reprint The interplay between the intestinal microbiota and the brain
    Stephen M Collins
    Farncombe Family Digestive Health Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton L8N 3Z5, Ontario, Canada
    Nat Rev Microbiol 10:735-42. 2012
    ..We also review how this extended communication system might influence a broad spectrum of diseases, including irritable bowel syndrome, psychiatric disorders and demyelinating conditions such as multiple sclerosis...
  15. ncbi request reprint Modulatory effects of estrogen in two murine models of experimental colitis
    Elena F Verdu
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 283:G27-36. 2002
    ..The net modulatory effect most likely reflects a combination of estrogen receptor-mediated effects and antioxidant activity and may explain, in part, conflicting results from clinical trials...
  16. doi request reprint Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis
    John L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 141:1314-22, 1322.e1-5. 2011
    ..However, suppression of gastric acid secretion by PPIs is unlikely to provide any protection against the damage caused by NSAIDs in the more distal small intestine...
  17. ncbi request reprint Adenoviral transfer of the murine oncostatin M gene suppresses dextran-sodium sulfate-induced colitis
    Ana L Sanchez
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    J Interferon Cytokine Res 23:193-201. 2003
    ..Thus, systemic administration of AdMuOSM given as a cotreatment and to a lesser extent as a therapy was found to be of benefit in DSS-induced colitis, a murine model of inflammatory bowel disease (IBD)...
  18. pmc Differential induction of antimicrobial REGIII by the intestinal microbiota and Bifidobacterium breve NCC2950
    Jane M M Natividad
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Appl Environ Microbiol 79:7745-54. 2013
    ..Treatment with this probiotic may enhance the mucosal barrier and protect the host from infection and inflammation. ..
  19. pmc Pathology of interstitial cells of Cajal in relation to inflammation revealed by ultrastructure but not immunohistochemistry
    Xuan Yu Wang
    Intestinal Disease Research Program and Department ofMedicine, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 160:1529-40. 2002
    ..From day 23 onward, immune cells withdrew from the musculature except macrophages, resulting in a markedly increased population of macrophages in the AP area at day 60 after infection...
  20. doi request reprint The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications
    Stephen M Collins
    Farncombe Family Digestive Health Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Microbiol 16:240-5. 2013
    ....
  21. ncbi request reprint Lack of pyloric interstitial cells of Cajal explains distinct peristaltic motor patterns in stomach and small intestine
    Xuan Yu Wang
    Intestinal Disease Research Program and Department of Medicine, McMaster Univ, HSC 3N5C, 1200 Main St West, Hamilton, Ontario, Canada L8N 3Z5
    Am J Physiol Gastrointest Liver Physiol 289:G539-49. 2005
    ..Throughout this coordinated motor activity, the pacemaker systems in antrum and duodenum remain independent...
  22. doi request reprint The commensal bacterium Faecalibacterium prausnitzii is protective in DNBS-induced chronic moderate and severe colitis models
    Rebeca Martín
    INRA, Commensal and Probiotics Host Interactions Laboratory, UMR 1319 Micalis, Jouy en Josas, France AgroParisTech, UMR 1319 Micalis, Jouy en Josas, France Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada Department of Gastroenterology and Nutrition, AP HP, Hôpital Saint Antoine and UPMC University of Paris, Paris, France and Equipe AVENIR Gut Microbiota and Immunity, INSERM U1057 UMR CNRS 7203, Universite Pierre et Marie Curie 6, Paris, France
    Inflamm Bowel Dis 20:417-30. 2014
    ..Here, we tested the effects of both F. prausnitzii and its SN in moderate and severe DNBS-induced chronic colitis mouse models...
  23. doi request reprint Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells
    Manuel A Silva
    Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
    Lab Invest 92:937-48. 2012
    ..We demonstrated that macrophages are related with bronchiolar GCH, and that they induced MUC5B and inhibited MUC5AC in HBEC, suggesting a role for them in the pathogenesis of airway MUC5B-related GCH...
  24. pmc Effect of probiotics on gastrointestinal function: evidence from animal models
    Elena F Verdu
    Department of Medicine, McMaster University, Hamilton, Canada
    Therap Adv Gastroenterol 2:31-5. 2009
    ..This article focuses on lessons learned from animal models of gut dysfunction...
  25. pmc Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism
    Emma Slack
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada
    Science 325:617-20. 2009
    ..Spontaneous hyper-activation of adaptive immunity against the intestinal microbiota, secondary to innate immune deficiency, may clarify the underlying mechanisms of inflammatory diseases where immune dysfunction is implicated...
  26. doi request reprint Pathogenic factors involved in the development of irritable bowel syndrome: focus on a microbial role
    Carolina M Bolino
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Infect Dis Clin North Am 24:961-75, ix. 2010
    ....
  27. ncbi request reprint The origin of segmentation motor activity in the intestine
    Jan D Huizinga
    Department of Medicine, Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N3Z5 2 Department of Gastroenterology, Wuhan University, Renmin Hospital, Wuhan, 430060, Hubei Province, Peoples Republic of China
    Nat Commun 5:3326. 2014
    ..Phase-amplitude modulation of the slow waves points to an underlying system of coupled nonlinear oscillators originating in the networks of ICC. ..