Research Topics
| Shannon M BatesSummaryAffiliation: McMaster University Country: Canada Publications
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Publications
Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice GuidelinesShannon M Bates
Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
Chest 141:e351S-418S. 2012..This guideline focuses on the identification of optimal strategies for the diagnosis of DVT in ambulatory adults...- VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice GuidelinesShannon M Bates
Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
Chest 141:e691S-736S. 2012..This guideline focuses on the management of VTE and thrombophilia as well as the use of antithrombotic agents during pregnancy... 
Clinical practice. Treatment of deep-vein thrombosisShannon M Bates
Department of Medicine, McMaster University, Hamilton, Ont, Canada
N Engl J Med 351:268-77. 2004
Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)Shannon M Bates
Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada
Chest 133:844S-886S. 2008....- A diagnostic strategy involving a quantitative latex D-dimer assay reliably excludes deep venous thrombosisShannon M Bates
McMaster University Medical Centre, HSC 3W11, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
Ann Intern Med 138:787-94. 2003..Because clinical diagnosis is inaccurate, objective testing is usually considered necessary when patients present with suspected deep venous thrombosis (DVT)... - Treatment and prophylaxis of venous thromboembolism during pregnancyShannon M Bates
Thromboembolism Unit Office, HSC 3W11, Department of Medicine, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
Thromb Res 108:97-106. 2002..This paper briefly reviews the areas of controversy and provides recommendations for the treatment and prophylaxis of acute deep vein thrombosis and pulmonary embolism in pregnant patients... - Imaging characteristics of a novel technetium Tc 99m-labeled platelet glycoprotein IIb/IIIa receptor antagonist in patients With acute deep vein thrombosis or a history of deep vein thrombosisShannon M Bates
Thromboembolism Unit Office, HSC 3W11, Department of Medicine, McMaster University Medical Centre, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5
Arch Intern Med 163:452-6. 2003.... - Consultative hematology: the pregnant patient pregnancy lossShannon M Bates
Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada
Hematology Am Soc Hematol Educ Program 2010:166-72. 2010.... - Use of a fixed activated partial thromboplastin time ratio to establish a therapeutic range for unfractionated heparinS M Bates
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Arch Intern Med 161:385-91. 2001..We sought to identify an aPTT ratio that corresponds to therapeutic anti--factor Xa heparin levels for combinations of several reagents and coagulometers that are commonly used... - Pregnancy-associated venous thromboembolism: prevention and treatmentShannon M Bates
Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada
Semin Hematol 48:271-84. 2011..This article reviews the available literature and provides guidance for the management and prevention of VTE during pregnancy... - A latex D-dimer reliably excludes venous thromboembolismS M Bates
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Arch Intern Med 161:447-53. 2001..D-Dimer, a cross-linked fibrin degradation product, has a high sensitivity in patients with suspected venous thrombosis. Traditional latex D-dimer assays, however, have not been sufficiently sensitive to exclude venous thromboembolism... - An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trialClive Kearon
McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada
Ann Intern Med 144:812-21. 2006..It may be safe to omit additional diagnostic testing in selected patients with suspected pulmonary embolism (PE) who have a negative D-dimer test, but this approach has never been evaluated in a randomized, controlled trial... - Are brand-name and generic warfarin interchangeable? A survey of Ontario patients and physiciansJennifer A Pereira
Centre for Evaluation of Medicines, St Joseph s Healthcare, Hamilton, ON
Can J Clin Pharmacol 12:e229-39. 2005..The issue of therapeutic equivalence has been a source of controversy in Canada since the approval of generic warfarin products in 2000... - 2009 evidence-based clinical practice guidelines for diagnosing a first episode of lower extremities deep vein thrombosis in ambulatory outpatientsRoman Jaeschke
Department of Medicine, McMaster University, Hamilton, Canada
Pol Arch Med Wewn 119:541-9. 2009..The framework mandates explicit evidence summaries, ratings of the quality of evidence, and specifying recommendations as strong or weak... - Coagulation assaysShannon M Bates
Department of Medicine, McMaster University, Henderson Research Centre, Hamilton, Ontario, Canada
Circulation 112:e53-60. 2005 - "ProC Global": a functional screening test that predicts recurrent venous thromboembolismAnne Grand'Maison
Department of Medicine, University of Toronto, Ontario, Canada
Thromb Haemost 93:600-4. 2005..04). These results suggest that ProC Global may serve as a predictor of recurrent VTE and potentially for first episode of idiopathic VTE. ProC Global may help identify patients at increased risk of initial and recurrent VTE... - The status of new anticoagulantsShannon M Bates
Department of Medicine, McMaster University, ON, Canada
Br J Haematol 134:3-19. 2006..This paper reviews the pharmacology of these new agents and describes the results of clinical trials with new anticoagulants in more advanced stages of clinical testing... - Selective D-dimer testing for diagnosis of a first suspected episode of deep venous thrombosis: a randomized trialLori Ann Linkins
McMaster University, Hamilton, Ontario, Canada
Ann Intern Med 158:93-100. 2013..Changing the use of testing and the threshold level for a positive test result on the basis of risk for DVT might improve the tradeoff between sensitivity and specificity and reduce the need for testing... - Low-dose warfarin in rehabilitating stroke survivorsJeffrey S Ginsberg
Department of Medicine, McMaster University Medical Centre, 1200 Main Street West Rm 3X28, Hamilton, Ontario L8N 3Z5, Canada
Thromb Res 107:287-90. 2002..0-3.0 is effective for the prevention of VTE. However, because stroke is a major risk factor for bleeding with warfarin, a less intense regimen (target INR < 2.0), might safely prevent VTE in stroke rehabilitation patients... - Anticoagulation of pregnant women with mechanical heart valvesJeffrey S Ginsberg
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Arch Intern Med 163:694-8. 2003..We believe a consensus conference among experts in the field to identify key unresolved issues and a commitment by the FDA and industry to perform appropriate studies are now critical... - The effect of prothrombotic blood abnormalities on risk of deep vein thrombosis in users of hormone replacement therapy: a prospective case-control studyJim D Douketis
Department of Medicine, McMaster University, Hamilton, Canada
Clin Appl Thromb Hemost 17:E106-13. 2011..Few studies have assessed the effect of prothrombotic blood abnormalities on the risk of deep vein thrombosis (DVT) with hormone replacement therapy (HRT)... - Are brand-name and generic warfarin interchangeable? Multiple n-of-1 randomized, crossover trialsJennifer A Pereira
Centre for Evaluation of Medicines, St Joseph s Healthcare, Hamilton, Ontario, Canada
Ann Pharmacother 39:1188-93. 2005..Warfarin is a commonly used anticoagulant in North America. Several generic formulations have been approved, raising concern over the safety and efficacy of these products compared with brand-name Coumadin... - Pregnancy and deep vein thrombosisS M Bates
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Semin Vasc Med 1:97-104. 2001..This article briefly reviews the areas of controversy and provides recommendations for the treatment of acute DVT and thromboprophylaxis in pregnant patients... - Accuracy and safety of (99m)Tc-labeled anti-D-dimer (DI-80B3) Fab' fragments (ThromboView®) in the diagnosis of deep vein thrombosis: a phase II studyJames D Douketis
Dept of Medicine, McMaster University, Hamilton, ON, Canada
Thromb Res 130:381-9. 2012..This test has an anatomic component to locate DVT and a functional component to differentiate acute (newly formed) thrombus from inactive (old) thrombus... - Accuracy and usefulness of a clinical prediction rule and D-dimer testing in excluding deep vein thrombosis in cancer patientsMarc Carrier
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Thromb Res 123:177-83. 2008.... - A randomized trial of diagnostic strategies after normal proximal vein ultrasonography for suspected deep venous thrombosis: D-dimer testing compared with repeated ultrasonographyClive Kearon
McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada
Ann Intern Med 142:490-6. 2005.... - New anticoagulants: beyond heparin, low-molecular-weight heparin and warfarinShannon M Bates
Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada
Br J Pharmacol 144:1017-28. 2005..After a brief review of thrombogenesis and its regulation, this paper focuses on new anticoagulant agents in more advanced stages of clinical testing... - How we manage venous thromboembolism during pregnancyShannon M Bates
Department of Medicine, McMaster University, Hamilton, ON, Canada
Blood 100:3470-8. 2002..A recent study has demonstrated that for women with a single episode of prior VTE, many can be managed without anticoagulants. However, for many, anticoagulant therapy with prophylactic UFH or LMWH is a reasonable option... - Should D-dimer testing be used to predict the risk of recurrence after discontinuation of anticoagulant therapy for a first unprovoked episode of venous thromboembolism?Cynthia Wu
Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, ON, Canada
Pol Arch Med Wewn 119:225-30. 2009..This paper reviews recent data surrounding the use of D-dimer to predict the risk of recurrent venous thromboembolism and how this test may help streamline decisions regarding duration of therapy... - Oral direct Factor Xa inhibitors versus low-molecular-weight heparin to prevent venous thromboembolism in patients undergoing total hip or knee replacement: a systematic review and meta-analysisIgnacio Neumann
McMaster University Health Sciences Centre, Clinical Epidemiology and Biostatistics, Room 2C12, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
Ann Intern Med 156:710-9. 2012..Thromboembolic disease is the most frequent medical complication of arthroplasty... - A population-based study of inferior vena cava filters in patients with acute venous thromboembolismFrederick A Spencer
Department of Medicine, Divisions of Cardiology and Hematology Thrombosis, Faculty of Health Sciences, McMaster University, 1200 Main St W, Hamilton, ON L8N 3Z5, Canada
Arch Intern Med 170:1456-62. 2010.... - Acute coronary syndromes: a focus on thrombinJeffrey I Weitz
Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada
J Invasive Cardiol 14:2B-7B. 2002 - Management of venous thromboembolism during pregnancyJ S Ginsberg
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Thromb Haemost 1:1435-42. 2003..Depending on the presence of one or both of these factors, clinical surveillance, with anticoagulant treatment where necessary, is recommended... - Decrease in sensitivity of D-dimer for acute venous thromboembolism after starting anticoagulant therapyF Couturaud
Hamilton Civic Hospitals Research Centre, and McMaster University, Hamilton, Ontario, Canada
Blood Coagul Fibrinolysis 13:241-6. 2002..0-98.6) to 89.4% (95% confidence interval, 83.7-95.1). There is a decrease in D-dimer levels in patients with acute VTE 24 h after starting heparin therapy that is expected to result in a clinically important drop in sensitivity... - Criteria for evaluating evidence that laboratory abnormalities are associated with the development of venous thromboembolismS M Bates
Department of Medicine, McMaster University, Hamilton, Ont
CMAJ 163:1016-21. 2000..Criteria for determining whether specific laboratory abnormalities have a relationship with venous thromboembolism are proposed here, and one example of the application of these guidelines is provided... - Does the type of hormone replacement therapy influence the risk of deep vein thrombosis? A prospective case-control studyJ D Douketis
Department of Medicine, McMaster University, Hamilton, Canada
J Thromb Haemost 3:943-8. 2005..Although hormone replacement therapy (HRT) is associated with an increased risk of deep vein thrombosis (DVT), it is not clear if the risk differs in users of combined estrogen-progestin HRT and estrogen-only HRT... - Evaluating patient values and preferences for thromboprophylaxis decision making during pregnancy: a study protocolPablo Alonso-Coello
Iberoamerican Cochrane Centre, CIBERESP IIB Sant Pau, Barcelona, 08041, Spain
BMC Pregnancy Childbirth 12:40. 2012..The values and treatment preferences of pregnant women, crucial when making recommendations for prophylaxis, are currently unknown. The objective of this study is to address this gap in knowledge... - Human-derived D-dimer for external quality assessment: results of four surveys in OntarioMark A Crowther
Hamilton Regional Laboratory Medicine Program, St Joseph s Hospital, McMaster University, Hamilton, Canada
Am J Clin Pathol 130:805-10. 2008..0%-1.5%), 2.3% (CI, 0.5%-6.6%), and 2.3% (CI, 0.4%-6.6%) of participants reporting an incorrect result in the first, second, third, and fourth surveys, respectively. A commercially prepared D-dimer is a suitable material for EQA testing... - Delayed-onset HIT caused by low-molecular-weight heparin manifesting during fondaparinux prophylaxisKhalid A Alsaleh
Department of Medicine, Michael G DeGroote School of Medicine McMaster University, Hamilton, Ontario, Canada
Am J Hematol 83:876-8. 2008..Confirmed delayed-onset HIT with LMWH has not been previously reported. Low dose fondaparinux does not necessarily prevent thrombotic complications of HIT... - Neither baseline tests of molecular hypercoagulability nor D-dimer levels predict deep venous thrombosis in critically ill medical-surgical patientsM A Crowther
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Intensive Care Med 31:48-55. 2005..CONCLUSION: In critically ill patients, neither tests of hypercoagulability nor D-dimer levels predict patients at risk of DVT and thus they should not be used to guide diagnostic testing for DVT... - Preventing thrombophilia-related complications of pregnancyNina Raju
Department of Medicine, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada
Expert Rev Hematol 2:183-96. 2009.... - Emerging anticoagulant drugsShannon M Bates
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Arterioscler Thromb Vasc Biol 23:1491-500. 2003..After a brief review of thrombogenesis and its regulation, this study focuses on new anticoagulant agents in more advanced stages of clinical testing... - Clinical trials that have influenced the treatment of venous thromboembolism: a historical perspectiveJ Hirsh
Hamilton Civic Hospitals Research Centre, Henderson Division, 711 Concession Street, Hamilton, Ontario L8V 1C3, Canada
Ann Intern Med 134:409-17. 2001..The studies are discussed from a historical perspective, and an attempt is made to analyze both the thought processes that prompted their design and the reasons why they changed practice... - New anticoagulantsJ I Weitz
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Thromb Haemost 3:1843-53. 2005..After a brief review of coagulation pathways, this paper focuses on new anticoagulants in advanced stages of clinical testing... - Use of different D-dimer levels to exclude venous thromboembolism depending on clinical pretest probabilityL A Linkins
Department of Medicine, Henderson Research Center, McMaster University, Hamilton, Canada
J Thromb Haemost 2:1256-60. 2004..Use of three pretest probability-specific D-dimer cut-off points rather than a single D-dimer cut-off point for all patients, has the potential to increase the utility of D-dimer testing for the diagnosis of venous thromboembolism... - Nonheparin anticoagulants for heparin-induced thrombocytopeniaJohn G Kelton
From the Department of Medicine, Michael G DeGroote School of Medicine, McMaster University J G K, D M A, S M B Canadian Blood Services D M A and the Thrombosis and Atherosclerosis Research Institute S M B all in Hamilton, ON, Canada
N Engl J Med 368:737-44. 2013..Several agents are in clinical use for this condition, including parenteral direct thrombin inhibitors and parenteral factor Xa inhibitors... - D-dimer testing is useful to exclude deep vein thrombosis in elderly outpatientsM Carrier
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
J Thromb Haemost 6:1072-6. 2008..Deep vein thrombosis (DVT) can be safely and reliably excluded in patients with a low clinical probability and a negative D-dimer result but the accuracy and utility of such a strategy is unclear in elderly patients... - Differences in clinical presentation of deep vein thrombosis in men and womenE Roseann Andreou
McMaster University, Henderson Research Centre, Hamilton, ON, Canada
J Thromb Haemost 6:1713-9. 2008..As assessment of clinical pretest probability is the first step in the diagnostic evaluation of deep vein thrombosis (DVT), it is important to know if the clinical features of DVT are the same in men and women... - Use of antithrombotic agents during pregnancy: the Seventh ACCP Conference on Antithrombotic and Thrombolytic TherapyShannon M Bates
McMaster University Medical Center, 1200 Main St West, Hamilton, ON L8N 325
Chest 126:627S-644S. 2004..In high-risk women with prosthetic heart valves, we suggest the addition of low-dose aspirin, 75 to 162 mg/d (Grade 2C)...