Research Topics
| D M ArnoldSummaryAffiliation: McMaster University Country: Canada Publications
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Detail Information
Publications
A systematic evaluation of laboratory testing for drug-induced immune thrombocytopeniaD M Arnold
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Thromb Haemost 11:169-76. 2013..Drug-induced immune thrombocytopenia (DITP) can be confirmed by the demonstration of drug-dependent platelet antibodies in vitro; however, laboratory testing is not readily accessible and test methods are not standardized...- Positioning new treatments in the management of immune thrombocytopeniaDonald M Arnold
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Pediatr Blood Cancer 60:S19-22. 2013..This review summarizes how these new agents might be positioned in the management of patients with chronic ITP... - A multifaceted strategy to reduce inappropriate use of frozen plasma transfusions in the intensive care unitDonald M Arnold
Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
J Crit Care 26:636.e7-636.e13. 2011..The purpose of this study is to determine the effect of a multifaceted behavior-change strategy on inappropriate use of frozen plasma (FP) transfusions in the intensive care unit (ICU)... - A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopeniaDonald M Arnold
Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Blood 119:1356-62. 2012..No difference in the frequency of the composite outcome was observed in this pilot trial (registered at www.clinicaltrials.gov NCT00372892)... 
Bleeding during critical illness: a prospective cohort study using a new measurement toolDonald M Arnold
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Clin Invest Med 30:E93-102. 2007..To estimate the incidence, severity, duration and consequences of bleeding during critical illness, and to test the performance characteristics of a new bleeding assessment tool...- Diagnosis and management of neonatal alloimmune thrombocytopeniaDonald M Arnold
The McMaster Platelet Immunology Diagnostic Laboratory, McMaster University, Hamilton, Ontario, Canada
Transfus Med Rev 22:255-67. 2008..Improvements in our understanding of the pathophysiology of NAT, and of clinical and laboratory predictors of severity, may help develop better treatments and improve our ability to identify mothers at risk... - New treatments for idiopathic thrombocytopenic purpura: rethinking old hypothesesDonald M Arnold
Michael G DeGroote School of Medicine, Medicine and Pathology and Molecular Medicine, McMaster University, 1200 Main Street W, Hamilton, Ontario, Canada
Expert Opin Investig Drugs 18:805-19. 2009..New strategies to reduce platelet destruction, like rituximab, are also effective... - The science of systematic reviewsDonald M Arnold
Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
Transfusion 47:1347-9. 2007 - Trends in the utilization and wastage of coagulation factor concentrates: the application of a regional tracking programmeD M Arnold
Department of Medicine, McMaster University, Hamilton, ON, Canada
Haemophilia 13:271-8. 2007..Utilization of coagulation factor concentrates increased steadily during the study period. A regional programme to track utilization is feasible and may be used to describe trends, assist planning, and reduce costs by minimizing wastage... 
Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic reviewDonald M Arnold
1Michael G DeGroote School of Medicine, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Haematologica 94:850-6. 2009..pylori infection and immune thrombocytopenia in some patients. Randomized trials are needed to determine the applicability of H. pylori eradication therapy across diverse geographical regions...- Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpuraDonald M Arnold
McMaster University and Juravinski Cancer Centre, Hamilton, Ontario, Canada
Ann Intern Med 146:25-33. 2007..Rituximab, a monoclonal anti-CD20 antibody, is increasingly used to treat idiopathic thrombocytopenic purpura (ITP)... - Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpuraDonald M Arnold
Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
Blood 115:29-31. 2010..Severe adverse events did not occur. Combination immunosuppressant therapy can produce a rise in the platelet count that is sometimes sustained in refractory ITP patients... - Misleading hepatitis B test results due to intravenous immunoglobulin administration: implications for a clinical trial of rituximab in immune thrombocytopeniaDonald M Arnold
Department of Medicine, Michael deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 50:2577-81. 2010..A high seroprevalence of anti-HBc observed among patients screened for the trial prompted this substudy to investigate for an association between anti-HBc seropositivity and exposure to intravenous immunoglobulin (IVIG)... - A rational approach to the diagnosis and management of thrombocytopenia in the hospitalized patientDonald M Arnold
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Semin Hematol 48:251-8. 2011.... - The use and abuse of surrogate endpoints in clinical research in transfusion medicineDonald M Arnold
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:1547-9. 2008 - Utilization of recombinant activated factor VII in southern Ontario in 85 patients with and without haemophiliaK E Webert
Division of Hematology, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
Haemophilia 13:518-26. 2007..The tracking system used in this study is a valuable tool to describe ongoing utilization patterns of rFVIIa... - A prospective study measuring the development of antibodies against platelet factor 4-heparin in healthy males after exposure to heparinsJ G Kelton
Michael G DeGroote School of Medicine, Departments of Medicine, Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada Division of Hematology, Duke University Medical Center, Durham, NC, USA Momenta Pharmaceutics, Cambridge, MA, USA
J Thromb Haemost 10:1446-9. 2012..A prospective study measuring the development of antibodies against platelet factor 4-heparin in healthy males after exposure to heparins. J Thromb Haemost 2012; 10: 1446-9... - A framework for resolving disagreement during end of life care in the critical care unitKaren Choong
Department of Pediatrics and Critical Care, McMaster Children s Hospital, McMaster University, Hamilton, Ontario
Clin Invest Med 33:E240-53. 2010..Such disagreements can cause tension and moral distress among families and clinicians... - Comparing the efficacy and safety of apheresis and whole blood-derived platelet transfusions: a systematic reviewNancy M Heddle
The Department of Medicine and the Department of Molecular Medicine and Pathology, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:1447-58. 2008.... - Current options for the treatment of idiopathic thrombocytopenic purpuraDonald M Arnold
Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Semin Hematol 44:S12-23. 2007..A move towards early aggressive therapy may alter the natural history of this self-perpetuating illness... - Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responsesDonald M Arnold
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 46:1286-91. 2006..A description of current platelet (PLT) transfusion practice in the intensive care unit (ICU) is needed... - Mortality rates and causes of death among all HIV-positive individuals with hemophilia in Canada over 21 years of follow-upDonald M Arnold
McMaster University Medical Center, Hamilton, ON, Canada
Blood 108:460-4. 2006..There were 1134 HCV-positive individuals, of whom only 444 (39.2%) were also HIV-positive. Liver disease is a growing health concern among many hemophiliacs, not only those who are HIV-positive... - Elicitation of utility scores in Canada for immune thrombocytopenia treated with romiplostim or watch and rescueM Iskedjian
PharmIdeas Research and Consulting Inc, Oakville, Ontario, Canada
J Med Econ 15:313-31. 2012..Utilities are needed to conduct a cost-utility analysis of romiplostim for formulary and reimbursement decisions... - Intravenous immunoglobulin as an adjunct to plasma exchange for the treatment of chronic thrombotic thrombocytopenic purpuraJ C Moore
Department of Medicine, Michael G de Groote School of Medicine, Health Sciences Centre, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
Vox Sang 93:173-5. 2007..Even during remission, anti-ADAMTS13 antibodies remained elevated. We conclude that IVIG may sustain remission in some patients with chronic, relapsing TTP... - Cardiobacterium hominis endocarditis associated with very severe thrombocytopenia and platelet autoantibodiesDonald M Arnold
Department of Hematology, McMaster University, Hamilton, Ontario, Canada
Am J Hematol 76:373-7. 2004..This report illustrates that the development of platelet autoantibodies can contribute to very severe thrombocytopenia in occasional patients with infective endocarditis... - Thrombocytopenia in medical-surgical critically ill patients: prevalence, incidence, and risk factorsMark A Crowther
Department of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
J Crit Care 20:348-53. 2005..Heparin-induced thrombocytopenia was frequently suspected but did not develop in these critically ill patients... - Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilateM D Lambourne
Canadian Blood Services, Research and Development, McMaster University, Hamilton, Ontario, Canada
J Thromb Haemost 10:1830-40. 2012..Limited clinical data exist linking oral anticoagulant reversal and bleeding tendency, as opposed to surrogate laboratory markers... - Missed opportunities for prevention of venous thromboembolism: an evaluation of the use of thromboprophylaxis guidelinesD M Arnold
Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Canada
Chest 120:1964-71. 2001..Inadequacy of prophylaxis was most often caused by omission of prophylaxis. Missed opportunities for prevention occurred most commonly in the settings of nonorthopedic surgery, pneumonia, and stroke... - In vivo recovery and survival of apheresis and whole blood-derived platelets: a paired comparison in healthy volunteersDonald M Arnold
Canadian Blood Services, Hamilton, Ontario, Canada
Transfusion 46:257-64. 2006..The reasons for this effect are not clear. These results may not apply to all apheresis and PRP methods of platelet preparation... - Delayed-onset HIT caused by low-molecular-weight heparin manifesting during fondaparinux prophylaxisKhalid A Alsaleh
Department of Medicine, Michael G DeGroote School of Medicine McMaster University, Hamilton, Ontario, Canada
Am J Hematol 83:876-8. 2008..Confirmed delayed-onset HIT with LMWH has not been previously reported. Low dose fondaparinux does not necessarily prevent thrombotic complications of HIT... - Testing for heparin-induced thrombocytopenia: are we there yet?D M Arnold
Michael G de Groote School of Medicine, McMaster University, Hamilton, ON, Canada
J Thromb Haemost 5:1371-2. 2007 - Transfusion premedication to prevent acute transfusion reactions: a retrospective observational study to assess current practicesJessica L Fry
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Transfusion 50:1722-30. 2010.... - Avoiding transfusions in children undergoing cardiac surgery: a meta-analysis of randomized trials of aprotininDonald M Arnold
Canadian Blood Services, Hamilton, Ontario, Canada
Anesth Analg 102:731-7. 2006..Further high-quality trials with clinically important outcomes may be warranted before aprotinin can be routinely recommended in this population... - Heparin-induced thrombocytopenia: an iceberg risingDonald M Arnold
Mayo Clin Proc 80:988-90. 2005 - Proceedings of a consensus conference: towards an understanding of TRALIMindy Goldman
Canadian Blood Services, Medical, Scientific and Research Affairs, Ottawa, Ontario K1G 4J5, Canada
Transfus Med Rev 19:2-31. 2005....