D M Arnold

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Approach to the diagnosis and management of drug-induced immune thrombocytopenia
    Donald M Arnold
    Michael G DeGroote School of Medicine, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfus Med Rev 27:137-45. 2013
  2. doi request reprint A systematic evaluation of laboratory testing for drug-induced immune thrombocytopenia
    D M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Thromb Haemost 11:169-76. 2013
  3. doi request reprint Positioning new treatments in the management of immune thrombocytopenia
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Pediatr Blood Cancer 60:S19-22. 2013
  4. doi request reprint A multifaceted strategy to reduce inappropriate use of frozen plasma transfusions in the intensive care unit
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 26:636.e7-636.e13. 2011
  5. doi request reprint A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopenia
    Donald M Arnold
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Blood 119:1356-62. 2012
  6. doi request reprint The use and abuse of surrogate endpoints in clinical research in transfusion medicine
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 48:1547-9. 2008
  7. doi request reprint Diagnosis and management of neonatal alloimmune thrombocytopenia
    Donald M Arnold
    The McMaster Platelet Immunology Diagnostic Laboratory, McMaster University, Hamilton, Ontario, Canada
    Transfus Med Rev 22:255-67. 2008
  8. ncbi request reprint New treatments for idiopathic thrombocytopenic purpura: rethinking old hypotheses
    Donald M Arnold
    Michael G DeGroote School of Medicine, Medicine and Pathology and Molecular Medicine, McMaster University, 1200 Main Street W, Hamilton, Ontario, Canada
    Expert Opin Investig Drugs 18:805-19. 2009
  9. pmc Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review
    Donald M Arnold
    1Michael G DeGroote School of Medicine, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Haematologica 94:850-6. 2009
  10. doi request reprint Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpura
    Donald M Arnold
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Blood 115:29-31. 2010

Detail Information

Publications37

  1. pmc Approach to the diagnosis and management of drug-induced immune thrombocytopenia
    Donald M Arnold
    Michael G DeGroote School of Medicine, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfus Med Rev 27:137-45. 2013
    ..Improved standardization and accessibility of laboratory testing should be a focus of future research. ..
  2. doi request reprint A systematic evaluation of laboratory testing for drug-induced immune thrombocytopenia
    D M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Thromb Haemost 11:169-76. 2013
    ..Drug-induced immune thrombocytopenia (DITP) can be confirmed by the demonstration of drug-dependent platelet antibodies in vitro; however, laboratory testing is not readily accessible and test methods are not standardized...
  3. doi request reprint Positioning new treatments in the management of immune thrombocytopenia
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Pediatr Blood Cancer 60:S19-22. 2013
    ..This review summarizes how these new agents might be positioned in the management of patients with chronic ITP...
  4. doi request reprint A multifaceted strategy to reduce inappropriate use of frozen plasma transfusions in the intensive care unit
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 26:636.e7-636.e13. 2011
    ..The purpose of this study is to determine the effect of a multifaceted behavior-change strategy on inappropriate use of frozen plasma (FP) transfusions in the intensive care unit (ICU)...
  5. doi request reprint A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopenia
    Donald M Arnold
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Blood 119:1356-62. 2012
    ..No difference in the frequency of the composite outcome was observed in this pilot trial (registered at www.clinicaltrials.gov NCT00372892)...
  6. doi request reprint The use and abuse of surrogate endpoints in clinical research in transfusion medicine
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 48:1547-9. 2008
  7. doi request reprint Diagnosis and management of neonatal alloimmune thrombocytopenia
    Donald M Arnold
    The McMaster Platelet Immunology Diagnostic Laboratory, McMaster University, Hamilton, Ontario, Canada
    Transfus Med Rev 22:255-67. 2008
    ..Improvements in our understanding of the pathophysiology of NAT, and of clinical and laboratory predictors of severity, may help develop better treatments and improve our ability to identify mothers at risk...
  8. ncbi request reprint New treatments for idiopathic thrombocytopenic purpura: rethinking old hypotheses
    Donald M Arnold
    Michael G DeGroote School of Medicine, Medicine and Pathology and Molecular Medicine, McMaster University, 1200 Main Street W, Hamilton, Ontario, Canada
    Expert Opin Investig Drugs 18:805-19. 2009
    ..New strategies to reduce platelet destruction, like rituximab, are also effective...
  9. pmc Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review
    Donald M Arnold
    1Michael G DeGroote School of Medicine, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Haematologica 94:850-6. 2009
    ..pylori infection and immune thrombocytopenia in some patients. Randomized trials are needed to determine the applicability of H. pylori eradication therapy across diverse geographical regions...
  10. doi request reprint Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpura
    Donald M Arnold
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Blood 115:29-31. 2010
    ..Severe adverse events did not occur. Combination immunosuppressant therapy can produce a rise in the platelet count that is sometimes sustained in refractory ITP patients...
  11. doi request reprint Misleading hepatitis B test results due to intravenous immunoglobulin administration: implications for a clinical trial of rituximab in immune thrombocytopenia
    Donald M Arnold
    Department of Medicine, Michael deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 50:2577-81. 2010
    ..A high seroprevalence of anti-HBc observed among patients screened for the trial prompted this substudy to investigate for an association between anti-HBc seropositivity and exposure to intravenous immunoglobulin (IVIG)...
  12. doi request reprint A rational approach to the diagnosis and management of thrombocytopenia in the hospitalized patient
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Hematol 48:251-8. 2011
    ....
  13. ncbi request reprint Bleeding during critical illness: a prospective cohort study using a new measurement tool
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Invest Med 30:E93-102. 2007
    ..To estimate the incidence, severity, duration and consequences of bleeding during critical illness, and to test the performance characteristics of a new bleeding assessment tool...
  14. ncbi request reprint Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura
    Donald M Arnold
    McMaster University and Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Ann Intern Med 146:25-33. 2007
    ..Rituximab, a monoclonal anti-CD20 antibody, is increasingly used to treat idiopathic thrombocytopenic purpura (ITP)...
  15. ncbi request reprint The science of systematic reviews
    Donald M Arnold
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Transfusion 47:1347-9. 2007
  16. ncbi request reprint Trends in the utilization and wastage of coagulation factor concentrates: the application of a regional tracking programme
    D M Arnold
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Haemophilia 13:271-8. 2007
    ..Utilization of coagulation factor concentrates increased steadily during the study period. A regional programme to track utilization is feasible and may be used to describe trends, assist planning, and reduce costs by minimizing wastage...
  17. ncbi request reprint Utilization of recombinant activated factor VII in southern Ontario in 85 patients with and without haemophilia
    K E Webert
    Division of Hematology, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Haemophilia 13:518-26. 2007
    ..The tracking system used in this study is a valuable tool to describe ongoing utilization patterns of rFVIIa...
  18. doi request reprint FcγRIIa proteolysis as a diagnostic biomarker for heparin-induced thrombocytopenia
    I Nazi
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Thromb Haemost 11:1146-53. 2013
    ..HIT is characterized by platelet activation, which leads to FcγRIIa proteolysis. This raises the possibility that identification of the proteolytic fragment of FcγRIIa could serve as a surrogate marker for HIT...
  19. ncbi request reprint Intravenous immunoglobulin as an adjunct to plasma exchange for the treatment of chronic thrombotic thrombocytopenic purpura
    J C Moore
    Department of Medicine, Michael G de Groote School of Medicine, Health Sciences Centre, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Vox Sang 93:173-5. 2007
    ..Even during remission, anti-ADAMTS13 antibodies remained elevated. We conclude that IVIG may sustain remission in some patients with chronic, relapsing TTP...
  20. ncbi request reprint A prospective study measuring the development of antibodies against platelet factor 4-heparin in healthy males after exposure to heparins
    J G Kelton
    Michael G DeGroote School of Medicine, Departments of Medicine, Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada Division of Hematology, Duke University Medical Center, Durham, NC, USA Momenta Pharmaceutics, Cambridge, MA, USA
    J Thromb Haemost 10:1446-9. 2012
    ..A prospective study measuring the development of antibodies against platelet factor 4-heparin in healthy males after exposure to heparins. J Thromb Haemost 2012; 10: 1446-9...
  21. doi request reprint Comparing the efficacy and safety of apheresis and whole blood-derived platelet transfusions: a systematic review
    Nancy M Heddle
    The Department of Medicine and the Department of Molecular Medicine and Pathology, McMaster University, Hamilton, Ontario, Canada
    Transfusion 48:1447-58. 2008
    ....
  22. ncbi request reprint Current options for the treatment of idiopathic thrombocytopenic purpura
    Donald M Arnold
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Hematol 44:S12-23. 2007
    ..A move towards early aggressive therapy may alter the natural history of this self-perpetuating illness...
  23. ncbi request reprint Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responses
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 46:1286-91. 2006
    ..A description of current platelet (PLT) transfusion practice in the intensive care unit (ICU) is needed...
  24. ncbi request reprint Mortality rates and causes of death among all HIV-positive individuals with hemophilia in Canada over 21 years of follow-up
    Donald M Arnold
    McMaster University Medical Center, Hamilton, ON, Canada
    Blood 108:460-4. 2006
    ..There were 1134 HCV-positive individuals, of whom only 444 (39.2%) were also HIV-positive. Liver disease is a growing health concern among many hemophiliacs, not only those who are HIV-positive...
  25. ncbi request reprint A framework for resolving disagreement during end of life care in the critical care unit
    Karen Choong
    Department of Pediatrics and Critical Care, McMaster Children s Hospital, McMaster University, Hamilton, Ontario
    Clin Invest Med 33:E240-53. 2010
    ..Such disagreements can cause tension and moral distress among families and clinicians...
  26. doi request reprint Elicitation of utility scores in Canada for immune thrombocytopenia treated with romiplostim or watch and rescue
    M Iskedjian
    PharmIdeas Research and Consulting Inc, Oakville, Ontario, Canada
    J Med Econ 15:313-31. 2012
    ..Utilities are needed to conduct a cost-utility analysis of romiplostim for formulary and reimbursement decisions...
  27. ncbi request reprint Testing for heparin-induced thrombocytopenia: are we there yet?
    D M Arnold
    Michael G de Groote School of Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 5:1371-2. 2007
  28. ncbi request reprint Thrombocytopenia in medical-surgical critically ill patients: prevalence, incidence, and risk factors
    Mark A Crowther
    Department of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:348-53. 2005
    ....
  29. ncbi request reprint Cardiobacterium hominis endocarditis associated with very severe thrombocytopenia and platelet autoantibodies
    Donald M Arnold
    Department of Hematology, McMaster University, Hamilton, Ontario, Canada
    Am J Hematol 76:373-7. 2004
    ..This report illustrates that the development of platelet autoantibodies can contribute to very severe thrombocytopenia in occasional patients with infective endocarditis...
  30. doi request reprint Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate
    M D Lambourne
    Canadian Blood Services, Research and Development, McMaster University, Hamilton, Ontario, Canada
    J Thromb Haemost 10:1830-40. 2012
    ..Limited clinical data exist linking oral anticoagulant reversal and bleeding tendency, as opposed to surrogate laboratory markers...
  31. ncbi request reprint Missed opportunities for prevention of venous thromboembolism: an evaluation of the use of thromboprophylaxis guidelines
    D M Arnold
    Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Canada
    Chest 120:1964-71. 2001
    ..Inadequacy of prophylaxis was most often caused by omission of prophylaxis. Missed opportunities for prevention occurred most commonly in the settings of nonorthopedic surgery, pneumonia, and stroke...
  32. ncbi request reprint In vivo recovery and survival of apheresis and whole blood-derived platelets: a paired comparison in healthy volunteers
    Donald M Arnold
    Canadian Blood Services, Hamilton, Ontario, Canada
    Transfusion 46:257-64. 2006
    ..As suggested by a recent clinical trial, platelet recovery may be better preserved with apheresis platelet preparations than with platelets prepared from whole blood by the platelet-rich plasma (PRP) method...
  33. doi request reprint Delayed-onset HIT caused by low-molecular-weight heparin manifesting during fondaparinux prophylaxis
    Khalid A Alsaleh
    Department of Medicine, Michael G DeGroote School of Medicine McMaster University, Hamilton, Ontario, Canada
    Am J Hematol 83:876-8. 2008
    ..Confirmed delayed-onset HIT with LMWH has not been previously reported. Low dose fondaparinux does not necessarily prevent thrombotic complications of HIT...
  34. doi request reprint Transfusion premedication to prevent acute transfusion reactions: a retrospective observational study to assess current practices
    Jessica L Fry
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Transfusion 50:1722-30. 2010
    ....
  35. ncbi request reprint Avoiding transfusions in children undergoing cardiac surgery: a meta-analysis of randomized trials of aprotinin
    Donald M Arnold
    Canadian Blood Services, Hamilton, Ontario, Canada
    Anesth Analg 102:731-7. 2006
    ..Further high-quality trials with clinically important outcomes may be warranted before aprotinin can be routinely recommended in this population...
  36. ncbi request reprint Heparin-induced thrombocytopenia: an iceberg rising
    Donald M Arnold
    Mayo Clin Proc 80:988-90. 2005
  37. ncbi request reprint Proceedings of a consensus conference: towards an understanding of TRALI
    Mindy Goldman
    Canadian Blood Services, Medical, Scientific and Research Affairs, Ottawa, Ontario K1G 4J5, Canada
    Transfus Med Rev 19:2-31. 2005
    ....