S S Anand

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Social disadvantage and cardiovascular disease: development of an index and analysis of age, sex, and ethnicity effects
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, Canada
    Int J Epidemiol 35:1239-45. 2006
  2. pmc The impact of social determinants on cardiovascular disease
    Catherine Kreatsoulas
    McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 26:8C-13C. 2010
  3. pmc Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 33:1629-34. 2010
  4. pmc Causal relationship between adiponectin and metabolic traits: a Mendelian randomization study in a multiethnic population
    Andrew Mente
    Population Health Research Institute, Hamilton, Canada
    PLoS ONE 8:e66808. 2013
  5. pmc Measures of body fat in South Asian adults
    S Kalra
    1 Bachelor of Health Sciences, McMaster University, Hamilton, Ontario, Canada 2 Chanchlani Research Centre, McMaster University, Hamilton, Ontario, Canada
    Nutr Diabetes 3:e69. 2013
  6. pmc Effectiveness of inpatient and outpatient strategies in increasing referral and utilization of cardiac rehabilitation: a prospective, multi-site study
    Sherry L Grace
    School of Kinesiology and Health Science, York University, 4700 Keele St, Toronto, Canada
    Implement Sci 7:120. 2012
  7. pmc Genetic information and the prediction of incident type 2 diabetes in a high-risk multiethnic population: the EpiDREAM genetic study
    Sonia S Anand
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada
    Diabetes Care 36:2836-42. 2013
  8. pmc Aboriginal birth cohort (ABC): a prospective cohort study of early life determinants of adiposity and associated risk factors among Aboriginal people in Canada
    Gita Wahi
    McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
    BMC Public Health 13:608. 2013
  9. pmc Rationale and design of South Asian Birth Cohort (START): a Canada-India collaborative study
    Sonia S Anand
    McMaster University, 1280 Main St West MDCL 3200, L8S 4K1, Hamilton, ON, Canada
    BMC Public Health 13:79. 2013
  10. pmc Contextual determinants of health behaviours in an aboriginal community in Canada: pilot project
    Pamela Joseph
    Department of Medicine and Epidemiology, McMaster University, 1280 Main St, Hamilton, Ontario L8S 4K1, Canada
    BMC Public Health 12:952. 2012

Collaborators

Detail Information

Publications94

  1. ncbi request reprint Social disadvantage and cardiovascular disease: development of an index and analysis of age, sex, and ethnicity effects
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, Canada
    Int J Epidemiol 35:1239-45. 2006
    ..We studied the relationship between social disadvantage, cardiovascular risk factors, and cardiovascular disease (CVD) among men and women from diverse ethno-racial backgrounds...
  2. pmc The impact of social determinants on cardiovascular disease
    Catherine Kreatsoulas
    McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 26:8C-13C. 2010
    ..Possible solutions and future directions to reduce the impact of social factors on cardiovascular health are proposed...
  3. pmc Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 33:1629-34. 2010
    ..To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance...
  4. pmc Causal relationship between adiponectin and metabolic traits: a Mendelian randomization study in a multiethnic population
    Andrew Mente
    Population Health Research Institute, Hamilton, Canada
    PLoS ONE 8:e66808. 2013
    ..Adiponectin, a secretagogue exclusively produced by adipocytes, has been associated with metabolic features, but its role in the development of the metabolic syndrome remains unclear...
  5. pmc Measures of body fat in South Asian adults
    S Kalra
    1 Bachelor of Health Sciences, McMaster University, Hamilton, Ontario, Canada 2 Chanchlani Research Centre, McMaster University, Hamilton, Ontario, Canada
    Nutr Diabetes 3:e69. 2013
    ..Furthermore, their correlations with % BF from BOD POD are significantly weakened among men and women with a BMI 21 kg m(-2)...
  6. pmc Effectiveness of inpatient and outpatient strategies in increasing referral and utilization of cardiac rehabilitation: a prospective, multi-site study
    Sherry L Grace
    School of Kinesiology and Health Science, York University, 4700 Keele St, Toronto, Canada
    Implement Sci 7:120. 2012
    ..The effect of each strategy on participants' CR referral and enrollment was examined using generalized estimating equations...
  7. pmc Genetic information and the prediction of incident type 2 diabetes in a high-risk multiethnic population: the EpiDREAM genetic study
    Sonia S Anand
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada
    Diabetes Care 36:2836-42. 2013
    ....
  8. pmc Aboriginal birth cohort (ABC): a prospective cohort study of early life determinants of adiposity and associated risk factors among Aboriginal people in Canada
    Gita Wahi
    McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
    BMC Public Health 13:608. 2013
    ....
  9. pmc Rationale and design of South Asian Birth Cohort (START): a Canada-India collaborative study
    Sonia S Anand
    McMaster University, 1280 Main St West MDCL 3200, L8S 4K1, Hamilton, ON, Canada
    BMC Public Health 13:79. 2013
    ..The South Asian Birth Cohort Study (START) will investigate the environmental and genetic basis of adiposity among 750 South Asian offspring recruited from highly divergent environments, namely, rural and urban India and urban Canada...
  10. pmc Contextual determinants of health behaviours in an aboriginal community in Canada: pilot project
    Pamela Joseph
    Department of Medicine and Epidemiology, McMaster University, 1280 Main St, Hamilton, Ontario L8S 4K1, Canada
    BMC Public Health 12:952. 2012
    ..The nature and influence of contextual factors on Aboriginal health behaviours are not well characterized...
  11. doi request reprint Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study
    S S Anand
    Population Health Research Institute, Hamilton, Ontario, Canada
    Eur J Prev Cardiol 19:755-64. 2012
    ..In an international prospective cohort study we assessed the relationship between glucose levels and incident cardiovascular events and death...
  12. pmc BRCA2 variants and cardiovascular disease in a multi-ethnic study
    Kevin Zbuk
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    BMC Med Genet 13:56. 2012
    ..We therefore tested the association of BRCA2 variants with clinical cardiovascular disease (CVD)...
  13. pmc Diet, physical activity, and adiposity in children in poor and rich neighbourhoods: a cross-sectional comparison
    Anwar T Merchant
    Population Health Research Institute, Hamilton ON, Canada
    Nutr J 6:1. 2007
    ..The objective of this pilot study was to compare diet, physical activity, and the built environment in two Hamilton area elementary schools serving socio-economically different communities...
  14. pmc Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008
    ..The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples...
  15. pmc Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample
    Rebecca L Pollex
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    BMC Med Genet 8:80. 2007
    ..The objective of this study is to examine the APOC3 -455T>C and the INSIG2 rs7566605 polymorphisms as potential genetic determinants for MetS in a multi-ethnic sample...
  16. ncbi request reprint Differences in the management and prognosis of women and men who suffer from acute coronary syndromes
    Sonia S Anand
    Department of Medicine and Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Am Coll Cardiol 46:1845-51. 2005
    ..The purpose of this research was to determine if sex and gender differences in the management of acute coronary syndromes (ACS) are associated with differences in prognosis after ACS...
  17. pmc Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: the Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE)
    Sonia S Anand
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e22112. 2011
    ..We sought to determine if differences in the distribution and characteristics of adipose tissue between South Asians and white Caucasians account for differences in risk factors for cardiovascular disease...
  18. ncbi request reprint Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. Law MR, Wald NJ, Rudnicka AR. BMJ 2003; 326: 1407-408
    Sonia S Anand
    McMaster University, Hamilton General Hospital, McMaster Clinic, Room 522, 237 Barton St East, Hamilton, Ontario, Canada L8L 2X2
    Vasc Med 8:289-90. 2003
  19. doi request reprint Risk factors for myocardial infarction in women and men: insights from the INTERHEART study
    Sonia S Anand
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Eur Heart J 29:932-40. 2008
    ..The purpose of this report is to determine if differences in risk factor distributions exist between women and men across various age categories to help explain why women develop acute MI later than men...
  20. ncbi request reprint C-reactive protein as a screening test for cardiovascular risk in a multiethnic population
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Arterioscler Thromb Vasc Biol 24:1509-15. 2004
    ..Small increases in the inflammatory marker C-reactive protein (CRP) are predictive of vascular events among asymptomatic individuals. There are few data supporting the use of CRP as a risk marker among nonwhite individuals...
  21. ncbi request reprint Sensitivity and specificity of the ankle-brachial index to predict future cardiovascular outcomes: a systematic review
    Anand V Doobay
    Department of Medicine and Population Health Research Institute, McMaster University, Hamilton Ontario, Canada
    Arterioscler Thromb Vasc Biol 25:1463-9. 2005
    ..The objective of this review is to determine the sensitivity and specificity of an ankle-brachial index <0.90 to predict future cardiovascular events, including coronary heart disease, stroke, and death...
  22. doi request reprint What information should a sponsor of a randomized trial receive during its conduct?
    Sonia S Anand
    Department of Medicine and Epidemiology, McMaster University, Hamilton, Ontario, Canada
    Clin Trials 8:716-9. 2011
    ..The relationship and roles among the steering committee, the Data Safety Monitoring Board (DSMB), and the sponsor of a randomized clinical trial (RCT) must be carefully defined to ensure the integrity of the trial...
  23. ncbi request reprint The value of studying gene-environment interactions in culturally diverse populations
    Sonia S Anand
    Canadian Institutes of Health Research, Population Health Research Institute, Mc Master University, Hamilton, ON, Canada
    Can J Physiol Pharmacol 83:42-6. 2005
    ..In this brief review, the advantage of studying gene-environment interactions across heterogeneous groups with diverse lifestyles is discussed...
  24. ncbi request reprint Oral anticoagulant and antiplatelet therapy and peripheral arterial disease
    Sonia Anand
    McMaster University, Hamilton, ON, Canada
    N Engl J Med 357:217-27. 2007
    ..Antiplatelet drugs reduce this risk, but the role of oral anticoagulant agents in the prevention of cardiovascular complications in patients with peripheral arterial disease is unclear...
  25. pmc Obesity: the emerging cost of economic prosperity
    Sonia S Anand
    McMaster University, Hamilton, Ont
    CMAJ 175:1081. 2006
  26. ncbi request reprint Risk factors, atherosclerosis, and cardiovascular disease among Aboriginal people in Canada: the Study of Health Assessment and Risk Evaluation in Aboriginal Peoples (SHARE-AP)
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Department of Medicine, McMaster University, Ontario, L8L 2X2, Hamilton, Canada
    Lancet 358:1147-53. 2001
    ..To establish the relative prevalence of risk factors, atherosclerosis, and CVD, we undertook a population-based study among people of Aboriginal and European ancestry in Canada...
  27. ncbi request reprint Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study
    Sonia S Anand
    Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada
    Circ Cardiovasc Genet 2:16-25. 2009
    ..Myocardial infarction (MI) is a leading cause of death globally, but specific genetic variants that influence MI and MI risk factors have not been assessed on a global basis...
  28. ncbi request reprint A family-based intervention to promote healthy lifestyles in an aboriginal community in Canada
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Can J Public Health 98:447-52. 2007
    ..Obesity is a major public health problem in North America, particularly in Aboriginal people...
  29. ncbi request reprint Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis. Pinede L, Ninet J, Duhaut P et al
    S S Anand
    Hamilton General Hospital, Ontario, Canada
    Vasc Med 6:269-70. 2001
    ..associated with acceptable recurrence and safety outcomes? Is anticoagulant therapy for 3 months duration for proximal deep vein thrombosis (DVT) or pulmonary embolism (PE) associated with acceptable recurrence and safety outcomes?..
  30. ncbi request reprint Oral anticoagulants in patients with coronary artery disease
    Sonia S Anand
    Department of Medicine, Division of Cardiology and Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 41:62S-69S. 2003
    ..Low-intensity oral anticoagulation (INR <2) in the presence of aspirin does not reduce CV complications and increases bleeding compared with aspirin alone...
  31. ncbi request reprint Relationship of activated partial thromboplastin time to coronary events and bleeding in patients with acute coronary syndromes who receive heparin
    Sonia S Anand
    McMaster Clinic Population Health Section, 237 Barton St E, Hamilton, Ontario L8L 2X2, Canada
    Circulation 107:2884-8. 2003
    ..Therefore, it is unclear whether there is an association between recurrent CV events and low APTT values and between bleeding and high APTT values...
  32. ncbi request reprint Diagnostic strategies to detect glucose intolerance in a multiethnic population
    Sonia S Anand
    Department of Medicine, Division of Cardiology and Population Health Research Institute, McMaster University, Ontario, Canada
    Diabetes Care 26:290-6. 2003
    ....
  33. ncbi request reprint The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE Investigators
    S S Anand
    Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario
    Can J Cardiol 14:1349-57. 1998
    ..The relationship between the conventional and emerging risk factors, and atherosclerosis, vascular disease and markers of end-organ damage will be evaluated between and within ethnic groups...
  34. ncbi request reprint Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)
    S S Anand
    Department of Medicine, McMaster University, Ontario, Canada
    Lancet 356:279-84. 2000
    ..To establish whether this variation can be explained by differences in disease risk factors and subclinical atherosclerosis, we undertook a population-based study of three ethnic groups in Canada: South Asians, Chinese, and Europeans...
  35. ncbi request reprint Long-term oral anticoagulant therapy in patients with unstable angina or suspected non-Q-wave myocardial infarction: organization to assess strategies for ischemic syndromes (OASIS) pilot study results
    S S Anand
    From the Preventive Cardiology and Therapeutics Program, Hamilton Civics Hospital Research Centre, and Division of Cardiology, McMaster University, Hamilton, Canada
    Circulation 98:1064-70. 1998
    ..We studied the effects of long-term warfarin at 2 intensities in patients with AIS without ST elevation in 2 consecutive randomized controlled studies...
  36. ncbi request reprint Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease
    Sonia S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 108:420-5. 2003
    ..Individuals with this syndrome suffer an excess of cardiovascular disease (CVD) for reasons that are unclear...
  37. ncbi request reprint Defining obesity cut points in a multiethnic population
    Fahad Razak
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Circulation 115:2111-8. 2007
    ..It is unknown whether these cut points are appropriate for non-European populations. We assessed the metabolic risk associated with BMI among South Asians, Chinese, Aboriginals, and Europeans...
  38. pmc Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample
    Matthew B Lanktree
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Lipid Res 50:1487-96. 2009
    ..The findings indicate the potential utility of the Illumina CVD beadchip, but they underscore the need to consider meta-analysis of results from commonly studied clinical or epidemiological samples...
  39. ncbi request reprint Anthropometric measures and glucose levels in a large multi-ethnic cohort of individuals at risk of developing type 2 diabetes
    L de Koning
    The Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Diabetologia 53:1322-30. 2010
    ..We also explored variation in anthropometric associations by sex and ethnicity...
  40. ncbi request reprint Oral anticoagulant therapy in patients with coronary artery disease: a meta-analysis
    S S Anand
    Program of Preventive Cardiology and Therapeutics, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada
    JAMA 282:2058-67. 1999
    ..Despite years of use in coronary artery disease (CAD) and several studies of its effectiveness, the role of oral anticoagulants (OAs) remains controversial...
  41. doi request reprint Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia
    S D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Diabet Med 30:e1-7. 2013
    ..Our objective was to determine if the high risk of cardiovascular disease in women with pre-eclampsia is accounted for by known cardiovascular risk factors including albuminuria...
  42. ncbi request reprint Recurrent venous thrombosis and heparin therapy: an evaluation of the importance of early activated partial thromboplastin times
    S S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 159:2029-32. 1999
    ..The presence of an association between early subtherapeutic activated partial thromboplastin times (aPTTs) and recurrent venous thromboembolism (VTE) remains controversial...
  43. ncbi request reprint Prognostic significance of thrombocytopenia during hirudin and heparin therapy in acute coronary syndrome without ST elevation: Organization to Assess Strategies for Ischemic Syndromes (OASIS-2)study
    J W Eikelboom
    Preventive Cardiology and Therapeutics Program, McMaster University, Hamilton, Canada
    Circulation 103:643-50. 2001
    ..The excess of major bleeding in hirudin-treated patients who develop thrombocytopenia suggests that thrombocytopenia may contribute to the increased risk of bleeding observed with hirudin...
  44. ncbi request reprint Low rates of preventive practices in patients with peripheral vascular disease
    S S Anand
    Hamilton Civic Hospitals Research Centre, McMaster University, Hamilton, Canada
    Can J Cardiol 15:1259-63. 1999
    ..Given the scarcity of data on the preventive practice patterns of this high risk patient group, the in-hospital management of patients admitted to hospital for a peripheral vascular intervention was reviewed...
  45. ncbi request reprint Identifying women with severe angiographic coronary disease
    C Kreatsoulas
    McMaster University, Hamilton, ON, Canada
    J Intern Med 268:66-74. 2010
    ..To determine sex/gender differences in the distribution of risk factors according to age and identify factors associated with the presence of severe coronary artery disease (CAD)...
  46. ncbi request reprint Oral antiplatelet therapy in cerebrovascular disease, coronary artery disease, and peripheral arterial disease
    Huyen Tran
    Thromboembolism Unit, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    JAMA 292:1867-74. 2004
    ..Antiplatelet agents, used alone or in combination, are effective in preventing recurrent vascular events among individuals with established vascular disease...
  47. ncbi request reprint Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada
    Debika Burman
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
    Atherosclerosis 203:192-200. 2009
    ..We examined the apolipoprotein E (ApoE) polymorphism, its association with lipid traits and atherosclerosis, and its influence on ethnic variations on lipid traits...
  48. ncbi request reprint The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression
    Z Samaan
    1 Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada 2 Population Health Research Institute, Hamilton, ON, Canada
    Mol Psychiatry 18:1281-6. 2013
    ..This study highlights the potential importance of obesity predisposing genes on depression...
  49. ncbi request reprint Using ethnicity as a classification variable in health research: perpetuating the myth of biological determinism, serving socio-political agendas, or making valuable contributions to medical sciences?
    S S Anand
    Department of Preventive Cardiology and Therapeutics, Hamilton Civic Hospitals Research Centre, McMaster University, Canada
    Ethn Health 4:241-4. 1999
    ....
  50. ncbi request reprint Interrelation of saturated fat, trans fat, alcohol intake, and subclinical atherosclerosis
    Anwar T Merchant
    Population Health Research Institute, Hamilton, Ontario, Canada
    Am J Clin Nutr 87:168-74. 2008
    ..Intake of saturated fat, trans fat, and alcohol alter cardiovascular disease risk, but their effect on subclinical atherosclerosis remains understudied...
  51. ncbi request reprint Oral anticoagulant therapy in patients with coronary artery disease
    Daniel G Hackam
    Department of MedicineMcMaster University, Hamilton, Ontario, Canada
    Semin Vasc Med 3:323-32. 2003
    ..0 to 3.0) should be considered an option for the prevention of recurrent CAD, particularly in high-risk patients...
  52. ncbi request reprint Metabolic syndrome and risk of acute myocardial infarction a case-control study of 26,903 subjects from 52 countries
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 55:2390-8. 2010
    ..This study examines the risk of acute myocardial infarction (MI) conferred by the metabolic syndrome (MS) and its individual factors in multiple ethnic populations...
  53. ncbi request reprint Fears and beliefs of patients regarding cardiac catheterization
    Patricia Helen Caldwell
    McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada
    Soc Sci Med 65:1038-48. 2007
    ..They viewed themselves as passive participants and not as actively consenting to the CATH. This paper offers previously undocumented insights from patients regarding CATH and provides the basis for developing future investigations...
  54. ncbi request reprint Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    John W Eikelboom
    Thrombosis Service, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Circulation 114:774-82. 2006
    ..The use of multiple antithrombotic drugs and aggressive invasive strategies has increased the risk of major bleeding in acute coronary syndrome (ACS) patients. It is not known to what extent bleeding determines clinical outcome...
  55. doi request reprint Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians
    Matthew B Lanktree
    Department of Medicine and Biochemistry, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Circ Cardiovasc Genet 3:39-46. 2010
    ..Genomic analysis of LPA, including both single-nucleotide polymorphisms (SNPs) and kringle IV type 2 (KIV-2) copy number, has yet to be performed...
  56. doi request reprint Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
    Guillaume Pare
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 363:1704-14. 2010
    ....
  57. ncbi request reprint Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
    ..We aimed to assess whether markers of obesity, especially waist-to-hip ratio, would be stronger indicators of myocardial infarction than body-mass index (BMI), the conventional measure...
  58. doi request reprint Association of diet, exercise, and smoking modification with risk of early cardiovascular events after acute coronary syndromes
    Clara K Chow
    Hamilton General Hospital, 237 Barton St E, Hamilton, Ontario, L8L 2X2, Canada
    Circulation 121:750-8. 2010
    ..The aim of this study was to examine the influence of adherence to behavioral recommendations in the short term on risk of cardiovascular events...
  59. pmc Dysglycemia and a history of reproductive risk factors
    Sarah D McDonald
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, McMaster Universityand Hamilton Health Sciences, Hamilton, Ontario, Canada
    Diabetes Care 31:1635-8. 2008
    ..The purpose of this study was to identify reproductive risk factors associated with dysglycemia (diabetes, impaired glucose tolerance, and impaired fasting glucose) in a contemporary multiethnic population...
  60. ncbi request reprint Gastrointestinal bleeding, angiodysplasia, cardiovascular disease, and acquired von Willebrand syndrome
    Theodore E Warkentin
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    Transfus Med Rev 17:272-86. 2003
    ....
  61. ncbi request reprint Impact of rosiglitazone on body composition, hepatic fat, fatty acids, adipokines and glucose in persons with impaired fasting glucose or impaired glucose tolerance: a sub-study of the DREAM trial
    Z Punthakee
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada Department of Medicine, McMaster University, Hamilton, ON, Canada
    Diabet Med 31:1086-92. 2014
    ..We aimed to measure these effects in people with impaired fasting glucose and/or impaired glucose tolerance...
  62. ncbi request reprint Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence
    Daniel G Hackam
    Population Health Research Institute and Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    JAMA 290:932-40. 2003
    ..Atherosclerotic vascular disease is an enormous public health problem. A number of emerging risk factors for atherosclerosis have recently been proposed to help identify high-risk individuals...
  63. doi request reprint Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray
    Matthew B Lanktree
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Stroke 40:3173-9. 2009
    ....
  64. doi request reprint Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration
    Matthew B Lanktree
    Department of Medicine, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    Blood 116:2160-3. 2010
    ..The protein products of 2 of these loci, hyaluronan binding protein 2 (HABP2) and hyaluronoglucosaminidase 1 (HYAL1), play key roles in hyaluronan metabolism, providing genetic evidence to link these pathways...
  65. pmc Guidelines as rationing tools: a qualitative analysis of psychosocial patient selection criteria for cardiac procedures
    M K Giacomini
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont
    CMAJ 164:634-40. 2001
    ..The aim of this study was to investigate the terms and justifications for and the meanings of psychosocial patient characteristics used in cardiac procedure guidelines...
  66. pmc Referrals in acute coronary events for CARdiac catheterization: The RACE CAR trial
    Catherine Kreatsoulas
    McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 26:290-6. 2010
    ..Women with acute coronary syndromes have lower rates of cardiac catheterization (CC) than men...
  67. ncbi request reprint Commentary: insights from cross-population studies: Rose revisited
    Anwar T Merchant
    Population Health Research Institute, Hamilton, Ontario L8L 2X2, Canada
    Int J Epidemiol 34:244-6. 2005
  68. ncbi request reprint Oral-anticoagulant-related intracerebral hemorrhage
    Xerxes Punthakee
    Department of Preventive Cardiology and Therapeutics, Hamilton Health Sciences Corporation, McMaster University, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Thromb Res 108:31-6. 2002
    ..The characteristics, management and outcomes of patients who suffer intracerebral hemorrhage (ICH) while taking oral anticoagulants (OAC) are relatively unreported...
  69. ncbi request reprint Commentary: cardiovascular implications of the epidemiological transition for the developing world: Thailand as a case in point
    Daniel G Hackam
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada L8L 2X2
    Int J Epidemiol 32:468-9. 2003
  70. ncbi request reprint C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events
    Peter Leong-Sit
    McMaster University, Department of Medicine, Ontario, Canada
    Vasc Med 8:147-8. 2003
  71. pmc Patterns of medical therapy in patients with peripheral artery disease in a tertiary care centre in Canada
    Kiran K Kundhal
    Department of Medicine, McMaster University, Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada
    Can J Cardiol 23:357-61. 2007
    ....
  72. ncbi request reprint Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies
    Lawrence de Koning
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada L8L 2X2
    Eur Heart J 28:850-6. 2007
    ....
  73. doi request reprint Oral anticoagulants and non-cardioembolic stroke prevention
    Michael E Schachter
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Vasc Med 13:55-62. 2008
    ..This systematic review evaluates the safety and efficacy of oral anticoagulation compared with control and antiplatelet therapy...
  74. ncbi request reprint Protein intake is inversely associated with abdominal obesity in a multi-ethnic population
    Anwar T Merchant
    Population Health Research Institute, Hamilton ON, Canada
    J Nutr 135:1196-201. 2005
    ..Substituting a modest amount of protein for carbohydrate may reduce abdominal obesity in a diverse multi-ethnic population. Smoking was positively related to abdominal obesity after accounting for BMI...
  75. ncbi request reprint Does this patient have deep vein thrombosis?
    S S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 279:1094-9. 1998
    ..To review the validity of the clinical assessment and diagnostic tests in patients with suspected deep vein thrombosis (DVT)...
  76. ncbi request reprint Carbohydrate intake and HDL in a multiethnic population
    Anwar T Merchant
    Population Health Research Institute, Hamilton, Canada
    Am J Clin Nutr 85:225-30. 2007
    ..Ethnic differences in serum lipids are not explained by genetics, central adiposity, lifestyle, or diet, possibly because dietary carbohydrate has not been considered...
  77. ncbi request reprint Does the clinical examination predict lower extremity peripheral arterial disease?
    Nadia A Khan
    Department of Medicine, University of British Columbia, Vancouver, Canada
    JAMA 295:536-46. 2006
    ..Physicians typically depend on the clinical examination to identify patients who need further diagnostic testing...
  78. ncbi request reprint Peripheral arterial disease
    Sonia S Anand
    McMaster University, Hamilton, Canada
    Am Fam Physician 65:2321-2. 2002
  79. pmc Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Nat Genet 42:684-7. 2010
    ..1% of affected individuals and 15.3% of controls (P = 2.6 x 10(-5)). Considering rare variants in these genes incrementally increased the proportion of genetic variation contributing to HTG...
  80. ncbi request reprint Sex and gender subgroup analyses of randomized trials
    Amandev K Aulakh
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Womens Health Issues 17:342-50. 2007
    ..However, sex/gender-based SGA have the potential to be misleading if their results are overinterpreted and may incorrectly influence medical management...
  81. ncbi request reprint The metabolic syndrome: an emerging risk state for cardiovascular disease
    Dorairaj Prabhakaran
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Canada
    Vasc Med 9:55-68. 2004
    ..To control elevated glucose levels (when there is failure of lifestyle modification), medications such as metformin, thiazolidinedione derivatives and alpha glucosidase inhibitors may be used...
  82. doi request reprint A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease
    Andrew Mente
    Population Health Research Institute, Hamilton General Hospital, 4 East Room 441, 237 Barton St E, Hamilton, ON L8L 2X2, Canada
    Arch Intern Med 169:659-69. 2009
    ..Although a wealth of literature links dietary factors and coronary heart disease (CHD), the strength of the evidence supporting valid associations has not been evaluated systematically in a single investigation...
  83. ncbi request reprint Adherence to a Mediterranean diet and survival in a Greek population. Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. N Engl J Med 2003; 348: 2599-608
    Lawrence deKoning
    McMaster University, Hamilton General Hospital, Hamilton, Ontario, Canada
    Vasc Med 9:145-6. 2004
  84. ncbi request reprint Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. N Engl J Med 2004; 350: 664-71
    Fahad Razak
    McMaster University, Hamilton General Hospital, Hamilton, Ontario, Canada
    Vasc Med 9:223-4. 2004
  85. pmc Risk factors, hospital management and outcomes after acute myocardial infarction in South Asian Canadians and matched control subjects
    Milan Gupta
    William Osler Health Centre, Brampton, Ont
    CMAJ 166:717-22. 2002
    ..We compared differences in presentation, risk factors and management of myocardial infarction (MI) between South Asian Canadians and matched control subjects...
  86. ncbi request reprint Aspirin resistance
    Huyen A Tran
    Department of Clinical Haematology, Monash Medical Centre, Clayton, Victoria, Australia
    Thromb Res 120:337-46. 2007
    ....
  87. ncbi request reprint Development and evaluation of cultural food frequency questionnaires for South Asians, Chinese, and Europeans in North America
    Linda E Kelemen
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    J Am Diet Assoc 103:1178-84. 2003
    ..Lower correlations for dietary fats among Chinese persons (0.17 to 0.31) may be improved with more direct questions on the FFQ regarding brand, type, and amount of oil consumed in stirfry servings...
  88. pmc Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol
    Guillaume Pare
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Am J Hum Genet 80:673-82. 2007
    ..Using an independent validation sample of 806 individuals, we confirm the EDN1 association (P<.005), whereas the LCAT association was nonsignificant (P=.12)...
  89. ncbi request reprint Associations of plasma homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism with carotid intima media thickness among South Asian, Chinese and European Canadians
    Linda E Kelemen
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, USA
    Atherosclerosis 176:361-70. 2004
    ..Few studies have evaluated the associations of plasma homocysteine concentration, the methylenetetrahydrofolate reductase (MTHFR) C677T genotype and B vitamin concentration with intima media thickness (IMT) in multiethnic populations...
  90. ncbi request reprint Oral anticoagulants in patients with coronary artery disease: an inexpensive and effective strategy
    Sonia S Anand
    Thromb Res 109:159-61. 2003
  91. doi request reprint Association of the FABP2 T54 variant with plasma triglycerides and insulin resistance in a multiethnic population
    Lawrence de Koning
    Clin Chem 54:1742-4. 2008
  92. ncbi request reprint Management of risk in peripheral artery disease: recent therapeutic advances
    Daniel G Hackam
    Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
    Am Heart J 150:35-40. 2005
    ..As a result of their high baseline risk and the proven effectiveness of these interventions, most patients with PAD will benefit substantially from aggressive medical therapy...