Research Topics
| Donald C McKenzieSummaryCountry: Canada Publications
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Detail Information
Publications
Understanding breast cancer patients' preference for two types of exercise training during chemotherapy in an unblinded randomized controlled trialKerry S Courneya
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
Int J Behav Nutr Phys Act 5:52. 2008..The purpose of the present study was to examine factors associated with breast cancer patients' preference for two types of exercise training during chemotherapy...
The asthmatic athlete: inhaled Beta-2 agonists, sport performance, and dopingDonald C McKenzie
Division of Sports Medicine, School of Human Kinetics, The University of British Columbia, 3055 Wesbrook Mall, Vancouver, BC, Canada
Clin J Sport Med 21:46-50. 2011..As a result of these changes, asthmatic athletes are being managed differently based on a World Anti-Doping Agency directive that has no foundation in pharmacological science or in clinical practice...
Asthma, outdoor air quality and the Olympic GamesDonald C McKenzie
Division of Sports Medicine and School of Human Kinetics, University of British Columbia, Vancouver, BC
CMAJ 179:543-8. 2008
Post-exercise hypotension and cardiovascular responses to moderate orthostatic stress in endurance-trained malesJessica M Scott
Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, BC, Canada
Appl Physiol Nutr Metab 33:246-53. 2008....
Preserved muscle metaboreflex in chronic obstructive pulmonary diseaseMegan F B Sherman
School of Kinesiology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
Appl Physiol Nutr Metab 36:821-30. 2011..We observed a preserved muscle metaboreflex in mild-to-severe COPD, suggesting the metaboreflex is not a contributing factor to the development of exercise intolerance in this population...
Sex differences in exercise-induced diaphragmatic fatigue in endurance-trained athletesJordan A Guenette
School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
J Appl Physiol 109:35-46. 2010..The findings from this study point to a female diaphragm that is more resistant to fatigue relative to their male counterparts...
Diaphragm fatigue after submaximal exercise with chest wall restrictionSimone E Tomczak
School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
Med Sci Sports Exerc 43:416-24. 2011..We asked whether submaximal exercise with chest wall restriction (CWR), as a model of restrictive pulmonary disease, would result in fatigue of the diaphragm in healthy humans...
Human lung density is not altered following normoxic and hypoxic moderate-intensity exercise: implications for transient edemaAlastair N H Hodges
Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada
J Appl Physiol 103:111-8. 2007..Transient interstitial pulmonary edema did not occur following sustained steady-state cycling exercise in N or H, indicating that transient edema does not result from pulmonary capillary leakage during sustained submaximal exercise...
Effects of intermittent hypoxia on the cerebrovascular responses to submaximal exercise in humansJordan S Querido
The School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
Eur J Appl Physiol 105:403-9. 2009..05); however, the magnitude of the response was unchanged following IH. Our findings indicate that ten daily hypoxia exposures does not alter the CBF response to submaximal exercise...
Respiratory mechanics during exercise in endurance-trained men and womenJordan A Guenette
School of Human Kinetics and Faculty of Medicine, Health and Integrative Physiology Laboratory, University of British Columbia, 6108 Thunderbird Blvd, Vancouver, BC, Canada V6T 1Z3
J Physiol 581:1309-22. 2007..Collectively, these findings suggest that women utilize a greater majority of their ventilatory reserve compared to men and this is associated with a higher cost of breathing...
Effects of enhanced human chemosensitivity on ventilatory responses to exerciseGlen E Foster
School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
Exp Physiol 91:221-8. 2006..30) and day 12 (r = 0.47; P > 0.05). Our findings point to a lack of functional significance of increasing HVR via intermittent hypoxia on ventilatory responses to exercise at sea level...
Effects of pseudoephedrine on maximal cycling power and submaximal cycling efficiencyAlastair N H Hodges
Allan McGavin Sports Medicine Centre and School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
Med Sci Sports Exerc 35:1316-9. 2003..8 +/- 1.8, P = 18.5 +/- 1.8%) or 60% power (D = 20.3 +/- 2.0, P = 20.1 +/- 2.1%). CONCLUSION: A therapeutic dose of pseudoephedrine hydrochloride does not affect anaerobic cycling performance or aerobic cycling efficiency...
Lung density is not altered following intense normobaric hypoxic interval training in competitive female cyclistsJordan A Guenette
Health and Integrative Physiology Laboratory, University of British Columbia, 6108 Thunderbird Blvd, Vancouver, BC, Canada V6T 1Z3
J Appl Physiol 103:875-82. 2007..Mean lung density did not change from pre (0.138 +/- 0.014 g/ml)- to postexercise (0.137 +/- 0.011 g/ml). These findings suggest that pulmonary edema does not occur in highly trained females following intense normobaric hypoxic exercise...
The asthmatic athlete, inhaled beta agonists, and performanceDonald C McKenzie
Division of Sports Medicine, The University of British Columbia, Vancouver, British Columbia, Canada
Clin J Sport Med 12:225-8. 2002..This review will examine the use of IBAs in the asthmatic athlete, the variability that exists between countries and sport, and outline a plan to justify the use of these medications...
Dose response of inhaled salbutamol on exercise performance and urine concentrationsBenjamin C Sporer
School of Human Kinetics, University of British Columbia, Vancouver, Canada
Med Sci Sports Exerc 40:149-57. 2008..This study determined the dose-response effects of inhaled salbutamol (SAL) on time-trial performance and urine concentrations of SAL (cSAL)...
Two patterns of daily hypoxic exposure and their effects on measures of chemosensitivity in humansMichael S Koehle
Allan McGavin Sport Medicine Centre, Vancouver, BC, Canada
J Appl Physiol 103:1973-8. 2007..These results also suggest that the two methods of measuring CO(2) response are not completely concordant and that the changes in CO(2) control do not correlate with the increase in the HVR...
Entrainment of breathing in cyclists and non-cyclists during arm and leg exerciseBen C Sporer
School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
Respir Physiol Neurobiol 155:64-70. 2007..These results suggest that during cycling exercise at intensities of 75% VO2max or less, regular training may result in higher %ENT and that ENT is not transferable to an unfamiliar mode of exercise using different muscle groups...
Human ventilatory responsiveness to hypoxia is unrelated to maximal aerobic capacityA William Sheel
School of Human Kinetics, The University of British Columbia, 210 6081 Univ Blvd, Vancouver, BC, Canada V6T 1Z1
J Appl Physiol 100:1204-9. 2006..We interpret these observations to mean that other factors are more important in determining hypoxic ventilatory control than physical conditioning per se...
Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxiaGlen E Foster
School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
J Physiol 567:689-99. 2005..Our findings indicate that the vascular processes required to control blood flow and oxygen supply to cerebral tissue in a healthy human are hindered following exposure to 12 days of isocapnic intermittent hypoxia...
Inhaled salbutamol and doping control: effects of dose on urine concentrationsBenjamin C Sporer
School of Human Kinetics, University of British Columbia, Vancouver, Canada
Clin J Sport Med 18:282-5. 2008....
Long-term intermittent hypoxia increases sympathetic activity and chemosensitivity during acute hypoxia in humansSarah-Jane C Lusina
Health and Integrative Physiology Laboratory, School of Human Kinetics, The University of British Columbia, 6108 Thunderbird Blvd, Vancouver, B.C, Canada
J Physiol 575:961-70. 2006..82) during the post-IH trial. Following IH the rise in MSNA burst frequency was strongly related to the change in HVR (r = 0.79, P < 0.05) suggesting that these sympathetic and ventilatory responses may have common central control...
Acute hypervolaemia improves arterial oxygen pressure in athletes with exercise-induced hypoxaemiaGerald S Zavorsky
Department of Experimental Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Center, Koerner Pavillion, S154, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
Exp Physiol 88:555-64. 2003..This suggests that arterial oxygen pressure is only minimally mediated by cardiac output...
Effects of upper extremity exercise training on peak aerobic and anaerobic fitness in patients after transplantationDarren E R Warburton
School of Human Kinetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Am J Cardiol 93:939-43. 2004..It also appears that patients with cardiac and noncardiac transplants have an increased reliance on anaerobic energy systems during exercise conditions compared with healthy control subjects...
Hemoglobin and aerobic fitness changes with supervised exercise training in breast cancer patients receiving chemotherapyLianne B Dolan
School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
Cancer Epidemiol Biomarkers Prev 19:2826-32. 2010..The purpose of this study was to examine the changes in hemoglobin (Hb) levels in the Supervised Trial of Aerobic versus Resistance Training (START) and to determine its association with changes in VO(2peak)...
Inspiratory muscle training attenuates the human respiratory muscle metaboreflexJonathan D Witt
School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
J Physiol 584:1019-28. 2007..We attribute our findings to a reduced activity of chemosensitive afferents within the inspiratory muscles and may provide a mechanism for some of the whole-body exercise endurance improvements associated with IMT...
Feasibility of a lifestyle intervention on body weight and serum biomarkers in breast cancer survivors with overweight and obesityKristin L Campbell
Department of Physical Therapy, University of British Columbia, 2177Wesbrook Mall, Vancouver, BC, Canada
J Acad Nutr Diet 112:559-67. 2012....
Prevalence of exercise-induced arterial hypoxemia in healthy womenJennifer C Richards
School of Human Kinetics, The University of British Columbia, Vancouver, Canada
Med Sci Sports Exerc 36:1514-21. 2004..CONCLUSION: It appears that the prevalence of EIAH in women is slightly greater than the 50% prevalence value that is typically reported for highly fit men...
Is there enhanced lymphatic function in upper body trained females?Lianne B Dolan
School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
Lymphat Res Biol 6:29-38. 2008....
Respiratory physiology: adaptations to high-level exerciseDonald C McKenzie
The University of British Columbia, Division of Sports Medicine, Vancouver
Br J Sports Med 46:381-4. 2012..All of these maladaptations may influence performance...
Effectiveness of high-intensity interval training for the rehabilitation of patients with coronary artery diseaseDarren E R Warburton
School of Human Kinetics and Faculty of Medicine, Unit II Osborne Center, University of British Columbia, Vancouver, British Columbia, Canada
Am J Cardiol 95:1080-4. 2005..This research supports the implementation of interval training for highly functional patients with coronary artery disease...
Salbutamol and the competitive athleteDonald C McKenzie
Division of Sport Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Clin J Sport Med 14:316. 2004
Physiological responses to indoor rock-climbing and their relationship to maximal cycle ergometryA William Sheel
School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
Med Sci Sports Exerc 35:1225-31. 2003..It was hypothesized that as climbing difficulty increased, oxygen consumption ([V02] and heart rate would increase, and that climbing would require utilization of a significant fraction of maximal cycling values...
Pulmonary oedema of immersionMichael S Koehle
Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada
Sports Med 35:183-90. 2005..Cases usually resolve within 24 hours. In some cases, diuretics have been used, but there are no data as to their efficacy. Nifedipine has been used to prevent recurrence, but there is only anecdotal evidence to support its use...
Repeated measurement of hypoxic ventilatory response as an intermittent hypoxic stimulusMichael S Koehle
Department of Family Medicine, Allan McGavin Sport Medicine Centre, University of British Columbia, Vancouver, BC, Canada V6T 1Z1
Respir Physiol Neurobiol 145:33-9. 2005..There is no evidence that the short exposure to hypoxia as part of HVR measurement is a co-intervention when measured repeatedly over 5 days in physiological studies...
Cardiovascular and splenic responses to exercise in humansIan B Stewart
School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
J Appl Physiol 94:1619-26. 2003..Splenic release of erythrocytes has no effect on indirect measures of plasma volume...
Pulmonary oedema following exercise in humansAlastair N H Hodges
School of Human Kinetics and Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, Canada
Sports Med 36:501-12. 2006..As such, this is a phenomenon of significance to pulmonary and exercise physiologists. This possibility warrants further study in the area with more precise measurement tools than has previously been undertaken...
Optimal mode for maximal aerobic exercise testing in breast cancer survivorsLianne B Dolan
University of British Columbia, Vancouver, British Columbia, Canada
Integr Cancer Ther 11:321-6. 2012..To determine which mode of exercise is preferred by breast cancer survivors and to evaluate this response between graded exercise testing on a treadmill and on a cycle ergometer...
The effects of 10 weeks of reforestation work on body compositionAlastair N H Hodges
Allan McGavin Sports Medicine Centre, School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
Wilderness Environ Med 16:3-8. 2005..To document changes in body composition and body mass in male and female tree planters...
Acute formoterol administration has no ergogenic effect in nonasthmatic athletesIan B Stewart
Allan McGavin Sports Medicine Centre and School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
Med Sci Sports Exerc 34:213-7. 2002..To determine the effect of formoterol (formoterol fumarate dihydrate) on the aerobic and anaerobic capacities of highly trained athletes...
Enhancing the effectiveness of clearance for physical activity participation: background and overall process (1) (1) This paper is one of a selection of papers published in the Special Issue entitled Evidence-based risk assessment and recommendations for Veronica K Jamnik
a Cardiovascular Physiology and Rehabilitation Laboratory, The University of British Columbia, 205 Unit II Osborne Centre, 6108 Thunderbird Boulevard, Vancouver, BC V6T 1Z3, Canada
Appl Physiol Nutr Metab 36:S3-S13. 2011....
Fitness, fatigue, disease activity, and quality of life in pediatric lupusKristin M Houghton
British Columbia Children s Hospital, Vancouver, British Columbia, Canada
Arthritis Rheum 59:537-45. 2008....
Incidence of exercise-induced arterial hypoxemia in prepubescent femalesPaul B Laursen
Allan McGavin Sports Medicine Clinic, School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Pulmonol 34:37-41. 2002..Therefore, in comparison to previous reports of EIAH in adult women with similar V'(O(2)peak), EIAH does not appear to occur in the prepubescent female population...
Changes in pulmonary transfer factor with menstrual cycle phaseCatherine J Bacon
Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Respir Physiol Neurobiol 146:195-203. 2005....
Field evaluation of energy expenditure in women using Tritrac accelerometersKristin L Campbell
School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
Med Sci Sports Exerc 34:1667-74. 2002..Activity specific linear regression equations are proposed as a tool to improve the measurement of EE using the Tritrac in the field...
Asthma and the elite athlete: summary of the International Olympic Committee's consensus conference, Lausanne, Switzerland, January 22-24, 2008Kenneth D Fitch
School of Sports Science, Exercise and Health, Faculty of Life Sciences, University of Western Australia, Crawley, Australia
J Allergy Clin Immunol 122:254-60, 260.e1-7. 2008..The policy of requiring Olympic athletes to demonstrate the presence of asthma, exercise-induced bronchoconstriction, or AHR to be approved to inhale beta(2)-agonists will continue...
