Donald C McKenzie

Summary

Country: Canada

Publications

  1. pmc Understanding breast cancer patients' preference for two types of exercise training during chemotherapy in an unblinded randomized controlled trial
    Kerry S Courneya
    Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
    Int J Behav Nutr Phys Act 5:52. 2008
  2. doi request reprint The asthmatic athlete: inhaled Beta-2 agonists, sport performance, and doping
    Donald C McKenzie
    Division of Sports Medicine, School of Human Kinetics, The University of British Columbia, 3055 Wesbrook Mall, Vancouver, BC, Canada
    Clin J Sport Med 21:46-50. 2011
  3. pmc Asthma, outdoor air quality and the Olympic Games
    Donald C McKenzie
    Division of Sports Medicine and School of Human Kinetics, University of British Columbia, Vancouver, BC
    CMAJ 179:543-8. 2008
  4. doi request reprint Post-exercise hypotension and cardiovascular responses to moderate orthostatic stress in endurance-trained males
    Jessica M Scott
    Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, BC, Canada
    Appl Physiol Nutr Metab 33:246-53. 2008
  5. pmc Exercise-induced arterial hypoxaemia and the mechanics of breathing in healthy young women
    Paolo B Dominelli
    School of Kinesiology, University of British Columbia, Vancouver, BC, Canada
    J Physiol 591:3017-34. 2013
  6. doi request reprint Preserved muscle metaboreflex in chronic obstructive pulmonary disease
    Megan F B Sherman
    School of Kinesiology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Appl Physiol Nutr Metab 36:821-30. 2011
  7. ncbi request reprint Human lung density is not altered following normoxic and hypoxic moderate-intensity exercise: implications for transient edema
    Alastair N H Hodges
    Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 103:111-8. 2007
  8. doi request reprint Sex differences in exercise-induced diaphragmatic fatigue in endurance-trained athletes
    Jordan A Guenette
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 109:35-46. 2010
  9. doi request reprint Diaphragm fatigue after submaximal exercise with chest wall restriction
    Simone E Tomczak
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Med Sci Sports Exerc 43:416-24. 2011
  10. doi request reprint Cardiorespiratory and neuromuscular deconditioning in fatigued and non-fatigued breast cancer survivors
    Sarah E Neil
    Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada
    Support Care Cancer 21:873-81. 2013

Collaborators

Detail Information

Publications49

  1. pmc Understanding breast cancer patients' preference for two types of exercise training during chemotherapy in an unblinded randomized controlled trial
    Kerry S Courneya
    Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
    Int J Behav Nutr Phys Act 5:52. 2008
    ..The purpose of the present study was to examine factors associated with breast cancer patients' preference for two types of exercise training during chemotherapy...
  2. doi request reprint The asthmatic athlete: inhaled Beta-2 agonists, sport performance, and doping
    Donald C McKenzie
    Division of Sports Medicine, School of Human Kinetics, The University of British Columbia, 3055 Wesbrook Mall, Vancouver, BC, Canada
    Clin J Sport Med 21:46-50. 2011
    ..As a result of these changes, asthmatic athletes are being managed differently based on a World Anti-Doping Agency directive that has no foundation in pharmacological science or in clinical practice...
  3. pmc Asthma, outdoor air quality and the Olympic Games
    Donald C McKenzie
    Division of Sports Medicine and School of Human Kinetics, University of British Columbia, Vancouver, BC
    CMAJ 179:543-8. 2008
  4. doi request reprint Post-exercise hypotension and cardiovascular responses to moderate orthostatic stress in endurance-trained males
    Jessica M Scott
    Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, BC, Canada
    Appl Physiol Nutr Metab 33:246-53. 2008
    ....
  5. pmc Exercise-induced arterial hypoxaemia and the mechanics of breathing in healthy young women
    Paolo B Dominelli
    School of Kinesiology, University of British Columbia, Vancouver, BC, Canada
    J Physiol 591:3017-34. 2013
    ..Mechanical ventilatory constraints are a primary mechanism for EIAH in some healthy women and prevent reversal of hypoxaemia in women for whom it is not the primary mechanism...
  6. doi request reprint Preserved muscle metaboreflex in chronic obstructive pulmonary disease
    Megan F B Sherman
    School of Kinesiology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Appl Physiol Nutr Metab 36:821-30. 2011
    ..We observed a preserved muscle metaboreflex in mild-to-severe COPD, suggesting the metaboreflex is not a contributing factor to the development of exercise intolerance in this population...
  7. ncbi request reprint Human lung density is not altered following normoxic and hypoxic moderate-intensity exercise: implications for transient edema
    Alastair N H Hodges
    Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 103:111-8. 2007
    ..Transient interstitial pulmonary edema did not occur following sustained steady-state cycling exercise in N or H, indicating that transient edema does not result from pulmonary capillary leakage during sustained submaximal exercise...
  8. doi request reprint Sex differences in exercise-induced diaphragmatic fatigue in endurance-trained athletes
    Jordan A Guenette
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 109:35-46. 2010
    ..The findings from this study point to a female diaphragm that is more resistant to fatigue relative to their male counterparts...
  9. doi request reprint Diaphragm fatigue after submaximal exercise with chest wall restriction
    Simone E Tomczak
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Med Sci Sports Exerc 43:416-24. 2011
    ..We asked whether submaximal exercise with chest wall restriction (CWR), as a model of restrictive pulmonary disease, would result in fatigue of the diaphragm in healthy humans...
  10. doi request reprint Cardiorespiratory and neuromuscular deconditioning in fatigued and non-fatigued breast cancer survivors
    Sarah E Neil
    Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada
    Support Care Cancer 21:873-81. 2013
    ....
  11. ncbi request reprint Effects of enhanced human chemosensitivity on ventilatory responses to exercise
    Glen E Foster
    School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    Exp Physiol 91:221-8. 2006
    ..30) and day 12 (r = 0.47; P > 0.05). Our findings point to a lack of functional significance of increasing HVR via intermittent hypoxia on ventilatory responses to exercise at sea level...
  12. doi request reprint Effects of intermittent hypoxia on the cerebrovascular responses to submaximal exercise in humans
    Jordan S Querido
    The School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    Eur J Appl Physiol 105:403-9. 2009
    ..05); however, the magnitude of the response was unchanged following IH. Our findings indicate that ten daily hypoxia exposures does not alter the CBF response to submaximal exercise...
  13. pmc Respiratory mechanics during exercise in endurance-trained men and women
    Jordan A Guenette
    School of Human Kinetics and Faculty of Medicine, Health and Integrative Physiology Laboratory, University of British Columbia, 6108 Thunderbird Blvd, Vancouver, BC, Canada V6T 1Z3
    J Physiol 581:1309-22. 2007
    ..Collectively, these findings suggest that women utilize a greater majority of their ventilatory reserve compared to men and this is associated with a higher cost of breathing...
  14. doi request reprint Optimal mode for maximal aerobic exercise testing in breast cancer survivors
    Lianne B Dolan
    University of British Columbia, Vancouver, British Columbia, Canada
    Integr Cancer Ther 11:321-6. 2012
    ..To determine which mode of exercise is preferred by breast cancer survivors and to evaluate this response between graded exercise testing on a treadmill and on a cycle ergometer...
  15. ncbi request reprint Effects of pseudoephedrine on maximal cycling power and submaximal cycling efficiency
    Alastair N H Hodges
    Allan McGavin Sports Medicine Centre and School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Med Sci Sports Exerc 35:1316-9. 2003
    ..To study the effects of a therapeutic dose of pseudoephedrine on anaerobic cycling power and aerobic cycling efficiency...
  16. ncbi request reprint Dose response of inhaled salbutamol on exercise performance and urine concentrations
    Benjamin C Sporer
    School of Human Kinetics, University of British Columbia, Vancouver, Canada
    Med Sci Sports Exerc 40:149-57. 2008
    ..This study determined the dose-response effects of inhaled salbutamol (SAL) on time-trial performance and urine concentrations of SAL (cSAL)...
  17. ncbi request reprint Lung density is not altered following intense normobaric hypoxic interval training in competitive female cyclists
    Jordan A Guenette
    Health and Integrative Physiology Laboratory, University of British Columbia, 6108 Thunderbird Blvd, Vancouver, BC, Canada V6T 1Z3
    J Appl Physiol (1985) 103:875-82. 2007
    ..Mean lung density did not change from pre (0.138 +/- 0.014 g/ml)- to postexercise (0.137 +/- 0.011 g/ml). These findings suggest that pulmonary edema does not occur in highly trained females following intense normobaric hypoxic exercise...
  18. ncbi request reprint The asthmatic athlete, inhaled beta agonists, and performance
    Donald C McKenzie
    Division of Sports Medicine, The University of British Columbia, Vancouver, British Columbia, Canada
    Clin J Sport Med 12:225-8. 2002
    ..This review will examine the use of IBAs in the asthmatic athlete, the variability that exists between countries and sport, and outline a plan to justify the use of these medications...
  19. ncbi request reprint Human ventilatory responsiveness to hypoxia is unrelated to maximal aerobic capacity
    A William Sheel
    School of Human Kinetics, The University of British Columbia, 210 6081 Univ Blvd, Vancouver, BC, Canada V6T 1Z1
    J Appl Physiol (1985) 100:1204-9. 2006
    ..We interpret these observations to mean that other factors are more important in determining hypoxic ventilatory control than physical conditioning per se...
  20. pmc Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia
    Glen E Foster
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    J Physiol 567:689-99. 2005
    ..Our findings indicate that the vascular processes required to control blood flow and oxygen supply to cerebral tissue in a healthy human are hindered following exposure to 12 days of isocapnic intermittent hypoxia...
  21. ncbi request reprint Entrainment of breathing in cyclists and non-cyclists during arm and leg exercise
    Ben C Sporer
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    Respir Physiol Neurobiol 155:64-70. 2007
    ..These results suggest that during cycling exercise at intensities of 75% VO2max or less, regular training may result in higher %ENT and that ENT is not transferable to an unfamiliar mode of exercise using different muscle groups...
  22. ncbi request reprint Two patterns of daily hypoxic exposure and their effects on measures of chemosensitivity in humans
    Michael S Koehle
    Allan McGavin Sport Medicine Centre, Vancouver, BC, Canada
    J Appl Physiol (1985) 103:1973-8. 2007
    ..These results also suggest that the two methods of measuring CO(2) response are not completely concordant and that the changes in CO(2) control do not correlate with the increase in the HVR...
  23. pmc Long-term intermittent hypoxia increases sympathetic activity and chemosensitivity during acute hypoxia in humans
    Sarah Jane C Lusina
    Health and Integrative Physiology Laboratory, School of Human Kinetics, The University of British Columbia, 6108 Thunderbird Blvd, Vancouver, B C, Canada
    J Physiol 575:961-70. 2006
    ..82) during the post-IH trial. Following IH the rise in MSNA burst frequency was strongly related to the change in HVR (r = 0.79, P < 0.05) suggesting that these sympathetic and ventilatory responses may have common central control...
  24. ncbi request reprint Acute hypervolaemia improves arterial oxygen pressure in athletes with exercise-induced hypoxaemia
    Gerald S Zavorsky
    Department of Experimental Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Center, Koerner Pavillion, S154, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
    Exp Physiol 88:555-64. 2003
    ..This suggests that arterial oxygen pressure is only minimally mediated by cardiac output...
  25. doi request reprint Inhaled salbutamol and doping control: effects of dose on urine concentrations
    Benjamin C Sporer
    School of Human Kinetics, University of British Columbia, Vancouver, Canada
    Clin J Sport Med 18:282-5. 2008
    ....
  26. ncbi request reprint Prevalence of exercise-induced arterial hypoxemia in healthy women
    Jennifer C Richards
    School of Human Kinetics, The University of British Columbia, Vancouver, Canada
    Med Sci Sports Exerc 36:1514-21. 2004
    ..It was hypothesized that EIAH would occur with a greater prevalence and at relatively lower predicted VO2max than that previously reported in males...
  27. doi request reprint Hemoglobin and aerobic fitness changes with supervised exercise training in breast cancer patients receiving chemotherapy
    Lianne B Dolan
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Epidemiol Biomarkers Prev 19:2826-32. 2010
    ..The purpose of this study was to examine the changes in hemoglobin (Hb) levels in the Supervised Trial of Aerobic versus Resistance Training (START) and to determine its association with changes in VO(2peak)...
  28. pmc Inspiratory muscle training attenuates the human respiratory muscle metaboreflex
    Jonathan D Witt
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    J Physiol 584:1019-28. 2007
    ..We attribute our findings to a reduced activity of chemosensitive afferents within the inspiratory muscles and may provide a mechanism for some of the whole-body exercise endurance improvements associated with IMT...
  29. ncbi request reprint Effects of upper extremity exercise training on peak aerobic and anaerobic fitness in patients after transplantation
    Darren E R Warburton
    School of Human Kinetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Cardiol 93:939-43. 2004
    ..It also appears that patients with cardiac and noncardiac transplants have an increased reliance on anaerobic energy systems during exercise conditions compared with healthy control subjects...
  30. doi request reprint Feasibility of a lifestyle intervention on body weight and serum biomarkers in breast cancer survivors with overweight and obesity
    Kristin L Campbell
    Department of Physical Therapy, University of British Columbia, 2177Wesbrook Mall, Vancouver, BC, Canada
    J Acad Nutr Diet 112:559-67. 2012
    ....
  31. doi request reprint Is there enhanced lymphatic function in upper body trained females?
    Lianne B Dolan
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Lymphat Res Biol 6:29-38. 2008
    ....
  32. doi request reprint Effects of exercise dose and type during breast cancer chemotherapy: multicenter randomized trial
    Kerry S Courneya
    Affiliations of authors Faculty of Physical Education and Recreation KSC, DC, CCF, LT, Department of Oncology JRM, School of Public Health YY, University of Alberta, Edmonton, Canada School of Kinesiology DCM, DJ, LBD, Department of Oncology KG, University of British Columbia, Vancouver, Canada Division of Medical Oncology, Cross Cancer Institute JRM, Edmonton, Canada Division of Medical Oncology, British Columbia Cancer Agency KG, Vancouver, Canada Department of Population Health Research, Alberta Health Services CMF, Calgary, Canada University of Ottawa Heart Institute RRD, Ottawa, Canada Ottawa Hospital Cancer Center CP, EW, RJS, Ottawa, Canada Ottawa Hospital Research Institute, Ottawa, Canada EW, RJS
    J Natl Cancer Inst 105:1821-32. 2013
    ..Exercise improves physical functioning and symptom management during breast cancer chemotherapy, but the effects of different doses and types of exercise are unknown...
  33. doi request reprint Respiratory physiology: adaptations to high-level exercise
    Donald C McKenzie
    The University of British Columbia, Division of Sports Medicine, Vancouver
    Br J Sports Med 46:381-4. 2012
    ..All of these maladaptations may influence performance...
  34. ncbi request reprint Effectiveness of high-intensity interval training for the rehabilitation of patients with coronary artery disease
    Darren E R Warburton
    School of Human Kinetics and Faculty of Medicine, Unit II Osborne Center, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Cardiol 95:1080-4. 2005
    ..This research supports the implementation of interval training for highly functional patients with coronary artery disease...
  35. doi request reprint Enhancing the effectiveness of clearance for physical activity participation: background and overall process
    Veronica K Jamnik
    Cardiovascular Physiology and Rehabilitation Laboratory, The University of British Columbia, 6108 Thunderbird Boulevard, Vancouver, BC, Canada
    Appl Physiol Nutr Metab 36:S3-13. 2011
    ....
  36. ncbi request reprint Pulmonary oedema following exercise in humans
    Alastair N H Hodges
    School of Human Kinetics and Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, Canada
    Sports Med 36:501-12. 2006
    ..As such, this is a phenomenon of significance to pulmonary and exercise physiologists. This possibility warrants further study in the area with more precise measurement tools than has previously been undertaken...
  37. ncbi request reprint Cardiovascular and splenic responses to exercise in humans
    Ian B Stewart
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    J Appl Physiol (1985) 94:1619-26. 2003
    ..Splenic release of erythrocytes has no effect on indirect measures of plasma volume...
  38. ncbi request reprint Physiological responses to indoor rock-climbing and their relationship to maximal cycle ergometry
    A William Sheel
    School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    Med Sci Sports Exerc 35:1225-31. 2003
    ..It was hypothesized that as climbing difficulty increased, oxygen consumption ([V02] and heart rate would increase, and that climbing would require utilization of a significant fraction of maximal cycling values...
  39. ncbi request reprint Pulmonary oedema of immersion
    Michael S Koehle
    Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Sports Med 35:183-90. 2005
    ..Cases usually resolve within 24 hours. In some cases, diuretics have been used, but there are no data as to their efficacy. Nifedipine has been used to prevent recurrence, but there is only anecdotal evidence to support its use...
  40. ncbi request reprint Salbutamol and the competitive athlete
    Donald C McKenzie
    Division of Sport Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Clin J Sport Med 14:316. 2004
  41. ncbi request reprint Repeated measurement of hypoxic ventilatory response as an intermittent hypoxic stimulus
    Michael S Koehle
    Department of Family Medicine, Allan McGavin Sport Medicine Centre, University of British Columbia, Vancouver, BC, Canada V6T 1Z1
    Respir Physiol Neurobiol 145:33-9. 2005
    ..There is no evidence that the short exposure to hypoxia as part of HVR measurement is a co-intervention when measured repeatedly over 5 days in physiological studies...
  42. doi request reprint Comparison of aerobic exercise intensity prescription methods in breast cancer
    Amy A Kirkham
    School of Kinesiology, University of British Columbia, Vancouver, BC, Canada
    Med Sci Sports Exerc 45:1443-50. 2013
    ..It is unknown whether different methods of prescribing aerobic exercise intensity achieve the same intensity. Breast cancer treatments may alter exercise response and thereby may affect the accuracy of these methods...
  43. ncbi request reprint Acute formoterol administration has no ergogenic effect in nonasthmatic athletes
    Ian B Stewart
    Allan McGavin Sports Medicine Centre and School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    Med Sci Sports Exerc 34:213-7. 2002
    ..To determine the effect of formoterol (formoterol fumarate dihydrate) on the aerobic and anaerobic capacities of highly trained athletes...
  44. ncbi request reprint The effects of 10 weeks of reforestation work on body composition
    Alastair N H Hodges
    Allan McGavin Sports Medicine Centre, School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Wilderness Environ Med 16:3-8. 2005
    ..To document changes in body composition and body mass in male and female tree planters...
  45. ncbi request reprint Changes in pulmonary transfer factor with menstrual cycle phase
    Catherine J Bacon
    Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Respir Physiol Neurobiol 146:195-203. 2005
    ....
  46. ncbi request reprint Field evaluation of energy expenditure in women using Tritrac accelerometers
    Kristin L Campbell
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    Med Sci Sports Exerc 34:1667-74. 2002
    ..To investigate the use of Tritrac accelerometers to measure energy expenditure (EE) of various activities for women in the field setting, as compared with portable indirect calorimetry...
  47. ncbi request reprint Incidence of exercise-induced arterial hypoxemia in prepubescent females
    Paul B Laursen
    Allan McGavin Sports Medicine Clinic, School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Pulmonol 34:37-41. 2002
    ..Therefore, in comparison to previous reports of EIAH in adult women with similar V'(O(2)peak), EIAH does not appear to occur in the prepubescent female population...
  48. doi request reprint Fitness, fatigue, disease activity, and quality of life in pediatric lupus
    Kristin M Houghton
    British Columbia Children s Hospital, Vancouver, British Columbia, Canada
    Arthritis Rheum 59:537-45. 2008
    ....
  49. doi request reprint Asthma and the elite athlete: summary of the International Olympic Committee's consensus conference, Lausanne, Switzerland, January 22-24, 2008
    Kenneth D Fitch
    School of Sports Science, Exercise and Health, Faculty of Life Sciences, University of Western Australia, Crawley, Australia
    J Allergy Clin Immunol 122:254-60, 260.e1-7. 2008
    ..The policy of requiring Olympic athletes to demonstrate the presence of asthma, exercise-induced bronchoconstriction, or AHR to be approved to inhale beta(2)-agonists will continue...