Sheridan J, Zago M, Nair P, Li P, Bourbeau J, Tan W, et al. Decreased expression of the NF-ÎºB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression. Respir Res. 2015;16:54 pubmed publisher
..Our data indicate that RelB attenuates COX-2 expression in lung structural cells, such that loss of pulmonary RelB may be an important determinant in the aberrant, heightened inflammation associated with COPD pathogenesis. ..