Simon N Young

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Clinical nutrition: 3. The fuzzy boundary between nutrition and psychopharmacology
    Simon N Young
    Department of Psychiatry, McGill University, Montreal, Que
    CMAJ 166:205-9. 2002
  2. pmc Ecological momentary assessment: what it is and why it is a method of the future in clinical psychopharmacology
    Debbie S Moskowitz
    Department of Psychology, McGill University, Montreal, Que
    J Psychiatry Neurosci 31:13-20. 2006
  3. ncbi request reprint Glucose enhances newborn memory for spoken words
    Pamela Horne
    McGill University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Dev Psychobiol 48:574-82. 2006
  4. ncbi request reprint The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels
    Simon N Young
    Department of Psychiatry, McGill University, 1033 Pine Avenue West, H3A 1A1, Montreal, Quebec, Canada
    Pharmacol Biochem Behav 71:857-65. 2002
  5. pmc Mood-elevating effects of d-amphetamine and incentive salience: the effect of acute dopamine precursor depletion
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Que
    J Psychiatry Neurosci 32:129-36. 2007
  6. doi request reprint The role of dopamine in alcohol self-administration in humans: individual differences
    Sean P Barrett
    Psychology Department, McGill University, 1033 Pine Avenue West, Montreal, Quebec, Canada
    Eur Neuropsychopharmacol 18:439-47. 2008
  7. ncbi request reprint Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa
    Kenneth R Bruce
    Eating Disorders Program, Research Centre, Douglas Hospital, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
    Am J Med Genet B Neuropsychiatr Genet 137:40-4. 2005
  8. pmc Impact of acute tryptophan depletion on mood and eating-related urges in bulimic and nonbulimic women
    Kenneth R Bruce
    Eating Disorders Program, Douglas Institute, Montreal, Canada
    J Psychiatry Neurosci 34:376-82. 2009
  9. ncbi request reprint Intrafamilial correspondences on platelet [3H-]paroxetine-binding indices in bulimic probands and their unaffected first-degree relatives
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, Montreal, QC, Canada
    Neuropsychopharmacology 31:1785-92. 2006
  10. pmc The effect of raising and lowering tryptophan levels on human mood and social behaviour
    Simon N Young
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Philos Trans R Soc Lond B Biol Sci 368:20110375. 2013

Collaborators

Detail Information

Publications46

  1. pmc Clinical nutrition: 3. The fuzzy boundary between nutrition and psychopharmacology
    Simon N Young
    Department of Psychiatry, McGill University, Montreal, Que
    CMAJ 166:205-9. 2002
  2. pmc Ecological momentary assessment: what it is and why it is a method of the future in clinical psychopharmacology
    Debbie S Moskowitz
    Department of Psychology, McGill University, Montreal, Que
    J Psychiatry Neurosci 31:13-20. 2006
    ..EMA methods will permit more sensitive assessments and will enable more wide-ranging and detailed measurements of mood and behaviour. These types of methods should be adopted more widely by clinical psychopharmacology researchers...
  3. ncbi request reprint Glucose enhances newborn memory for spoken words
    Pamela Horne
    McGill University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Dev Psychobiol 48:574-82. 2006
    ..Only infants who subsequently oriented towards a different word, indicating that they remained alert, were used in the data analysis. The results suggest that glucose enhanced memory for a spoken word in neonates...
  4. ncbi request reprint The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels
    Simon N Young
    Department of Psychiatry, McGill University, 1033 Pine Avenue West, H3A 1A1, Montreal, Quebec, Canada
    Pharmacol Biochem Behav 71:857-65. 2002
    ..Higher levels of serotonin may help to promote more constructive social interactions by decreasing aggression and increasing dominance...
  5. pmc Mood-elevating effects of d-amphetamine and incentive salience: the effect of acute dopamine precursor depletion
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Que
    J Psychiatry Neurosci 32:129-36. 2007
    ..In the present study, we tested whether decreasing dopamine synthesis, as produced by acute phenylalanine/tyrosine depletion (APTD), would alter responses to the stimulant drug, d-amphetamine...
  6. doi request reprint The role of dopamine in alcohol self-administration in humans: individual differences
    Sean P Barrett
    Psychology Department, McGill University, 1033 Pine Avenue West, Montreal, Quebec, Canada
    Eur Neuropsychopharmacol 18:439-47. 2008
    ..To clarify dopamine's role in alcohol self-administration in a heterogeneous sample of drinkers using acute phenylalanine/tyrosine depletion (APTD)...
  7. ncbi request reprint Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa
    Kenneth R Bruce
    Eating Disorders Program, Research Centre, Douglas Hospital, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
    Am J Med Genet B Neuropsychiatr Genet 137:40-4. 2005
    ..These findings implicate the GG genotype in the co-aggregation of impulsive behaviors and alterations of post-synaptic 5-HT functioning in women with BN...
  8. pmc Impact of acute tryptophan depletion on mood and eating-related urges in bulimic and nonbulimic women
    Kenneth R Bruce
    Eating Disorders Program, Douglas Institute, Montreal, Canada
    J Psychiatry Neurosci 34:376-82. 2009
    ..We investigated mood and other consequences of ATD in women with bulimia nervosa who were or were not using concurrent serotonergic medications compared with women without bulimia...
  9. ncbi request reprint Intrafamilial correspondences on platelet [3H-]paroxetine-binding indices in bulimic probands and their unaffected first-degree relatives
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, Montreal, QC, Canada
    Neuropsychopharmacology 31:1785-92. 2006
    ..We propose that, under conducive circumstances, such a trait may increase risk of binge-eating behavior, or associated symptoms of affective or behavioral dysregulation...
  10. pmc The effect of raising and lowering tryptophan levels on human mood and social behaviour
    Simon N Young
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Philos Trans R Soc Lond B Biol Sci 368:20110375. 2013
    ....
  11. ncbi request reprint Bright light exposure during acute tryptophan depletion prevents a lowering of mood in mildly seasonal women
    Marije aan het Rot
    Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Eur Neuropsychopharmacol 18:14-23. 2008
    ..Bright light might help protect against ATD-induced mood change by increasing serotonin above the threshold level below which there is a lowering of mood...
  12. pmc Social behaviour and mood in everyday life: the effects of tryptophan in quarrelsome individuals
    Marije aan het Rot
    Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec
    J Psychiatry Neurosci 31:253-62. 2006
    ....
  13. doi request reprint Recognizing emotions in faces: effects of acute tryptophan depletion and bright light
    Marije aan het Rot
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Psychopharmacol 24:1447-54. 2010
    ..The effects of ATD on facial emotion perception may be less emotion-specific than thought previously, and occurred in a direction opposite to what might be expected based on theories of mood-congruent bias...
  14. ncbi request reprint The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-] paroxetine binding in bulimic syndromes
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
    Int J Eat Disord 37:57-60. 2005
    ....
  15. ncbi request reprint Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokers
    Kevin F Casey
    Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Eur Neuropsychopharmacol 16:512-20. 2006
    ..Nicotine increases dopamine (DA) release but its role in nicotine dependence remains unclear...
  16. ncbi request reprint Tryptophan, serotonin and human social behavior
    Deborah S Moskowitz
    Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1
    Adv Exp Med Biol 527:215-24. 2003
    ..Tryptophan caused a significant decrease in quarrelsome behaviors and a significant increase in dominant behaviors...
  17. pmc A new method for rapidly and simultaneously decreasing serotonin and catecholamine synthesis in humans
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Que
    J Psychiatry Neurosci 28:464-7. 2003
    ..In the present study, we assessed whether a mixture that was simultaneously deficient in tryptophan, phenylalanine and tyrosine could induce sufficient protein synthesis that plasma levels of all 3 monoamine precursors would decrease...
  18. pmc Serotonergic contribution to boys' behavioral regulation
    Amélie Nantel-Vivier
    Psychology Department, McGill University, Montreal, Canada
    PLoS ONE 6:e20304. 2011
    ..Whether these findings apply to children is unclear. The present study investigated serotonergic functioning in boys with a history of behavior regulation difficulties through a double-blind, acute tryptophan supplementation procedure...
  19. ncbi request reprint Lack of effects on core obsessive-compulsive symptoms of tryptophan depletion during symptom provocation in remitted obsessive-compulsive disorder patients
    Alexandre Berney
    Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, Canada
    Biol Psychiatry 59:853-7. 2006
    ..We hypothesized that the putative symptom exacerbation resulting from ATD would only be observed during symptom provocation but not at rest...
  20. pmc Dopamine and light: dissecting effects on mood and motivational states in women with subsyndromal seasonal affective disorder
    Elizabeth I Cawley
    Department of Psychiatry, McGill University, Montreal, Que, Canada
    J Psychiatry Neurosci 38:388-97. 2013
    ..In the present study, we measured the effects of transiently decreasing dopamine (DA) synthesis on mood and motivational states in healthy women with mild seasonal mood changes who were tested in either bright or dim light...
  21. doi request reprint Alcohol in a social context: findings from event-contingent recording studies of everyday social interactions
    Marije aan het Rot
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Alcohol Clin Exp Res 32:459-71. 2008
    ..Data concerning the effects of alcohol on social interaction in everyday life are limited...
  22. pmc The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, 6875 LaSalle Blvd, Montreal QC H4H 1R3, Canada
    J Psychiatry Neurosci 32:354-62. 2007
    ..In women with bulimic syndromes, we explored associations with personality pathology of 5HTTLPR and prior sexual or physical maltreatment...
  23. ncbi request reprint Laxative misuse and behavioral disinhibition in bulimia nervosa
    Kenneth R Bruce
    Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
    Int J Eat Disord 33:92-7. 2003
    ..Various reports suggest that purging with laxatives is associated with greater behavioral impulsivity in bulimia nervosa (BN) patients. We investigated the extent to which laxative misuse corresponds to specific impulse-control problems...
  24. ncbi request reprint Sweet taste and blood pressure-related analgesia
    Maxim D Lewkowski
    Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, Que, Canada H3A 1B1
    Pain 106:181-6. 2003
    ..Individuals with higher blood pressure may not be as sensitive to the presumably opioid-mediated analgesic effects of sweet taste, perhaps due to opioid dysregulation...
  25. ncbi request reprint Implications of compulsive and impulsive traits for serotonin status in women with bulimia nervosa
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada
    Psychiatry Res 120:219-29. 2003
    ..Our findings suggest that 5-HT status in BN may correspond to impulsive or compulsive traits, and they encourage multidimensional modeling of the pathophysiological role of 5-HT in BN...
  26. doi request reprint The effect of acute tryptophan depletion on mood and impulsivity in polydrug ecstasy users
    Simon N Young
    Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada
    Psychopharmacology (Berl) 231:707-16. 2014
    ..Several studies suggest users of 3,4-methylenedioxymethamphetamine (ecstasy) have low levels of serotonin. Low serotonin may make them susceptible to lowered mood...
  27. pmc Single treatments that have lasting effects: some thoughts on the antidepressant effects of ketamine and botulinum toxin and the anxiolytic effect of psilocybin
    Simon N Young
    Department of Psychiatry, McGill University, Montreal, Que
    J Psychiatry Neurosci 38:78-83. 2013
    ....
  28. pmc The effect of methionine and S-adenosylmethionine on S-adenosylmethionine levels in the rat brain
    Simon N Young
    Department of Psychiatry, McGill University, Montreal, QC
    J Psychiatry Neurosci 30:44-8. 2005
    ..We also aimed to test the relative abilities of SAMe and methionine to increase tail-flick latency after a thermal stimulus. This test was used to measure changes in CNS function...
  29. ncbi request reprint Serotonin function, personality-trait variations, and childhood abuse in women with bulimia-spectrum eating disorders
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, Verdun, Quebec, Canada
    J Clin Psychiatry 65:830-7. 2004
    ..We explored relationships among measures of 5-HT system functioning, behavioral inhibition/disinhibition, and childhood abuse in women with bulimia-spectrum eating syndromes...
  30. pmc Possible role of more positive social behaviour in the clinical effect of antidepressant drugs
    Simon N Young
    Department of Psychiatry, McGill University, Montreal, Que, Canada
    J Psychiatry Neurosci 39:60-5. 2014
    ..The more positive social responses of interaction partners would initiate a cycle of more positive social behaviour, and this iterative process would result in a clinically significant improvement in mood. ..
  31. doi request reprint Salivary cortisol and interpersonal functioning: an event-contingent recording study in the offspring of parents with bipolar disorder
    Mark A Ellenbogen
    Centre for Research in Human Development, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Psychoneuroendocrinology 38:997-1006. 2013
    ....
  32. ncbi request reprint Effects of opioid blockade on the modulation of pain and mood by sweet taste and blood pressure in young adults
    Maxim D Lewkowski
    Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, Canada
    Pain 135:75-81. 2008
    ..These results are consistent with findings suggesting that endogenous opioid activity may contribute to generally reduced pain sensitivity, and perhaps mood reactivity, in those with higher BP...
  33. ncbi request reprint Decreasing amphetamine-induced dopamine release by acute phenylalanine/tyrosine depletion: A PET/[11C]raclopride study in healthy men
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 29:427-32. 2004
    ..82, p<0.05). Together, the results provide the first direct evidence that APTD decreases stimulated DA release in human brain. APTD may be a suitable new tool for human neuropsychopharmacology research...
  34. pmc The 25th annual meeting of the Canadian College of Neuropsychopharmacology. Ottawa, Ontario, Canada, June 9-12, 2002
    Marco Leyton
    Department of Psychiatry, McGill University, 1033 Pine Ave W, Montreal, QC H3A 1A1
    J Psychiatry Neurosci 27:438-50. 2002
  35. pmc Are SAMe and 5-HTP safe and effective treatments for depression?
    Simon N Young
    Department of Psychiatry, McGill University, Montreal, Que
    J Psychiatry Neurosci 28:471. 2003
  36. ncbi request reprint A typical feeding enhances memory for spoken words in healthy 2- to 3-day-old newborns
    A Grace Valiante
    Department of Developmental Pediatrics, Montreal Children s Hospital, McGill University Health Centre, Montreal, QC, Canada
    Pediatrics 117:e476-86. 2006
    ....
  37. pmc Fish oils for depression?
    Simon N Young
    Department of Psychiatry, McGill University, Montreal, Canada
    J Psychiatry Neurosci 33:80. 2008
  38. pmc L-tyrosine to alleviate the effects of stress?
    Simon N Young
    Department of Psychiatry, McGill University, Montreal, Canada
    J Psychiatry Neurosci 32:224. 2007
  39. ncbi request reprint Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation
    Pierre Blier
    Department of Psychiatry, McGill University, Montreal, Canada
    Neuropsychopharmacology 27:301-8. 2002
    ....
  40. ncbi request reprint Prolonged and unsoothable crying bouts in infants with and without colic
    Ronald G Barr
    Departments of Pediatrics and Psychiatry, McGill University and the McGill University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    J Dev Behav Pediatr 26:14-23. 2005
    ..These features of parental experience may be important in preventive efforts to reduce negative impacts of early increased crying such as shaken baby syndrome...
  41. ncbi request reprint Estrogen administration negatively alters mood following monoaminergic depletion and psychosocial stress in postmenopausal women
    Paul A Newhouse
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05401, USA
    Neuropsychopharmacology 33:1514-27. 2008
    ..This modulation appears to be independent of alterations in monoaminergic neurotransmission. The dose of estrogen used after menopause may be important in determining the effects of gonadal steroids on emotional regulation...
  42. pmc How to increase serotonin in the human brain without drugs
    Simon N Young
    J Psychiatry Neurosci 32:394-9. 2007
  43. ncbi request reprint Effects of tryptophan depletion on acute smoking abstinence symptoms and the acute smoking response
    Mary Perugini
    Department of Psychology, Rehabilitation Centre, Ottawa Hospital, Ottawa, ON, Canada
    Pharmacol Biochem Behav 74:513-22. 2003
    ..These results, although not supporting a role for the serotonergic system in acute smoking and early smoking abstinence symptoms, are discussed in relation to the neuropharmacology of smoking behavior and suggestions for future work...
  44. pmc Folate and depression--a neglected problem
    Simon N Young
    J Psychiatry Neurosci 32:80-2. 2007
  45. pmc Lifestyle drugs, mood, behaviour and cognition
    Simon N Young
    J Psychiatry Neurosci 28:87-9. 2003
  46. pmc The ethics of placebo in clinical psychopharmacology: the urgent need for consistent regulation
    Simon N Young
    J Psychiatry Neurosci 27:319-21. 2002