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Genomes and GenesSpecies | Simon N YoungSummaryAffiliation: McGill University Country: Canada Publications
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Publications
Clinical nutrition: 3. The fuzzy boundary between nutrition and psychopharmacologySimon N Young
Department of Psychiatry, McGill University, Montreal, Que
CMAJ 166:205-9. 2002- Ecological momentary assessment: what it is and why it is a method of the future in clinical psychopharmacologyDebbie S Moskowitz
Department of Psychology, McGill University, Montreal, Que
J Psychiatry Neurosci 31:13-20. 2006..EMA methods will permit more sensitive assessments and will enable more wide-ranging and detailed measurements of mood and behaviour. These types of methods should be adopted more widely by clinical psychopharmacology researchers... 
Glucose enhances newborn memory for spoken wordsPamela Horne
McGill University-Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada
Dev Psychobiol 48:574-82. 2006..Only infants who subsequently oriented towards a different word, indicating that they remained alert, were used in the data analysis. The results suggest that glucose enhanced memory for a spoken word in neonates...- The role of serotonin in human mood and social interaction. Insight from altered tryptophan levelsSimon N Young
Department of Psychiatry, McGill University, 1033 Pine Avenue West, H3A 1A1, Montreal, Quebec, Canada
Pharmacol Biochem Behav 71:857-65. 2002..Higher levels of serotonin may help to promote more constructive social interactions by decreasing aggression and increasing dominance... - Mood-elevating effects of d-amphetamine and incentive salience: the effect of acute dopamine precursor depletionMarco Leyton
Department of Psychiatry, McGill University, Montreal, Que
J Psychiatry Neurosci 32:129-36. 2007..In the present study, we tested whether decreasing dopamine synthesis, as produced by acute phenylalanine/tyrosine depletion (APTD), would alter responses to the stimulant drug, d-amphetamine... 
The role of dopamine in alcohol self-administration in humans: individual differencesSean P Barrett
Psychology Department, McGill University, 1033 Pine Avenue West, Montreal, Quebec, Canada
Eur Neuropsychopharmacol 18:439-47. 2008..To clarify dopamine's role in alcohol self-administration in a heterogeneous sample of drinkers using acute phenylalanine/tyrosine depletion (APTD)...- Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosaKenneth R Bruce
Eating Disorders Program, Research Centre, Douglas Hospital, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
Am J Med Genet B Neuropsychiatr Genet 137:40-4. 2005..These findings implicate the GG genotype in the co-aggregation of impulsive behaviors and alterations of post-synaptic 5-HT functioning in women with BN... - Impact of acute tryptophan depletion on mood and eating-related urges in bulimic and nonbulimic womenKenneth R Bruce
Eating Disorders Program, Douglas Institute, Montreal, Canada
J Psychiatry Neurosci 34:376-82. 2009..We investigated mood and other consequences of ATD in women with bulimia nervosa who were or were not using concurrent serotonergic medications compared with women without bulimia... - Intrafamilial correspondences on platelet [3H-]paroxetine-binding indices in bulimic probands and their unaffected first-degree relativesHoward Steiger
Eating Disorders Program, Douglas Hospital, Montreal, QC, Canada
Neuropsychopharmacology 31:1785-92. 2006..We propose that, under conducive circumstances, such a trait may increase risk of binge-eating behavior, or associated symptoms of affective or behavioral dysregulation... - Bright light exposure during acute tryptophan depletion prevents a lowering of mood in mildly seasonal womenMarije aan het Rot
Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
Eur Neuropsychopharmacol 18:14-23. 2008..Bright light might help protect against ATD-induced mood change by increasing serotonin above the threshold level below which there is a lowering of mood... - The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-] paroxetine binding in bulimic syndromesHoward Steiger
Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
Int J Eat Disord 37:57-60. 2005.... - Social behaviour and mood in everyday life: the effects of tryptophan in quarrelsome individualsMarije aan het Rot
Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec
J Psychiatry Neurosci 31:253-62. 2006.... - Recognizing emotions in faces: effects of acute tryptophan depletion and bright lightMarije aan het Rot
Department of Psychiatry, McGill University, Montreal, Quebec, Canada
J Psychopharmacol 24:1447-54. 2010..The effects of ATD on facial emotion perception may be less emotion-specific than thought previously, and occurred in a direction opposite to what might be expected based on theories of mood-congruent bias... - A new method for rapidly and simultaneously decreasing serotonin and catecholamine synthesis in humansMarco Leyton
Department of Psychiatry, McGill University, Montreal, Que
J Psychiatry Neurosci 28:464-7. 2003..In the present study, we assessed whether a mixture that was simultaneously deficient in tryptophan, phenylalanine and tyrosine could induce sufficient protein synthesis that plasma levels of all 3 monoamine precursors would decrease... - Tryptophan, serotonin and human social behaviorDeborah S Moskowitz
Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1
Adv Exp Med Biol 527:215-24. 2003..Tryptophan caused a significant decrease in quarrelsome behaviors and a significant increase in dominant behaviors... - Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokersKevin F Casey
Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
Eur Neuropsychopharmacol 16:512-20. 2006.... - Serotonergic contribution to boys' behavioral regulationAmélie Nantel-Vivier
Psychology Department, McGill University, Montreal, Canada
PLoS ONE 6:e20304. 2011..Whether these findings apply to children is unclear. The present study investigated serotonergic functioning in boys with a history of behavior regulation difficulties through a double-blind, acute tryptophan supplementation procedure... - Lack of effects on core obsessive-compulsive symptoms of tryptophan depletion during symptom provocation in remitted obsessive-compulsive disorder patientsAlexandre Berney
Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, Canada
Biol Psychiatry 59:853-7. 2006..In contrast to its apparent lack of effect on core OC symptoms, ATD affected the patient's mood and distress level resulting from provocation... - Alcohol in a social context: findings from event-contingent recording studies of everyday social interactionsMarije aan het Rot
Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Alcohol Clin Exp Res 32:459-71. 2008..Data concerning the effects of alcohol on social interaction in everyday life are limited... - The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromesHoward Steiger
Eating Disorders Program, Douglas Hospital, 6875 LaSalle Blvd, Montreal QC H4H 1R3, Canada
J Psychiatry Neurosci 32:354-62. 2007..In women with bulimic syndromes, we explored associations with personality pathology of 5HTTLPR and prior sexual or physical maltreatment... - Implications of compulsive and impulsive traits for serotonin status in women with bulimia nervosaHoward Steiger
Eating Disorders Program, Douglas Hospital, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada
Psychiatry Res 120:219-29. 2003..Our findings suggest that 5-HT status in BN may correspond to impulsive or compulsive traits, and they encourage multidimensional modeling of the pathophysiological role of 5-HT in BN... - Sweet taste and blood pressure-related analgesiaMaxim D Lewkowski
Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, Que, Canada H3A 1B1
Pain 106:181-6. 2003..Individuals with higher blood pressure may not be as sensitive to the presumably opioid-mediated analgesic effects of sweet taste, perhaps due to opioid dysregulation... - Laxative misuse and behavioral disinhibition in bulimia nervosaKenneth R Bruce
Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
Int J Eat Disord 33:92-7. 2003..Various reports suggest that purging with laxatives is associated with greater behavioral impulsivity in bulimia nervosa (BN) patients. We investigated the extent to which laxative misuse corresponds to specific impulse-control problems... - The effect of methionine and S-adenosylmethionine on S-adenosylmethionine levels in the rat brainSimon N Young
Department of Psychiatry, McGill University, Montreal, QC
J Psychiatry Neurosci 30:44-8. 2005..We also aimed to test the relative abilities of SAMe and methionine to increase tail-flick latency after a thermal stimulus. This test was used to measure changes in CNS function... - Serotonin function, personality-trait variations, and childhood abuse in women with bulimia-spectrum eating disordersHoward Steiger
Eating Disorders Program, Douglas Hospital, Verdun, Quebec, Canada
J Clin Psychiatry 65:830-7. 2004..We explored relationships among measures of 5-HT system functioning, behavioral inhibition/disinhibition, and childhood abuse in women with bulimia-spectrum eating syndromes... - Effects of opioid blockade on the modulation of pain and mood by sweet taste and blood pressure in young adultsMaxim D Lewkowski
Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, Canada
Pain 135:75-81. 2008..These results are consistent with findings suggesting that endogenous opioid activity may contribute to generally reduced pain sensitivity, and perhaps mood reactivity, in those with higher BP... - Decreasing amphetamine-induced dopamine release by acute phenylalanine/tyrosine depletion: A PET/[11C]raclopride study in healthy menMarco Leyton
Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Neuropsychopharmacology 29:427-32. 2004..82, p<0.05). Together, the results provide the first direct evidence that APTD decreases stimulated DA release in human brain. APTD may be a suitable new tool for human neuropsychopharmacology research... - Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediationPierre Blier
Department of Psychiatry, McGill University, Montreal, Canada
Neuropsychopharmacology 27:301-8. 2002.... - Are SAMe and 5-HTP safe and effective treatments for depression?Simon N Young
Department of Psychiatry, McGill University, Montreal, Que
J Psychiatry Neurosci 28:471. 2003 - A typical feeding enhances memory for spoken words in healthy 2- to 3-day-old newbornsA Grace Valiante
Department of Developmental Pediatrics, Montreal Children s Hospital, McGill University Health Centre, Montreal, QC, Canada
Pediatrics 117:e476-86. 2006.... - The 25th annual meeting of the Canadian College of Neuropsychopharmacology. Ottawa, Ontario, Canada, June 9-12, 2002Marco Leyton
Department of Psychiatry, McGill University, 1033 Pine Ave. W, Montreal, QC H3A 1A1
J Psychiatry Neurosci 27:438-50. 2002 - Fish oils for depression?Simon N Young
Department of Psychiatry, McGill University, Montreal, Canada
J Psychiatry Neurosci 33:80. 2008 - L-tyrosine to alleviate the effects of stress?Simon N Young
Department of Psychiatry, McGill University, Montreal, Canada
J Psychiatry Neurosci 32:224. 2007 - Prolonged and unsoothable crying bouts in infants with and without colicRonald G Barr
Departments of Pediatrics and Psychiatry, McGill University and the McGill University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
J Dev Behav Pediatr 26:14-23. 2005..These features of parental experience may be important in preventive efforts to reduce negative impacts of early increased crying such as shaken baby syndrome... - How to increase serotonin in the human brain without drugsSimon N Young
J Psychiatry Neurosci 32:394-9. 2007 - Estrogen administration negatively alters mood following monoaminergic depletion and psychosocial stress in postmenopausal womenPaul A Newhouse
Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05401, USA
Neuropsychopharmacology 33:1514-27. 2008..This modulation appears to be independent of alterations in monoaminergic neurotransmission. The dose of estrogen used after menopause may be important in determining the effects of gonadal steroids on emotional regulation... - Effects of tryptophan depletion on acute smoking abstinence symptoms and the acute smoking responseMary Perugini
Department of Psychology, Rehabilitation Centre, Ottawa Hospital, Ottawa, ON, Canada
Pharmacol Biochem Behav 74:513-22. 2003..These results, although not supporting a role for the serotonergic system in acute smoking and early smoking abstinence symptoms, are discussed in relation to the neuropharmacology of smoking behavior and suggestions for future work... - The ethics of placebo in clinical psychopharmacology: the urgent need for consistent regulationSimon N Young
J Psychiatry Neurosci 27:319-21. 2002 - Folate and depression--a neglected problemSimon N Young
J Psychiatry Neurosci 32:80-2. 2007 - Lifestyle drugs, mood, behaviour and cognitionSimon N Young
J Psychiatry Neurosci 28:87-9. 2003