Research Topics
Genomes and Genes
| Xiang Jiao YangSummaryAffiliation: McGill University Country: Canada Publications
| Collaborators
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Detail Information
Publications
A recurrent phospho-sumoyl switch in transcriptional repression and beyondXiang Jiao Yang
Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec H3A 1A1, Canada
Mol Cell 23:779-86. 2006..This motif is present in many proteins, integrates cellular signals from diverse pathways, and serves as a valuable signature for in silico identification of proteins regulated by adjacent phosphorylation and sumoylation...
Lysine acetylation: codified crosstalk with other posttranslational modificationsXiang Jiao Yang
Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, QC H3A1A1, Canada
Mol Cell 31:449-61. 2008....- Class II histone deacetylases: from sequence to function, regulation, and clinical implicationXiang-Jiao Yang
Molecular Oncology Group, Royal Victoria Hospital, Room H5.41, McGill University Health Center, 687 Pine Ave. West, , Quebec H3A 1A1, Canada
Mol Cell Biol 25:2873-84. 2005 - HATs and HDACs: from structure, function and regulation to novel strategies for therapy and preventionX J Yang
Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
Oncogene 26:5310-8. 2007.... - Lysine acetylation and the bromodomain: a new partnership for signalingXiang Jiao Yang
Molecular Oncology Group, Royal Victoria Hospital, Room H5 41, Department of Medicine, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
Bioessays 26:1076-87. 2004..Therefore, lysine acetylation forges a novel signaling partnership with bromodomains to govern the temporal and spatial regulation of protein functions in vivo... - Metabolism, cytoskeleton and cellular signalling in the grip of protein Nepsilon - and O-acetylationXiang Jiao Yang
Molecular Oncology Group, Department of Medicine, Royal Victoria Hospital, Room H5 41, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
EMBO Rep 8:556-62. 2007..Thus, N(epsilon)- and O-acetylation are becoming recognized as two prominent mechanisms for regulating protein functions in diverse organisms... - The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and menXiang Jiao Yang
Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, H3A 1A1, Canada
Nat Rev Mol Cell Biol 9:206-18. 2008..Little is known about class IV HDAC11, although its evolutionary conservation implies a fundamental role in various organisms... - Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylasesAudrey H Wang
Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
J Biol Chem 280:29117-27. 2005..These results identify ANKRA, RFXANK, and CIITA as novel targets of class IIa HDACs and suggest that these deacetylases play a role in regulating MHCII expression... - Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factorsSerge Gregoire
Molecular Oncology Group, Department of Medicine, McGill University Health Centre, 687 Pine Ave West, Montreal, Quebec H3A 1A1, Canada
Mol Cell Biol 25:2273-87. 2005..These results thus identify sumoylation as a novel regulatory mechanism for MEF2 and suggest that this modification interplays with phosphorylation to promote intramolecular signaling for coordinated regulation in vivo... - Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2Serge Gregoire
Molecular Oncology Group, Royal Victoria Hospital, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
Mol Cell Biol 27:1280-95. 2007..These results reveal an unexpected role for HDAC3 and suggest a novel pathway through which MEF2 activity is controlled in vivo... - Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylasesDonald R Walkinshaw
Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada
J Biol Chem 288:5591-605. 2013..These results thus unravel a previously unrecognized mechanism whereby cAMP promotes dephosphorylation and differentially regulates multisite phosphorylation and the nuclear localization of class IIa HDACs... - Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylationSerge Gregoire
Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
J Biol Chem 281:4423-33. 2006.... - Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domainJenny J Tong
Molecular Oncology Group, Department of Medicine, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
Nucleic Acids Res 30:1114-23. 2002..Furthermore, HDAC10 interacts with HDAC3 but not with HDAC4 or HDAC6. These results indicate that HDAC10 is a novel class II histone deacetylase possessing a unique leucine-rich domain... - Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retentionNicholas R Bertos
Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
J Biol Chem 279:48246-54. 2004.... - Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanismsIsabelle Fernandes
Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6
Mol Cell 11:139-50. 2003..LCoR represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms... - Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motifAnnie M Tremblay
Molecular Oncology Group, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
Mol Endocrinol 22:570-84. 2008..Taken together, these results show that the interplay of phosphorylation and sumoylation in the amino-terminal domain provides an additional mechanism to regulate the transcriptional activity of ERRalpha and -gamma... - Function of histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoRAna Palijan
Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 284:30264-74. 2009..Taken together, these data establish that HDAC6 can function as a cofactor of LCoR but suggest that they may act in enhance expressing some target genes... - Corepressor recruitment by agonist-bound nuclear receptorsJohn H White
Department of Physiology, McGill University, McIntyre Medical Sciences Bldg, Montreal, Quebec H3G 1Y6, Canada
Vitam Horm 68:123-43. 2004.... - MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2Nadine Pelletier
Molecular Oncology Group, Department of Medicine, McGill University Health Center, Quebec, Canada
Oncogene 21:2729-40. 2002..These results thus identify Runx2 as an interaction partner of MOZ and MORF and suggest that both acetyltransferases are involved in regulating transcriptional activation mediated by Runx2 and its homologues... - Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexesMukta Ullah
Department of Medicine, McGill University Health Centre, Montreal, Quebec H3G 0B1, Canada
Mol Cell Biol 28:6828-43. 2008..These findings thus indicate that BRPF proteins play a key role in assembling and activating MOZ/MORF acetyltransferase complexes... - The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseasesXiang Jiao Yang
Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec H3A 1A1, Canada
Nucleic Acids Res 32:959-76. 2004..Therefore, the diverse superfamily of lysine acetyltransferases executes an acetylation program that is important for different cellular processes and perturbation of such a program may cause the development of cancer and other diseases... 
Analysis of protein lysine acetylation in vitro and in vivoNadine Pelletier
Rosalind and Morris Goodman Cancer Center and Department of Medicine, McGill University, Montreal, Canada
Curr Protoc Protein Sci . 2008..This unit describes and discusses methods used for in vitro and in vivo determination of lysine acetylation...- Lysine acetylation: enzymes, bromodomains and links to different diseasesLinya You
The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada
Essays Biochem 52:1-12. 2012..In this chapter, we provide a brief overview of these proteins and emphasize their direct links to related human diseases... - Reconstitution of active and stoichiometric multisubunit lysine acetyltransferase complexes in insect cellsKezhi Yan
Department of Biochemistry, The Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada
Methods Mol Biol 809:445-64. 2012..Similar methods have been used for reconstituting active complexes of histone deacetylases, lysine demethylases, and ubiquitin ligases, so this simple approach can be adapted for molecular dissection of various multisubunit complexes... - Histone deacetylases as transducers and targets of nuclear signalingDonald R Walkinshaw
Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada H3A 1A1
J Cell Biochem 104:1541-52. 2008..Here, we examine the nuclear roles of these enzymes, with a specific focus on their active crosstalk with different chromatin regulators... - Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferationNikita Avvakumov
Laval University Cancer Research Center, Hotel Dieu de Quebec, Quebec City, Quebec, Canada
Mol Cell Biol 32:689-703. 2012..These results demonstrate the importance of ING association with MYST acetyltransferases in controlling cell proliferation, a regulated link that accounts for the reported tumor suppressor activities of these complexes... - Comprehensive lysine acetylomes emerging from bacteria to humansGo Woon Kim
The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada
Trends Biochem Sci 36:211-20. 2011.... - Multisite protein modification and intramolecular signalingXiang Jiao Yang
Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada H3A 1A1
Oncogene 24:1653-62. 2005..Multisite modification thus coordinates intermolecular and intramolecular signaling for the qualitative and quantitative control of protein function in vivo... - A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cellsMaite Hernandez
Departments of Medicine, Oncology, and Pharmacology and Therapeutics, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, McGill University, 3755 Chemin de la Cote Ste-Catherine, Montreal, Quebec, Canada
Prostate 66:1151-61. 2006..TSA increased the level of hyperacetylated histones bound to cx43 promoter. CONCLUSION: Our results highlight the potential utility of inhibitors of HDAC to restore cx43 gene expression in prostate cancer... - K-acetylation and its enzymes: overview and new developmentsJuliette Adjo Aka
The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, QC, Canada
Handb Exp Pharmacol 206:1-12. 2011.... - YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human diseaseKainan Wang
Department of Medicine, McGill University Health Centre, Montreal, QCH3A1A1, Canada
Biochem Cell Biol 87:77-91. 2009.... - Transforming growth factor-beta inhibits telomerase through SMAD3 and E2F transcription factorsAnnie Lacerte
Hormones and Cancer Research Unit, Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, H3A 1A1, Montreal, Quebec, Canada
Cell Signal 20:50-9. 2008..These findings highlight the prominent role of TGFbeta in regulating telomerase expression and identify Smad3 and E2F-1 as critical mediators of TGFbeta effects in both normal and cancer cells... - Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseasesClaire Bonfils
MethylGene, Inc, 7220 Frederick Banting, Montreal, Quebec H4S 2A1, Canada
Expert Opin Drug Discov 3:1041-65. 2008..The identification of the appropriate target spectrum and the development of class- or isotype-selective inhibitors will be central events in the future... - Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expressionXiang-Jiao Yang
Molecular Oncology Group, Department of Medicine, McGill University Health Centre, , , Canada
Curr Opin Genet Dev 13:143-53. 2003..Histone deacetylases are important targets for drugs with potential therapeutic value in the treatment of cancer, neurodegenerative disorders, cardiac hypertrophy and other human diseases... - Expression, purification, and analysis of MOZ and MORF histone acetyltransferasesNadine Pelletier
Molecular Oncology Group, Department of Medicine, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada
Methods 31:24-32. 2003..These methods are useful not only for functional characterization of MOZ, MORF, PCAF, and other HATs, but also for preparation of HAT proteins to screen compound libraries and obtain inhibitors with potential therapeutic value... - HDAC6 modulates cell motility by altering the acetylation level of cortactinXiaohong Zhang
Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Mol Cell 27:197-213. 2007.... - MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylationYetao Jin
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
J Biol Chem 277:30838-43. 2002..These results demonstrate that MDM2 can inhibit PCAF-mediated p53 acetylation and activation... - Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activityJonathan K L Chan
Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
J Biol Chem 278:23515-21. 2003..Combined with data from others, our data suggest that the full-length HDAC4 can repress MEF2 through multiple independent repressive domains... - Substrate and functional diversity of lysine acetylation revealed by a proteomics surveySung Chan Kim
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Mol Cell 23:607-18. 2006..The combined data sets offer a rich source for further characterization of the contribution of this modification to cellular physiology and human diseases... - Caspase-mediated specific cleavage of human histone deacetylase 4Fang Liu
Department of Radiation Oncology, University of Pennsylvania School of Medicine, John Morgan 180H, Philadelphia, PA 19104, USA
J Biol Chem 279:34537-46. 2004..These results therefore unexpectedly link the regulation of HDAC4 protein stability to caspases, enzymes that are important for controlling cell death and differentiation... - ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuationYannick Doyon
Laval University Cancer Research Center, , , , Canada
Mol Cell 21:51-64. 2006..Since INGs, HBO1, and MOZ/MORF contribute to oncogenic transformation, the multisubunit assemblies characterized here underscore the critical role of epigenetic regulation in cancer development... - Dephosphorylation and caspase processing generate distinct nuclear pools of histone deacetylase 4Gabriela Paroni
Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Biologia, and MATI Center of Excellence, Universita di Udine, Udine, Italy
Mol Cell Biol 27:6718-32. 2007..These two nuclear pools of HDAC4 are characterized by different repression potentials and divergent dynamics of chromatin interaction... - Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiationLuguo Sun
Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
J Cell Sci 117:3021-9. 2004.... - PCAF is a coactivator for p73-mediated transactivationLisa Y Zhao
Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL 32610 0235, USA
Oncogene 22:8316-29. 2003..Furthermore, cotransfection of PCAF and p73 leads to increased apoptosis and reduced colony formation. Collectively, these data suggest that p73 recruit PCAF to specific promoters to activate the transcription of p73 target genes... - p38 Mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expressionQing Xu
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
Mol Biol Cell 13:1940-52. 2002....