Xiang Jiao Yang

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint A recurrent phospho-sumoyl switch in transcriptional repression and beyond
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec H3A 1A1, Canada
    Mol Cell 23:779-86. 2006
  2. pmc The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, H3A 1A1, Canada
    Nat Rev Mol Cell Biol 9:206-18. 2008
  3. pmc Lysine acetylation: codified crosstalk with other posttranslational modifications
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, QC H3A1A1, Canada
    Mol Cell 31:449-61. 2008
  4. ncbi request reprint HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention
    X J Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
    Oncogene 26:5310-8. 2007
  5. ncbi request reprint Lysine acetylation and the bromodomain: a new partnership for signaling
    Xiang Jiao Yang
    Molecular Oncology Group, Royal Victoria Hospital, Room H5 41, Department of Medicine, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Bioessays 26:1076-87. 2004
  6. pmc Class II histone deacetylases: from sequence to function, regulation, and clinical implication
    Xiang Jiao Yang
    Molecular Oncology Group, Royal Victoria Hospital, Room H5 41, McGill University Health Center, 687 Pine Ave West, Montreal, Quebec H3A 1A1, Canada
    Mol Cell Biol 25:2873-84. 2005
  7. pmc Metabolism, cytoskeleton and cellular signalling in the grip of protein Nepsilon - and O-acetylation
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, Royal Victoria Hospital, Room H5 41, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    EMBO Rep 8:556-62. 2007
  8. ncbi request reprint Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases
    Audrey H Wang
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 280:29117-27. 2005
  9. pmc Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors
    Serge Gregoire
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, 687 Pine Ave West, Montreal, Quebec H3A 1A1, Canada
    Mol Cell Biol 25:2273-87. 2005
  10. pmc Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2
    Serge Gregoire
    Molecular Oncology Group, Royal Victoria Hospital, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Mol Cell Biol 27:1280-95. 2007

Collaborators

Detail Information

Publications48

  1. ncbi request reprint A recurrent phospho-sumoyl switch in transcriptional repression and beyond
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec H3A 1A1, Canada
    Mol Cell 23:779-86. 2006
    ..This motif is present in many proteins, integrates cellular signals from diverse pathways, and serves as a valuable signature for in silico identification of proteins regulated by adjacent phosphorylation and sumoylation...
  2. pmc The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, H3A 1A1, Canada
    Nat Rev Mol Cell Biol 9:206-18. 2008
    ..Little is known about class IV HDAC11, although its evolutionary conservation implies a fundamental role in various organisms...
  3. pmc Lysine acetylation: codified crosstalk with other posttranslational modifications
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, QC H3A1A1, Canada
    Mol Cell 31:449-61. 2008
    ....
  4. ncbi request reprint HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention
    X J Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
    Oncogene 26:5310-8. 2007
    ....
  5. ncbi request reprint Lysine acetylation and the bromodomain: a new partnership for signaling
    Xiang Jiao Yang
    Molecular Oncology Group, Royal Victoria Hospital, Room H5 41, Department of Medicine, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Bioessays 26:1076-87. 2004
    ..Therefore, lysine acetylation forges a novel signaling partnership with bromodomains to govern the temporal and spatial regulation of protein functions in vivo...
  6. pmc Class II histone deacetylases: from sequence to function, regulation, and clinical implication
    Xiang Jiao Yang
    Molecular Oncology Group, Royal Victoria Hospital, Room H5 41, McGill University Health Center, 687 Pine Ave West, Montreal, Quebec H3A 1A1, Canada
    Mol Cell Biol 25:2873-84. 2005
  7. pmc Metabolism, cytoskeleton and cellular signalling in the grip of protein Nepsilon - and O-acetylation
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, Royal Victoria Hospital, Room H5 41, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    EMBO Rep 8:556-62. 2007
    ..Thus, N(epsilon)- and O-acetylation are becoming recognized as two prominent mechanisms for regulating protein functions in diverse organisms...
  8. ncbi request reprint Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases
    Audrey H Wang
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 280:29117-27. 2005
    ..These results identify ANKRA, RFXANK, and CIITA as novel targets of class IIa HDACs and suggest that these deacetylases play a role in regulating MHCII expression...
  9. pmc Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors
    Serge Gregoire
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, 687 Pine Ave West, Montreal, Quebec H3A 1A1, Canada
    Mol Cell Biol 25:2273-87. 2005
    ..These results thus identify sumoylation as a novel regulatory mechanism for MEF2 and suggest that this modification interplays with phosphorylation to promote intramolecular signaling for coordinated regulation in vivo...
  10. pmc Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2
    Serge Gregoire
    Molecular Oncology Group, Royal Victoria Hospital, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Mol Cell Biol 27:1280-95. 2007
    ..These results reveal an unexpected role for HDAC3 and suggest a novel pathway through which MEF2 activity is controlled in vivo...
  11. pmc Dephosphorylation at a Conserved SP Motif Governs cAMP Sensitivity and Nuclear Localization of Class IIa Histone Deacetylases
    Donald R Walkinshaw
    From the Rosalind and Morris Goodman Cancer Research Center
    J Biol Chem 288:5591-605. 2013
    ..These results thus unravel a previously unrecognized mechanism whereby cAMP promotes dephosphorylation and differentially regulates multisite phosphorylation and the nuclear localization of class IIa HDACs...
  12. ncbi request reprint Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation
    Serge Gregoire
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    J Biol Chem 281:4423-33. 2006
    ....
  13. pmc Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain
    Jenny J Tong
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Nucleic Acids Res 30:1114-23. 2002
    ..Furthermore, HDAC10 interacts with HDAC3 but not with HDAC4 or HDAC6. These results indicate that HDAC10 is a novel class II histone deacetylase possessing a unique leucine-rich domain...
  14. pmc The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases
    Donald R Walkinshaw
    Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada
    J Biol Chem 288:9345-62. 2013
    ....
  15. ncbi request reprint Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retention
    Nicholas R Bertos
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 279:48246-54. 2004
    ....
  16. ncbi request reprint A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells
    Maite Hernandez
    Departments of Medicine, Oncology, and Pharmacology and Therapeutics, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, 3755 Chemin de la Cote Ste Catherine, Montreal, Quebec, Canada
    Prostate 66:1151-61. 2006
    ..cx43 is frequently downregulated in prostate cancer. We investigated the role of a histone deacetylase (HDAC)-dependent mechanism in the transcriptional repression of cx43 in a panel of prostate cancer cells...
  17. ncbi request reprint Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms
    Isabelle Fernandes
    Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell 11:139-50. 2003
    ..LCoR represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms...
  18. pmc Function of histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoR
    Ana Palijan
    Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 284:30264-74. 2009
    ..Taken together, these data establish that HDAC6 can function as a cofactor of LCoR but suggest that they may act in enhance expressing some target genes...
  19. ncbi request reprint Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif
    Annie M Tremblay
    Molecular Oncology Group, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Mol Endocrinol 22:570-84. 2008
    ..Taken together, these results show that the interplay of phosphorylation and sumoylation in the amino-terminal domain provides an additional mechanism to regulate the transcriptional activity of ERRalpha and -gamma...
  20. ncbi request reprint MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2
    Nadine Pelletier
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, Quebec, Canada
    Oncogene 21:2729-40. 2002
    ..These results thus identify Runx2 as an interaction partner of MOZ and MORF and suggest that both acetyltransferases are involved in regulating transcriptional activation mediated by Runx2 and its homologues...
  21. ncbi request reprint Corepressor recruitment by agonist-bound nuclear receptors
    John H White
    Department of Physiology, McGill University, McIntyre Medical Sciences Bldg, Montreal, Quebec H3G 1Y6, Canada
    Vitam Horm 68:123-43. 2004
    ....
  22. pmc Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes
    Mukta Ullah
    Department of Medicine, McGill University Health Centre, Montreal, Quebec H3G 0B1, Canada
    Mol Cell Biol 28:6828-43. 2008
    ..These findings thus indicate that BRPF proteins play a key role in assembling and activating MOZ/MORF acetyltransferase complexes...
  23. doi request reprint Analysis of protein lysine acetylation in vitro and in vivo
    Nadine Pelletier
    Rosalind and Morris Goodman Cancer Center and Department of Medicine, McGill University, Montreal, Canada
    Curr Protoc Protein Sci . 2008
    ..This unit describes and discusses methods used for in vitro and in vivo determination of lysine acetylation...
  24. pmc Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation
    Nikita Avvakumov
    Laval University Cancer Research Center, Hotel Dieu de Quebec, Quebec City, Quebec, Canada
    Mol Cell Biol 32:689-703. 2012
    ..These results demonstrate the importance of ING association with MYST acetyltransferases in controlling cell proliferation, a regulated link that accounts for the reported tumor suppressor activities of these complexes...
  25. pmc The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec H3A 1A1, Canada
    Nucleic Acids Res 32:959-76. 2004
    ..Therefore, the diverse superfamily of lysine acetyltransferases executes an acetylation program that is important for different cellular processes and perturbation of such a program may cause the development of cancer and other diseases...
  26. ncbi request reprint Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    Curr Opin Genet Dev 13:143-53. 2003
    ..Histone deacetylases are important targets for drugs with potential therapeutic value in the treatment of cancer, neurodegenerative disorders, cardiac hypertrophy and other human diseases...
  27. doi request reprint Lysine acetylation: enzymes, bromodomains and links to different diseases
    Linya You
    The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada
    Essays Biochem 52:1-12. 2012
    ..In this chapter, we provide a brief overview of these proteins and emphasize their direct links to related human diseases...
  28. doi request reprint Reconstitution of active and stoichiometric multisubunit lysine acetyltransferase complexes in insect cells
    Kezhi Yan
    Department of Biochemistry, The Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada
    Methods Mol Biol 809:445-64. 2012
    ..Similar methods have been used for reconstituting active complexes of histone deacetylases, lysine demethylases, and ubiquitin ligases, so this simple approach can be adapted for molecular dissection of various multisubunit complexes...
  29. doi request reprint Histone deacetylases as transducers and targets of nuclear signaling
    Donald R Walkinshaw
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada H3A 1A1
    J Cell Biochem 104:1541-52. 2008
    ..Here, we examine the nuclear roles of these enzymes, with a specific focus on their active crosstalk with different chromatin regulators...
  30. pmc Sumoylation of Krüppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation
    Soroush Tahmasebi
    Department of Anatomy and Cell Biology, McGill University Health Center, Montreal, Quebec H3A 1A3, Canada
    J Biol Chem 288:12791-804. 2013
    ..Furthermore, sumoylation of KLF4 but not KLF2 or KLF5 stimulated adipocyte differentiation. These results thus demonstrate the importance KLF4 sumoylation in regulating pluripotency and adipocyte differentiation...
  31. doi request reprint Comprehensive lysine acetylomes emerging from bacteria to humans
    Go Woon Kim
    The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada
    Trends Biochem Sci 36:211-20. 2011
    ....
  32. ncbi request reprint Multisite protein modification and intramolecular signaling
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada H3A 1A1
    Oncogene 24:1653-62. 2005
    ..Multisite modification thus coordinates intermolecular and intramolecular signaling for the qualitative and quantitative control of protein function in vivo...
  33. doi request reprint K-acetylation and its enzymes: overview and new developments
    Juliette Adjo Aka
    The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, QC, Canada
    Handb Exp Pharmacol 206:1-12. 2011
    ....
  34. pmc Mice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortion
    Go Woon Kim
    Rosalind and Morris Goodman Cancer Research Center, Montreal, Quebec H3A 1A3, Canada
    J Biol Chem 288:20334-50. 2013
    ..These results thus suggest that mouse Atat1 may regulate advanced functions such as learning and memory, thereby shedding novel light on the physiological roles of α-tubulin acetylation in mammals. ..
  35. doi request reprint YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease
    Kainan Wang
    Department of Medicine, McGill University Health Centre, Montreal, QCH3A1A1, Canada
    Biochem Cell Biol 87:77-91. 2009
    ....
  36. ncbi request reprint Transforming growth factor-beta inhibits telomerase through SMAD3 and E2F transcription factors
    Annie Lacerte
    Hormones and Cancer Research Unit, Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, H3A 1A1, Montreal, Quebec, Canada
    Cell Signal 20:50-9. 2008
    ..These findings highlight the prominent role of TGFbeta in regulating telomerase expression and identify Smad3 and E2F-1 as critical mediators of TGFbeta effects in both normal and cancer cells...
  37. doi request reprint Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseases
    Claire Bonfils
    MethylGene, Inc, 7220 Frederick Banting, Montreal, Quebec H4S 2A1, Canada
    Expert Opin Drug Discov 3:1041-65. 2008
    ..The identification of the appropriate target spectrum and the development of class- or isotype-selective inhibitors will be central events in the future...
  38. ncbi request reprint Expression, purification, and analysis of MOZ and MORF histone acetyltransferases
    Nadine Pelletier
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada
    Methods 31:24-32. 2003
    ..These methods are useful not only for functional characterization of MOZ, MORF, PCAF, and other HATs, but also for preparation of HAT proteins to screen compound libraries and obtain inhibitors with potential therapeutic value...
  39. ncbi request reprint ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation
    Yannick Doyon
    Laval University Cancer Research Center, Hôtel Dieu de Québec CHUQ, Quebec City, Quebec G1R 2J6, Canada
    Mol Cell 21:51-64. 2006
    ..Since INGs, HBO1, and MOZ/MORF contribute to oncogenic transformation, the multisubunit assemblies characterized here underscore the critical role of epigenetic regulation in cancer development...
  40. ncbi request reprint MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation
    Yetao Jin
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    J Biol Chem 277:30838-43. 2002
    ..These results demonstrate that MDM2 can inhibit PCAF-mediated p53 acetylation and activation...
  41. pmc Dephosphorylation and caspase processing generate distinct nuclear pools of histone deacetylase 4
    Gabriela Paroni
    Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Biologia, and MATI Center of Excellence, Universita di Udine, Udine, Italy
    Mol Cell Biol 27:6718-32. 2007
    ..These two nuclear pools of HDAC4 are characterized by different repression potentials and divergent dynamics of chromatin interaction...
  42. ncbi request reprint Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity
    Jonathan K L Chan
    Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
    J Biol Chem 278:23515-21. 2003
    ..Combined with data from others, our data suggest that the full-length HDAC4 can repress MEF2 through multiple independent repressive domains...
  43. pmc HDAC6 modulates cell motility by altering the acetylation level of cortactin
    Xiaohong Zhang
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Mol Cell 27:197-213. 2007
    ....
  44. ncbi request reprint Caspase-mediated specific cleavage of human histone deacetylase 4
    Fang Liu
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, John Morgan 180H, Philadelphia, PA 19104, USA
    J Biol Chem 279:34537-46. 2004
    ..These results therefore unexpectedly link the regulation of HDAC4 protein stability to caspases, enzymes that are important for controlling cell death and differentiation...
  45. ncbi request reprint Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
    Sung Chan Kim
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 23:607-18. 2006
    ..The combined data sets offer a rich source for further characterization of the contribution of this modification to cellular physiology and human diseases...
  46. pmc p38 Mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression
    Qing Xu
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    Mol Biol Cell 13:1940-52. 2002
    ....
  47. ncbi request reprint Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation
    Luguo Sun
    Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
    J Cell Sci 117:3021-9. 2004
    ....
  48. ncbi request reprint PCAF is a coactivator for p73-mediated transactivation
    Lisa Y Zhao
    Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL 32610 0235, USA
    Oncogene 22:8316-29. 2003
    ..Furthermore, cotransfection of PCAF and p73 leads to increased apoptosis and reduced colony formation. Collectively, these data suggest that p73 recruit PCAF to specific promoters to activate the transcription of p73 target genes...