Research Topics
Genomes and Genes
| John H WhiteSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
Regulation of intracrine production of 1,25-dihydroxyvitamin D and its role in innate immune defense against infectionJohn H White
Department of Physiology, McIntyre Bldg, Rm 1112, 3655 Drummond St, Montreal, QC, Canada H3G 1Y6
Arch Biochem Biophys 523:58-63. 2012..This review will describe our current knowledge of the signaling pathways that lead to 1,25D production in the immune system and the downstream signaling events it controls in response to pathogen recognition...- Vitamin D metabolism and signaling in the immune systemJohn H White
Department of Physiology, McGill University, McIntyre Bldg, Rm 1112, 3655 Drummond St, Montreal, QC, H3G 1Y6, Canada
Rev Endocr Metab Disord 13:21-9. 2012.... 
Asthma and genes encoding components of the vitamin D pathwayYohan Bosse
Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
Respir Res 10:98. 2009..Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy...- Vitamin D signaling, infectious diseases, and regulation of innate immunityJohn H White
Department of Physiology and Medicine, McGill University, Montreal, Quebec, Canada
Infect Immun 76:3837-43. 2008 - Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: past, present and futureJohn H White
Department of Physiology, McGill University, Montreal, QC, Canada
J Steroid Biochem Mol Biol 121:234-8. 2010.... 
Profiling 1,25-dihydroxyvitamin D3-regulated gene expression by microarray analysisJohn H White
Department of Physiology, McIntyre Medical Sciences Bldg, Room 1128, McGill University, 3655 Drummond St, Montreal, Que, Canada H3G 1Y6
J Steroid Biochem Mol Biol 89:239-44. 2004..In addition, they have underlined the therapeutic potential of 1,25(OH)(2)D(3) analogues as modulators of immune system function...- Ligand-dependent corepressor LCoR is an attenuator of progesterone-regulated gene expressionAna Palijan
Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 284:30275-87. 2009..They also reveal a role for LCoR and CtBP1 as attenuators of progesterone-regulated transcription but suggest that LCoR and CtBP1 can act to enhance transcription of some genes... - Function of histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoRAna Palijan
Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 284:30264-74. 2009..Taken together, these data establish that HDAC6 can function as a cofactor of LCoR but suggest that they may act in enhance expressing some target genes... - Convergence of vitamin D and retinoic acid signalling at a common hormone response elementLuz Tavera-Mendoza
Department of Medicine, McGill University, 3655 Drummond St, Montreal, Quebec, Canada H3G 1Y6
EMBO Rep 7:180-5. 2006..These results show a limited crosstalk between 1,25D3 and RA signalling by means of overlapping nuclear receptor DNA binding specificities, and uncover a role for p19INK4D in control of cell survival... - Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cellsVeronique Bourdeau
Institute for Research in Immunology and Cancer and Biochemistry Department, Universite de Montreal, C P 6128 Succursale Centre Ville, Montreal, QC H3C 3J7, Canada
Nucleic Acids Res 36:76-93. 2008.... - Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybridsMarc Lamblin
Department of Chemistry, McGill University, Montreal, QC, Canada
Bioorg Med Chem 18:4119-37. 2010..These bifunctional hybrids display in vitro antiproliferative activity against the AT84 squamous carcinoma cell line while lacking the in vivo hypercalcemic effects of 1,25D... - Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolutionDavid Laperriere
Department of Biochemistry, University of Montreal, Montreal, Quebec, H3C 3J7, Canada
BMC Genomics 8:23. 2007..Although many known such response elements are conserved in the mouse and human genomes, it is unclear to which extent transcriptional regulation by nuclear receptors has evolved specifically in primates... - Corepressor recruitment by agonist-bound nuclear receptorsJohn H White
Department of Physiology, McGill University, McIntyre Medical Sciences Bldg, Montreal, Quebec H3G 1Y6, Canada
Vitam Horm 68:123-43. 2004.... - Vitamin D receptor as a master regulator of the c-MYC/MXD1 networkReyhaneh Salehi-Tabar
Department of Medicine, McGill University, Montreal, QC, Canada H3G 1Y6
Proc Natl Acad Sci U S A 109:18827-32. 2012..Thus, 1,25D and the VDR regulate the c-MYC/MXD1 network to suppress c-MYC function, providing a molecular basis for cancer preventive actions of vitamin D... - Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequencesJulie Deschênes
Institute for Research in Immunology and Cancer, Department of Biochemistry, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
J Biol Chem 282:17335-9. 2007..Furthermore, estradiol induced physical association between EREs, suggesting that these elements function as a potent multipartite enhancer to regulate GREB1 transcription... - Phosphorylation of the human retinoid X receptor alpha at serine 260 impairs coactivator(s) recruitment and induces hormone resistance to multiple ligandsMichael Macoritto
McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
J Biol Chem 283:4943-56. 2008..Our data suggest that phosphorylation at serine 260 plays a critical role in inducing hormone resistance of RXRalpha-mediated signaling likely through structural changes in the H1-H3 omega loop-AF2 coactivator(s) interacting domain... - Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genesTian-Tian Wang
Department of Physiology, McIntyre Building, Room 1128, McGill University, 3655 Drummond Street, Montreal, Quebec H3G 1Y6, Canada
Mol Endocrinol 19:2685-95. 2005..The combined approaches used here thus provide numerous insights into the direct target genes underlying the broad physiological actions of 1,25(OH)2D3... - Synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibitionJoshua Fischer
Department of Chemistry, McGill University, Montreal, Quebec H3A 0G4, Canada
Chem Biol 19:963-71. 2012..Remarkably, modeling and X-ray crystallography reveal non-secosteroidal hybrids bind in the VDR ligand binding domain in the opposite orientation of their secosteroidal counterparts... - Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptorBeum Soo An
Department of Physiology, McGill University, Montreal, Quebec, Canada
Mol Cell Biol 30:4890-900. 2010..These studies link 1,25D signaling through the VDR directly to Sirt1 and FoxO function and provide a molecular basis for the cancer chemopreventive actions of 1,25D... - The pleiotropic actions of vitamin DRoberto Lin
Department of Physiology, McGill University, Montreal, Quebec, Canada
Bioessays 26:21-8. 2004..Here, we survey the most-recent findings and discuss their implications for the potential therapeutic uses of vitamin D analogues... - Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn diseaseTian Tian Wang
Department of Physiology, Montreal General Hospital, Canada
J Biol Chem 285:2227-31. 2010.... - Ligand-dependent corepressor (LCoR) recruitment by Kruppel-like factor 6 (KLF6) regulates expression of the cyclin-dependent kinase inhibitor CDKN1A geneMario R Calderon
Department of Physiology, McGill University, Montreal, Quebec, Canada
J Biol Chem 287:8662-74. 2012.... - An o-aminoanilide analogue of 1α,25-dihydroxyvitamin D(3) functions as a strong vitamin D receptor antagonistMarc Lamblin
Departments of Chemistry, McGill University, Montreal, Quebec, H3A 2K6, Canada
J Med Chem 53:7461-5. 2010..Modeling studies indicate that antagonism arises from side chain rigidity, when compared to a more flexible saturated analogue, which interferes with H12 folding/alignment... - Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expressionTian-Tian Wang
Department of Physiology, McGill University, Montreal, Quebec, Canada
J Immunol 173:2909-12. 2004..1,25(OH)(2)D(3) thus directly regulates antimicrobial peptide gene expression, revealing the potential of its analogues in treatment of opportunistic infections... - Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonistLuz E Tavera-Mendoza
Departments of Medicine and Physiology, McIntyre Building, McGill University, 3655 Drummond Street, Montreal, QC, Canada
Proc Natl Acad Sci U S A 105:8250-5. 2008..These studies demonstrate the feasibility of combining HDAC inhibition with nuclear receptor agonism to enhance their therapeutic potential... - Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cellsRoberto Lin
Department of Physiology, McGill University, , , Canada
Endocrinology 144:749-53. 2003..Our results reveal that 1,25(OH)(2)D(3) analogs increase levels of p27(KIP1) in different cell types by inhibiting expression of SCF(SKP2) subunits and reducing turnover of p27(KIP1) protein... - 1Alpha,25-dihydroxyvitamin D3 promotes vascularization of the chondro-osseous junction by stimulating expression of vascular endothelial growth factor and matrix metalloproteinase 9Roberto Lin
Department of Physiology, McGill University, Montreal, Quebec, Canada
J Bone Miner Res 17:1604-12. 2002..These results provide evidence that 1alpha,25(OH)2D3 signaling stimulates VEGF and MMP-9 gene expression and promotes neovascularization of the epiphyseal growth plate in vivo through increased availability of active growth factor... - Retrograde BMP signaling controls synaptic growth at the NMJ by regulating trio expression in motor neuronsRobin W Ball
Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada
Neuron 66:536-49. 2010..Based on our findings, we propose a model in which a retrograde BMP signal from the muscle modulates GTPase activity through transcriptional regulation of Rac GEF trio, thereby regulating the homeostasis of synaptic growth at the NMJ... - Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulationRoberto Lin
Department of Physiology, McGill University, , , Canada
Mol Endocrinol 16:1243-56. 2002..This suggests that differences in action of the two compounds arise more from their relative sensitivities to metabolism than from differing effects on VDR function... - p19INK4D and cell deathLuz E Tavera-Mendoza
Department of Physiology, McGill University, Montreal, Quebec, Canada
Cell Cycle 5:596-8. 2006..We discuss the relevance of our studies and recent findings of others to the cell death observed in p19(INK4D)-deficient animals and to a possible role for p19(INK4D) induction in chemoprevention... - Fas ligand acts as a counter-receptor in Schwann cells and induces the secretion of bioactive nerve growth factorManuelle Mimouni-Rongy
Department of Physiology, McGill University, Montreal, Quebec, Canada
J Neuroimmunol 230:17-25. 2011..FasL can therefore act as a signal-transducing molecule in Schwann cells, leading to the secretion of NGF, and may contribute to peripheral nerve regeneration... - Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanismsIsabelle Fernandes
Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6
Mol Cell 11:139-50. 2003..LCoR represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms... - Genome-wide identification of high-affinity estrogen response elements in human and mouseVeronique Bourdeau
Departement de Biochimie, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
Mol Endocrinol 18:1411-27. 2004..Our results demonstrate that near-consensus EREs occur frequently in both genomes and that whereas chromatin structure likely modulates access to binding sites, far upstream elements can be evolutionarily conserved and bind ERs in vivo... - Expression of human kinase suppressor of Ras 2 (hKSR-2) gene in HL60 leukemia cells is directly upregulated by 1,25-dihydroxyvitamin D(3) and is required for optimal cell differentiationXuening Wang
Department of Pathology and Laboratory Medicine, UMDNJ New Jersey Medical School, 185 South Orange Avenue, C 543, Newark, NJ 07103, USA
Exp Cell Res 313:3034-45. 2007..These results demonstrate that hKSR-2 is a direct target of 1,25D in HL60 cells, and is required for optimal monocytic differentiation... - Cell defenses and the sunshine vitaminLuz E Tavera-Mendoza
McGill University
Sci Am 297:62-5, 68-70, 72. 2007