John H White

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Regulation of intracrine production of 1,25-dihydroxyvitamin D and its role in innate immune defense against infection
    John H White
    Department of Physiology, McIntyre Bldg, Rm 1112, 3655 Drummond St, Montreal, QC, Canada H3G 1Y6
    Arch Biochem Biophys 523:58-63. 2012
  2. doi request reprint Vitamin D metabolism and signaling in the immune system
    John H White
    Department of Physiology, McGill University, McIntyre Bldg, Rm 1112, 3655 Drummond St, Montreal, QC, H3G 1Y6, Canada
    Rev Endocr Metab Disord 13:21-9. 2012
  3. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
  4. ncbi request reprint Profiling 1,25-dihydroxyvitamin D3-regulated gene expression by microarray analysis
    John H White
    Department of Physiology, McIntyre Medical Sciences Bldg, Room 1128, McGill University, 3655 Drummond St, Montreal, Que, Canada H3G 1Y6
    J Steroid Biochem Mol Biol 89:239-44. 2004
  5. pmc Vitamin D signaling, infectious diseases, and regulation of innate immunity
    John H White
    Department of Physiology and Medicine, McGill University, Montreal, Quebec, Canada
    Infect Immun 76:3837-43. 2008
  6. doi request reprint Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: past, present and future
    John H White
    Department of Physiology, McGill University, Montreal, QC, Canada
    J Steroid Biochem Mol Biol 121:234-8. 2010
  7. pmc Ligand-dependent corepressor LCoR is an attenuator of progesterone-regulated gene expression
    Ana Palijan
    Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 284:30275-87. 2009
  8. pmc Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells
    Veronique Bourdeau
    Institute for Research in Immunology and Cancer and Biochemistry Department, Universite de Montreal, C P 6128 Succursale Centre Ville, Montreal, QC H3C 3J7, Canada
    Nucleic Acids Res 36:76-93. 2008
  9. pmc Function of histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoR
    Ana Palijan
    Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 284:30264-74. 2009
  10. doi request reprint Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids
    Marc Lamblin
    Department of Chemistry, McGill University, Montreal, QC, Canada
    Bioorg Med Chem 18:4119-37. 2010

Collaborators

Detail Information

Publications38

  1. doi request reprint Regulation of intracrine production of 1,25-dihydroxyvitamin D and its role in innate immune defense against infection
    John H White
    Department of Physiology, McIntyre Bldg, Rm 1112, 3655 Drummond St, Montreal, QC, Canada H3G 1Y6
    Arch Biochem Biophys 523:58-63. 2012
    ..This review will describe our current knowledge of the signaling pathways that lead to 1,25D production in the immune system and the downstream signaling events it controls in response to pathogen recognition...
  2. doi request reprint Vitamin D metabolism and signaling in the immune system
    John H White
    Department of Physiology, McGill University, McIntyre Bldg, Rm 1112, 3655 Drummond St, Montreal, QC, H3G 1Y6, Canada
    Rev Endocr Metab Disord 13:21-9. 2012
    ....
  3. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
    ..Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy...
  4. ncbi request reprint Profiling 1,25-dihydroxyvitamin D3-regulated gene expression by microarray analysis
    John H White
    Department of Physiology, McIntyre Medical Sciences Bldg, Room 1128, McGill University, 3655 Drummond St, Montreal, Que, Canada H3G 1Y6
    J Steroid Biochem Mol Biol 89:239-44. 2004
    ..In addition, they have underlined the therapeutic potential of 1,25(OH)(2)D(3) analogues as modulators of immune system function...
  5. pmc Vitamin D signaling, infectious diseases, and regulation of innate immunity
    John H White
    Department of Physiology and Medicine, McGill University, Montreal, Quebec, Canada
    Infect Immun 76:3837-43. 2008
  6. doi request reprint Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: past, present and future
    John H White
    Department of Physiology, McGill University, Montreal, QC, Canada
    J Steroid Biochem Mol Biol 121:234-8. 2010
    ....
  7. pmc Ligand-dependent corepressor LCoR is an attenuator of progesterone-regulated gene expression
    Ana Palijan
    Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 284:30275-87. 2009
    ..They also reveal a role for LCoR and CtBP1 as attenuators of progesterone-regulated transcription but suggest that LCoR and CtBP1 can act to enhance transcription of some genes...
  8. pmc Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells
    Veronique Bourdeau
    Institute for Research in Immunology and Cancer and Biochemistry Department, Universite de Montreal, C P 6128 Succursale Centre Ville, Montreal, QC H3C 3J7, Canada
    Nucleic Acids Res 36:76-93. 2008
    ....
  9. pmc Function of histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoR
    Ana Palijan
    Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 284:30264-74. 2009
    ..Taken together, these data establish that HDAC6 can function as a cofactor of LCoR but suggest that they may act in enhance expressing some target genes...
  10. doi request reprint Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids
    Marc Lamblin
    Department of Chemistry, McGill University, Montreal, QC, Canada
    Bioorg Med Chem 18:4119-37. 2010
    ..These bifunctional hybrids display in vitro antiproliferative activity against the AT84 squamous carcinoma cell line while lacking the in vivo hypercalcemic effects of 1,25D...
  11. pmc Convergence of vitamin D and retinoic acid signalling at a common hormone response element
    Luz Tavera-Mendoza
    Department of Medicine, McGill University, 3655 Drummond St, Montreal, Quebec, Canada H3G 1Y6
    EMBO Rep 7:180-5. 2006
    ..These results show a limited crosstalk between 1,25D3 and RA signalling by means of overlapping nuclear receptor DNA binding specificities, and uncover a role for p19INK4D in control of cell survival...
  12. ncbi request reprint Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences
    Julie Deschênes
    Institute for Research in Immunology and Cancer, Department of Biochemistry, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 282:17335-9. 2007
    ..Furthermore, estradiol induced physical association between EREs, suggesting that these elements function as a potent multipartite enhancer to regulate GREB1 transcription...
  13. pmc Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution
    David Laperriere
    Department of Biochemistry, University of Montreal, Montreal, Quebec, H3C 3J7, Canada
    BMC Genomics 8:23. 2007
    ..Although many known such response elements are conserved in the mouse and human genomes, it is unclear to which extent transcriptional regulation by nuclear receptors has evolved specifically in primates...
  14. ncbi request reprint Corepressor recruitment by agonist-bound nuclear receptors
    John H White
    Department of Physiology, McGill University, McIntyre Medical Sciences Bldg, Montreal, Quebec H3G 1Y6, Canada
    Vitam Horm 68:123-43. 2004
    ....
  15. pmc Vitamin D receptor as a master regulator of the c-MYC/MXD1 network
    Reyhaneh Salehi-Tabar
    Department of Medicine, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 109:18827-32. 2012
    ..Thus, 1,25D and the VDR regulate the c-MYC/MXD1 network to suppress c-MYC function, providing a molecular basis for cancer preventive actions of vitamin D...
  16. ncbi request reprint Phosphorylation of the human retinoid X receptor alpha at serine 260 impairs coactivator(s) recruitment and induces hormone resistance to multiple ligands
    Michael Macoritto
    McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 283:4943-56. 2008
    ..Our data suggest that phosphorylation at serine 260 plays a critical role in inducing hormone resistance of RXRalpha-mediated signaling likely through structural changes in the H1-H3 omega loop-AF2 coactivator(s) interacting domain...
  17. ncbi request reprint Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes
    Tian Tian Wang
    Department of Physiology, McIntyre Building, Room 1128, McGill University, 3655 Drummond Street, Montreal, Quebec H3G 1Y6, Canada
    Mol Endocrinol 19:2685-95. 2005
    ..The combined approaches used here thus provide numerous insights into the direct target genes underlying the broad physiological actions of 1,25(OH)2D3...
  18. doi request reprint Synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition
    Joshua Fischer
    Department of Chemistry, McGill University, Montreal, Quebec H3A 0G4, Canada
    Chem Biol 19:963-71. 2012
    ..Remarkably, modeling and X-ray crystallography reveal non-secosteroidal hybrids bind in the VDR ligand binding domain in the opposite orientation of their secosteroidal counterparts...
  19. ncbi request reprint The pleiotropic actions of vitamin D
    Roberto Lin
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    Bioessays 26:21-8. 2004
    ..Here, we survey the most-recent findings and discuss their implications for the potential therapeutic uses of vitamin D analogues...
  20. pmc Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor
    Beum Soo An
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 30:4890-900. 2010
    ..These studies link 1,25D signaling through the VDR directly to Sirt1 and FoxO function and provide a molecular basis for the cancer chemopreventive actions of 1,25D...
  21. pmc Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease
    Tian Tian Wang
    Department of Physiology, Montreal General Hospital, Canada
    J Biol Chem 285:2227-31. 2010
    ....
  22. pmc Vitamin D induces interleukin-1β expression: paracrine macrophage epithelial signaling controls M. tuberculosis infection
    Mark Verway
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    PLoS Pathog 9:e1003407. 2013
    ..These data provide evidence that the anti-microbial actions of vitamin D extend beyond the macrophage by modulating paracrine signaling, reinforcing its role in innate immune regulation in humans...
  23. ncbi request reprint Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression
    Tian Tian Wang
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    J Immunol 173:2909-12. 2004
    ..1,25(OH)(2)D(3) thus directly regulates antimicrobial peptide gene expression, revealing the potential of its analogues in treatment of opportunistic infections...
  24. ncbi request reprint Opposite effects of histone deacetylase inhibitors on glucocorticoid and estrogen signaling in human endometrial Ishikawa cells
    Walter Rocha
    Department of Biochemistry, Universite de Montreal, Montreal, Quebec, Canada
    Mol Pharmacol 68:1852-62. 2005
    ..Together, our results demonstrate striking and opposite effects of HDACi on ER and GR signaling that involve regulatory events independent of histone hyperacetylation on receptor target promoters...
  25. pmc Ligand-dependent corepressor (LCoR) recruitment by Kruppel-like factor 6 (KLF6) regulates expression of the cyclin-dependent kinase inhibitor CDKN1A gene
    Mario R Calderon
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    J Biol Chem 287:8662-74. 2012
    ....
  26. doi request reprint An o-aminoanilide analogue of 1α,25-dihydroxyvitamin D(3) functions as a strong vitamin D receptor antagonist
    Marc Lamblin
    Departments of Chemistry, McGill University, Montreal, Quebec, H3A 2K6, Canada
    J Med Chem 53:7461-5. 2010
    ..Modeling studies indicate that antagonism arises from side chain rigidity, when compared to a more flexible saturated analogue, which interferes with H12 folding/alignment...
  27. ncbi request reprint Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells
    Roberto Lin
    Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Endocrinology 144:749-53. 2003
    ..Our results reveal that 1,25(OH)(2)D(3) analogs increase levels of p27(KIP1) in different cell types by inhibiting expression of SCF(SKP2) subunits and reducing turnover of p27(KIP1) protein...
  28. pmc Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist
    Luz E Tavera-Mendoza
    Departments of Medicine and Physiology, McIntyre Building, McGill University, 3655 Drummond Street, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 105:8250-5. 2008
    ..These studies demonstrate the feasibility of combining HDAC inhibition with nuclear receptor agonism to enhance their therapeutic potential...
  29. doi request reprint Retrograde BMP signaling controls synaptic growth at the NMJ by regulating trio expression in motor neurons
    Robin W Ball
    Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada
    Neuron 66:536-49. 2010
    ..Based on our findings, we propose a model in which a retrograde BMP signal from the muscle modulates GTPase activity through transcriptional regulation of Rac GEF trio, thereby regulating the homeostasis of synaptic growth at the NMJ...
  30. ncbi request reprint 1Alpha,25-dihydroxyvitamin D3 promotes vascularization of the chondro-osseous junction by stimulating expression of vascular endothelial growth factor and matrix metalloproteinase 9
    Roberto Lin
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    J Bone Miner Res 17:1604-12. 2002
    ..These results provide evidence that 1alpha,25(OH)2D3 signaling stimulates VEGF and MMP-9 gene expression and promotes neovascularization of the epiphyseal growth plate in vivo through increased availability of active growth factor...
  31. ncbi request reprint p19INK4D and cell death
    Luz E Tavera-Mendoza
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    Cell Cycle 5:596-8. 2006
    ..We discuss the relevance of our studies and recent findings of others to the cell death observed in p19(INK4D)-deficient animals and to a possible role for p19(INK4D) induction in chemoprevention...
  32. ncbi request reprint Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation
    Roberto Lin
    Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Mol Endocrinol 16:1243-56. 2002
    ..This suggests that differences in action of the two compounds arise more from their relative sensitivities to metabolism than from differing effects on VDR function...
  33. doi request reprint An electrochemically controlled microcantilever biosensor
    Yoshihiko Nagai
    Research Institute of the McGill University Health Centre, 2155 Guy Street, Montreal, Quebec H3H 2R9, Canada
    Langmuir 29:9951-7. 2013
    ..A similar potential-actuated change in surface stress also results from the interaction between an oligonucleotide aptamer and its cognate ligand, demonstrating the broad applicability of this methodology. ..
  34. ncbi request reprint Genome-wide identification of high-affinity estrogen response elements in human and mouse
    Veronique Bourdeau
    Departement de Biochimie, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    Mol Endocrinol 18:1411-27. 2004
    ..Our results demonstrate that near-consensus EREs occur frequently in both genomes and that whereas chromatin structure likely modulates access to binding sites, far upstream elements can be evolutionarily conserved and bind ERs in vivo...
  35. ncbi request reprint Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms
    Isabelle Fernandes
    Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell 11:139-50. 2003
    ..LCoR represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms...
  36. doi request reprint Fas ligand acts as a counter-receptor in Schwann cells and induces the secretion of bioactive nerve growth factor
    Manuelle Mimouni-Rongy
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    J Neuroimmunol 230:17-25. 2011
    ..FasL can therefore act as a signal-transducing molecule in Schwann cells, leading to the secretion of NGF, and may contribute to peripheral nerve regeneration...
  37. ncbi request reprint Cell defenses and the sunshine vitamin
    Luz E Tavera-Mendoza
    McGill University
    Sci Am 297:62-5, 68-70, 72. 2007
  38. pmc Expression of human kinase suppressor of Ras 2 (hKSR-2) gene in HL60 leukemia cells is directly upregulated by 1,25-dihydroxyvitamin D(3) and is required for optimal cell differentiation
    Xuening Wang
    Department of Pathology and Laboratory Medicine, UMDNJ New Jersey Medical School, 185 South Orange Avenue, C 543, Newark, NJ 07103, USA
    Exp Cell Res 313:3034-45. 2007
    ..These results demonstrate that hKSR-2 is a direct target of 1,25D in HL60 cells, and is required for optimal monocytic differentiation...