Research Topics
| H A WeilerSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
Osteocalcin and vitamin D status are inversely associated with homeostatic model assessment of insulin resistance in Canadian Aboriginal and white women: the First Nations Bone Health StudyHope A Weiler
School of Dietetics and Human Nutrition, McGill University, Montreal, QC, Canada
J Nutr Biochem 24:412-8. 2013..This study was conducted to simultaneously explore the relationships among osteocalcin, vitamin D status and indicators of glucose metabolism and adiposity in a mixed-ethnicity cohort of adult women...- Maternal supplementation with dietary arachidonic and docosahexaenoic acids during lactation elevates bone mass in weanling rat and guinea pig offspring even if born small sizedHope A Weiler
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Prostaglandins Leukot Essent Fatty Acids 86:61-70. 2012..LCPUFA minimized loss of whole body BMC in dams and elevated osteocalcin in sows. LCPUFA during lactation enhances bone in normal and small neonates without compromising maternal bone... 
Canadian Aboriginal women have a higher prevalence of vitamin D deficiency than non-Aboriginal women despite similar dietary vitamin D intakesHope A Weiler
Human Nutritional Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, R3T 2N2 MB, Canada
J Nutr 137:461-5. 2007..5 nmol/L. The high prevalence of vitamin D deficiency among Aboriginal women, combined with lower dietary intake of calcium, especially in older women, likely contributes to the higher incidence of fracture in this population...- Feeding flaxseed oil but not secoisolariciresinol diglucoside results in higher bone mass in healthy rats and rats with kidney diseaseH A Weiler
School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Que, Canada H9X 3V9
Prostaglandins Leukot Essent Fatty Acids 76:269-75. 2007..The benefit of flaxseed oil on body composition is sex specific but the effect on bone mass is not. Lastly, reduced weight due to early rat kidney disease is not due to loss of lean body mass... - Parathyroid hormone is predictive of low bone mass in Canadian Aboriginal and White womenHope A Weiler
Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
Bone 42:498-504. 2008..In conclusion, PTH is a better predictor of BMD than 25(OH)D in this population of Aboriginal and White women... - Dietary conjugated linoleic acid in the cis-9, trans-11 isoform reduces parathyroid hormone in male, but not female, ratsHope A Weiler
School of Dietetics and Human Nutrition, McGill University, QC, Canada H9X 3V9
J Nutr Biochem 19:762-9. 2008..Whether such reductions in PTH might be observed in females lacking sex hormones such as ovariectomized rats and also in humans is required to expand health implications of dietary CLA... - Bone mass in First Nations, Asian and white newborn infantsHope A Weiler
School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, QC H9X 3V9, Canada
Growth Dev Aging 71:35-43. 2008..These data suggest that white and First Nations newborn infants have comparable bone mass. Asian infants have lower spine bone mass which is more than a factor of body size and independent of vitamin D status at birth... - Minimal enteral feeding within 3 d of birth in prematurely born infants with birth weight < or = 1200 g improves bone mass by term ageHope A Weiler
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
Am J Clin Nutr 83:155-62. 2006..Evidence-based practice guidelines for aggressive nutritional intervention by using parenteral amino acids (AAs) and minimal enteral feeding (MEF) as early as the first day of life have not been tested for benefits to bone mass... - Percent body fat and bone mass in healthy Canadian females 10 to 19 years of ageH A Weiler
Department of Foods and Nutrition, University of Manitoba, Winnipeg, Manitoba, Canada
Bone 27:203-7. 2000..The females in this study appeared to be within reference limits for percent body fat. However, greater amounts of body fat relative to weight could be a marker for lifestyles that do not support attainment of optimal peak bone mass... - Zinc deficiency reduces bone mineral density in the spine of young adult rats: a pilot studyNatasha R Ryz
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Man, Canada
Ann Nutr Metab 54:218-26. 2009..These findings indicate that severe zinc deficiency initiated during adolescence may have important implications for future bone health, especially with regards to bone consolidation in the spine... - Bone density and bone area in Canadian Aboriginal women: the First Nations Bone Health StudyW D Leslie
Department of Medicine C5121, University of Manitoba, Winnipeg, Manitoba, Canada
Osteoporos Int 17:1755-62. 2006..Canadian Aboriginal women are at increased risk of fracture compared with the general population... - Postnatal vitamin D supplementation following maternal dietary vitamin D deficiency does not affect bone mass in weanling guinea pigsSarah L Finch
School of Dietetics and Human Nutrition, McGill University, Quebec, Canada
J Nutr 140:1574-81. 2010.... - Ethnic differences in adiposity and body composition: the First Nations bone health studyWilliam D Leslie
Faculty of Medicine C5121, 409 Tache Ave, University of Manitoba, Winnipeg, MB R2H 2A6, Canada
Appl Physiol Nutr Metab 32:1065-72. 2007..First Nations women had a preferential increase in trunk fat and this may contribute to high reported rates of diabetes, metabolic syndrome, and cardiovascular events... - Growth and bone mineralization of young adults weighing less than 1500 g at birthH A Weiler
Department of Foods and Nutrition, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
Early Hum Dev 67:101-12. 2002..Preterm infants are at risk for suboptimal growth and bone mineralization compared to infants born at term but long-term outcomes into early adulthood are unclear... - Concurrent nematode infection and pregnancy induce physiological responses that impair linear growth in the murine foetusM R Odiere
Institute of Parasitology, McGill University Macdonald Campus, 21 111 Lakeshore Road, Ste Anne de Bellevue, QC H9X 3V9, Canada
Parasitology 137:991-1002. 2010..Infection also reduced foetal crown-rump length which was associated with higher amniotic fluid IL-1 beta... - The effect of dietary n-3 long-chain polyunsaturated fatty acids on femur mineral density and biomarkers of bone metabolism in healthy, diabetic and dietary-restricted growing ratsKathy H Green
Department of Human Nutritional Sciences, H513 Duff Roblin Building, University of Manitoba, Winnipeg, Manitoba, Canada
Prostaglandins Leukot Essent Fatty Acids 71:121-30. 2004..CONCLUSIONS: These data suggest that the benefit of a diet high in n-3 long-chain polyunsaturated fatty acid is most advantageous to long bone density in healthy states... - A high mixed protein diet reduces body fat without altering the mechanical properties of bone in female ratsKathleen M Pye
School of Dietetics and Human Nutrition, McGill University, Macdonald Campus, Ste Anne de Bellevue, Quebec, Canada
J Nutr 139:2099-105. 2009..In conclusion, HP diets at 35% of energy lower body fat content without hindering the mechanical and weight-bearing properties of bone... - Body composition and bone density in Canadian White and Aboriginal women: the First Nations Bone Health StudyWilliam D Leslie
University of Manitoba, Department of Medicine, Canada
Bone 42:990-5. 2008.... - Dietary long-chain inulin reduces abdominal fat but has no effect on bone density in growing female ratsJennifer A Jamieson
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
Br J Nutr 100:451-9. 2008..In summary, LC-inulin lowered body fat mass, without consequence to bone density in growing female rats... - Dietary arachidonic acid and docosahexaenoic acid elevate femur calcium and reduce zinc content in pigletsRebecca C Mollard
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
Pediatr Res 60:418-22. 2006..Thus, AA:DHA in a ratio of 5:1 does not affect mineral accretion, but AA plus DHA, in amounts similar to the upper limit of human milk, might be detrimental to bone mineralization over time due to lower zinc... - Zinc-deficient rats have more limited bone recovery during repletion than diet-restricted ratsHeather J Hosea
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada
Exp Biol Med (Maywood) 229:303-11. 2004..Zinc deficiency was associated with a greater impairment in bone development than diet restriction, and both deficiencies limited bone recovery during repletion in growing rats... - Dietary long-chain polyunsaturated fatty acids minimize dexamethasone-induced reductions in arachidonic acid status but not bone mineral content in pigletsHope A Weiler
Department of Foods and Nutrition, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
Pediatr Res 51:282-9. 2002..Release of prostaglandin E(2) was elevated only with supplementation of AA. These data indicate that supplemental AA is associated with elevated whole body and femur BMC but that BMC is not enhanced during glucocorticoid treatment... - (n-3) fatty acids reduce the release of prostaglandin E2 from bone but do not affect bone mass in obese (fa/fa) and lean Zucker ratsRebecca C Mollard
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 Canada
J Nutr 135:499-504. 2005..Whether reduced PGE(2) will support optimal peak bone mass during childhood and conserve bone mass with aging warrants investigation... - Marginal zinc deficiency exacerbates bone lead accumulation and high dietary zinc attenuates lead accumulation at the expense of bone density in growing ratsJennifer A Jamieson
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
Toxicol Sci 92:286-94. 2006..SZ was protective against bone lead but was detrimental to BMD, suggesting that the optimal level of SZ to reduce lead absorption, while supporting growth and bone development, requires further investigation... - Modification of polycystic kidney disease and fatty acid status by soy protein dietM R Ogborn
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Kidney Int 57:159-66. 2000..Modification of polycystic kidney disease and fatty acid status by soy protein diet... - Leptin predicts bone and fat mass after accounting for the effects of diet and glucocorticoid treatment in pigletsHope A Weiler
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
Exp Biol Med (Maywood) 227:639-44. 2002..Both human and porcine neonates share similar characteristics with respect to relationships of leptin with fat and bone mass... - Dietary conjugated linoleic acid renal benefits and possible toxicity vary with isomer, dose and gender in rat polycystic kidney diseaseMalcolm R Ogborn
Department of Pediatrics and Child Health, University of Manitoba, JBRC513 715 McDermot Avenue, Winnipeg, MB, R3C 3P4, Canada
Lipids 43:783-91. 2008..CLA reduces histologic renal injury in the Han:SPRD-cy rat model probably inversely proportionate to c9,t11 renal content. Possible functional CLA toxicity at high dose in female animals warrants further exploration... - Dietary conjugated linoleic acid does not adversely affect bone mass in obese fa/fa or lean Zucker ratsLaura L Burr
School of Dietetics and Human Nutrition, McGill University, 111 Lakeshore Road, Ste-Anne-de-Bellevue, QC H9X 3V9, Canada
Exp Biol Med (Maywood) 231:1602-9. 2006..Thus, commercially available CLA mixtures and single CLA isomers do not affect bone mass in a hyperinsulinemic, obese state... - Dietary conjugated linoleic acid reduces PGE2 release and interstitial injury in rat polycystic kidney diseaseMalcolm R Ogborn
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Kidney Int 64:1214-21. 2003..We studied CLA supplementation in the modification of inflammatory outcomes in the Han:SPRD-cy rat... - Dietary arachidonic acid suppresses bone turnover in contrast to low dosage exogenous prostaglandin E(2) that elevates bone formation in the pigletVienna D Lucia
Department of Human Nutritional Sciences, University of Manitoba, H513 Duff Roblin Building, Winnipeg, Manitoba, Canada R3T 2N2
Prostaglandins Leukot Essent Fatty Acids 68:407-13. 2003..Both PGE(2) and FA treatments independently lead to elevated femur mineral content, but the combined treatment caused a reduction. Thus the mechanisms by which PGE(2) and FA lead to enhanced bone mass are distinct... - Proximal intestinal absorption of calcium is elevated in proportion to growth rate but not bone mass is small for gestational age pigletsRebecca C Mollard
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
J Nutr Biochem 15:149-54. 2004..However, at 21 days of age small for gestational age piglets are similar in size but have lower bone mass compared to appropriate for gestational age piglets... - Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in pigletsHope A Weiler
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2 Canada
J Nutr 132:2667-72. 2002..The results may be of relevance to the nutritional management of preterm infants whose DHA status is often too low and bone resorption too high... - Vitamin D supplementation of Canadian infants: practices of Montreal mothersSina Gallo
School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, QC H9X 3V9, Canada
Appl Physiol Nutr Metab 35:303-9. 2010..day-1 of vitamin D. Therefore there may still be gaps in knowledge regarding vitamin D supplementation... - Dietary soy protein attenuates renal disease progression after 1 and 3 weeks in Han:SPRD-cy weanling ratsDenise E Fair
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
J Nutr 134:1504-7. 2004..These data demonstrate that dietary soy protein compared with casein delays disease progression in an early stage of chronic kidney disease... - Plasma adipokines and body composition in response to modest dietary manipulations in the mouseJosef V Silha
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3
Obesity (Silver Spring) 14:1320-9. 2006..DISCUSSION: These data suggest that in the mouse, modest dietary perturbations have little effect on resistin and adiponectin levels despite significant effects on glycemia, insulin levels, and bone parameters... - Long-term high intake of whole proteins results in renal damage in pigsYong Jia
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
J Nutr 140:1646-52. 2010..These findings suggest that long-term intakes of protein at the upper limit of the AMDR from whole protein sources may compromise renal health... - Protein deficiency and nematode infection during pregnancy and lactation reduce maternal bone mineralization and neonatal linear growth in miceMaurice R Odiere
Institute of Parasitology, McGill University, Ste Anne de Bellevue, QC, Canada
J Nutr 140:1638-45. 2010..This mouse model provides a novel framework to study the impact of diet and nematode infection on bone... - Bone resorption varies as a function of time of day and quantity of dietary long chain polyunsaturated fatty acidsRebecca C Mollard
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2
J Nutr Biochem 19:482-8. 2008..In regression, plasma AA and DHA were not associated with urinary NTx:creatinine. Dietary AA and DHA at amounts similar to that found in breast milk reduce bone resorption, but do not alter its circadian rhythm... - Low levels of dietary arachidonic and docosahexaenoic acids improve bone mass in neonatal piglets, but higher levels provide no benefitRebecca C Mollard
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 Canada
J Nutr 135:505-12. 2005..0:0.4 g AA:DHA/100 g of fat (P = 0.039). The diets did not affect the other biochemical variables measured. Low levels of dietary AA:DHA (0.5:0.1 g/100 g of fat) elevate bone mass, but higher amounts are not beneficial... - Dose response of bone mass to dietary arachidonic acid in piglets fed cow milk-based formulaJanice L Blanaru
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
Am J Clin Nutr 79:139-47. 2004..Because the amount of dietary DHA was held constant, whether other amounts of DHA are related to bone mass requires investigation... - Cortisol reactivity and regulation associated with shame responding in early childhoodRosemary S L Mills
Department of Family Social Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Dev Psychol 44:1369-80. 2008..For girls, high initial shame, but not cortisol response, predicted subsequent shame responding... - Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal genderMalcolm R Ogborn
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada
Lipids 41:1141-9. 2006..Gender-based responses to environmental factors, such as dietary lipid sources and micronutrients, may contribute to gender-based differences in disease progression rates... - Summary of evidence-based review on vitamin D efficacy and safety in relation to bone healthAnn Cranney
Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa Hospital, and The University of Ottawa Evidence based Practice Center, Ottawa, Ontario, Canada
Am J Clin Nutr 88:513S-519S. 2008..We found fair evidence that adults tolerated vitamin D at doses above current dietary reference intake levels, but we had no data on the association between long-term harms and higher doses of vitamin D... - Polyunsaturated fatty acids and bone massHope A Weiler
Am J Clin Nutr 80:1085-6; author reply 1086-7. 2004 - Dietary flax oil reduces renal injury, oxidized LDL content, and tissue n-6/n-3 FA ratio in experimental polycystic kidney diseaseMalcolm R Ogborn
University of Manitoba, Winnipeg, Manitoba, R3E 3P4 Canada
Lipids 37:1059-65. 2002..The consumption of FO-based products may prove a more practical way of obtaining health benefit than attempts to increase dietary content of unrefined seed...