M A Wainberg

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Public health implications of antiretroviral therapy and HIV drug resistance
    M A Wainberg
    McGill University AIDS Centre, Jewish General Hospital, Montreal, Quebec, Canada
    JAMA 279:1977-83. 1998
  2. pmc Novel, live attenuated simian immunodeficiency virus constructs containing major deletions in leader RNA sequences
    Y Guan
    McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 75:2776-85. 2001
  3. ncbi request reprint Role of distal zinc finger of nucleocapsid protein in genomic RNA dimerization of human immunodeficiency virus type 1; no role for the palindrome crowning the R-U5 hairpin
    M Laughrea
    McGill AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, H3T 1E2, Canada
    Virology 281:109-16. 2001
  4. pmc Construction and in vitro properties of a series of attenuated simian immunodeficiency viruses with all accessory genes deleted
    Y Guan
    McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 75:4056-67. 2001
  5. pmc Role for human immunodeficiency virus type 1 Tat protein in suppression of viral reverse transcriptase activity during late stages of viral replication
    M Kameoka
    McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 75:2675-83. 2001
  6. pmc Hydrophobic amino acids in the human immunodeficiency virus type 1 p2 and nucleocapsid proteins can contribute to the rescue of deleted viral RNA packaging signals
    L Rong
    McGill AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 75:7230-43. 2001
  7. pmc Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells
    A Roulston
    Lady Davis Institute for Medical Research, Quebec, Canada
    J Exp Med 175:751-63. 1992
  8. pmc An intact U5-leader stem is important for efficient replication of simian immunodeficiency virus
    Y Guan
    McGill AIDS Center, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 75:11924-9. 2001
  9. ncbi request reprint Effects of drug resistance on viral load in patients failing antiretroviral therapy
    N Machouf
    Clinique M├ędicale l Actuel, Montreal, Quebec, Canada
    J Med Virol 78:608-13. 2006
  10. pmc Role of stem B, loop B, and nucleotides next to the primer binding site and the kissing-loop domain in human immunodeficiency virus type 1 replication and genomic-RNA dimerization
    N Shen
    McGill AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 75:10543-9. 2001

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Public health implications of antiretroviral therapy and HIV drug resistance
    M A Wainberg
    McGill University AIDS Centre, Jewish General Hospital, Montreal, Quebec, Canada
    JAMA 279:1977-83. 1998
    ..Unless this topic is appropriately addressed, the likelihood is that drug-resistant variants of HIV, if able to successfully replicate, will sustain the epidemic and limit the effectiveness of antiviral therapy...
  2. pmc Novel, live attenuated simian immunodeficiency virus constructs containing major deletions in leader RNA sequences
    Y Guan
    McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 75:2776-85. 2001
    ..One of these viruses, termed SD4, may be appropriate for study with rhesus macaques, in order to determine whether reversions will occur in vivo and to further study this virus as a candidate for attenuated vaccination...
  3. ncbi request reprint Role of distal zinc finger of nucleocapsid protein in genomic RNA dimerization of human immunodeficiency virus type 1; no role for the palindrome crowning the R-U5 hairpin
    M Laughrea
    McGill AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, H3T 1E2, Canada
    Virology 281:109-16. 2001
    ..Genome dimerization and mature tRNA placement would then become two RNA-RNA interactions sharing similar NC sequence requirements...
  4. pmc Construction and in vitro properties of a series of attenuated simian immunodeficiency viruses with all accessory genes deleted
    Y Guan
    McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 75:4056-67. 2001
    ..We hope to shortly evaluate these simplified constructs in rhesus macaques to determine their long-term safety as well as ability to induce protective immune responsiveness as proviral DNA vaccines...
  5. pmc Role for human immunodeficiency virus type 1 Tat protein in suppression of viral reverse transcriptase activity during late stages of viral replication
    M Kameoka
    McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 75:2675-83. 2001
    ....
  6. pmc Hydrophobic amino acids in the human immunodeficiency virus type 1 p2 and nucleocapsid proteins can contribute to the rescue of deleted viral RNA packaging signals
    L Rong
    McGill AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 75:7230-43. 2001
    ..Therefore, the long hydrophobic side chains of V, L, I, and M are necessary for these amino acids to rescue the BH-D1, BH-D2, and BH-LD3 mutated viruses...
  7. pmc Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells
    A Roulston
    Lady Davis Institute for Medical Research, Quebec, Canada
    J Exp Med 175:751-63. 1992
    ....
  8. pmc An intact U5-leader stem is important for efficient replication of simian immunodeficiency virus
    Y Guan
    McGill AIDS Center, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 75:11924-9. 2001
    ..Secondary structure suggests that an intact U5-leader stem is important in SIV for infectiousness and that the additional mutants described played important roles in restoration of this motif...
  9. ncbi request reprint Effects of drug resistance on viral load in patients failing antiretroviral therapy
    N Machouf
    Clinique M├ędicale l Actuel, Montreal, Quebec, Canada
    J Med Virol 78:608-13. 2006
    ..Together, these findings suggest that long-term maintenance of a sub-optimal antiretroviral regimen may have deleterious consequences for the patient...
  10. pmc Role of stem B, loop B, and nucleotides next to the primer binding site and the kissing-loop domain in human immunodeficiency virus type 1 replication and genomic-RNA dimerization
    N Shen
    McGill AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 75:10543-9. 2001
    ..Two exceptions were Delta200-226 and Delta236-242 genomic RNAs, which dimerized relatively poorly despite having neutral or positive influences on stem B, loop B, and klh folding...
  11. ncbi request reprint Temporal coordination between initiation of HIV (+)-strand DNA synthesis and primer removal
    M Gotte
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 274:11159-69. 1999
    ..These data show that the initiation of (+)-strand synthesis is accompanied by a conformational change of the polymerase-competent complex...
  12. ncbi request reprint Synergistic inhibition of HIV-1 reverse transcriptase DNA polymerase activity and virus replication in vitro by combinations of carboxanilide nonnucleoside compounds
    R S Fletcher
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Biochemistry 34:10106-12. 1995
    ..We believe this to be the first example of synergistic inhibition of HIV-1 RT by combinations of structurally related nonnucleoside inhibitors...
  13. ncbi request reprint Correlation between high level gp160 expression and reduced CD4 biosynthesis in clonal derivatives of human immunodeficiency virus type 1-infected U-937 cells
    R Geleziunas
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Canada
    J Gen Virol 75:857-65. 1994
    ..In general, there was a good correlation between high levels of expression of gp160 and reduced CD4 biosynthesis. These results suggest that HIV-1 env gene products may contribute to the observed reduction in levels of CD4 biosynthesis...
  14. ncbi request reprint Inhibition of CD4 translation mediated by human immunodeficiency virus type 1 envelope protein in a cell-free system
    S Bour
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montr eal, Qu ebec H3T 1E2, Canada
    J Biol Chem 272:29005-14. 1997
    ..We further propose a mechanism whereby direct interactions between gp160 and nascent CD4 molecules can cause interference with and premature termination of CD4 protein elongation...
  15. ncbi request reprint Development of HIV-1 resistance to (-)2'-deoxy-3'-thiacytidine in patients with AIDS or advanced AIDS-related complex
    M A Wainberg
    McGill University AIDS Centre, Jewish General Hospital, Montreal, Quebec, Canada
    AIDS 9:351-7. 1995
    ..The development of resistance to 3TC was associated with appearance of mutated viral forms and the disappearance of wild-type virus, with regard to codon 184, in both patient plasma and PBMC...
  16. pmc Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase
    G Borkow
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 71:3023-30. 1997
    ..These unique properties of UC781 indicate that this nonnucleoside inhibitor may have considerable promise for use in retrovirucidal formulations to minimize the spread of HIV from infected to noninfected individuals...
  17. ncbi request reprint Analysis of efficiency and fidelity of HIV-1 (+)-strand DNA synthesis reveals a novel rate-limiting step during retroviral reverse transcription
    M Gotte
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 276:6711-9. 2001
    ..Our data show that the initiation of HIV-1 (+)-strand DNA synthesis differs significantly from reactions involving other primer/template combinations, including tRNA-primed (-)-strand DNA synthesis...
  18. ncbi request reprint Rationale for maintenance of the M184v resistance mutation in human immunodeficiency virus type 1 reverse transcriptase in treatment experienced patients
    D Turner
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
    New Microbiol 27:31-9. 2004
    ..Collectively, these factors might explain the residual antiviral effect and clinical benefit observed with continued use of 3TC in combination therapy regimens following the emergence of M184V...
  19. ncbi request reprint HIV drug resistance and implications for the introduction of antiretroviral therapy in resource-poor countries
    M Petrella
    McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    Drug Resist Updat 4:339-46. 2001
    ....
  20. pmc Partial restoration of replication of simian immunodeficiency virus by point mutations in either the dimerization initiation site (DIS) or Gag region after deletion mutagenesis within the DIS
    Y Guan
    McGill AIDS Center, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 75:11920-3. 2001
    ..A set of all three mutations was required in each case for restoration of replication capacity, and either set of mutations could be substituted for the other in both the C8166 and CEMx174 cell lines...
  21. ncbi request reprint HIV-1 nucleocapsid protein and the secondary structure of the binary complex formed between tRNA(Lys.3) and viral RNA template play different roles during initiation of (-) strand DNA reverse transcription
    L Rong
    McGill AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 276:47725-32. 2001
    ..Thus, this stem structure is essential for optimal reverse transcription, despite its role in promotion of the +3 pausing event...
  22. ncbi request reprint Effect of insulin-like growth factor I on HIV type 1 long terminal repeat-driven chloramphenicol acetyltransferase expression
    R J Germinario
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    AIDS Res Hum Retroviruses 15:829-36. 1999
    ..This inhibition may occur at the level of the tat/TAR interaction. Finally, this IGF-I effect is seen in target cell lines and similar paths of inhibition may be involved in the various cell types employed...
  23. pmc Heat shock protein-based therapeutic strategies against human immunodeficiency virus type 1 infection
    B G Brenner
    McGill AIDS Centre, Lady Davis Institute, Jewish General Hospital, and Department of Experimental Surgery, McGill University, Montreal, Quebec, Canada
    Infect Dis Obstet Gynecol 7:80-90. 1999
    ....
  24. ncbi request reprint The role of CD4 and its downmodulation in establishment and maintenance of HIV-1 infection
    S Bour
    Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada
    Immunol Rev 140:147-71. 1994
  25. ncbi request reprint Sensitivity and resistance to (+)-calanolide A of wild-type and mutated forms of HIV-1 reverse transcriptase
    Y Quan
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
    Antivir Ther 4:203-9. 1999
    ..These results suggest that (+)-calanolide A and nevirapine might have rationale as a combination therapy for HIV disease...
  26. ncbi request reprint The long-term effects of anti-retroviral protease inhibitors on sugar transport in L6 cells
    R J Germinario
    Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, 3755 Cote St Catherine Road, Montreal, Quebec, Canada
    J Endocrinol 178:449-56. 2003
    ..The mechanism(s) involved indicates ready reversibility of PI effects on transporters. The mechanism(s) why reversibility of PI-induced 2-DG transport was similar plus or minus PI was not apparent...
  27. ncbi request reprint Diminution of CD4 surface protein but not CD4 messenger RNA levels in monocytic cells infected by HIV-1
    R Geleziunas
    McGill AIDS Centre, McGill University, Montreal, Canada
    AIDS 5:29-33. 1991
    ..These data suggest that HIV-1-mediated depletion of cell-surface CD4 in monocytes does not involve transcript down-modulation as has been reported in T lymphocytes...
  28. ncbi request reprint Inhibition of human lymphocyte mitogenesis by human and other retroviruses. Differential effect of interleukin-2 in restoration of responsiveness
    M A Wainberg
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    AIDS 1:83-7. 1987
    ....
  29. pmc Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors
    A Roulston
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Microbiol Rev 59:481-505. 1995
    ..Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals. Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders...
  30. pmc Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase
    Karidia Diallo
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital and Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3T 1E2, Canada
    Antimicrob Agents Chemother 47:3377-83. 2003