Genomes and Genes
Alexandra Chloe Villani
Affiliation: McGill University
- Common variants in the NLRP3 region contribute to Crohn's disease susceptibilityAlexandra Chloe Villani
Division of Gastroenterology, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
Nat Genet 41:71-6. 2009..Mutations in NLRP3 are known to be responsible for three rare autoinflammatory disorders. These results suggest that the NLRP3 region is also implicated in the susceptibility of more common inflammatory diseases such as Crohn's disease...
- Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitisAlexandra Chloe Villani
Department of Gastroenterology, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
PLoS ONE 4:e7154. 2009..The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene...
- Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritisAlexandra Chloe Villani
Division of Gastroenterology, Department of Medicine, McGill University, Montreal, Quebec, Canada
Gastroenterology 138:1502-13. 2010..2% of these developed IBS. We used this cohort to study genetic susceptibility to post-infectious (PI)-IBS...
- Tumor necrosis factor receptor gene polymorphisms in Crohn's disease: association with clinical phenotypesKevin A Waschke
Department of Medicine, Division of Gastroenterology, McGill University Inflammatory Bowel Disease Program, Montreal, Canada
Am J Gastroenterol 100:1126-33. 2005..Our purpose was to determine whether single nucleotide polymorphisms (SNPs) in the TNF receptors confer susceptibility to Crohn's disease and whether they are associated with clinical phenotype...