Silvia M Vidal

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response
    Agnieszka Kielczewska
    Department of Human Genetics, McGill University, Montreal, Quebec, H3A 1B1, Canada
    J Exp Med 206:515-23. 2009
  2. pmc Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience
    Silvia M Vidal
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Curr Opin Virol 1:497-512. 2011
  3. doi request reprint Altered IFN-γ-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease
    Megan M Eva
    Department of Human Genetics, McGill University, Montreal, Quebec H3G 0B1, Canada
    J Immunol 192:259-70. 2014
  4. ncbi request reprint Critical residues at the Ly49 natural killer receptor's homodimer interface determine functional recognition of m157, a mouse cytomegalovirus MHC class I-like protein
    Agnieszka Kielczewska
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    J Immunol 178:369-77. 2007
  5. ncbi request reprint Cmv4, a new locus linked to the NK cell gene complex, controls innate resistance to cytomegalovirus in wild-derived mice
    Sonia Girard Adam
    Department of Human Genetics, McGill Center for Host Resistance, McGill University, Montreal, Quebec, Canada
    J Immunol 176:5478-85. 2006
  6. pmc THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis
    Sabrina Torre
    Department of Human Genetics, McGill University, Montreal, QC, Canada Complex Traits Group, McGill University, Montreal, QC, Canada
    Infect Immun 83:759-68. 2015
  7. pmc Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant
    Kyoko E Yuki
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e55331. 2013
  8. doi request reprint Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival
    Ian Gaël Rodrigue-Gervais
    Department of Medicine, McGill University, Montreal, QC H3A 1B1, Canada
    Cell Host Microbe 15:23-35. 2014
  9. pmc Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection
    Marie Pierre Desrosiers
    Department of Human Genetics, McGill University, Montreal, Quebec, H3A 1B1, Canada
    Nat Genet 37:593-9. 2005
  10. doi request reprint NK cell receptors and their MHC class I ligands in host response to cytomegalovirus: insights from the mouse genome
    Michal Pyzik
    McGill Centre for the Study of Host Resistance, Department of Human Genetics, Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada H3A 2B4
    Semin Immunol 20:331-42. 2008

Collaborators

Detail Information

Publications34

  1. pmc Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response
    Agnieszka Kielczewska
    Department of Human Genetics, McGill University, Montreal, Quebec, H3A 1B1, Canada
    J Exp Med 206:515-23. 2009
    ..These findings reveal a novel mechanism of major histocompatibility complex class I-restricted recognition of virally infected cells by an activating NK cell receptor...
  2. pmc Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience
    Silvia M Vidal
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Curr Opin Virol 1:497-512. 2011
    ..They suggest that individual experiences as well as genes influence the innate immune resources available to fight off an infection...
  3. doi request reprint Altered IFN-γ-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease
    Megan M Eva
    Department of Human Genetics, McGill University, Montreal, Quebec H3G 0B1, Canada
    J Immunol 192:259-70. 2014
    ..The following study further elucidates the pathophysiological impact of STAT4 during Salmonella infection. ..
  4. ncbi request reprint Critical residues at the Ly49 natural killer receptor's homodimer interface determine functional recognition of m157, a mouse cytomegalovirus MHC class I-like protein
    Agnieszka Kielczewska
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    J Immunol 178:369-77. 2007
    ..These results link Ly49 homodimerization variability to the direct recognition of pathogen products...
  5. ncbi request reprint Cmv4, a new locus linked to the NK cell gene complex, controls innate resistance to cytomegalovirus in wild-derived mice
    Sonia Girard Adam
    Department of Human Genetics, McGill Center for Host Resistance, McGill University, Montreal, Quebec, Canada
    J Immunol 176:5478-85. 2006
    ..Identification of Cmv4 will expand our understanding of the specificity of the innate recognition of infection by NK cells...
  6. pmc THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis
    Sabrina Torre
    Department of Human Genetics, McGill University, Montreal, QC, Canada Complex Traits Group, McGill University, Montreal, QC, Canada
    Infect Immun 83:759-68. 2015
    ..Themis(I23N) mice can be used to study the newly discovered association of THEMIS (6p22.33) with inflammatory bowel disease and multiple sclerosis. ..
  7. pmc Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant
    Kyoko E Yuki
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e55331. 2013
    ..This study illustrates that the regulation of Hamp and iron balance are crucial in the host response to Salmonella infection in Ank1 mutants...
  8. doi request reprint Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival
    Ian Gaël Rodrigue-Gervais
    Department of Medicine, McGill University, Montreal, QC H3A 1B1, Canada
    Cell Host Microbe 15:23-35. 2014
    ..Thus, cIAP2-dependent antagonism of RIPK3-mediated programmed necrosis critically protects the host from influenza infection through maintenance of pulmonary tissue homeostasis rather than through pathogen control by the immune system. ..
  9. pmc Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection
    Marie Pierre Desrosiers
    Department of Human Genetics, McGill University, Montreal, Quebec, H3A 1B1, Canada
    Nat Genet 37:593-9. 2005
    ....
  10. doi request reprint NK cell receptors and their MHC class I ligands in host response to cytomegalovirus: insights from the mouse genome
    Michal Pyzik
    McGill Centre for the Study of Host Resistance, Department of Human Genetics, Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada H3A 2B4
    Semin Immunol 20:331-42. 2008
    ..Activating receptors of MHC class I may represent a window of therapeutic intervention during human infection with viruses, of which cytomegalovirus remains an important health threat...
  11. doi request reprint Mapping of clinical and expression quantitative trait loci in a sex-dependent effect of host susceptibility to mouse-adapted influenza H3N2/HK/1/68
    Gregory A Boivin
    Department of Human Genetics, McGill University, Montreal, Quebec H3A 1B1, Canada
    J Immunol 188:3949-60. 2012
    ..The latter includes the phospholipase gene Pla2g7 and Tnfrsf21, a member of the TNFR superfamily. Confirmation of the gene underlying the chromosome 17 QTL may reveal new strategies for influenza treatment...
  12. doi request reprint Viral MHC class I-like molecule allows evasion of NK cell effector responses in vivo
    Michal Pyzik
    Department of Human Genetics, McGill University, Montreal, Quebec H3G 0B1, Canada Complex Traits Group, McGill University, Montreal, Quebec H3G 0B1, Canada
    J Immunol 193:6061-9. 2014
    ..Of value for human studies is that only a few genetic assortments conditional on the repertoires of viral MHC-I-like proteins/host NK receptors/MHC haplotypes should allow efficient protection against CMV infection. ..
  13. pmc Distinct MHC class I-dependent NK cell-activating receptors control cytomegalovirus infection in different mouse strains
    Michał Pyzik
    Department of Human Genetics, McGill University, Montreal, Quebec H3A 2T5, Canada
    J Exp Med 208:1105-17. 2011
    ..K mice. These results suggest that multiple activating Ly49 receptors participate in H-2-dependent recognition of MCMV infection, providing a common mechanism of NK cell-mediated resistance against viral infection...
  14. pmc Characterization of two ENU-induced mutations affecting mouse skeletal morphology
    Shauna M Dauphinee
    Department of Human Genetics, McGill University, Montreal, Quebec H3G 0B1, Canada
    G3 (Bethesda) 3:1753-8. 2013
    ..Skm2 mice, carrying a mutation in Flnb, present with scoliosis and lordosis. These mutant mice will serve as useful models for the study of vertebral malformations. ..
  15. pmc Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC
    Lee Hwa Tai
    Laboratory of Molecular Immunology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    J Exp Med 205:3187-99. 2008
    ..Finally, TLR9-dependent antiviral responses were compromised in Ly49Q-null mice infected with mouse cytomegalovirus. Thus, class I MHC recognition by Ly49Q on pDCs is necessary for optimal activation of innate immune responses in vivo...
  16. pmc NK cell receptor/H2-Dk-dependent host resistance to viral infection is quantitatively modulated by H2q inhibitory signals
    Nassima Fodil-Cornu
    Department of Human Genetics, McGill University, Life Sciences Complex, Montreal, Canada
    PLoS Genet 7:e1001368. 2011
    ..Thus, the integration of activating and inhibitory signals emanating from various MHC-I/NK cell receptor interactions regulates NK cell-mediated control of viral load...
  17. pmc N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-αß signaling and suppresses STAT4-induced IFN-γ production, resulting in increased susceptibility to Salmonella typhimurium
    Etienne Richer
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    J Immunol 185:3593-601. 2010
    ..The reduced IFN-gamma levels, along with the increased inflammation, rationalize the S. Typhimurium susceptibility in terms of increased bacterial load in target organs and cytokine-induced septic shock and death...
  18. pmc Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1
    Gregory Caignard
    Departments of Human Genetics and Medicine, McGill University, Montreal, Quebec, Canada
    PLoS Pathog 9:e1003637. 2013
    ..Altogether, these results revealed the CD45-mediated T cell function as potentially critical for infection and viral spread to the brain, and also for subsequent HSE development...
  19. pmc An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria
    Silayuv E Bongfen
    Department of Biochemistry, McGill University, Montreal, Canada
    PLoS ONE 7:e31012. 2012
    ..CM resistance in Jak3(W81R/+) heterozygotes occurs in presence of normal T, B and NK cell numbers. These findings highlight the pathological role of CD8(+) T cells and Jak3-dependent IFN-γ-mediated Th1 responses in CM pathogenesis...
  20. pmc The impact of Ly49-NK cell-dependent recognition of MCMV infection on innate and adaptive immune responses
    Michal Pyzik
    Department of Human Genetics, McGill University, Montreal, QC, Canada H3G OB1
    J Biomed Biotechnol 2011:641702. 2011
    ..Here, we will concisely review the newly acquired evidence pertaining to NK cell Ly49-dependent recognition of MCMV-infected cell and the ensuing NK cell regulatory responses...
  21. ncbi request reprint Enemy at the gates: forward genetics of the mouse antiviral response
    Agnieszka Kielczewska
    McGill Centre for the Study of Host Resistance, Department of Human Genetics, McGill University, Montreal, Quebec, H3A 2B4, Canada
    Curr Opin Immunol 18:617-26. 2006
    ....
  22. pmc Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells
    Julien Pothlichet
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    PLoS Pathog 9:e1003256. 2013
    ..These findings demonstrate that in IAV-infected lung epithelial cells RIG-I activates the inflammasome both directly and through a type I IFN positive feedback loop...
  23. doi request reprint Use of inbred mouse strains to map recognition receptors of MCMV infected cells in the NK cell gene locus
    Nassima Fodil-Cornu
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Methods Mol Biol 612:393-409. 2010
    ..In this chapter, we provide a practical guide to the genetic mapping and functional characterization of NK cell receptors that control innate immunity against MCMV via specific recognition of infected cells...
  24. doi request reprint Type I interferon response to cytomegalovirus infection: the kick-start
    Nassima Fodil-Cornu
    Department of Human Genetics, McGill University, Montreal, Quebec H3A 1B1, Canada
    Cell Host Microbe 3:59-61. 2008
    ....
  25. pmc Genetic control of high density lipoprotein-cholesterol in AcB/BcA recombinant congenic strains of mice
    Sean A Wiltshire
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Physiol Genomics 44:843-52. 2012
    ..The possibility of dissecting the specific effects of this new ApoA1 deficiency in the context of isogenic controls makes the BcA68 mouse a valuable new tool...
  26. pmc CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation
    James M Kennedy
    Department of Biochemistry, Department of Human Genetics, McGill and Genome Quebec Innovation Center, Complex Traits Group, McGill University, Montreal, Quebec H3A 0G4, Canada Department of Biochemistry, Department of Human Genetics, McGill and Genome Quebec Innovation Center, Complex Traits Group, McGill University, Montreal, Quebec H3A 0G4, Canada
    J Exp Med 211:2519-35. 2014
    ..Our findings strongly suggest that CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q13 locus on inflammation. ..
  27. doi request reprint Unc93b1 -Dependent Endosomal Toll-Like Receptor Signaling Regulates Inflammation and Mortality during Coxsackievirus B3 Infection
    Erin I Lafferty
    Meakins Christie Laboratories, McGill University, Montreal, Que, Canada
    J Innate Immun 7:315-30. 2015
    ..2015 S. Karger AG, Basel. ..
  28. doi request reprint Self or nonself? That is the question: sensing of cytomegalovirus infection by innate immune receptors
    Michal Pyzik
    Department of Human Genetics and Centre for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada
    Mamm Genome 22:6-18. 2011
    ..Here, we review evidence derived from the animal models and human studies that supports the central role played by innate immune receptors in the recognition of virus infection and their participation in the many layers of defense...
  29. doi request reprint Increased resistance to malaria in mice with methylenetetrahydrofolate reductase (Mthfr) deficiency suggests a mechanism for selection of the MTHFR 677C>T (c.665C>T) variant
    Danielle N Meadows
    Department of Human Genetics, McGill University, McGill University Health Center, Montreal, Quebec, Canada
    Hum Mutat 35:594-600. 2014
    ..We suggest that mild MTHFR deficiency protects against malarial infection and that this phenomenon may have led to the high frequency of the 677C>T/c.665C>T variant in human populations. ..
  30. doi request reprint Quantitative trait locus analysis, pathway analysis, and consomic mapping show genetic variants of Tnni3k, Fpgt, or H28 control susceptibility to viral myocarditis
    Sean A Wiltshire
    Department of Human Genetics, McGill University, Montreal, Quebec H3A 1B1, Canada
    J Immunol 186:6398-405. 2011
    ..Differentially expressed pathways were identified by microarray, and candidate gene analysis revealed Fpgt, H28, and Tnni3k as likely candidates for Vms1...
  31. pmc Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex
    Nassima Fodil-Cornu
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    J Immunol 181:6394-405. 2008
    ..Taken together, these results confirm the pivotal role of the Ly49H receptor during MCMV infection and open the way for further investigations in host-pathogen interactions...
  32. pmc Mapping of a chromosome 12 region associated with airway hyperresponsiveness in a recombinant congenic mouse strain and selection of potential candidate genes by expression and sequence variation analyses
    Cynthia Kanagaratham
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    PLoS ONE 9:e104234. 2014
    ..Overall, through QTL analysis of a recombinant congenic strain, microarray analysis and coding variant analysis we identified Chromosome 12 and three potential candidate genes to be in linkage with airway responsiveness...
  33. doi request reprint Chemical mutagenesis: a new strategy against the global threat of infectious diseases
    Etienne Richer
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Mamm Genome 19:309-17. 2008
    ..In this review we highlight the current progress of these efforts and propose a toolbox for other groups that are interested in this endeavor...
  34. pmc Genetic dissection of NK cell responses
    Peter Moussa
    Department of Human Genetics and Department of Microbiology and Immunology, McGill University, Life Sciences Complex Montreal, QC, Canada
    Front Immunol 3:425. 2012
    ..In this review, we provide an overview of how human and mouse quantitative trait locis (QTLs) have facilitated the identification of genes that modulate NK cell development, recognition, and killing of target cells...