G Turecki

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Regulation of a truncated form of tropomyosin-related kinase B (TrkB) by Hsa-miR-185* in frontal cortex of suicide completers
    Gilles Maussion
    McGill Group for Suicide Studies, Douglas Hospital Research Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e39301. 2012
  2. pmc Association of polyaminergic loci with anxiety, mood disorders, and attempted suicide
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 5:e15146. 2010
  3. pmc Epigenetic modulation of glucocorticoid receptors in posttraumatic stress disorder
    B Labonte
    1 McGill Group for Suicide Studies, Department of Psychiatry, McGill University, Montreal, QC, Canada 2 Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada
    Transl Psychiatry 4:e368. 2014
  4. pmc Age and haplotype variations within FADS1 interact and associate with alterations in fatty acid composition in human male cortical brain tissue
    Erika Freemantle
    Department of Genetics, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e42696. 2012
  5. pmc Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression
    Adolfo Sequeira
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 4:e6585. 2009
  6. pmc Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder
    Cristiana Cruceanu
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e32680. 2012
  7. ncbi request reprint Suicide and the polyamine system
    Jeffrey A Gross
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 Boul LaSalle, Verdun, Quebec, H4H 1R3, Canada
    CNS Neurol Disord Drug Targets 12:980-8. 2013
  8. doi request reprint The neurodevelopmental origins of suicidal behavior
    Gustavo Turecki
    McGill Group for Suicide Studies, Department of Psychiatry, McGill University, Montreal, Canada
    Trends Neurosci 35:14-23. 2012
  9. pmc Lithium: a key to the genetics of bipolar disorder
    Cristiana Cruceanu
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec H4H 1R3, Canada
    Genome Med 1:79. 2009
  10. pmc Broad and narrow personality traits as markers of one-time and repeated suicide attempts: a population-based study
    Jelena Brezo
    McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Canada
    BMC Psychiatry 8:15. 2008

Collaborators

Detail Information

Publications57

  1. pmc Regulation of a truncated form of tropomyosin-related kinase B (TrkB) by Hsa-miR-185* in frontal cortex of suicide completers
    Gilles Maussion
    McGill Group for Suicide Studies, Douglas Hospital Research Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e39301. 2012
    ..Previous studies indicate that downregulation of TrkB-T1 in frontal cortex may be involved in neurobiological processes underlying suicide...
  2. pmc Association of polyaminergic loci with anxiety, mood disorders, and attempted suicide
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 5:e15146. 2010
    ..Studies have identified associations between genetic variants in spermidine/spermine N1-acetyltransferase (SAT1) and both anxiety and suicide, and several polymorphisms appear to play important roles in determining gene expression...
  3. pmc Epigenetic modulation of glucocorticoid receptors in posttraumatic stress disorder
    B Labonte
    1 McGill Group for Suicide Studies, Department of Psychiatry, McGill University, Montreal, QC, Canada 2 Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada
    Transl Psychiatry 4:e368. 2014
    ..Our results also point toward an important role of hGR 1B variant in PTSD...
  4. pmc Age and haplotype variations within FADS1 interact and associate with alterations in fatty acid composition in human male cortical brain tissue
    Erika Freemantle
    Department of Genetics, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e42696. 2012
    ..The contribution to alterations of FAs within the brain by local synthesis is still a matter of debate. Thus, the impact of genetic variants in FADS genes on gene expression and brain FA levels is an important avenue to investigate...
  5. pmc Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression
    Adolfo Sequeira
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 4:e6585. 2009
    ..In this study we investigated brain regions that are known to be implicated in the neurobiology of suicide and major depression are likely to represent valid global molecular alterations...
  6. pmc Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder
    Cristiana Cruceanu
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e32680. 2012
    ..In both in vitro models, we found SYN2 to be modulated by the presence of Li. By focusing on Li-responsive BD we have identified a potential mechanism for Li response in some patients...
  7. ncbi request reprint Suicide and the polyamine system
    Jeffrey A Gross
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 Boul LaSalle, Verdun, Quebec, H4H 1R3, Canada
    CNS Neurol Disord Drug Targets 12:980-8. 2013
    ..In addition, we will also describe potential avenues for future work. ..
  8. doi request reprint The neurodevelopmental origins of suicidal behavior
    Gustavo Turecki
    McGill Group for Suicide Studies, Department of Psychiatry, McGill University, Montreal, Canada
    Trends Neurosci 35:14-23. 2012
    ....
  9. pmc Lithium: a key to the genetics of bipolar disorder
    Cristiana Cruceanu
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec H4H 1R3, Canada
    Genome Med 1:79. 2009
    ....
  10. pmc Broad and narrow personality traits as markers of one-time and repeated suicide attempts: a population-based study
    Jelena Brezo
    McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Canada
    BMC Psychiatry 8:15. 2008
    ..One approach may be to examine whether narrow, i.e., lower-order personality traits may be more useful than their underlying, broad personality trait dimensions...
  11. pmc Psychiatric diagnoses in 3275 suicides: a meta-analysis
    Geneviève Arsenault-Lapierre
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Canada
    BMC Psychiatry 4:37. 2004
    ..This study provides overall rates of total and specific psychiatric disorders in suicide completers and presents evidence supporting gender and geographic differences in their relative proportion...
  12. pmc Application of microarray outlier detection methodology to psychiatric research
    Carl Ernst
    McGill Group for Suicide Studies, McGill University, Montreal, Canada
    BMC Psychiatry 8:29. 2008
    ..While microarrays generate a substantial amount of false positive and spurious results, some of the extreme expression values may be valid and could represent true biological findings...
  13. pmc Suicide and no axis I psychopathology
    Carl Ernst
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Montreal, Canada
    BMC Psychiatry 4:7. 2004
    ..To better understand this issue, we studied suicide completers without an axis I diagnosis and compared them, on measures of psychopathology other than axis I, to normal controls and suicide cases with axis I psychopathology...
  14. pmc No association between the PREP gene and lithium responsive bipolar disorder
    Firoza Mamdani
    Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    BMC Psychiatry 7:9. 2007
    ....
  15. ncbi request reprint Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers
    G Turecki
    Center for Suicide Studies, Douglas Hospital Research Institute, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Verdun, Quebec H4H 1R3, Canada
    Am J Med Genet B Neuropsychiatr Genet 118:36-40. 2003
    ..Moreover, further analysis according to suicide method or psychopathology also failed to reveal differences between groups. Our results do not support a substantial role of these serotonergic receptors in suicide completion...
  16. ncbi request reprint Lack of association between the hSKCa3 channel gene CAG polymorphism and schizophrenia
    R Joober
    Montreal General Hospital Research Institute, Department of Psychiatry, McGill University, Quebec, Canada
    Am J Med Genet 88:154-7. 1999
    ..In addition, hSKCa3 was mapped to chromosome 1. Our results do not support the involvement of this particular CAG repeat-containing gene in schizophrenia...
  17. ncbi request reprint A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior
    M Anguelova
    Dougals Hospital Research Center, McGill University, Montreal, Canada
    Mol Psychiatry 8:646-53. 2003
    ..09 CI : 0.93-1.27, P=0.319). The 5-HTT result was robust and remained significant following sensitivity analysis, suggesting that 5-HTT may play a role in the predisposition to suicide...
  18. doi request reprint Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study
    J Brezo
    The McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Montreal, QC, Canada
    Mol Psychiatry 15:831-43. 2010
    ..To identify where these pathways diverge, we need to understand the differential, phenotype-specific gene-environment interactions such as the ones observed in the present study, using suitably powered samples...
  19. pmc Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q
    A Desautels
    Centre d Etude du Sommeil, Hôpital du Sacré Coeur de Montréal and Centre de recherche en sciences neurologiques, Universite de Montreal, Montreal, Quebec, Canada
    Am J Hum Genet 69:1266-70. 2001
    ..59. Haplotype analysis refined the genetic interval, positioning the RLS-predisposing gene in a 14.71-cM region between D12S1044 and D12S78. These findings represent the first mapping of a locus conferring susceptibility to RLS...
  20. ncbi request reprint Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression
    T A Klempan
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, QC, Canada
    Mol Psychiatry 14:175-89. 2009
    ..The pronounced misexpression of genes central to GABAergic signaling and astrocyte/oligodendrocyte function provides further support for a central glial pathology in depression and suicidal behavior...
  21. ncbi request reprint Lithium responsive bipolar disorder, unilineality, and chromosome 18: A linkage study
    G Turecki
    Centre for Research in Neuroscience, The Montreal General Hospital, McGill University, Montreal, Canada
    Am J Med Genet 88:411-5. 1999
    ..In conclusion, our results are congruent with previous reports that suggest an advantage of unilineal pedigrees in linkage analysis of bipolar disorder and cannot rule out a parent-of-origin effect in this genomic region...
  22. ncbi request reprint TPH and suicidal behavior: a study in suicide completers
    G Turecki
    Douglas Hospital Research Institute, Department of Psychiatry, McGill University, Verdun, Quebec, Canada
    Mol Psychiatry 6:98-102. 2001
    ..These and other results continue to point to the substantial role that the gene that codes for TPH may play in the neurobiology of suicidal behavior...
  23. ncbi request reprint MAOA: association and linkage studies with lithium responsive bipolar disorder
    G Turecki
    Centre for Research in Neuroscience, Montreal General Hospital, McGill University, Canada
    Psychiatr Genet 9:13-6. 1999
    ..The investigation used 138 patients and 108 normal controls. In addition, 25 families were also studied. Our results were not supportive of a major role of MAOA in the predisposition to bipolar disorder...
  24. ncbi request reprint Polyglutamine coding genes in bipolar disorder: lack of association with selected candidate loci
    G Turecki
    Centre for Research in Neuroscience, The Montreal General Hospital, McGill University, 1650 Cedar Ave, Montreal, Canada
    J Affect Disord 58:63-8. 2000
    ..Results obtained with the repeat expansion detection technique (RED) have indicated that bipolar patients have an excess of expanded CAG repeats. However, it is not clear which loci account for this difference...
  25. ncbi request reprint Patterns of gene expression in the limbic system of suicides with and without major depression
    A Sequeira
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, QC, Canada
    Mol Psychiatry 12:640-55. 2007
    ..Overall, these data suggest that specific patterns of expression in the limbic system contribute to the etiology of depression and suicidal behaviors and highlight the role of the hippocampus in major depression...
  26. doi request reprint X chromosome and suicide
    L M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
    Mol Psychiatry 16:216-26. 2011
    ....
  27. ncbi request reprint Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide
    G Turecki
    Centre for Research in Neuroscience, Montreal General Hospital, McGill University, Canada
    Am J Psychiatry 156:1456-8. 1999
    ..However, there remains some controversy regarding the biological specificity of these findings. The authors hypothesized that the variance observed in brain 5-HTR2A binding is genetically mediated, at least in part...
  28. pmc Gene expression biomarkers of response to citalopram treatment in major depressive disorder
    F Mamdani
    McGill Group for Suicide Studies and Depressive Disorders Program, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Transl Psychiatry 1:e13. 2011
    ..These findings point to IRF7 as a gene of interest in studies investigating genomic factors associated with antidepressant response...
  29. ncbi request reprint Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI study
    M Alda
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Med Genet 96:178-81. 2000
    ..In conclusion, our study does not support the hypothesis that genes coding for CRH or PENK contribute to the genetic susceptibility to bipolar disorder. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:178-181, 2000...
  30. ncbi request reprint Impulsive-aggressive behaviours and completed suicide across the life cycle: a predisposition for younger age of suicide
    A McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Canada
    Psychol Med 38:407-17. 2008
    ..It is unclear whether the association between impulsive-aggressive behaviours and suicide exists across different ages...
  31. ncbi request reprint Is lithium response related to G(s)alpha levels in transformed lymphoblasts from subjects with bipolar disorder?
    M Alda
    Department of Psychiatry, Dalhousie University, Halifax, Canada
    J Affect Disord 65:117-22. 2001
    ..Long-term lithium administration blunts G-protein coupled cAMP signaling and may regulate G(s)alpha levels...
  32. ncbi request reprint Canadian restless legs syndrome twin study
    L Xiong
    Center for the Study of Brain Diseases, CHUM Research Center Notre Dame Hospital, University of Montreal, Montreal, Quebec, Canada
    Neurology 68:1631-3. 2007
  33. doi request reprint Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans
    L Booij
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Mol Psychiatry 17:809-17. 2012
    ..Associations in the OBFC remained statistically significant in a mixed larger sample of patients and controls. These results suggest that in humans, genetic factors might partly account for variations in serotonin synthesis in the OBFC...
  34. ncbi request reprint Evidence for a genetic association between monoamine oxidase A and restless legs syndrome
    A Desautels
    Centre d Etude du Sommeil, Hôpital du Sacré Coeur de Montréal and Centre de recherche en sciences neurologiques, Universite de Montreal, Quebec, Canada
    Neurology 59:215-9. 2002
    ..Impairment in the central dopaminergic system has been consistently suggested as an etiologic factor in restless legs syndrome (RLS)...
  35. ncbi request reprint Lack of association between bipolar disorder and tyrosine hydroxylase: a meta-analysis
    G Turecki
    Department of Neurology and Neuroscience, Centre for Research in Neuroscience, McGill University, Montreal, Canada
    Am J Med Genet 74:348-52. 1997
    ..02 (0.68-1.54). Test of the null hypothesis that the mean log odds ratio equals zero (chi2 = 0.11; 5 df; P > 0.05) indicated that there was no overall association between bipolar disorder and tyrosine hydroxylase...
  36. ncbi request reprint DRD3 and DAT1 genes in schizophrenia: an association study
    R Joober
    Douglas Hospital Research Centre, 6875 Boulevard LaSalle, H4H 1R3, Verdun, Canada
    J Psychiatr Res 34:285-91. 2000
    ..To investigate the role of the dopamine receptor 3 (DRD3) and transporter 1 (DAT1) genes in schizophrenia or in modulating its phenotype...
  37. ncbi request reprint Mapping susceptibility genes for bipolar disorder: a pharmacogenetic approach based on excellent response to lithium
    G Turecki
    Douglas Hospital Research Institute, McGill University Health Centre, Montreal, Canada
    Mol Psychiatry 6:570-8. 2001
    ..2 locus may be relevant for lithium response. In conclusion, our results provide original evidence suggesting that loci on 15q14 and 7q11.2 may be implicated in the pathogenesis of BD responsive to lithium...
  38. ncbi request reprint Patterns of co-morbidity in male suicide completers
    C Kim
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Verdun, Quebec, Canada
    Psychol Med 33:1299-309. 2003
    ..Psychiatric co-morbidity is thought to be an important problem in suicide, but it has been little investigated. This study aims to investigate patterns of co-morbidity in a group of male suicide completers...
  39. ncbi request reprint SNAT1 and a family with high rates of suicidal behavior
    C Ernst
    McGill Group for Suicide Studies, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Montreal, QC, Canada H4H 1R3
    Neuroscience 162:415-22. 2009
    ..Complete DNA sequencing of the SNAT1 gene was performed in the family and 276 controls. The family was homozygous for rare alleles which suggests a possible association between low expression of SNAT1 and suicidal behavior...
  40. ncbi request reprint CAG repeat length in RAI1 is associated with age at onset variability in spinocerebellar ataxia type 2 (SCA2)
    S Hayes
    Department of Biology, Centre for Research in Neurosciences and Douglas Hospital Research Institute, McGill University, Montreal, Quebec H3G 1A4, Canada
    Hum Mol Genet 9:1753-8. 2000
    ..This result implicates RAI1 as a possible contributor to SCA2 neurodegeneration and raises the possibility that other CAG-containing proteins may play a role in the pathogenesis of other polyglutamine disorders...
  41. ncbi request reprint A functional myeloperoxidase polymorphic variant is associated with coronary artery disease in French-Canadians
    B Nikpoor
    Center for Research in Neuroscience, McGill University, and the Montreal General Hospital Research Institute, Montreal, Quebec, Canada
    Am Heart J 142:336-9. 2001
    ..436-0.937). CONCLUSION: Our findings suggest that the -463 G/A polymorphism of the MPO gene influences the risk of CAD. This effect may be mediated by the effect of this polymorphism on the transcription level of the MPO gene...
  42. ncbi request reprint A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13
    A Levchenko
    Center for the Study of Brain Diseases, CHUM Research Center Notre Dame Hospital, Montreal, Quebec, Canada
    Neurology 67:900-1. 2006
    ..86 at marker D20S849. This is the third reported autosomal-dominant locus for RLS and the first autosomal-dominant RLS locus in the French-Canadian population...
  43. ncbi request reprint Familial aggregation of suicidal behavior: a family study of male suicide completers from the general population
    Caroline D Kim
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Blvd, Verdun, QC H4H 1R3, Canada
    Am J Psychiatry 162:1017-9. 2005
    ..This study compared suicidality in families of adult male suicide completers and community comparison subjects...
  44. ncbi request reprint Association between the methylenetetrahydrofolate reductase 677C-->T missense mutation and schizophrenia
    R Joober
    Centre for Research in Neuroscience, Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal H3G 1A4, Canada
    Mol Psychiatry 5:323-6. 2000
    ....
  45. ncbi request reprint Analysis of 14 CAG repeat-containing genes in schizophrenia
    R Joober
    Montreal General Hospital Research Institute, Montreal, Canada rjoob
    Am J Med Genet 88:694-9. 1999
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:694-699, 1999...
  46. pmc T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variability
    R Joober
    Montreal General Hospital Research Institute, Douglas Hospital Research Centre, Verdun QC
    J Psychiatry Neurosci 24:141-6. 1999
    ..These result suggest that the 5HT2A-receptor gene may play a role in a subset of schizophrenia characterized by poor long-term outcome and poor response to neuroleptics...
  47. pmc dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients
    C Manitt
    Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
    Transl Psychiatry 3:e338. 2013
    ..Variations in DCC may determine differential predisposition to mPFC disorders in humans. Indeed, DCC expression is elevated in brains of antidepressant-free subjects who committed suicide. ..
  48. ncbi request reprint Identification of three polymorphisms in the translated region of PLC-gamma1 and their investigation in lithium responsive bipolar disorder
    N Ftouhi-Paquin
    Douglas Hospital Research Institute, Douglas Hospital, McGill University, Montreal, Canada
    Am J Med Genet 105:301-5. 2001
    ..13), or exon 31 (chi-square = 1.41, df = 2, P = 0.49). Similar results were observed for allele distributions. These results suggest that our previous findings were not the result of linkage disequilibrium with these variants...
  49. ncbi request reprint A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders
    M Anguelova
    Douglas Hospital Research Center, McGill University, Montreal, Canada
    Mol Psychiatry 8:574-91. 2003
    ..Therefore, these results suggest that, although promising, further studies are required to assess appropriately the evidence suggesting an association between BD and 5-HTT...
  50. ncbi request reprint Gene expression profiling of suicide completers
    L M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Eur Psychiatry 25:287-90. 2010
    ....
  51. ncbi request reprint Personality traits as correlates of suicidal ideation, suicide attempts, and suicide completions: a systematic review
    J Brezo
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Canada
    Acta Psychiatr Scand 113:180-206. 2006
    ..Here, we review conceptual background and empirical evidence investigating roles of traits in suicidal behaviors...
  52. ncbi request reprint Suicidal behavior: is there a genetic predisposition?
    G Turecki
    Douglas Hospital Research Institute, Department of Psychiatry, McGill University, Montreal, Canada
    Bipolar Disord 3:335-49. 2001
    ..To review molecular genetic studies carried out in suicidal behavior...
  53. doi request reprint Childhood trajectories of anxiousness and disruptiveness explain the association between early-life adversity and attempted suicide
    B Wanner
    Research Unit on Children s Psychosocial Maladjustment, Universite de Montreal, Montreal, Quebec, Canada
    Psychol Med 42:2373-82. 2012
    ....
  54. ncbi request reprint Pharmacogenetics and bipolar disorder
    F Mamdani
    Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    Pharmacogenomics J 4:161-70. 2004
    ..A major problem has been comparability between studies, in part, because of differences in the criteria used to define response. More attention should be paid to standardize the criteria for drug response definition...
  55. ncbi request reprint Meta-analysis of the association between tryptophan hydroxylase and suicidal behavior
    A Lalovic
    Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Verdun, Quebec, Canada
    Am J Med Genet 114:533-40. 2002
    ..97-1.34 for the former and OR = 0.96, 95% CI = 0.77-1.20 for the latter). The combined results from comparisons within both groups showed no overall association between suicidal behavior and an intron 7 polymorphism of the TPH gene...
  56. ncbi request reprint Risk factors for completed suicide in schizophrenia and other chronic psychotic disorders: a case-control study
    A McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, 6875 LaSalle Blvd, Montreal QC, Canada H4H 1R3
    Schizophr Res 84:132-43. 2006
    ..Using a case-control design, this study aimed to investigate clinical and behavioural risk factors for suicide completion in schizophrenia and other chronic psychotic disorders...
  57. ncbi request reprint Dopaminergic neurotransmission and restless legs syndrome: a genetic association analysis
    A Desautels
    , , , Canada
    Neurology 57:1304-6. 2001
    ..Furthermore, no effect of the loci examined was observed with stratification using clinical parameters such as age at onset or periodic leg movements during sleep index...

Research Grants3

  1. Suicidal Behavior in Mood Disorders: Genes and Intermediate Phenotypes
    Gustavo Turecki; Fiscal Year: 2008
    ..This study will screen the genome in the largest collection of samples ever assembled for such a study of suicidal behavior in order to identify the responsible genes. ..
  2. Suicidal Behavior in Mood Disorders: Genes and Intermediate Phenotypes
    Gustavo Turecki; Fiscal Year: 2009
    ..This study will screen the genome in the largest collection of samples ever assembled for such a study of suicidal behavior in order to identify the responsible genes. ..
  3. Suicidal Behavior in Mood Disorders: Genes and Intermediate Phenotypes
    Gustavo Turecki; Fiscal Year: 2010
    ..This study will screen the genome in the largest collection of samples ever assembled for such a study of suicidal behavior in order to identify the responsible genes. ..