Bernard Turcotte

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi Transcriptional regulation of nonfermentable carbon utilization in budding yeast
    Bernard Turcotte
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, QC, Canada
    FEMS Yeast Res 10:2-13. 2010
  2. ncbi Complex interplay among regulators of drug resistance genes in Saccharomyces cerevisiae
    Bassel Akache
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 279:27855-60. 2004
  3. pmc Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production
    Marc Larochelle
    Department of Medicine, Room H7 83, Royal Victoria Hospital, McGill University, 687 Pine Ave West, Montreal, Quebec, Canada
    Mol Cell Biol 26:6690-701. 2006
  4. pmc Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes
    Sarah MacPherson
    Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Ave West, Montreal, Quebec, Canada H3A 1A1
    Antimicrob Agents Chemother 49:1745-52. 2005
  5. pmc Regulation of gluconeogenesis in Saccharomyces cerevisiae is mediated by activator and repressor functions of Rds2
    Nitnipa Soontorngun
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A1
    Mol Cell Biol 27:7895-905. 2007
  6. pmc A fungal family of transcriptional regulators: the zinc cluster proteins
    Sarah MacPherson
    Department of Microbiology and Immunology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A
    Microbiol Mol Biol Rev 70:583-604. 2006
  7. pmc Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of γ-aminobutyrate responsive genes
    Marc André Sylvain
    Department of Microbiology and Immunology, McGill University Health Centre, McGill University, Montreal, Quebec H3A 1A1, Canada
    Genetics 188:523-34. 2011
  8. ncbi New regulators of drug sensitivity in the family of yeast zinc cluster proteins
    Bassel Akache
    Departments of Medicine, Biochemistry, and Microbiology and Immunology, McGill University Health Centre, Royal Victoria Hospital, McGill University, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 277:21254-60. 2002
  9. ncbi New tools for phenotypic analysis in Candida albicans: the WAR1 gene confers resistance to sorbate
    Karine Lebel
    Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Yeast 23:249-59. 2006
  10. pmc Motor protein Myo5p is required to maintain the regulatory circuit controlling WOR1 expression in Candida albicans
    Nadezda Kachurina
    Department of Medicine, Division of Experimental Medicine, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    Eukaryot Cell 11:626-37. 2012

Collaborators

  • Francois Robert
  • Guillaume Lesage
  • Malcolm Whiteway
  • Sarah MacPherson
  • Bassel Akache
  • Karen Hellauer
  • Nadezda Kachurina
  • Marc Larochelle
  • Marc André Sylvain
  • Natalia Klimova
  • Zarna Shah
  • Nitnipa Soontorngun
  • Simon Drouin
  • Karine Lebel
  • Ralph Yeung
  • Raya Mahbuba
  • Xiao Bei Liang
  • Sandra Weber
  • Martine Raymond
  • Anne Marie Sdicu
  • Xavier De Deken
  • Edith Sirard

Detail Information

Publications14

  1. doi Transcriptional regulation of nonfermentable carbon utilization in budding yeast
    Bernard Turcotte
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, QC, Canada
    FEMS Yeast Res 10:2-13. 2010
    ..Finally, the role of additional regulators such as Adr1, Ert1, Oaf1, and Pip2 is also discussed...
  2. ncbi Complex interplay among regulators of drug resistance genes in Saccharomyces cerevisiae
    Bassel Akache
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 279:27855-60. 2004
    ..Our data demonstrate a complex interplay among these activators and suggest that Pdr1p is a master drug regulator involved in recruiting other zinc cluster proteins to fine tune the regulation of multidrug resistance genes...
  3. pmc Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production
    Marc Larochelle
    Department of Medicine, Room H7 83, Royal Victoria Hospital, McGill University, 687 Pine Ave West, Montreal, Quebec, Canada
    Mol Cell Biol 26:6690-701. 2006
    ..These data suggest that Stb5 is a key player in the control of NADPH production for resistance to oxidative stress...
  4. pmc Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes
    Sarah MacPherson
    Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Ave West, Montreal, Quebec, Canada H3A 1A1
    Antimicrob Agents Chemother 49:1745-52. 2005
    ..These results provide an important link between changes in the ergosterol biosynthetic pathway and azole resistance in this opportunistic fungal species...
  5. pmc Regulation of gluconeogenesis in Saccharomyces cerevisiae is mediated by activator and repressor functions of Rds2
    Nitnipa Soontorngun
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A1
    Mol Cell Biol 27:7895-905. 2007
    ..Finally, we show that upon a shift to ethanol, Rds2 activation is correlated with its hyperphosphorylation by the Snf1 kinase. In summary, we have characterized Rds2 as a novel major regulator of gluconeogenesis...
  6. pmc A fungal family of transcriptional regulators: the zinc cluster proteins
    Sarah MacPherson
    Department of Microbiology and Immunology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A
    Microbiol Mol Biol Rev 70:583-604. 2006
    ..With the number of characterized zinc cluster proteins growing rapidly, it is becoming more and more apparent that they are important regulators of fungal physiology...
  7. pmc Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of γ-aminobutyrate responsive genes
    Marc André Sylvain
    Department of Microbiology and Immunology, McGill University Health Centre, McGill University, Montreal, Quebec H3A 1A1, Canada
    Genetics 188:523-34. 2011
    ..Thus, under artificial conditions, both Dal81 and Uga3 can activate transcription independently of each other. However, under physiological conditions, both factors cooperate by targeting common coactivators...
  8. ncbi New regulators of drug sensitivity in the family of yeast zinc cluster proteins
    Bassel Akache
    Departments of Medicine, Biochemistry, and Microbiology and Immunology, McGill University Health Centre, Royal Victoria Hospital, McGill University, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 277:21254-60. 2002
    ..These results strongly suggest that Stb5p is a transcriptional activator of multidrug resistance genes. Thus, we have identified new regulators of drug sensitivity in the family of zinc cluster proteins...
  9. ncbi New tools for phenotypic analysis in Candida albicans: the WAR1 gene confers resistance to sorbate
    Karine Lebel
    Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Yeast 23:249-59. 2006
    ..albicans orf19.1035 gene results in sensitivity to the weak acid sorbate, while its overexpression increases resistance to this compound. We named it WAR1, in analogy to its S. cerevisiae orthologue...
  10. pmc Motor protein Myo5p is required to maintain the regulatory circuit controlling WOR1 expression in Candida albicans
    Nadezda Kachurina
    Department of Medicine, Division of Experimental Medicine, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    Eukaryot Cell 11:626-37. 2012
    ..It appears that while myosin I is not directly required for mating in C. albicans, it is involved in WOR1 expression and the white-opaque transition and thus is indirectly implicated in mating...
  11. doi The anticancer drug tirapazamine has antimicrobial activity against Escherichia coli, Staphylococcus aureus and Clostridium difficile
    Zarna Shah
    Department of Biochemistry, McGill University, Montreal, QC, Canada
    FEMS Microbiol Lett 347:61-9. 2013
    ..5 μg mL(-1) ), as were pathogenic strains of Clostridium difficile (MIC = 7.5 ng mL(-1) ). TPZ may merit additional study as a broad-spectrum antibacterial, particularly for anaerobes. ..
  12. ncbi Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter
    Karen Hellauer
    Department of Medicine, McGill University Health Centre, Royal Victoria Hospital, McGill University, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 277:17671-6. 2002
    ..Moreover, mutations known to reduce binding of Pdr1/Pdr3p abolished the induction observed in the Deltardr1 strain. Thus, we have identified a transcriptional repressor involved in the control of multidrug resistance...
  13. ncbi Large-scale analysis of genes that alter sensitivity to the anticancer drug tirapazamine in Saccharomyces cerevisiae
    Karen Hellauer
    Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Mol Pharmacol 68:1365-75. 2005
    ..This suggests that permeases may be involved in intracellular uptake of TPZ. Our discoveries in yeast may lead to a better understanding of TPZ biology in humans...
  14. pmc Phenotypic analysis of a family of transcriptional regulators, the zinc cluster proteins, in the human fungal pathogen Candida glabrata
    Natalia Klimova
    Department of Medicine, McGill University Health Centre, McGill University, Montreal, Quebec, Canada H3A 1A1
    G3 (Bethesda) 4:931-40. 2014
    ..In summary, we have assigned phenotypes to more than half of the zinc cluster genes in C. glabrata. Our study provides a resource that will be useful to better understand the biological role of these transcription factors. ..