Research Topics
Genomes and Genes | Michel L TremblaySummaryAffiliation: McGill University Country: Canada Publications
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Publications
Impact of oncogenic protein tyrosine phosphatases in cancerSerge Hardy
Goodman Research Cancer Centre, McGill University, 1160 Pine Avenue, Room 601 Montreal, QC, Canada H3A 1A3
Anticancer Agents Med Chem 12:4-18. 2012..Finally, we will discuss the therapeutic implications of targeting these oncogenic PTPs in cancer...- [Basic cancer research in Québec]Michel L Tremblay
Centre de recherche sur le cancer de l Université McGill, 3655 Promenade Sir William Osler, McIntyre Medical Sciences Building, Universite McGill, Montreal, Quebec, Canada, H3G 1Y6
Bull Cancer 93:827-30. 2006..Direct and growing collaborations between these centres and their usage of state of the art technological platforms place them in an excellent position to participate into first-rate oncology studies on the international scene... 
Phosphatases at the heart of FoxO metabolic controlMichel L Tremblay
McGill Cancer Centre, McGill University, Montreal, PQ, H3G 1Y6, Canada
Cell Metab 7:101-3. 2008..A new study by Ni et al. (2007) shows that sustained activation of FoxO1 or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling through inhibition of calcineurin and PP2A...- The PTP family photo albumMichel L Tremblay
Goodman Cancer Centre, Biochemistry Department, Montreal, Quebec H3G 0B1, Canada
Cell 136:213-4. 2009..2009) analyze 22 different PTP structures to define their common and unique features. This effort provides key insights into the regulation of PTP activity that could lead to the development of new therapeutics... 
Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptorsVeena Sangwan
Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A1, Canada
J Biol Chem 286:45000-13. 2011..Finally, we show that PTP1B dephosphorylated NSF and that this interaction was required for physiological RTK trafficking and appropriate attenuation of downstream signaling...- PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2Matthew Stuible
Rosalind and Morris Goodman Cancer Centre and Departments of Biochemistry and Oncology, McGill University, Montreal, Quebec H3A 1A3, Canada
J Biol Chem 285:23899-907. 2010..These results reveal a novel link between the dephosphorylation and endocytic machinery and suggest that PTP1B can affect RTK signaling in a previously unrecognized manner... - The role of protein tyrosine phosphatase 1B in Ras signalingNadia Dubé
McGill Cancer Centre and Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Room 715, Montreal, QC, Canada H3G 1Y6
Proc Natl Acad Sci U S A 101:1834-9. 2004..This finding may in part explain the absence of increased tumor incidence in PTP1B-deficient mice. Thus, PTP1B can positively regulate Ras activity by acting on pathways distal to those of receptor tyrosine kinases... - The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3Paul D Simoncic
Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
Curr Biol 12:446-53. 2002..To date, the molecular basis underlying this phenotype has not been reported... - Gr-1+ myeloid cells lacking T cell protein tyrosine phosphatase inhibit lymphocyte proliferation by an IFN-gamma- and nitric oxide-dependent mechanismMaryse Dupuis
Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Laval, Quebec, Canada
J Immunol 171:726-32. 2003..These findings demonstrate an important function of TC-PTP in the induction of the NO pathway that mediates inhibition of T cell proliferation... - TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}Annie Bourdeau
McGill Cancer Centre, McGill University, Montreal, QC, Canada
Blood 109:4220-8. 2007..Our results unraveled a new role for TC-PTP in normal B lymphopoiesis and suggest that modulation of bone marrow microenvironment is a potential therapeutic approach for selected B-cell leukemia... - T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory diseaseKrista M Heinonen
Division of Experimental Medicine, McGill University, Montreal, QC, Canada
Blood 103:3457-64. 2004..These results identify T-cell protein tyrosine phosphatase as a key modulator of inflammatory signals and macrophage function... - Relationship between angiotensin-converting enzyme gene polymorphism and body composition, functional performance, and blood biomarkers in advanced cancer patientsAntonio Vigano
McGill Nutrition and Performance Laboratory, McGill University Health Centre, McGill University, Montreal, Canada
Clin Cancer Res 15:2442-7. 2009.... - Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other graninsGeoffrey N Hendy
Department of Medicine, Royal Victoria Hospital, Montreal, Quebec, Canada
Mol Endocrinol 20:1935-47. 2006..Hence, the increased expression of the other granin family members is likely to compensate for the Chga deficiency... - Ablation of the Sam68 RNA binding protein protects mice from age-related bone lossStephane Richard
Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
PLoS Genet 1:e74. 2005.... - Organization of the Sec61 translocon, studied by high resolution native electrophoresisKurt Dejgaard
Department of Biochemistry, and McGill Cancer Centre, McIntyre Medical Building, McGill University, 3655 Promenade Sir William Osler, Montreal, Canada
J Proteome Res 9:1763-71. 2010..On the lumenal side, the BiP cochaperone ERdj3 resides with the three RAMP complexes. Our observations may hint at how subcompartmentalization is achieved in the ER membrane continuum... - Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formationJennifer F Raven
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Cell Cycle 10:794-804. 2011..Our data reveal a previous uncharacterized anti-tumor activity of Stat1 in ErbB2/Neu-mediated cell transformation and breast oncogenesis with possible implications in the diagnosis and treatment of ErbB2-positive breast cancers... - PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASPJean Francois Cote
Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 277:2973-86. 2002..This finding suggests a possible mechanism for PTP-PEST to directly modulate actin remodeling through the PSTPIP-WASP interaction... - Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouseSyed Wajahat Hassan
Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, Canada
PLoS ONE 5:e8868. 2010..These novel findings in TC-PTP hemi-deficiency support the hypothesis that TC-PTP is an important regulator of inflammatory cytokine signaling and that it may be implicated in the pathophysiology of IBD... - Protein tyrosine phosphatase 1B in hematopoiesisKrista M Heinonen
Division of Experimental Medicine, McGill Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada
Cell Cycle 5:1053-6. 2006..Here we further discuss the role of PTP-1B in monocyte/macrophage differentiation as well as the implications of our findings in the context of PTP-1B inhibitors... - Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signalingFeng Gu
McGill Cancer Center and Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
Mol Cell Biol 23:3753-62. 2003..These results indicate that PTP-1B regulates GH signaling by reducing the extent of JAK2 phosphorylation and suggest that PTP-1B is essential for limiting the action of GH during metabolic stress such as fasting... - Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasisSofi G Julien
McGill Cancer Centre, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec H3G 1Y6, Canada
Nat Genet 39:338-46. 2007..This report provides a rationale for the development of PTP1B as a new therapeutic target in breast cancer... - Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell developmentNadia Dubé
McGill Cancer Centre, Department of Biochemistry, and Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
Cancer Res 65:10088-95. 2005..We conclude that PTP1B is an important determinant of the latency and type of tumors in a p53-deficient background through its role in the regulation of B-cell development... - Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigmaMelanie J Chagnon
McGill Cancer Centre and Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada
Can J Physiol Pharmacol 84:755-63. 2006.... - Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signalingKrista M Heinonen
Division of Experimental Medicine, McGill University, Montreal, QC, Canada H3G 1Y6
Proc Natl Acad Sci U S A 103:2776-81. 2006..Collectively, our data indicate that PTP-1B is an important modulator of myeloid differentiation and macrophage activation in vivo and provide a demonstration of a physiological role for PTP-1B in immune regulation... - Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stressFeng Gu
McGill Cancer Centre and Department of Biochemistry, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 279:49689-93. 2004..We demonstrate that PTP-1B is not just a passive resident of the ER but on the contrary has an essential role in potentiating IRE1-mediated ER stress signaling pathways... - Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failureVeena Sangwan
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
J Biol Chem 281:221-8. 2006..This study identifies a previously unknown physiological role for PTP1B in Fas-mediated liver damage and points to PTP1B as a potential therapeutic target against hepatotoxic agents... - Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1BAlan Cheng
McGill Cancer Center, McGill University, H3G 1Y6, Montreal, Quebec, Canada
Dev Cell 2:497-503. 2002..These results suggest that PTP1B negatively regulates leptin signaling, and provide one mechanism by which it may regulate obesity... - Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancerNadia Dubé
McGill Cancer Centre and Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Room 701, Montreal, QC, Canada H3G 1Y6
Biochim Biophys Acta 1754:108-17. 2005..Here, we review the function of PTP1B and TC-PTP in diabetes, obesity, and processes related to cancer... - Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatasesMaria Adelaida Gomez
Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada
Sci Signal 2:ra58. 2009.... - Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNSPrzemyslaw S Sapieha
Department of Pathology and Cell Biology, Universite de Montreal, 2900, Boulevard Edouard Montpetit, Pavillon Principal, Room N 535, Montreal, Quebec, Canada H3T 1J4
Mol Cell Neurosci 28:625-35. 2005..Our results support a model in which RPTPsigma inhibits axon regeneration in the adult injured CNS... - Protein tyrosine phosphatases in cancer: friends and foes!David P Labbé
Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada
Prog Mol Biol Transl Sci 106:253-306. 2012..In conclusion, we present our perspective on the potential of these PTPs to serve as therapeutic targets in cancer... - Receptor tyrosine phosphatase sigma (RPTPσ) regulates, p250GAP, a novel substrate that attenuates Rac signalingMelanie J Chagnon
Rosalind and Morris Goodman Cancer Centre, McGill University, Canada
Cell Signal 22:1626-33. 2010..Taken together, our results demonstrate for the first time that RPTPsigma modulates Rac dependent activity through regulating a novel substrate, p250GAP... - Inside the human cancer tyrosine phosphatomeSofi G Julien
Goodman Cancer Research Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Nat Rev Cancer 11:35-49. 2011..Progress in understanding the regulation and function of PTPs has provided insights into which PTPs might be potential therapeutic targets in human cancer... - In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosisMatthew Stuible
Rosalind and Morris Goodman Cancer Centre and Departments of Biochemistry and Oncology, McGill University, Montreal, Quebec, Canada
Trends Cell Biol 20:672-9. 2010..These findings reveal a novel link between two important mechanisms of RTK signal attenuation and highlight the multifaceted impact of PTP1B on cell signaling... - Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progressionSerge Hardy
Department of Biochemistry, The Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
Cancer Res 70:8959-67. 2010..Together, our results argue that PRL-2 plays a role in breast cancer progression... - Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient miceElizabeth J Fry
Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
Glia 58:423-33. 2010..Our data suggest that RPTPsigma may function to prevent axonal growth after injury in the adult mammalian spinal cord and could be a target for promoting long distance regeneration after spinal cord injury... - Modulation of bone marrow-derived endothelial progenitor cell activity by protein tyrosine phosphatasesSébastien Trop
Division of Cardiac Surgery, McGill University Health Center, McGill University, Montreal, QC, Canada
Trends Cardiovasc Med 18:180-6. 2008..The use of protein tyrosine phosphatase inhibitors to modulate the development and function of endothelial progenitor cells as a potential novel therapy for peripheral vascular and coronary artery disease in humans is discussed... - Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphataseVeena Sangwan
Department of Biochemistry, McGill University, Canada
J Biol Chem 283:34374-83. 2008..Our data demonstrate that PTP1B and TCPTP play distinct and non-redundant roles in the regulation of the Met receptor-tyrosine kinase... - Protein tyrosine phosphatases PTP-1B and TC-PTP play nonredundant roles in macrophage development and IFN-gamma signalingKrista M Heinonen
Division of Experimental Medicine, Goodman Cancer Centre, and Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Proc Natl Acad Sci U S A 106:9368-72. 2009..Together, these data indicate a nonredundant role for PTP-1B and TC-PTP in the regulation of IFN signaling... - Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP)Marie Claude Gingras
Goodman Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Int J Dev Biol 53:1069-74. 2009..Our results show that Ptpn23 is expressed early during mouse development and that its expression is maintained in adult tissues, markedly in the epithelial cells of many organs... - T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human diseaseKaren M Doody
Department of Biochemistry, McGill University, Montreal, QC, Canada
Immunol Rev 228:325-41. 2009.... - The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivationMaxime Halle
Rosalind and Morris Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, Canada
J Biol Chem 284:6893-908. 2009..Our results establish that GP63 plays a central role in a number of hostcell molecular events that likely contribute to the infectivity of Leishmania... - Insulin receptor kinase-associated phosphotyrosine phosphatases in hepatic endosomes: assessing the role of phosphotyrosine phosphatase-1BChaoyang Li
Polypeptide Hormone Laboratory, McGill Cancer Center, Montreal, Quebec, Canada
Endocrinology 147:912-8. 2006..These data suggest that LAR , PTP-alpha, and PTP-1B are not candidates for the IRK-associated PTP in hepatic ENs, and that IRK dephosphorylation in ENs may result from the concerted actions of several PTPs... - Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and deltaNoriko Uetani
McGill Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
J Neurosci 26:5872-80. 2006.... - PTP1B and TC-PTP: regulators of transformation and tumorigenesisMatthew Stuible
McGill Cancer Centre and Department of Biochemistry, McGill University, Montreal, QC, Canada
Cancer Metastasis Rev 27:215-30. 2008..Given the challenge of developing inhibitors specific for PTP1B alone, it is necessary to consider both enzymes and their roles in various cancer models... - The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphataseShuo Wang
Department of Oncology, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
J Biol Chem 281:9439-49. 2006..These data reveal a novel function of PKR as a negative regulator of Stat1 and Stat3 with important implications in cell signaling... - Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivativesMatthew Stuible
McGill Cancer Centre, Department of Biochemistry, McGill University, 3655 Prom Sir William Osler, Montreal, Quebec, H3G 1Y6, Canada
Chembiochem 8:179-86. 2007..These compounds should be useful in the elucidation of cellular PTP function and could represent a starting point for development of therapeutic PTP inhibitors... - Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseasesMelanie J Chagnon
McGill Cancer Centre and Department of Biochemistry, McGill University, McIntyre Medical Sciences Building, 3655 Promenade Sir William Osler, Room 701, Montreal, QC H3G 1Y6, Canada
Biochem Cell Biol 82:664-75. 2004..This RPTP subfamily is likely to become important as drug targets in these various human pathologies, but further understanding of their complex signal transduction cascades will be required... - Beyond the metabolic function of PTP1BNadia Dubé
McGill Cancer Centre, McGill University, Montreal, QC Canada
Cell Cycle 3:550-3. 2004..Our recent results show that loss of PTP1B can lead to decreased Ras signaling, despite enhanced signaling of other pathways. Here, we discuss how these findings implicate PTP1B as a positive and negative regulator of oncogenesis... - Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatasesNoriko Uetani
Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
J Clin Invest 119:924-35. 2009..Together, these results suggest that ureter positioning is controlled by the opposing actions of Ret and LAR family phosphatases regulating apoptosis-mediated tissue morphogenesis... - Coordinated action of protein tyrosine phosphatases in insulin signal transductionAlan Cheng
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
Eur J Biochem 269:1050-9. 2002..The present review will discuss the current knowledge of these two and other potential PTPs involved in the insulin signaling pathway... - Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTPAnnie Bourdeau
McGill Cancer Centre, McGill University, 3655 Promenade Sir-William-Osler, Room 701, Montreal, QC, H3G 1Y6, Canada
Curr Opin Cell Biol 17:203-9. 2005..Gene-targeting approaches will help us to unravel the physiological functions of these enzymes... - PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446Matthew Stuible
McGill Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 283:15740-6. 2008..This study advances the importance of Tyr(446) in the regulation of cortactin and provides a potential mechanism to explain the effects of PTP1B on processes including cell adhesion, migration, and tumorigenesis... - NRAMP-1 expression modulates protein-tyrosine phosphatase activity in macrophages: impact on host cell signaling and functionsMaria Adelaida Gomez
Department of Medicine, McGill University, Montreal, Quebec H3A 2B4, Canada
J Biol Chem 282:36190-8. 2007.... - Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver developmentJacinthe Sirois
McGill Cancer Center and Biochemistry Department, McGill University, 3655 Sir William Osler Promenade, Montreal, Que, Canada H3G 1Y6
Mech Dev 123:869-80. 2006.... - Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linkerJennifer S Jamieson
Department of Cell and Developmental Biology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
J Cell Sci 118:5835-47. 2005..These data provide mechanistic insight into how the paxillin-PTP-PEST interaction contributes to integrin signaling events associated with the spatiotemporal regulation of key modulators of the cytoskeleton and cell motility machinery... - Firing up mitochondrial activities with PTPMT1Yves Boisclair
Department of Animal Science, Cornell University, 259 Morrison Hall, Ithaca, New York 14853, USA
Mol Cell 19:291-2. 2005..This report comments on its consequences for mitochondrial function and on its potential to act as a therapeutic target in diabetes and cancer... - T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiationPaul D Simoncic
Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Department of Medical Biophysics, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Mol Cell Biol 26:4149-60. 2006..These data implicate Tcptp as a critical regulator of CSF-1 signaling and mononuclear phagocyte development in hematopoiesis... - Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblastsDeirdre A Buckley
Cell Biology Laboratory, Department of Biochemistry and Bioscience Research Institute, National University of Ireland, Cork, Ireland
Mol Cell Biol 22:1998-2010. 2002..These findings demonstrate that PTP-1B can regulate IGF-IR kinase activity and function and that loss of PTP-1B can enhance IGF-I-mediated cell survival, growth, and motility in transformed cells... - Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphataseCatherine van Vliet
Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
Nat Immunol 6:253-60. 2005..These results link TCPTP and Src tyrosine kinases to the selective regulation of TNF-induced MAPK signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF... - Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphataseCamilla Persson
Ludwig Institute for Cancer Research, Uppsala Branch, Biomedical Center, S 751 24 Uppsala, Sweden
Mol Cell Biol 24:2190-201. 2004..In summary, our findings identify TC-PTP as a previously unrecognized negative regulator of PDGF beta receptor signaling and support the general notion that PTPs display site selectivity in their action on tyrosine kinase receptors... - PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAPSarita K Sastry
Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
J Biol Chem 281:11627-36. 2006..These data suggest that PTP-PEST couples protrusion and retraction by acting on VAV2 and p190RhoGAP to reciprocally modulate the activity of Rac1 and RhoA... - Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible miceSeung Hwan Lee
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
J Exp Med 197:515-26. 2003..This panel of transgenic animals provides a unique resource to study possible pleiotropic effect of Cmv1... - Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: evidence from protein tyrosine phosphatase-1B overexpression, knockout, and RNAi studiesWei Qiu
Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Diabetes 53:3057-66. 2004.... - Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomicsPhilipp Mertins
Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
Mol Cell Proteomics 7:1763-77. 2008..Importantly the MS-based strategies described here are entirely generic and can be used to address the poorly understood aspects of cellular PTP function... - Phosphatases in cell-matrix adhesion and migrationMelinda Larsen
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30 Room 421, 30 Convent Drive, MSC 4370, Bethesda, Maryland 20892 4370, USA
Nat Rev Mol Cell Biol 4:700-11. 2003.... - Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic responseMaxime Halle
Institute of Biological Chemistry, Academia Sinica, 128 Academia Road, Section 2, Nankang 115, Taipei, Taiwan
Mol Cell Biol 27:1172-90. 2007..Together, our data demonstrate that PTP-PEST actively contributes to the cellular apoptotic response and reveal the importance of caspases as regulators of PTPs in apoptosis... - PTP1B and TC-PTP: novel roles in immune-cell signalingPaul D Simoncic
The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
Can J Physiol Pharmacol 84:667-75. 2006..This review will focus on the substrate specificities of PTP1B and TC-PTP and their roles in immune cell signaling, and will discuss some new data implicating PTP1B and TC-PTP in myeloid development...