Michel L Tremblay

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse
    Syed Wajahat Hassan
    Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, Canada
    PLoS ONE 5:e8868. 2010
  2. pmc Inhibition of T cell protein tyrosine phosphatase enhances interleukin-18-dependent hematopoietic stem cell expansion
    Annie Bourdeau
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    Stem Cells 31:293-304. 2013
  3. ncbi request reprint Prostate Cancer Genetic-susceptibility Locus on Chromosome 20q13 is Amplified and Coupled to Androgen Receptor-regulation in Metastatic Tumors
    David P Labbé
    Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue, Room 617, Montreal, QC, Canada H3A 1A3
    Mol Cancer Res 12:184-9. 2014
  4. doi request reprint The PTP family photo album
    Michel L Tremblay
    Goodman Cancer Centre, Biochemistry Department, Montreal, Quebec H3G 0B1, Canada
    Cell 136:213-4. 2009
  5. ncbi request reprint [Basic cancer research in Québec]
    Michel L Tremblay
    Centre de recherche sur le cancer de l Université McGill, 3655 Promenade Sir William Osler, McIntyre Medical Sciences Building, Universite McGill, Montreal, Quebec, Canada, H3G 1Y6
    Bull Cancer 93:827-30. 2006
  6. doi request reprint Phosphatases at the heart of FoxO metabolic control
    Michel L Tremblay
    McGill Cancer Centre, McGill University, Montreal, PQ, H3G 1Y6, Canada
    Cell Metab 7:101-3. 2008
  7. ncbi request reprint TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}
    Annie Bourdeau
    McGill Cancer Centre, McGill University, Montreal, QC, Canada
    Blood 109:4220-8. 2007
  8. pmc Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase
    Veena Sangwan
    Department of Biochemistry, McGill University, Canada
    J Biol Chem 283:34374-83. 2008
  9. pmc PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2
    Matthew Stuible
    Rosalind and Morris Goodman Cancer Centre and Departments of Biochemistry and Oncology, McGill University, Montreal, Quebec H3A 1A3, Canada
    J Biol Chem 285:23899-907. 2010
  10. ncbi request reprint Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma
    Melanie J Chagnon
    McGill Cancer Centre and Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada
    Can J Physiol Pharmacol 84:755-63. 2006

Detail Information

Publications82

  1. pmc Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse
    Syed Wajahat Hassan
    Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, Canada
    PLoS ONE 5:e8868. 2010
    ..These novel findings in TC-PTP hemi-deficiency support the hypothesis that TC-PTP is an important regulator of inflammatory cytokine signaling and that it may be implicated in the pathophysiology of IBD...
  2. pmc Inhibition of T cell protein tyrosine phosphatase enhances interleukin-18-dependent hematopoietic stem cell expansion
    Annie Bourdeau
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    Stem Cells 31:293-304. 2013
    ....
  3. ncbi request reprint Prostate Cancer Genetic-susceptibility Locus on Chromosome 20q13 is Amplified and Coupled to Androgen Receptor-regulation in Metastatic Tumors
    David P Labbé
    Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue, Room 617, Montreal, QC, Canada H3A 1A3
    Mol Cancer Res 12:184-9. 2014
    ..Visual Overview: http://mcr.aacrjournals.org/content/early/2014/02/07/1541-7786.MCR-13-0477/F1.large.jpg. Mol Cancer Res; 12(2); 184-9. ©2013 AACR. ..
  4. doi request reprint The PTP family photo album
    Michel L Tremblay
    Goodman Cancer Centre, Biochemistry Department, Montreal, Quebec H3G 0B1, Canada
    Cell 136:213-4. 2009
    ..2009) analyze 22 different PTP structures to define their common and unique features. This effort provides key insights into the regulation of PTP activity that could lead to the development of new therapeutics...
  5. ncbi request reprint [Basic cancer research in Québec]
    Michel L Tremblay
    Centre de recherche sur le cancer de l Université McGill, 3655 Promenade Sir William Osler, McIntyre Medical Sciences Building, Universite McGill, Montreal, Quebec, Canada, H3G 1Y6
    Bull Cancer 93:827-30. 2006
    ..Direct and growing collaborations between these centres and their usage of state of the art technological platforms place them in an excellent position to participate into first-rate oncology studies on the international scene...
  6. doi request reprint Phosphatases at the heart of FoxO metabolic control
    Michel L Tremblay
    McGill Cancer Centre, McGill University, Montreal, PQ, H3G 1Y6, Canada
    Cell Metab 7:101-3. 2008
    ..A new study by Ni et al. (2007) shows that sustained activation of FoxO1 or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling through inhibition of calcineurin and PP2A...
  7. ncbi request reprint TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}
    Annie Bourdeau
    McGill Cancer Centre, McGill University, Montreal, QC, Canada
    Blood 109:4220-8. 2007
    ..Our results unraveled a new role for TC-PTP in normal B lymphopoiesis and suggest that modulation of bone marrow microenvironment is a potential therapeutic approach for selected B-cell leukemia...
  8. pmc Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase
    Veena Sangwan
    Department of Biochemistry, McGill University, Canada
    J Biol Chem 283:34374-83. 2008
    ..Our data demonstrate that PTP1B and TCPTP play distinct and non-redundant roles in the regulation of the Met receptor-tyrosine kinase...
  9. pmc PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2
    Matthew Stuible
    Rosalind and Morris Goodman Cancer Centre and Departments of Biochemistry and Oncology, McGill University, Montreal, Quebec H3A 1A3, Canada
    J Biol Chem 285:23899-907. 2010
    ..These results reveal a novel link between the dephosphorylation and endocytic machinery and suggest that PTP1B can affect RTK signaling in a previously unrecognized manner...
  10. ncbi request reprint Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma
    Melanie J Chagnon
    McGill Cancer Centre and Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada
    Can J Physiol Pharmacol 84:755-63. 2006
    ....
  11. doi request reprint Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP)
    Marie Claude Gingras
    Goodman Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Int J Dev Biol 53:1069-74. 2009
    ..Our results show that Ptpn23 is expressed early during mouse development and that its expression is maintained in adult tissues, markedly in the epithelial cells of many organs...
  12. doi request reprint PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer
    Laurent Lessard
    Goodman Cancer Research Centre, Montreal, Quebec, Canada
    Cancer Res 72:1529-37. 2012
    ..Our findings support the preclinical testing of PTP1B inhibitors for prostate cancer treatment...
  13. doi request reprint Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression
    Serge Hardy
    Department of Biochemistry, The Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
    Cancer Res 70:8959-67. 2010
    ..Together, our results argue that PRL-2 plays a role in breast cancer progression...
  14. pmc Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling
    Krista M Heinonen
    Division of Experimental Medicine, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 103:2776-81. 2006
    ..Collectively, our data indicate that PTP-1B is an important modulator of myeloid differentiation and macrophage activation in vivo and provide a demonstration of a physiological role for PTP-1B in immune regulation...
  15. doi request reprint Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases
    Maria Adelaida Gomez
    Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Sci Signal 2:ra58. 2009
    ....
  16. ncbi request reprint Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta
    Noriko Uetani
    McGill Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    J Neurosci 26:5872-80. 2006
    ....
  17. ncbi request reprint Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development
    Nadia Dubé
    McGill Cancer Centre, Department of Biochemistry, and Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Cancer Res 65:10088-95. 2005
    ..We conclude that PTP1B is an important determinant of the latency and type of tumors in a p53-deficient background through its role in the regulation of B-cell development...
  18. ncbi request reprint Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure
    Veena Sangwan
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Biol Chem 281:221-8. 2006
    ..This study identifies a previously unknown physiological role for PTP1B in Fas-mediated liver damage and points to PTP1B as a potential therapeutic target against hepatotoxic agents...
  19. pmc Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases
    Noriko Uetani
    Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Clin Invest 119:924-35. 2009
    ..Together, these results suggest that ureter positioning is controlled by the opposing actions of Ret and LAR family phosphatases regulating apoptosis-mediated tissue morphogenesis...
  20. pmc Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors
    Veena Sangwan
    Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 286:45000-13. 2011
    ..Finally, we show that PTP1B dephosphorylated NSF and that this interaction was required for physiological RTK trafficking and appropriate attenuation of downstream signaling...
  21. doi request reprint Protein tyrosine phosphatases in cancer: friends and foes!
    David P Labbé
    Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada
    Prog Mol Biol Transl Sci 106:253-306. 2012
    ..In conclusion, we present our perspective on the potential of these PTPs to serve as therapeutic targets in cancer...
  22. ncbi request reprint Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development
    Jacinthe Sirois
    McGill Cancer Center and Biochemistry Department, McGill University, 3655 Sir William Osler Promenade, Montreal, Que, Canada H3G 1Y6
    Mech Dev 123:869-80. 2006
    ....
  23. ncbi request reprint Protein tyrosine phosphatase 1B in hematopoiesis
    Krista M Heinonen
    Division of Experimental Medicine, McGill Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada
    Cell Cycle 5:1053-6. 2006
    ..Here we further discuss the role of PTP-1B in monocyte/macrophage differentiation as well as the implications of our findings in the context of PTP-1B inhibitors...
  24. pmc PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446
    Matthew Stuible
    McGill Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 283:15740-6. 2008
    ..This study advances the importance of Tyr(446) in the regulation of cortactin and provides a potential mechanism to explain the effects of PTP1B on processes including cell adhesion, migration, and tumorigenesis...
  25. pmc Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility
    Emily Ayoub
    Goodman Cancer Research Centre and Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, Canada
    J Biol Chem 288:25739-48. 2013
    ..These findings suggest a novel role of SKAP-Hom and its phosphorylation in the regulation of cellular motility. Moreover, these results open new avenues by which PTP-PEST regulates cellular migration, a hallmark of metastasis. ..
  26. doi request reprint Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence
    Katherine Stewart
    Goodman Cancer Research Centre, Department of Biochemistry, McGill University, Montreal, 1160 Pine Avenue W Montreal, QC H3A 1A3, Canada
    Development 140:3413-22. 2013
    ..Together these results identify LAR RPTPs as important regulators of craniofacial morphogenesis and provide insight into the etiology of Pierre-Robin sequence. ..
  27. ncbi request reprint Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation
    Jennifer F Raven
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Cell Cycle 10:794-804. 2011
    ..Our data reveal a previous uncharacterized anti-tumor activity of Stat1 in ErbB2/Neu-mediated cell transformation and breast oncogenesis with possible implications in the diagnosis and treatment of ErbB2-positive breast cancers...
  28. ncbi request reprint Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis
    Sofi G Julien
    McGill Cancer Centre, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec H3G 1Y6, Canada
    Nat Genet 39:338-46. 2007
    ..This report provides a rationale for the development of PTP1B as a new therapeutic target in breast cancer...
  29. pmc The role of protein tyrosine phosphatase 1B in Ras signaling
    Nadia Dubé
    McGill Cancer Centre and Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Room 715, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 101:1834-9. 2004
    ..This finding may in part explain the absence of increased tumor incidence in PTP1B-deficient mice. Thus, PTP1B can positively regulate Ras activity by acting on pathways distal to those of receptor tyrosine kinases...
  30. pmc The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation
    Maxime Halle
    Rosalind and Morris Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, Canada
    J Biol Chem 284:6893-908. 2009
    ..Our results establish that GP63 plays a central role in a number of hostcell molecular events that likely contribute to the infectivity of Leishmania...
  31. ncbi request reprint T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease
    Krista M Heinonen
    Division of Experimental Medicine, McGill University, Montreal, QC, Canada
    Blood 103:3457-64. 2004
    ..These results identify T-cell protein tyrosine phosphatase as a key modulator of inflammatory signals and macrophage function...
  32. doi request reprint Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo
    Michael D Perron
    Lady Davis Institute Jewish General Hospital M P, S C, H U S, Departments of Pharmacology and Therapeutics M P, H U S, Biochemistry I A, E P, M L T, and Oncology H U S, Goodman Cancer Research Center M L T, and Segal Cancer Center, McGill University, Montreal, Quebec, Canada H U S and Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, Canada E P
    Mol Pharmacol 85:553-63. 2014
    ..This work demonstrates a novel approach to develop effective allosteric inhibitors that can be expanded to target the corresponding allosteric domains of other receptor PTPs. ..
  33. pmc Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling
    Feng Gu
    McGill Cancer Center and Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Mol Cell Biol 23:3753-62. 2003
    ..These results indicate that PTP-1B regulates GH signaling by reducing the extent of JAK2 phosphorylation and suggest that PTP-1B is essential for limiting the action of GH during metabolic stress such as fasting...
  34. pmc Protein tyrosine phosphatases PTP-1B and TC-PTP play nonredundant roles in macrophage development and IFN-gamma signaling
    Krista M Heinonen
    Division of Experimental Medicine, Goodman Cancer Centre, and Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Proc Natl Acad Sci U S A 106:9368-72. 2009
    ..Together, these data indicate a nonredundant role for PTP-1B and TC-PTP in the regulation of IFN signaling...
  35. ncbi request reprint Impact of oncogenic protein tyrosine phosphatases in cancer
    Serge Hardy
    Goodman Research Cancer Centre, McGill University, 1160 Pine Avenue, Room 601 Montreal, QC, Canada H3A 1A3
    Anticancer Agents Med Chem 12:4-18. 2012
    ..Finally, we will discuss the therapeutic implications of targeting these oncogenic PTPs in cancer...
  36. doi request reprint Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice
    Elizabeth J Fry
    Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Glia 58:423-33. 2010
    ..Our data suggest that RPTPsigma may function to prevent axonal growth after injury in the adult mammalian spinal cord and could be a target for promoting long distance regeneration after spinal cord injury...
  37. doi request reprint In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis
    Matthew Stuible
    Rosalind and Morris Goodman Cancer Centre and Departments of Biochemistry and Oncology, McGill University, Montreal, Quebec, Canada
    Trends Cell Biol 20:672-9. 2010
    ..These findings reveal a novel link between two important mechanisms of RTK signal attenuation and highlight the multifaceted impact of PTP1B on cell signaling...
  38. doi request reprint The two faces of PTP1B in cancer
    Laurent Lessard
    Goodman Cancer Centre and Department of Biochemistry, McGill University, 1160 Pine Avenue, Montreal, Quebec, Canada H3G 0B1
    Biochim Biophys Acta 1804:613-9. 2010
    ..Together, these results highlight not only the great potential of PTP1B inhibitors in cancer therapy but also the need for a better understanding of PTP1B function prior to use of these compounds in human patients...
  39. ncbi request reprint Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer
    Nadia Dubé
    McGill Cancer Centre and Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Room 701, Montreal, QC, Canada H3G 1Y6
    Biochim Biophys Acta 1754:108-17. 2005
    ..Here, we review the function of PTP1B and TC-PTP in diabetes, obesity, and processes related to cancer...
  40. doi request reprint Inside the human cancer tyrosine phosphatome
    Sofi G Julien
    Goodman Cancer Research Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Nat Rev Cancer 11:35-49. 2011
    ..Progress in understanding the regulation and function of PTPs has provided insights into which PTPs might be potential therapeutic targets in human cancer...
  41. ncbi request reprint The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3
    Paul D Simoncic
    Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
    Curr Biol 12:446-53. 2002
    ..To date, the molecular basis underlying this phenotype has not been reported...
  42. doi request reprint Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity
    Katherine E Horn
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurochem 122:147-61. 2012
    ..Furthermore, RPTPσ nulls exhibit reduced long-term potentiation and enhanced novel object recognition memory. We conclude that RPTPσ limits synapse number and regulates synapse structure and function in the mature CNS...
  43. pmc Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia
    Charles V Rajadurai
    Department of Biochemistry, McGill University, Montréal Québec H3A 1Y6, Canada
    J Cell Sci 125:2940-53. 2012
    ..These findings provide insights into the molecular mechanisms of invadopodia formation and identify Gab1 as a scaffold protein involved in this process...
  44. doi request reprint Modulation of bone marrow-derived endothelial progenitor cell activity by protein tyrosine phosphatases
    Sébastien Trop
    Division of Cardiac Surgery, McGill University Health Center, McGill University, Montreal, QC, Canada
    Trends Cardiovasc Med 18:180-6. 2008
    ..The use of protein tyrosine phosphatase inhibitors to modulate the development and function of endothelial progenitor cells as a potential novel therapy for peripheral vascular and coronary artery disease in humans is discussed...
  45. ncbi request reprint Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS
    Przemyslaw S Sapieha
    Department of Pathology and Cell Biology, Universite de Montreal, 2900, Boulevard Edouard Montpetit, Pavillon Principal, Room N 535, Montreal, Quebec, Canada H3T 1J4
    Mol Cell Neurosci 28:625-35. 2005
    ..Our results support a model in which RPTPsigma inhibits axon regeneration in the adult injured CNS...
  46. doi request reprint PTP1B and TC-PTP: regulators of transformation and tumorigenesis
    Matthew Stuible
    McGill Cancer Centre and Department of Biochemistry, McGill University, Montreal, QC, Canada
    Cancer Metastasis Rev 27:215-30. 2008
    ..Given the challenge of developing inhibitors specific for PTP1B alone, it is necessary to consider both enzymes and their roles in various cancer models...
  47. doi request reprint Receptor tyrosine phosphatase sigma (RPTPσ) regulates, p250GAP, a novel substrate that attenuates Rac signaling
    Melanie J Chagnon
    Rosalind and Morris Goodman Cancer Centre, McGill University, Canada
    Cell Signal 22:1626-33. 2010
    ..Taken together, our results demonstrate for the first time that RPTPsigma modulates Rac dependent activity through regulating a novel substrate, p250GAP...
  48. ncbi request reprint Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives
    Matthew Stuible
    McGill Cancer Centre, Department of Biochemistry, McGill University, 3655 Prom Sir William Osler, Montreal, Quebec, H3G 1Y6, Canada
    Chembiochem 8:179-86. 2007
    ..These compounds should be useful in the elucidation of cellular PTP function and could represent a starting point for development of therapeutic PTP inhibitors...
  49. doi request reprint Organization of the Sec61 translocon, studied by high resolution native electrophoresis
    Kurt Dejgaard
    Department of Biochemistry, and McGill Cancer Centre, McIntyre Medical Building, McGill University, 3655 Promenade Sir William Osler, Montreal, Canada
    J Proteome Res 9:1763-71. 2010
    ..On the lumenal side, the BiP cochaperone ERdj3 resides with the three RAMP complexes. Our observations may hint at how subcompartmentalization is achieved in the ER membrane continuum...
  50. ncbi request reprint Protein Tyrosine Phosphatase 1B Is a Regulator of the Interleukin-10-Induced Transcriptional Program in Macrophages
    Kelly A Pike
    1Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue, Montreal, Quebec H3A 1A3, Canada
    Sci Signal 7:ra43. 2014
    ..These findings identify PTP1B as a central regulator of IL-10R-STAT3 and IL-10R-STAT1 signaling, and demonstrate that phosphatases can tailor the quantitative and qualitative properties of cytokine-induced transcriptional responses. ..
  51. doi request reprint T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice
    Karen M Doody
    Rosalind and Morris Goodman Cancer Research Centre and McGill University, Montreal, Quebec, Canada
    Arthritis Rheum 64:752-61. 2012
    ..The aim of this study was to evaluate the effect of TC-PTP deficiency on the bone and joint environment using a knockout mouse model...
  52. doi request reprint T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease
    Karen M Doody
    Department of Biochemistry, McGill University, Montreal, QC, Canada
    Immunol Rev 228:325-41. 2009
    ....
  53. ncbi request reprint The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase
    Shuo Wang
    Department of Oncology, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Biol Chem 281:9439-49. 2006
    ..These data reveal a novel function of PKR as a negative regulator of Stat1 and Stat3 with important implications in cell signaling...
  54. ncbi request reprint Insulin receptor kinase-associated phosphotyrosine phosphatases in hepatic endosomes: assessing the role of phosphotyrosine phosphatase-1B
    Chaoyang Li
    Polypeptide Hormone Laboratory, McGill Cancer Center, Montreal, Quebec, Canada
    Endocrinology 147:912-8. 2006
    ..These data suggest that LAR , PTP-alpha, and PTP-1B are not candidates for the IRK-associated PTP in hepatic ENs, and that IRK dephosphorylation in ENs may result from the concerted actions of several PTPs...
  55. ncbi request reprint Gr-1+ myeloid cells lacking T cell protein tyrosine phosphatase inhibit lymphocyte proliferation by an IFN-gamma- and nitric oxide-dependent mechanism
    Maryse Dupuis
    Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Laval, Quebec, Canada
    J Immunol 171:726-32. 2003
    ..These findings demonstrate an important function of TC-PTP in the induction of the NO pathway that mediates inhibition of T cell proliferation...
  56. ncbi request reprint Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress
    Feng Gu
    McGill Cancer Centre and Department of Biochemistry, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 279:49689-93. 2004
    ..We demonstrate that PTP-1B is not just a passive resident of the ER but on the contrary has an essential role in potentiating IRE1-mediated ER stress signaling pathways...
  57. doi request reprint Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival
    Francis Robert
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Cancer Res 72:747-56. 2012
    ..Together, our findings suggest a new paradigm to treat ACS by strategies which target protein synthesis to block the production of procachexic factors...
  58. ncbi request reprint Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP
    Annie Bourdeau
    McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Room 701, Montreal, QC, H3G 1Y6, Canada
    Curr Opin Cell Biol 17:203-9. 2005
    ..Gene-targeting approaches will help us to unravel the physiological functions of these enzymes...
  59. doi request reprint Relationship between angiotensin-converting enzyme gene polymorphism and body composition, functional performance, and blood biomarkers in advanced cancer patients
    Antonio Vigano
    McGill Nutrition and Performance Laboratory, McGill University Health Centre, McGill University, Montreal, Canada
    Clin Cancer Res 15:2442-7. 2009
    ....
  60. ncbi request reprint Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins
    Geoffrey N Hendy
    Department of Medicine, Royal Victoria Hospital, Montreal, Quebec, Canada
    Mol Endocrinol 20:1935-47. 2006
    ..Hence, the increased expression of the other granin family members is likely to compensate for the Chga deficiency...
  61. pmc Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss
    Stephane Richard
    Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    PLoS Genet 1:e74. 2005
    ....
  62. ncbi request reprint NRAMP-1 expression modulates protein-tyrosine phosphatase activity in macrophages: impact on host cell signaling and functions
    Maria Adelaida Gomez
    Department of Medicine, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 282:36190-8. 2007
    ....
  63. ncbi request reprint Beyond the metabolic function of PTP1B
    Nadia Dubé
    McGill Cancer Centre, McGill University, Montreal, QC Canada
    Cell Cycle 3:550-3. 2004
    ..Our recent results show that loss of PTP1B can lead to decreased Ras signaling, despite enhanced signaling of other pathways. Here, we discuss how these findings implicate PTP1B as a positive and negative regulator of oncogenesis...
  64. ncbi request reprint Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases
    Melanie J Chagnon
    McGill Cancer Centre and Department of Biochemistry, McGill University, McIntyre Medical Sciences Building, 3655 Promenade Sir William Osler, Room 701, Montreal, QC H3G 1Y6, Canada
    Biochem Cell Biol 82:664-75. 2004
    ..This RPTP subfamily is likely to become important as drug targets in these various human pathologies, but further understanding of their complex signal transduction cascades will be required...
  65. pmc Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol
    Regina Cencic
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 4:e5223. 2009
    ..One flavagline, silvestrol, is capable of modulating chemosensitivity in a mechanism-based mouse model...
  66. ncbi request reprint PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP
    Jean Francois Cote
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 277:2973-86. 2002
    ..This finding suggests a possible mechanism for PTP-PEST to directly modulate actin remodeling through the PSTPIP-WASP interaction...
  67. ncbi request reprint Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
    Alan Cheng
    McGill Cancer Center, McGill University, H3G 1Y6, Montreal, Quebec, Canada
    Dev Cell 2:497-503. 2002
    ..These results suggest that PTP1B negatively regulates leptin signaling, and provide one mechanism by which it may regulate obesity...
  68. ncbi request reprint Coordinated action of protein tyrosine phosphatases in insulin signal transduction
    Alan Cheng
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Eur J Biochem 269:1050-9. 2002
    ..The present review will discuss the current knowledge of these two and other potential PTPs involved in the insulin signaling pathway...
  69. pmc Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase
    Camilla Persson
    Ludwig Institute for Cancer Research, Uppsala Branch, Biomedical Center, S 751 24 Uppsala, Sweden
    Mol Cell Biol 24:2190-201. 2004
    ..In summary, our findings identify TC-PTP as a previously unrecognized negative regulator of PDGF beta receptor signaling and support the general notion that PTPs display site selectivity in their action on tyrosine kinase receptors...
  70. pmc Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts
    Deirdre A Buckley
    Cell Biology Laboratory, Department of Biochemistry and Bioscience Research Institute, National University of Ireland, Cork, Ireland
    Mol Cell Biol 22:1998-2010. 2002
    ..These findings demonstrate that PTP-1B can regulate IGF-IR kinase activity and function and that loss of PTP-1B can enhance IGF-I-mediated cell survival, growth, and motility in transformed cells...
  71. ncbi request reprint Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase
    Catherine van Vliet
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    Nat Immunol 6:253-60. 2005
    ..These results link TCPTP and Src tyrosine kinases to the selective regulation of TNF-induced MAPK signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF...
  72. pmc T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation
    Paul D Simoncic
    Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Department of Medical Biophysics, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Mol Cell Biol 26:4149-60. 2006
    ..These data implicate Tcptp as a critical regulator of CSF-1 signaling and mononuclear phagocyte development in hematopoiesis...
  73. ncbi request reprint PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP
    Sarita K Sastry
    Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    J Biol Chem 281:11627-36. 2006
    ..These data suggest that PTP-PEST couples protrusion and retraction by acting on VAV2 and p190RhoGAP to reciprocally modulate the activity of Rac1 and RhoA...
  74. ncbi request reprint Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker
    Jennifer S Jamieson
    Department of Cell and Developmental Biology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    J Cell Sci 118:5835-47. 2005
    ..These data provide mechanistic insight into how the paxillin-PTP-PEST interaction contributes to integrin signaling events associated with the spatiotemporal regulation of key modulators of the cytoskeleton and cell motility machinery...
  75. ncbi request reprint Firing up mitochondrial activities with PTPMT1
    Yves Boisclair
    Department of Animal Science, Cornell University, 259 Morrison Hall, Ithaca, New York 14853, USA
    Mol Cell 19:291-2. 2005
    ..This report comments on its consequences for mitochondrial function and on its potential to act as a therapeutic target in diabetes and cancer...
  76. ncbi request reprint Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: evidence from protein tyrosine phosphatase-1B overexpression, knockout, and RNAi studies
    Wei Qiu
    Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Diabetes 53:3057-66. 2004
    ....
  77. ncbi request reprint PTP1B and TC-PTP: novel roles in immune-cell signaling
    Paul D Simoncic
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Can J Physiol Pharmacol 84:667-75. 2006
    ..This review will focus on the substrate specificities of PTP1B and TC-PTP and their roles in immune cell signaling, and will discuss some new data implicating PTP1B and TC-PTP in myeloid development...
  78. pmc Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice
    Seung Hwan Lee
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Exp Med 197:515-26. 2003
    ..This panel of transgenic animals provides a unique resource to study possible pleiotropic effect of Cmv1...
  79. pmc Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response
    Maxime Halle
    Institute of Biological Chemistry, Academia Sinica, 128 Academia Road, Section 2, Nankang 115, Taipei, Taiwan
    Mol Cell Biol 27:1172-90. 2007
    ..Together, our data demonstrate that PTP-PEST actively contributes to the cellular apoptotic response and reveal the importance of caspases as regulators of PTPs in apoptosis...
  80. pmc Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics
    Philipp Mertins
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell Proteomics 7:1763-77. 2008
    ..Importantly the MS-based strategies described here are entirely generic and can be used to address the poorly understood aspects of cellular PTP function...
  81. ncbi request reprint Phosphatases in cell-matrix adhesion and migration
    Melinda Larsen
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30 Room 421, 30 Convent Drive, MSC 4370, Bethesda, Maryland 20892 4370, USA
    Nat Rev Mol Cell Biol 4:700-11. 2003
    ....