Research Topics
Genomes and Genes | Jacquetta M TraslerSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosidesJ Trasler
Department of Pediatrics, The McGill University Montréal Children s Hospital Research Institute, Quebec, Canada
Endocrinology 139:3280-8. 1998....- Gamete imprinting: setting epigenetic patterns for the next generationJacquetta M Trasler
McGill University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
Reprod Fertil Dev 18:63-9. 2006.... - Translational research in male mediated developmental toxicityJacquetta M Trasler
Department of Pediatrics, McGill University and The McGill University-Montreal Children's Hospital, Research Institute, 2300 Tupper Street, Montreal, Quebec, Canada H3H 1P3
Adv Exp Med Biol 518:279-84. 2003 
Epigenetic alterations in sperm DNA associated with testicular cancer treatmentDonovan Chan
Research Institute of the McGill University Health Centre at Montreal Children s Hospital, Montreal, Quebec H3Z 2Z3, Canada
Toxicol Sci 125:532-43. 2012..The results indicate that a combination chemotherapy regimen used for testicular cancer treatment can result in altered DNA methylation patterns in spermatozoa and that some loci are more susceptible to damage than others...- Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient miceDonovan Chan
Montreal Children s Hospital Research Institute, 2300 Tupper Street, Montreal, Quebec, Canada H3H 1P3
Endocrinology 151:3363-73. 2010..These results showing strain-specific defects in MTHFR-deficient mice may help to explain population differences in infertility among men with common MTHFR polymorphisms... 
Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3LSophie La Salle
Department of Pharmacology and Therapeutics, McGill University and the Montreal Children s Hospital Research Institute, Montreal, QC H3H 1P3, Canada
BMC Dev Biol 7:104. 2007..Here we report on the role of DNMT3L in male germ cell development...- Reproductive and epigenetic outcomes associated with aging mouse oocytesFlavia L Lopes
Department of Human Genetics, McGill University and Montreal Children s Hospital of the McGill University Health Centre Research Institute, Montreal, Quebec, Canada H3H 1P3
Hum Mol Genet 18:2032-44. 2009.... - Critical period of nonpromoter DNA methylation acquisition during prenatal male germ cell developmentKirsten M Niles
Department of Pharmacology and Therapeutics, McGill University and Research Institute at The Montreal Children s Hospital of the McGill University Health Centre, Montreal, Quebec, Canada
PLoS ONE 6:e24156. 2011.... - Restriction digestion and real-time PCR (qAMP)Christopher C Oakes
Department of Pharmacology and Therapeutics and The Montreal Children s Hospital Research Institute, McGill University, Quebec, Montreal, Canada
Methods Mol Biol 507:271-80. 2009..This approach generates accurate and reproducible results without the requirement for prior treatment of the DNA with sodium bisulfite... - Evaluation of a quantitative DNA methylation analysis technique using methylation-sensitive/dependent restriction enzymes and real-time PCRChristopher C Oakes
Department of Pharmacology and Therapeutics, The Montreal Children's Hospital Research Institute, McGill University, Montreal, Quebec, Canada
Epigenetics 1:146-52. 2006..This approach is also adaptable for use with smaller amounts of starting material. We propose this method as a rapid, quantitative method for the analysis of DNA methylation at single sites or within small regions of DNA... - Coordinate regulation of DNA methyltransferase expression during oogenesisDiana Lucifero
Montreal Children s Hospital Research Institute and Department of Pediatrics, McGill University, Montreal, Quebec, Canada
BMC Dev Biol 7:36. 2007..Here we report the expression dynamics of Dnmt3a and Dnmt3b, as well as a regulator of DNA methylation, Dnmt3L, in isolated female germ cells... - Superovulation alters the expression of imprinted genes in the midgestation mouse placentaAmanda L Fortier
Department of Human Genetics, McGill University, Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
Hum Mol Genet 17:1653-65. 2008..Our findings contribute to the evidence that mechanisms for maintaining imprinting are less robust in trophectoderm-derived tissues, and have clinical implications for the screening of patients following assisted reproduction... - Adverse effects of 5-aza-2'-deoxycytidine on spermatogenesis include reduced sperm function and selective inhibition of de novo DNA methylationChristopher C Oakes
Department of Pharmacology and Therapeutics, McGill University Montreal Children s Hospital Research Institute, 2300 Tupper St, Montreal, QC, Canada
J Pharmacol Exp Ther 322:1171-80. 2007.... - Impact of the chemotherapy cocktail used to treat testicular cancer on the gene expression profile of germ cells from male Brown-Norway ratsGeraldine Delbes
Department of Pharmacology and Therapeutics, McGill University, Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada H3G 1Y6
Biol Reprod 80:320-7. 2009..Thus, BEP exposure triggers an oxidative stress response in round spermatids and induces many pathways that may lead to the survival of damaged cells and production of abnormal sperm... - Epigenetics in spermatogenesisJacquetta M Trasler
Departments of Pediatrics, McGill University, Montreal Children s Hospital, McGill University Health Centre Research Institute, Montreal, QC, Canada
Mol Cell Endocrinol 306:33-6. 2009..In man altered sperm DNA methylation patterns have been reported in individuals with oligospermia... - Profound phenotypic variation among mice deficient in the maintenance of genomic imprintsMarc Toppings
McGill University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada H3H 1P3
Hum Reprod 23:807-18. 2008..Here, we examined the consequences of a loss of maintenance methylation at one specific stage of preimplantation, induced by a deficiency of the oocyte-derived Dnmt1o protein and known to produce biallelic expression of imprinted genes... - Bovine SNRPN methylation imprint in oocytes and day 17 in vitro-produced and somatic cell nuclear transfer embryosDiana Lucifero
McGill University and Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
Biol Reprod 75:531-8. 2006.... - In utero exposure to tributyltin chloride differentially alters male and female fetal gonad morphology and gene expression profiles in the Sprague-Dawley ratOsama Kishta
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3G 1Y6, Canada
Reprod Toxicol 23:1-11. 2007..In conclusion, in utero exposure to TBT resulted in gender-specific alterations in gonadal development and gene expression profiles suggesting that there may be different adaptive changes to toxicity in developing male and female rats... - Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementationTamara L J Kelly
Department of Pediatrics, McGill University and the Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
Biol Reprod 72:667-77. 2005.... - Postnatal development and regulation of beta-hexosaminidase in epithelial cells of the rat epididymisLouis Hermo
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
J Androl 25:69-81. 2004.... - Gene-specific timing and epigenetic memory in oocyte imprintingDiana Lucifero
McGill University, Montreal Children s Hospital Research Institute and Departments of Pediatrics, Human Genetics and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3H 1P3
Hum Mol Genet 13:839-49. 2004..These findings contribute to our understanding of the epigenetic mechanisms underlying imprint acquisition during female germ cell development and have implications for the practice of assisted reproductive technologies... - Methylation dynamics of imprinted genes in mouse germ cellsDiana Lucifero
McGill University-Montreal Children's Hospital Research Institute and Departments of Pediatrics, Human Genetics, and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3H 1P3, Canada
Genomics 79:530-8. 2002..These findings raise the possibility that assisted reproductive technologies that involve in vitro maturation of oocytes may result in developmental abnormalities due to incomplete methylation imprints in immature oocytes... - Effects of in utero tributyltin chloride exposure in the rat on pregnancy outcomeAdedayo Adeeko
Department of Pharmacology and Therapeutics, McGill University, , , Canada H3G 1Y6
Toxicol Sci 74:407-15. 2003..5 and 10 mg/kg exposures. Thus, maternal thyroid hormone homeostasis may be important in mediating the developmental toxicity of organotins... - Buthionine sulfoximine embryotoxicity is associated with prolonged AP-1 activationTerence R S Ozolins
Department of Pharmacology and Therapeutics, McGill University, , , Canada H3G 1Y6
Teratology 66:192-200. 2002..These data suggest that AP-1 induction may serve as a biomarker of embryo stress... - 5-aza-2'-deoxycytidine induces alterations in murine spermatogenesis and pregnancy outcomeTamara L J Kelly
Departments of Pediatrics, McGill University, and McGill University-Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada
J Androl 24:822-30. 2003.... - Potential significance of genomic imprinting defects for reproduction and assisted reproductive technologyDiana Lucifero
McGill University-Montreal Children's Hospital Research Institute and Department of Paediatrics, McGill University, Montreal, Quebec, H3H 1P3, Canada
Hum Reprod Update 10:3-18. 2004.... - Gamete imprinting: implications for assisted reproductive technologiesJacquetta M Trasler
Department of Pediatrics, McGill University and Montreal Children's Hospital Research Institute, Quebec, Canada
J Assist Reprod Genet 20:483-4. 2003 - Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cellsSophie La Salle
Department of Pharmacology and Therapeutics and The Montreal Children s Hospital Research Institute, McGill University, Montreal, QC, Canada H3H 1P3
Dev Biol 268:403-15. 2004..Together, the results provide clues to specific roles for the different DNMT family members in de novo and maintenance methylation in the developing testis and ovary... - Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinationsDominic J Smiraglia
Department of Cancer Genetics, and Comprehensive Cancer Center, Roswell Park Cancer Institute, Buffalo, NY, USA
BMC Genomics 8:446. 2007..However, a limitation to the utility of this method has been the ability to assign specific genomic sequences to RLGS spots, a process commonly referred to as "RLGS spot cloning.".. - Aging results in hypermethylation of ribosomal DNA in sperm and liver of male ratsChristopher C Oakes
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada H3H 1P3
Proc Natl Acad Sci U S A 100:1775-80. 2003..Failure to maintain normal DNA methylation patterns in male germ cells could be one of the mechanisms underlying age-related abnormalities in fertility and progeny outcome...