Jacquetta M Trasler

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides
    J Trasler
    Department of Pediatrics, The McGill University Montréal Children s Hospital Research Institute, Quebec, Canada
    Endocrinology 139:3280-8. 1998
  2. ncbi Gamete imprinting: setting epigenetic patterns for the next generation
    Jacquetta M Trasler
    McGill University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Reprod Fertil Dev 18:63-9. 2006
  3. ncbi Translational research in male mediated developmental toxicity
    Jacquetta M Trasler
    Department of Pediatrics, McGill University and The McGill University Montreal Children s Hospital, Research Institute, 2300 Tupper Street, Montreal, Quebec, Canada H3H 1P3
    Adv Exp Med Biol 518:279-84. 2003
  4. doi Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer
    Geraldine Delbes
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Reprod Toxicol 36:24-32. 2013
  5. doi Epigenetic alterations in sperm DNA associated with testicular cancer treatment
    Donovan Chan
    Research Institute of the McGill University Health Centre at Montreal Children s Hospital, Montreal, Quebec H3Z 2Z3, Canada
    Toxicol Sci 125:532-43. 2012
  6. doi Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice
    Donovan Chan
    Montreal Children s Hospital Research Institute, 2300 Tupper Street, Montreal, Quebec, Canada H3H 1P3
    Endocrinology 151:3363-73. 2010
  7. pmc Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L
    Sophie La Salle
    Department of Pharmacology and Therapeutics, McGill University and the Montreal Children s Hospital Research Institute, Montreal, QC H3H 1P3, Canada
    BMC Dev Biol 7:104. 2007
  8. doi Reproductive and epigenetic outcomes associated with aging mouse oocytes
    Flavia L Lopes
    Department of Human Genetics, McGill University and Montreal Children s Hospital of the McGill University Health Centre Research Institute, Montreal, Quebec, Canada H3H 1P3
    Hum Mol Genet 18:2032-44. 2009
  9. pmc Critical period of nonpromoter DNA methylation acquisition during prenatal male germ cell development
    Kirsten M Niles
    Department of Pharmacology and Therapeutics, McGill University and Research Institute at The Montreal Children s Hospital of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS ONE 6:e24156. 2011
  10. doi Restriction digestion and real-time PCR (qAMP)
    Christopher C Oakes
    Department of Pharmacology and Therapeutics and The Montreal Children s Hospital Research Institute, McGill University, Quebec, Montreal, Canada
    Methods Mol Biol 507:271-80. 2009

Collaborators

Detail Information

Publications31

  1. ncbi Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides
    J Trasler
    Department of Pediatrics, The McGill University Montréal Children s Hospital Research Institute, Quebec, Canada
    Endocrinology 139:3280-8. 1998
    ....
  2. ncbi Gamete imprinting: setting epigenetic patterns for the next generation
    Jacquetta M Trasler
    McGill University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Reprod Fertil Dev 18:63-9. 2006
    ....
  3. ncbi Translational research in male mediated developmental toxicity
    Jacquetta M Trasler
    Department of Pediatrics, McGill University and The McGill University Montreal Children s Hospital, Research Institute, 2300 Tupper Street, Montreal, Quebec, Canada H3H 1P3
    Adv Exp Med Biol 518:279-84. 2003
  4. doi Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer
    Geraldine Delbes
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Reprod Toxicol 36:24-32. 2013
    ..As GSTs are involved in drug resistance mechanisms, we hypothesize that BEP induction of GST expression may lead to the survival of damaged germ cells and the production of abnormal sperm...
  5. doi Epigenetic alterations in sperm DNA associated with testicular cancer treatment
    Donovan Chan
    Research Institute of the McGill University Health Centre at Montreal Children s Hospital, Montreal, Quebec H3Z 2Z3, Canada
    Toxicol Sci 125:532-43. 2012
    ..The results indicate that a combination chemotherapy regimen used for testicular cancer treatment can result in altered DNA methylation patterns in spermatozoa and that some loci are more susceptible to damage than others...
  6. doi Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice
    Donovan Chan
    Montreal Children s Hospital Research Institute, 2300 Tupper Street, Montreal, Quebec, Canada H3H 1P3
    Endocrinology 151:3363-73. 2010
    ..These results showing strain-specific defects in MTHFR-deficient mice may help to explain population differences in infertility among men with common MTHFR polymorphisms...
  7. pmc Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L
    Sophie La Salle
    Department of Pharmacology and Therapeutics, McGill University and the Montreal Children s Hospital Research Institute, Montreal, QC H3H 1P3, Canada
    BMC Dev Biol 7:104. 2007
    ..Here we report on the role of DNMT3L in male germ cell development...
  8. doi Reproductive and epigenetic outcomes associated with aging mouse oocytes
    Flavia L Lopes
    Department of Human Genetics, McGill University and Montreal Children s Hospital of the McGill University Health Centre Research Institute, Montreal, Quebec, Canada H3H 1P3
    Hum Mol Genet 18:2032-44. 2009
    ....
  9. pmc Critical period of nonpromoter DNA methylation acquisition during prenatal male germ cell development
    Kirsten M Niles
    Department of Pharmacology and Therapeutics, McGill University and Research Institute at The Montreal Children s Hospital of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS ONE 6:e24156. 2011
    ....
  10. doi Restriction digestion and real-time PCR (qAMP)
    Christopher C Oakes
    Department of Pharmacology and Therapeutics and The Montreal Children s Hospital Research Institute, McGill University, Quebec, Montreal, Canada
    Methods Mol Biol 507:271-80. 2009
    ..This approach generates accurate and reproducible results without the requirement for prior treatment of the DNA with sodium bisulfite...
  11. ncbi Evaluation of a quantitative DNA methylation analysis technique using methylation-sensitive/dependent restriction enzymes and real-time PCR
    Christopher C Oakes
    Department of Pharmacology and Therapeutics, The Montreal Children s Hospital Research Institute, McGill University, Montreal, Quebec, Canada
    Epigenetics 1:146-52. 2006
    ..This approach is also adaptable for use with smaller amounts of starting material. We propose this method as a rapid, quantitative method for the analysis of DNA methylation at single sites or within small regions of DNA...
  12. ncbi Adverse effects of 5-aza-2'-deoxycytidine on spermatogenesis include reduced sperm function and selective inhibition of de novo DNA methylation
    Christopher C Oakes
    Department of Pharmacology and Therapeutics, McGill University Montreal Children s Hospital Research Institute, 2300 Tupper St, Montreal, QC, Canada
    J Pharmacol Exp Ther 322:1171-80. 2007
    ....
  13. doi Superovulation alters the expression of imprinted genes in the midgestation mouse placenta
    Amanda L Fortier
    Department of Human Genetics, McGill University, Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Hum Mol Genet 17:1653-65. 2008
    ..Our findings contribute to the evidence that mechanisms for maintaining imprinting are less robust in trophectoderm-derived tissues, and have clinical implications for the screening of patients following assisted reproduction...
  14. pmc Coordinate regulation of DNA methyltransferase expression during oogenesis
    Diana Lucifero
    Montreal Children s Hospital Research Institute and Department of Pediatrics, McGill University, Montreal, Quebec, Canada
    BMC Dev Biol 7:36. 2007
    ..Here we report the expression dynamics of Dnmt3a and Dnmt3b, as well as a regulator of DNA methylation, Dnmt3L, in isolated female germ cells...
  15. pmc Impact of the chemotherapy cocktail used to treat testicular cancer on the gene expression profile of germ cells from male Brown-Norway rats
    Geraldine Delbes
    Department of Pharmacology and Therapeutics, McGill University, Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada H3G 1Y6
    Biol Reprod 80:320-7. 2009
    ..Thus, BEP exposure triggers an oxidative stress response in round spermatids and induces many pathways that may lead to the survival of damaged cells and production of abnormal sperm...
  16. doi Epigenetics in spermatogenesis
    Jacquetta M Trasler
    Departments of Pediatrics, McGill University, Montreal Children s Hospital, McGill University Health Centre Research Institute, Montreal, QC, Canada
    Mol Cell Endocrinol 306:33-6. 2009
    ..In man altered sperm DNA methylation patterns have been reported in individuals with oligospermia...
  17. doi Profound phenotypic variation among mice deficient in the maintenance of genomic imprints
    Marc Toppings
    McGill University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada H3H 1P3
    Hum Reprod 23:807-18. 2008
    ..Here, we examined the consequences of a loss of maintenance methylation at one specific stage of preimplantation, induced by a deficiency of the oocyte-derived Dnmt1o protein and known to produce biallelic expression of imprinted genes...
  18. ncbi Bovine SNRPN methylation imprint in oocytes and day 17 in vitro-produced and somatic cell nuclear transfer embryos
    Diana Lucifero
    McGill University and Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Biol Reprod 75:531-8. 2006
    ....
  19. ncbi In utero exposure to tributyltin chloride differentially alters male and female fetal gonad morphology and gene expression profiles in the Sprague-Dawley rat
    Osama Kishta
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Reprod Toxicol 23:1-11. 2007
    ..In conclusion, in utero exposure to TBT resulted in gender-specific alterations in gonadal development and gene expression profiles suggesting that there may be different adaptive changes to toxicity in developing male and female rats...
  20. ncbi Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation
    Tamara L J Kelly
    Department of Pediatrics, McGill University and the Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Biol Reprod 72:667-77. 2005
    ....
  21. ncbi Postnatal development and regulation of beta-hexosaminidase in epithelial cells of the rat epididymis
    Louis Hermo
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    J Androl 25:69-81. 2004
    ....
  22. ncbi Gene-specific timing and epigenetic memory in oocyte imprinting
    Diana Lucifero
    McGill University, Montreal Children s Hospital Research Institute and Departments of Pediatrics, Human Genetics and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3H 1P3
    Hum Mol Genet 13:839-49. 2004
    ..These findings contribute to our understanding of the epigenetic mechanisms underlying imprint acquisition during female germ cell development and have implications for the practice of assisted reproductive technologies...
  23. ncbi Methylation dynamics of imprinted genes in mouse germ cells
    Diana Lucifero
    McGill University Montreal Children s Hospital Research Institute and Departments of Pediatrics, Human Genetics, and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3H 1P3, Canada
    Genomics 79:530-8. 2002
    ..These findings raise the possibility that assisted reproductive technologies that involve in vitro maturation of oocytes may result in developmental abnormalities due to incomplete methylation imprints in immature oocytes...
  24. ncbi Effects of in utero tributyltin chloride exposure in the rat on pregnancy outcome
    Adedayo Adeeko
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Toxicol Sci 74:407-15. 2003
    ..5 and 10 mg/kg exposures. Thus, maternal thyroid hormone homeostasis may be important in mediating the developmental toxicity of organotins...
  25. ncbi Buthionine sulfoximine embryotoxicity is associated with prolonged AP-1 activation
    Terence R S Ozolins
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Teratology 66:192-200. 2002
    ..The goal of these studies was to determine the consequences of altering glutathione homeostasis during organogenesis on embryo development, total DNA methylation, and activator protein-1 (AP-1) DNA binding activity and gene expression...
  26. ncbi 5-aza-2'-deoxycytidine induces alterations in murine spermatogenesis and pregnancy outcome
    Tamara L J Kelly
    Departments of Pediatrics, McGill University, and McGill University Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    J Androl 24:822-30. 2003
    ....
  27. ncbi Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology
    Diana Lucifero
    McGill University Montreal Children s Hospital Research Institute and Department of Paediatrics, McGill University, Montreal, Quebec, H3H 1P3, Canada
    Hum Reprod Update 10:3-18. 2004
    ....
  28. ncbi Gamete imprinting: implications for assisted reproductive technologies
    Jacquetta M Trasler
    Department of Pediatrics, McGill University and Montreal Children s Hospital Research Institute, Quebec, Canada
    J Assist Reprod Genet 20:483-4. 2003
  29. ncbi Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells
    Sophie La Salle
    Department of Pharmacology and Therapeutics and The Montreal Children s Hospital Research Institute, McGill University, Montreal, QC, Canada H3H 1P3
    Dev Biol 268:403-15. 2004
    ..Together, the results provide clues to specific roles for the different DNMT family members in de novo and maintenance methylation in the developing testis and ovary...
  30. pmc Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations
    Dominic J Smiraglia
    Department of Cancer Genetics, and Comprehensive Cancer Center, Roswell Park Cancer Institute, Buffalo, NY, USA
    BMC Genomics 8:446. 2007
    ..However, a limitation to the utility of this method has been the ability to assign specific genomic sequences to RLGS spots, a process commonly referred to as "RLGS spot cloning."..
  31. pmc Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats
    Christopher C Oakes
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada H3H 1P3
    Proc Natl Acad Sci U S A 100:1775-80. 2003
    ..Failure to maintain normal DNA methylation patterns in male germ cells could be one of the mechanisms underlying age-related abnormalities in fertility and progeny outcome...