E Tchetina

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Developmental mechanisms in articular cartilage degradation in osteoarthritis
    Elena V Tchetina
    Institute of Rheumatology, Russian Academy of Medical Sciences, Kashirskoye Shosse 34A, Moscow 115522, Russia
    Arthritis 2011:683970. 2011
  2. pmc Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production
    Elena V Tchetina
    Joint Diseases Laboratory, Shriners Hospitals for Children, 1529 Cedar Ave, Quebec H3G 1A6, Canada
    Am J Pathol 168:131-40. 2006
  3. ncbi Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions
    Elena V Tchetina
    Joint Diseases Laboratory, Shriners Hospitals for Children, Montreal, Quebec, Canada
    J Rheumatol 32:876-86. 2005
  4. ncbi Distinct phases of coordinated early and late gene expression in growth plate chondrocytes in relationship to cell proliferation, matrix assembly, remodeling, and cell differentiation
    E Tchetina
    Joint Diseases Laboratory, Shriners Hospitals for Children, Montreal, Quebec, Canada
    J Bone Miner Res 18:844-51. 2003
  5. ncbi Cartilage matrix resorption in skeletogenesis
    W Wu
    Joint Diseases Laboratory, Shriners Hospitals for Children and Division of Surgical Research, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec, Canada H3G 1A6
    Novartis Found Symp 232:158-66; discussion 166-70. 2001
  6. pmc Type II collagen degradation and its regulation in articular cartilage in osteoarthritis
    A R Poole
    Shriners Hospitals for Children, Department of Surgery, McGill University, Montreal, Quebec, Canada
    Ann Rheum Dis 61:ii78-81. 2002
  7. pmc Identification of Lrp-regulated genes by inverse PCR and sequencing: regulation of two mal operons of Escherichia coli by leucine-responsive regulatory protein
    E Tchetina
    Biology Department, Concordia University, Montreal, Quebec, Canada
    J Bacteriol 177:2679-83. 1995
  8. ncbi Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization
    C William Wu
    Joint Diseases Laboratory, Shriners Hospitals for Children, Canadian Hospital, Montreal, Quebec
    J Bone Miner Res 17:639-51. 2002
  9. ncbi Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis
    Elena V Tchetina
    Joint Diseases Laboratory, Shriners Hospitals for Children and Department of Surgery, McGill University, Montreal, Quebec, Canada
    Matrix Biol 26:247-58. 2007
  10. pmc Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypert
    Elena V Tchetina
    Shriners Hospitals for Children, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec H3G 1A6, Canada
    Arthritis Res Ther 9:R75. 2007

Collaborators

Detail Information

Publications10

  1. pmc Developmental mechanisms in articular cartilage degradation in osteoarthritis
    Elena V Tchetina
    Institute of Rheumatology, Russian Academy of Medical Sciences, Kashirskoye Shosse 34A, Moscow 115522, Russia
    Arthritis 2011:683970. 2011
    ..This suggests common regulatory mechanisms of matrix degradation in OA and in the development and can provide new approaches for the treatment of the disease by targeting reparation of chondrocyte phenotype...
  2. pmc Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production
    Elena V Tchetina
    Joint Diseases Laboratory, Shriners Hospitals for Children, 1529 Cedar Ave, Quebec H3G 1A6, Canada
    Am J Pathol 168:131-40. 2006
    ..Therefore TGF-beta2 could provide therapeutic control of type II collagen degeneration in OA...
  3. ncbi Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions
    Elena V Tchetina
    Joint Diseases Laboratory, Shriners Hospitals for Children, Montreal, Quebec, Canada
    J Rheumatol 32:876-86. 2005
    ....
  4. ncbi Distinct phases of coordinated early and late gene expression in growth plate chondrocytes in relationship to cell proliferation, matrix assembly, remodeling, and cell differentiation
    E Tchetina
    Joint Diseases Laboratory, Shriners Hospitals for Children, Montreal, Quebec, Canada
    J Bone Miner Res 18:844-51. 2003
    ..Together these results identify separate phases of coordinated gene expression associated with the development of the physis in endochondral bone formation...
  5. ncbi Cartilage matrix resorption in skeletogenesis
    W Wu
    Joint Diseases Laboratory, Shriners Hospitals for Children and Division of Surgical Research, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec, Canada H3G 1A6
    Novartis Found Symp 232:158-66; discussion 166-70. 2001
    ..Inhibition of collagenase leads to arrest of hypertrophy as well as gene expression of MMP13. Thus proteolysis and in particular MMP13 are required for chondrocyte differentiation and for matrix resorption in skeletal development...
  6. pmc Type II collagen degradation and its regulation in articular cartilage in osteoarthritis
    A R Poole
    Shriners Hospitals for Children, Department of Surgery, McGill University, Montreal, Quebec, Canada
    Ann Rheum Dis 61:ii78-81. 2002
  7. pmc Identification of Lrp-regulated genes by inverse PCR and sequencing: regulation of two mal operons of Escherichia coli by leucine-responsive regulatory protein
    E Tchetina
    Biology Department, Concordia University, Montreal, Quebec, Canada
    J Bacteriol 177:2679-83. 1995
    ..lacZ transcription is also increased in the presence of Lrp. However, the growth rate of the Lrp mutant on maltose and lactose is not decreased by Lrp deficiency...
  8. ncbi Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization
    C William Wu
    Joint Diseases Laboratory, Shriners Hospitals for Children, Canadian Hospital, Montreal, Quebec
    J Bone Miner Res 17:639-51. 2002
    ..These results suggest that proteolysis involving MMP-13 is required for chondrocyte differentiation that occurs as part of growth plate development and which is associated with matrix mineralization...
  9. ncbi Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis
    Elena V Tchetina
    Joint Diseases Laboratory, Shriners Hospitals for Children and Department of Surgery, McGill University, Montreal, Quebec, Canada
    Matrix Biol 26:247-58. 2007
    ..This response of the chondrocyte to a cryptic sequence of denatured type II collagen may play a role in naturally occurring hypertrophy in endochondral ossification and in the development of cartilage pathology in osteoarthritis...
  10. pmc Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypert
    Elena V Tchetina
    Shriners Hospitals for Children, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec H3G 1A6, Canada
    Arthritis Res Ther 9:R75. 2007
    ..Together these initial observations reveal the importance of very low concentrations of PGE2 in maintaining a more normal chondrocyte phenotype...