Samy Suissa

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis
    Allison L Smitten
    Duke University School of Medicine, Duke South, Durham, NC, 27710 USA
    Arthritis Res Ther 10:R45. 2008
  2. ncbi request reprint ACE-inhibitor use and the long-term risk of renal failure in diabetes
    S Suissa
    The Department of Epidemiology and Biostatistics, Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Ross 429, Montreal, Quebec, Canada H3A 1A1
    Kidney Int 69:913-9. 2006
  3. ncbi request reprint Contribution of pharmacoepidemiological studies to the evaluation of treatment-related adverse events
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Ross 4 29 Montreal, Quebec, Canada H3A 1A1
    Joint Bone Spine 73:627-8. 2006
  4. ncbi request reprint Risk factors of poor prognosis after whiplash injury
    Samy Suissa
    McGill Univerisity, Montreal, Canada
    Pain Res Manag 8:69-75. 2003
  5. ncbi request reprint Inhaled and nasal corticosteroid use and the risk of fracture
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 169:83-8. 2004
  6. ncbi request reprint Inhaled corticosteroid use in asthma and the prevention of myocardial infarction
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, and Epidemiology and Biostatistics and Medicine, McGill University, Montreal, Quebec, Canada
    Am J Med 115:377-81. 2003
  7. pmc Mortality benefit from unrestricted access to clopidogrel: too good to be true?
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre and the Department of Epidemiology and Biostatistics, McGill University, Montreal, Que
    CMAJ 178:425-7. 2008
  8. ncbi request reprint Inhaled steroids and mortality in COPD: bias from unaccounted immortal time
    S Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Eur Respir J 23:391-5. 2004
  9. ncbi request reprint Antirheumatic drug use and the risk of acute myocardial infarction
    Samy Suissa
    McGill University Health Centre, Montreal, Canada
    Arthritis Rheum 55:531-6. 2006
  10. ncbi request reprint Newer disease-modifying antirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritis
    Samy Suissa
    Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Canada
    Am J Med 117:87-92. 2004

Detail Information

Publications131 found, 100 shown here

  1. pmc A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis
    Allison L Smitten
    Duke University School of Medicine, Duke South, Durham, NC, 27710 USA
    Arthritis Res Ther 10:R45. 2008
    ..The risk of malignancies in patients with rheumatoid arthritis (RA) has raised some concern, particularly with immunosuppressive approaches to disease management...
  2. ncbi request reprint ACE-inhibitor use and the long-term risk of renal failure in diabetes
    S Suissa
    The Department of Epidemiology and Biostatistics, Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Ross 429, Montreal, Quebec, Canada H3A 1A1
    Kidney Int 69:913-9. 2006
    ..Our data suggest instead that ACE inhibitors might actually increase this risk, which may possibly contribute to the continued increasing incidence of ESRD owing to diabetes...
  3. ncbi request reprint Contribution of pharmacoepidemiological studies to the evaluation of treatment-related adverse events
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Ross 4 29 Montreal, Quebec, Canada H3A 1A1
    Joint Bone Spine 73:627-8. 2006
  4. ncbi request reprint Risk factors of poor prognosis after whiplash injury
    Samy Suissa
    McGill Univerisity, Montreal, Canada
    Pain Res Manag 8:69-75. 2003
    ..These patients should be targeted for an early intervention programme aimed at managing whiplash patients with a poor prognosis...
  5. ncbi request reprint Inhaled and nasal corticosteroid use and the risk of fracture
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 169:83-8. 2004
    ..In conclusion, the long-term use of inhaled and nasal corticosteroids at the usual recommended doses is not associated with a risk of fracture in older patients with respiratory disease...
  6. ncbi request reprint Inhaled corticosteroid use in asthma and the prevention of myocardial infarction
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, and Epidemiology and Biostatistics and Medicine, McGill University, Montreal, Quebec, Canada
    Am J Med 115:377-81. 2003
    ..We investigated whether inhaled corticosteroids, which are known to improve asthma control and reduce exacerbations, are associated with a lower rate of myocardial infarction...
  7. pmc Mortality benefit from unrestricted access to clopidogrel: too good to be true?
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre and the Department of Epidemiology and Biostatistics, McGill University, Montreal, Que
    CMAJ 178:425-7. 2008
  8. ncbi request reprint Inhaled steroids and mortality in COPD: bias from unaccounted immortal time
    S Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Eur Respir J 23:391-5. 2004
    ..Suggestion of this benefit from a previous observational study is the result of bias from unaccounted immortal time in its cohort design and analysis...
  9. ncbi request reprint Antirheumatic drug use and the risk of acute myocardial infarction
    Samy Suissa
    McGill University Health Centre, Montreal, Canada
    Arthritis Rheum 55:531-6. 2006
    ..To assess the risk of acute myocardial infarction (AMI) associated with the use of disease-modifying antirheumatic drugs (DMARDs) and other medications commonly used in rheumatoid arthritis (RA)...
  10. ncbi request reprint Newer disease-modifying antirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritis
    Samy Suissa
    Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Canada
    Am J Med 117:87-92. 2004
    ..We assessed the risk of hepatic events associated with the use of leflunomide and other DMARDs...
  11. ncbi request reprint Furosemide use and hospitalization for benign prostatic hyperplasia
    J A C Delaney
    Division of Clinical Epidemiology, Royal Victoria Hospital and the Department of Epidemiology and Biostatistics, McGill University Health Center, Montreal, Canada
    Can J Clin Pharmacol 13:e75-80. 2006
    ..Recent studies have shown that furosemide may have anti-inflammatory properties. We explored whether exposure to furosemide would reduce the risk of being hospitalized with prostatism, a marker of benign prostatic hyperplasia...
  12. ncbi request reprint Bias in observational study of the effectiveness of nasal corticosteroids in asthma
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    J Allergy Clin Immunol 115:714-9. 2005
    ..The approach to data analysis may have led to biased results because of misclassification of immortal time...
  13. ncbi request reprint Leflunomide use and the risk of interstitial lung disease in rheumatoid arthritis
    Samy Suissa
    McGill University Health Centre, Montreal, Quebec, Canada
    Arthritis Rheum 54:1435-9. 2006
    ..To assess this risk, we conducted a population-based epidemiologic study...
  14. ncbi request reprint Statistical treatment of exacerbations in therapeutic trials of chronic obstructive pulmonary disease
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Canada
    Am J Respir Crit Care Med 173:842-6. 2006
    ..The only two studies that used the correct statistical approach found insignificant effects with these drugs...
  15. ncbi request reprint Effectiveness of inhaled corticosteroids in chronic obstructive pulmonary disease: immortal time bias in observational studies
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, 687 Pine Avenue West, Ross 4 29, Montreal, PQ, H3A 1A1 Canada
    Am J Respir Crit Care Med 168:49-53. 2003
    ..Although observational studies can be valuable, the recent reports of reductions in mortality and morbidity with inhaled corticosteroids are biased by their inappropriate allocation of exposure and analysis of immortal time...
  16. ncbi request reprint Use of anti-inflammatory therapy and asthma mortality in Japan
    S Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, Montreal, Quebec, Canada
    Eur Respir J 21:101-4. 2003
    ..The increasing use of inhaled corticosteroids and leukotriene receptor antagonists may have contributed to the significant reduction in asthma mortality among young asthmatics in Japan...
  17. ncbi request reprint Immortal time bias in observational studies of drug effects
    Samy Suissa
    McGill Pharmacoepidemiology Research Unit, McGill University Health Centre, Montreal, Canada
    Pharmacoepidemiol Drug Saf 16:241-9. 2007
    ..We describe the bias from 20 of these studies and illustrate it by showing that unrelated drugs can be made to appear effective at treating cardiovascular disease (CVD)...
  18. ncbi request reprint Primer: administrative health databases in observational studies of drug effects--advantages and disadvantages
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Ross 4 29, Montreal, Quebec, Canada
    Nat Clin Pract Rheumatol 3:725-32. 2007
    ..With careful attention to their design and analysis, observational database studies are powerful and modern tools for providing crucial data on drug effects...
  19. ncbi request reprint TNF-alpha antagonists and the prevention of hospitalisation for chronic obstructive pulmonary disease
    Samy Suissa
    Division of Clinical Epidemiology, McGill University Health Centre, Canada
    Pulm Pharmacol Ther 21:234-8. 2008
    ..TNF-alpha may be important in the pathogenesis of COPD. Consequently, the use of TNF-alpha antagonists has been advocated for its treatment...
  20. ncbi request reprint Low-dose inhaled corticosteroids and the prevention of death from asthma
    S Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada
    N Engl J Med 343:332-6. 2000
    ..Although inhaled corticosteroids are effective for the treatment of asthma, it is uncertain whether their use can prevent death from asthma...
  21. pmc The relation between initial symptoms and signs and the prognosis of whiplash
    S Suissa
    McGill University, Division of Clinical Epidemiology, Royal Victoria Hospital, 687 Pine Ave W, Montreal, Quebec, Canada, H3A 1A1
    Eur Spine J 10:44-9. 2001
    ..These patients can easily be identified and closely monitored and targeted for the evaluation of early intervention programmes aimed at managing whiplash patients with a poor prognosis...
  22. ncbi request reprint Immortal time bias in pharmaco-epidemiology
    Samy Suissa
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
    Am J Epidemiol 167:492-9. 2008
    ..In conclusion, observational studies of drug benefit in which computerized databases are used must be designed and analyzed properly to avoid immortal time bias...
  23. doi request reprint Methodological issues in therapeutic trials of COPD
    S Suissa
    McGill Pharmacoepidemiology Research Unit, McGill University Health Centre, Montreal, Quebec, Canada
    Eur Respir J 31:927-33. 2008
    ....
  24. pmc Inhaled short acting beta agonist use in COPD and the risk of acute myocardial infarction
    S Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Canada
    Thorax 58:43-6. 2003
    ..We investigated this hypothesis in patients with COPD already at high risk of cardiac disease...
  25. pmc Regular use of inhaled corticosteroids and the long term prevention of hospitalisation for asthma
    S Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Canada
    Thorax 57:880-4. 2002
    ..Inhaled corticosteroids are effective at preventing asthma morbidity and mortality. Most studies, however, have focused on short term effects, raising uncertainty about their effectiveness in the long term...
  26. pmc Patterns of antibiotic use and risk of hospital admission because of Clostridium difficile infection
    Sandra Dial
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Que
    CMAJ 179:767-72. 2008
    ....
  27. doi request reprint Thiazolidinediones and the risk of incident strokes in patients with type 2 diabetes: a nested case-control study
    Laurent Azoulay
    McGill Pharmacoepidemiology Research Unit, Division of Clinical Epidemiology, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Pharmacoepidemiol Drug Saf 19:343-50. 2010
    ..To determine whether the use of thiazolidinediones (TZDs) decreases the risk of incident strokes in patients with type 2 diabetes...
  28. ncbi request reprint Antibiotics in primary prevention of stroke in the elderly
    Paul Brassard
    Department of Medicine, McGill University, Montreal, Canada
    Stroke 34:e163-6. 2003
    ..Thus, use of antibiotics may lower the risk of developing cerebrovascular disease. We investigated whether antibiotic use is associated with the risk of stroke in elderly individuals treated for hypertension...
  29. pmc Proton pump inhibitor use and risk of community-acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapy
    Sandra Dial
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, and the Department of Epidemiology and Biostatistics, McGill University, Montreal, Que
    CMAJ 175:745-8. 2006
    ..In this study we re-examined a previously reported association between the use of proton pump inhibitors and the development of community-acquired CDAD, this time using an alternative case definition of the disease...
  30. doi request reprint Androgen deprivation therapy and the risk of colorectal cancer in patients with prostate cancer
    Jonathan Assayag
    Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Cote Sainte Catherine, H 425 1, Montreal, QC, H3T 1E2, Canada
    Cancer Causes Control 24:839-45. 2013
    ....
  31. ncbi request reprint Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designs
    Caroline Hebert
    Division of Clinical Epidemiology, McGill University Health Center, Montreal, Canada
    Pharmacoepidemiol Drug Saf 16:845-9. 2007
    ..The use of different study designs could explain the differences observed in these studies...
  32. doi request reprint Combination therapy with sulfonylureas and metformin and the prevention of death in type 2 diabetes: a nested case-control study
    Laurent Azoulay
    Division of Clinical Epidemiology, SMBD Jewish General Hospital, Montreal, Quebec, Canada
    Pharmacoepidemiol Drug Saf 19:335-42. 2010
    ..To determine whether combination of sulfonylureas and metformin increases the risk of death from any cause in patients with type 2 diabetes...
  33. doi request reprint Inhaled corticosteroids and the risks of diabetes onset and progression
    Samy Suissa
    Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada
    Am J Med 123:1001-6. 2010
    ..We assessed whether the use and dose of inhaled corticosteroids increase the risk of diabetes onset and progression...
  34. doi request reprint Immeasurable time bias in observational studies of drug effects on mortality
    Samy Suissa
    McGill Pharmacoepidemiology Research Unit, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Am J Epidemiol 168:329-35. 2008
    ..35 (95% CI: 1.14, 1.60). In conclusion, immeasurable time bias may be present in several observational database studies suggesting that certain drugs are effective at reducing mortality...
  35. doi request reprint Rheumatoid arthritis, its treatments, and the risk of tuberculosis in Quebec, Canada
    Paul Brassard
    Division of Clinical Epidemiology, McGill University Health Center, Montreal, Quebec, Canada
    Arthritis Rheum 61:300-4. 2009
    ..To determine the risk of tuberculosis (TB) among a cohort of patients with rheumatoid arthritis (RA) in Quebec and assess whether this risk is associated with exposure to nonbiologic disease-modifying antirheumatic drugs (DMARDs)...
  36. doi request reprint Effectiveness of combination therapies in asthma: an observational study
    Samy Suissa
    McGill Pharmacoepidemiology Research Unit, McGill University Health Centre, Montreal, Canada
    Pulm Pharmacol Ther 22:194-8. 2009
    ..We compared the effectiveness in a real world setting of two such combinations available in a single inhaler...
  37. doi request reprint Androgen deprivation therapy and risk of acute kidney injury in patients with prostate cancer
    Francesco Lapi
    Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
    JAMA 310:289-96. 2013
    ....
  38. pmc A net clinical benefit analysis of warfarin and aspirin on stroke in patients with atrial fibrillation: a nested case-control study
    Laurent Azoulay
    Centre for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, 3755 Cote Sainte Catherine, H 461, Montreal, Quebec, Canada H3T 1E2
    BMC Cardiovasc Disord 12:49. 2012
    ....
  39. pmc Gastro-intestinal haemorrhage risks of selective serotonin receptor antagonist therapy: a new look
    Lucie Opatrny
    Division of Clinical Epidemiology, McGill University Health Center, McGill University, Montreal, Canada
    Br J Clin Pharmacol 66:76-81. 2008
    ....
  40. doi request reprint Validating the effects of drug treatment on blood pressure in the General Practice Research Database
    Joseph A C Delaney
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    Pharmacoepidemiol Drug Saf 17:535-45. 2008
    ..Blood pressure data which are measured at variable intervals and are often missing present a particular methodological challenge to the analysis of such studies...
  41. ncbi request reprint Antirheumatic drugs and the risk of tuberculosis
    Paul Brassard
    Department of Medicine, McGill University, Montreal, QC, Canada
    Clin Infect Dis 43:717-22. 2006
    ....
  42. ncbi request reprint Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumonia
    Pierre Ernst
    Pharmacoepidemiology Research Unit, Department of Medicine, McGill University Health Centre, and Division of Clinical Epidemiology, Ross 4 29, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, PQ, Quebec, H3A 1A1 Canada
    Am J Respir Crit Care Med 176:162-6. 2007
    ..Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD)...
  43. ncbi request reprint Antibiotics in primary prevention of myocardial infarction among elderly patients with hypertension
    Paul Brassard
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Am Heart J 145:E20. 2003
    ....
  44. doi request reprint Inhaled corticosteroids and risk of tuberculosis in patients with respiratory diseases
    Paul Brassard
    Center for Clinical Epidemiology, Lady Davis Research Institute, Department of Medicine, Jewish General Hospital, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 183:675-8. 2011
    ..Treatment with substantial doses of oral corticosteroids (OCS) for prolonged periods increases the risk of tuberculosis (TB). However, little is known about the effect of inhaled corticosteroids (ICS) in this respect...
  45. doi request reprint The concurrent use of antithrombotic therapies and the risk of bleeding in patients with atrial fibrillation
    Laurent Azoulay
    Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, and Department of Oncology, McGill University, 3755 Cote Sainte Catherine, H 461, Montreal, Quebec, H3T 1E2, Canada
    Thromb Haemost 109:431-9. 2013
    ....
  46. pmc Pramipexole use and the risk of pneumonia
    Pierre Ernst
    Center for Clinical Epidemiology, Lady Davis Research Institute Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, QC, H3T 1E2, Canada
    BMC Neurol 12:113. 2012
    ..It is uncertain whether pramipexole or other dopamine agonists increase the risk of pneumonia...
  47. doi request reprint Antibacterial drugs and the risk of community-associated methicillin-resistant Staphylococcus aureus in children
    Verena Schneider-Lindner
    Centre for Clinical Epidemiology, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine, Ste H4, Montreal, QC H3T 1E2, Canada
    Arch Pediatr Adolesc Med 165:1107-14. 2011
    ..To investigate in children the association between antibacterial drugs and subsequent diagnosis of methicillin-resistant Staphylococcus aureus (MRSA) in the community...
  48. ncbi request reprint Cardiovascular morbidity and mortality in COPD
    Laetitia Huiart
    Division of Clinical Epidemiology, Royal Victoria Hospital and Department of Epidemiology and Biostatistics, McGill University, 687 Pine Ave West, Ross 4 29, Montreal, QC, Canada, H3A 1A1
    Chest 128:2640-6. 2005
    ..COPD and cardiovascular disease (CVD) share common risk factors. We undertook to estimate rates of hospitalization and death from CVD in COPD patients relative to the general population...
  49. pmc Antimicrobial drugs and community-acquired Clostridium difficile-associated disease, UK
    J A Chris Delaney
    McGill University Health Center, Montreal, Quebec, Canada
    Emerg Infect Dis 13:761-3. 2007
    ..CDAD risk increased 3-fold with use of any antimicrobial agent and 6-fold with use of fluoroquinolones. Prior use of antimicrobial agents did not affect risk for CDAD after 6 months...
  50. doi request reprint Trends in the prescription of anti-diabetic medications in the United Kingdom: a population-based analysis
    Kristian B Filion
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada
    Pharmacoepidemiol Drug Saf 18:973-6. 2009
    ..The objective of this study was to describe trends in the prescription of anti-diabetic medications among patients with type 2 diabetes in the United Kingdom (UK)...
  51. doi request reprint Risk of glaucoma in elderly patients treated with inhaled corticosteroids for chronic airflow obstruction
    Anne V Gonzalez
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Canada
    Pulm Pharmacol Ther 23:65-70. 2010
    ..We sought to determine the risk of new onset ocular hypertension or glaucoma requiring treatment, associated with the use of ICS in elderly patients treated for airways disease...
  52. doi request reprint The use of inhaled corticosteroids and the risk of adrenal insufficiency
    Francesco Lapi
    Centre for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, Canada
    Eur Respir J 42:79-86. 2013
    ..ICS at high doses appear to be a significant independent risk factor for adrenal insufficiency. Physicians prescribing ICS at such dosages should be sensitive to the signs and symptoms of adrenal insufficiency in their patients. ..
  53. pmc Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study
    Francesco Lapi
    Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Côte Sainte Catherine Montreal, Quebec H3T 1E2, Canada
    BMJ 346:e8525. 2013
    ....
  54. doi request reprint Bronchodilator use and the risk of arrhythmia in COPD: part 2: reassessment in the larger Quebec cohort
    Machelle Wilchesky
    Donald Berman Maimonides Geriatric Centre, McGill University, Montreal, QC, Canada
    Chest 142:305-11. 2012
    ..A previous study suggested a potential increased risk of cardiac arrhythmia with new use of long-acting β-agonists and ipratropium bromide in patients with COPD, although conclusions were limited by the small cohort size...
  55. pmc Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality
    Samy Suissa
    Center for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Canada
    Thorax 67:957-63. 2012
    ..The long-term natural history of chronic obstructive pulmonary disease (COPD) in terms of successive severe exacerbations and mortality is unknown...
  56. pmc Risk of herpes zoster in patients prescribed inhaled corticosteroids: a cohort study
    Pierre Ernst
    Center for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, Canada
    BMC Pulm Med 11:59. 2011
    ..We hypothesised that inhaled corticosteroids (ICS) are a risk factor for herpes zoster especially among users of inhibitors of cytochrome P450 enzymes involved in their metabolism...
  57. pmc Mortality after infection with methicillin-resistant Staphylococcus aureus (MRSA) diagnosed in the community
    J A Chris Delaney
    Division of Clinical Epidemiology, McGill University Health Center, Royal Victoria Hospital, 687 Pine Avenue West, Ross 4, 29, Montreal, H3A 1A1, Canada
    BMC Med 6:2. 2008
    ..We conducted a population based cohort study to assess the magnitude of mortality associated with MRSA infections diagnosed in the community...
  58. doi request reprint Systemic effects of inhaled corticosteroids
    Pierre Ernst
    Centre for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada
    Curr Opin Pulm Med 18:85-9. 2012
    ..We review the articles appearing in the last year which have addressed the safety of ICSs when used in the treatment of asthma and chronic obstructive pulmonary disease (COPD)...
  59. doi request reprint Hormone replacement therapy use and the risk of stroke
    Christel Renoux
    McGill Pharmacoepidemiology Research Unit, Jewish General Hospital, Departments of Epidemiology and Biostatistics and of Medicine, McGill University, Montreal, Canada
    Maturitas 61:305-9. 2008
    ..A recent trial also reported an increased risk with tibolone, a selective tissue estrogenic activity regulator...
  60. pmc Oral corticosteroid use and the risk of acute myocardial infarction in chronic obstructive pulmonary disease
    Laetitia Huiart
    Division of Clinical Epidemiology, Royal Victoria Hospital and Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Can Respir J 13:134-8. 2006
    ..The impact of the use of oral corticosteroids on the risk of acute myocardial infarction (AMI) in a cohort of patients with COPD was studied...
  61. doi request reprint Discontinuation of statin therapy following an acute myocardial infarction: a population-based study
    Stella S Daskalopoulou
    Division of Internal Medicine, Department of Medicine, McGill University, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, B2 236, Montreal, QC, Canada
    Eur Heart J 29:2083-91. 2008
    ..Our objective was to estimate the extent to which different patterns of statin use are associated with post-AMI mortality...
  62. pmc Antimicrobial drugs and community-acquired methicillin-resistant Staphylococcus aureus, United Kingdom
    Verena Schneider-Lindner
    McGill University Health Center, Montreal, Quebec, Canada
    Emerg Infect Dis 13:994-1000. 2007
    ..37, CI 2.80-4.09) and macrolides (OR 2.50, CI 2.14-2.91)...
  63. pmc Long-term use of angiotensin receptor blockers and the risk of cancer
    Laurent Azoulay
    Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
    PLoS ONE 7:e50893. 2012
    ..Additional research is needed to further investigate a potentially increased risk of lung cancer with angiotensin-converting enzyme inhibitors and calcium channel blockers...
  64. pmc The use of metformin and the incidence of lung cancer in patients with type 2 diabetes
    Brielan B Smiechowski
    Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
    Diabetes Care 36:124-9. 2013
    ..The objective of this study was to determine whether metformin use is associated with a decreased risk of lung cancer in patients with type 2 diabetes, while avoiding previous biases...
  65. doi request reprint Thiazolidinediones and the risk of incident congestive heart failure among patients with type 2 diabetes mellitus
    Kristian B Filion
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada
    Pharmacoepidemiol Drug Saf 20:785-96. 2011
    ..Clinical trials suggest that thiazolidinediones (TZDs) may increase the risk of congestive heart failure (CHF). However, their effect on the risk of incident CHF in unselected populations has not been thoroughly investigated...
  66. pmc Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding
    Joseph A Delaney
    Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Que
    CMAJ 177:347-51. 2007
    ..We assessed whether antithrombotic drug combinations increased the risk of such bleeding in a general practice population...
  67. pmc Use of lithium and the risk of injurious motor vehicle crash in elderly adults: case-control study nested within a cohort
    Mahyar Etminan
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Ave, West Montreal, Quebec, Canada
    BMJ 328:558-9. 2004
  68. doi request reprint Bronchodilator use and the risk of arrhythmia in COPD: part 1: Saskatchewan cohort study
    Machelle Wilchesky
    Donald Berman Maimonides Geriatric Centre, McGill University, Montreal, Canada
    Chest 142:298-304. 2012
    ..Bronchodilators are first-line therapy for COPD. There is some evidence that they may increase the risk of cardiac arrhythmias...
  69. doi request reprint Dopamine agonist use and the risk of heart failure
    Christel Renoux
    Center for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada
    Pharmacoepidemiol Drug Saf 21:34-41. 2012
    ..A potential risk of heart failure was recently observed in randomized trials of the dopamine agonist pramipexole. The extent of the risk with this and other dopamine agonists is unknown...
  70. doi request reprint Androgen-deprivation therapy and the risk of stroke in patients with prostate cancer
    Laurent Azoulay
    Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Eur Urol 60:1244-50. 2011
    ..Some evidence indicates that androgen-deprivation therapy (ADT) increases the risk of diabetes and cardiovascular disease. To date, few studies have investigated whether this therapy also increases the risk of cerebrovascular events...
  71. pmc Lifestyle variables and the risk of myocardial infarction in the general practice research database
    Joseph A C Delaney
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    BMC Cardiovasc Disord 7:38. 2007
    ..As a secondary objective, we considered the association between other lifestyle variables, smoking and heavy alcohol use, and AMI risk...
  72. doi request reprint Number needed to treat is incorrect without proper time-related considerations
    Daniel Suissa
    Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Quebec, Canada
    J Clin Epidemiol 65:42-6. 2012
    ....
  73. pmc Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study
    Carlos Martinez
    Centre for Clinical Epidemiology, Jewish General Hospital, and Department of Epidemiology, McGill University, Montreal, Canada
    BMJ 340:c249. 2010
    ..To assess whether use of the antidepressant venlafaxine is associated with an increased risk of sudden cardiac death or near death compared with other commonly used antidepressants...
  74. doi request reprint Gender differences in survival following hospitalisation for COPD
    Anne V Gonzalez
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Montreal, Canada
    Thorax 66:38-42. 2011
    ..Gender differences in survival and rate of rehospitalisation were investigated in a large cohort of elderly patients with chronic airflow obstruction hospitalised for COPD...
  75. ncbi request reprint Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease
    Sandra Dial
    Division of Critical Care and Respiratory and Clinical Research, Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec
    JAMA 294:2989-95. 2005
    ..Recent reports suggest an increasing occurrence and severity of Clostridium difficile-associated disease. We assessed whether the use of gastric acid-suppressive agents is associated with an increased risk in the community...
  76. doi request reprint Transdermal and oral hormone replacement therapy and the risk of stroke: a nested case-control study
    Christel Renoux
    McGill Pharmacoepidemiology Research Unit, Center for Clinical Epidemiology, Jewish General Hospital, Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada H3T 1E2
    BMJ 340:c2519. 2010
    ..To determine the risk of stroke associated with oral and transdermal routes of administration of hormone replacement therapy...
  77. ncbi request reprint Lung cancer after exposure to disease modifying anti-rheumatic drugs
    Sasha Bernatsky
    Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Guebec, Canada
    Lung Cancer 59:266-9. 2008
    ..To assess the effects of disease modifying anti-rheumatic drugs (DMARDs) on lung cancer risk in a large rheumatoid arthritis (RA) cohort...
  78. ncbi request reprint Antihypertensives and myocardial infarction risk: the modifying effect of history of drug use
    C Bourgault
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
    Pharmacoepidemiol Drug Saf 10:287-94. 2001
    ..In addition, the estimates significantly varied across drug history profiles thus suggesting the presence of preferential prescribing of specific drug classes to high-risk patients...
  79. doi request reprint Combined oral contraceptive use and the risk of systemic lupus erythematosus
    Marie Odile Bernier
    McGill Pharmacoepidemiology Research Unit, McGill University, Montreal, Quebec, Canada
    Arthritis Rheum 61:476-81. 2009
    ....
  80. doi request reprint Demyelinating events in rheumatoid arthritis after drug exposures
    Sasha Bernatsky
    Centre for Clinical Epidemiology, Jewish General Hospital Lady Davis Institute, 3755 Cote Ste Catherine, Montreal, Quebec, Canada
    Ann Rheum Dis 69:1691-3. 2010
    ..To estimate the effects of biological drugs on the risk of demyelinating events in rheumatoid arthritis (RA)...
  81. doi request reprint Concurrent use of tamoxifen with CYP2D6 inhibitors and the risk of breast cancer recurrence
    Laurent Azoulay
    Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Sainte Catherine, H 425 1, Montreal, QC H3T 1E2, Canada
    Breast Cancer Res Treat 126:695-703. 2011
    ..These results remained consistent after performing sensitivity analyses. The results of this large population-based study indicate that concurrent use of tamoxifen with CYP2D6 inhibitors does not increase the risk of recurrence...
  82. ncbi request reprint Inhaled corticosteroids and hospitalisation due to exacerbation of COPD
    J Bourbeau
    Respiratory Epidemiology Unit, Joint Depts of Epidemiology and Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada
    Eur Respir J 22:286-9. 2003
    ..No reduction in chronic obstructive pulmonary disease exacerbations requiring hospitalisation, in relation to the use of inhaled corticosteroids, were observed...
  83. doi request reprint The multitime case-control design for time-varying exposures
    Samy Suissa
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
    Epidemiology 21:876-83. 2010
    ..The conventional approach to improve precision of the odds ratio in a case-control study is to increase the number of controls per case. With time-varying exposures, an alternative is to increase the number of observations per control...
  84. doi request reprint [Methodological controversies in chronic obstructive pulmonary disease therapeutic trials]
    Samy Suissa
    Hôpital Général Juif de Montréal et Départements d Epidémiologie et Biostatistique, et de Médecine, Universite McGill, Montreal, Canada
    Presse Med 38:445-51. 2009
    ..They should be prescribed in COPD for at most a limited population of patients...
  85. doi request reprint Hematologic malignant neoplasms after drug exposure in rheumatoid arthritis
    Sasha Bernatsky
    Division of Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada
    Arch Intern Med 168:378-81. 2008
    ..There is increasing concern about the influence of rheumatoid arthritis therapy on the risk for hematologic malignant neoplasms...
  86. ncbi request reprint The impact of over-the-counter simvastatin on the number of statin prescriptions in the United Kingdom: a view from the General Practice Research Database
    Kristian B Filion
    McGill University, Division of Clinical Epidemiology, Royal Victoria Hospital, Montreal, Canada
    Pharmacoepidemiol Drug Saf 16:1-4. 2007
    ..We assessed the impact of this policy change on statin prescribing...
  87. ncbi request reprint Mega trials in COPD--clinical data analysis and design issues
    Samy Suissa
    Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Department of Epidemiology, McGill University, Montreal, Canada
    Pneumonol Alergol Pol 79:227-31. 2011
    ..With COPD one of the major causes of morbidity and mortality worldwide, mega trials such as TORCH and UPLIFT are much needed, but must achieve the utmost scientific rigour in their design and analysis...
  88. doi request reprint Time-window bias in case-control studies: statins and lung cancer
    Samy Suissa
    Center for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada
    Epidemiology 22:228-31. 2011
    ..99 (0.85-1.16)-suggesting no benefit of statins on lung cancer risk. We show analytically that the magnitude of the bias is proportional to the ratio of the unequal time-window lengths...
  89. doi request reprint Metformin and the incidence of prostate cancer in patients with type 2 diabetes
    Laurent Azoulay
    Sir Mortimer B Davis Jewish General Hospital Centre for Clinical Epidemiology and Community Studies 3755 Côte Sainte Catherine, H 425 1 Montreal, Quebec, Canada H3T 1E2
    Cancer Epidemiol Biomarkers Prev 20:337-44. 2011
    ..The objective of this study was to determine whether metformin decreases the risk of prostate cancer in patients with type 2 diabetes...
  90. ncbi request reprint The impact of hepatitis C virus coinfection on HIV progression before and after highly active antiretroviral therapy
    Marina B Klein
    Division of Infectious Diseases Immunodeficiency, Department of Medicine, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    J Acquir Immune Defic Syndr 33:365-72. 2003
    ..HCV coinfection and comorbidity associated with injection drug use are preventing the realization of substantial health benefits associated with HAART...
  91. doi request reprint The use of atypical antipsychotics and the risk of breast cancer
    Laurent Azoulay
    Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Sainte Catherine, H 425 1, Montreal, QC, H3T 1E2, Canada
    Breast Cancer Res Treat 129:541-8. 2011
    ..The results of this study should provide reassurance that compared to typical antipsychotics, atypical antipsychotics do not increase the risk of breast cancer...
  92. ncbi request reprint Inhaled corticosteroids: impact on asthma morbidity and mortality
    S Suissa
    Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    J Allergy Clin Immunol 107:937-44. 2001
    ..In all, the evidence to date strongly indicates that regular use of inhaled corticosteroids, even at low doses, would prevent the major portion of asthma hospitalizations and deaths...
  93. ncbi request reprint Inhaled corticosteroids and the risk of a first exacerbation in COPD patients
    M N de Melo
    Dept of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Eur Respir J 23:692-7. 2004
    ..51; 95% CI: 1.22-1.87), and it increased with increasing daily doses of ICS. Inhaled corticosteroids do not seem to be beneficial in reducing the risk of a first exacerbation of chronic obstructive pulmonary disease...
  94. ncbi request reprint Low-dose inhaled and nasal corticosteroid use and the risk of cataracts
    P Ernst
    Division of Clinical Epidemiology, Royal Victoria Hospital, 687 Pine Avenue West, Ross 4 29, Montreal, Quebec H3A 1A1, Canada
    Eur Respir J 27:1168-74. 2006
    ..Such an excess risk was not observed with nasal corticosteroids...
  95. ncbi request reprint Antihypertensive drug therapy in Saskatchewan: patterns of use and determinants in hypertension
    C Bourgault
    Department of Epidemiology and Biostastics, Royal Victoria Hospital, McGill University Health Centre (MUHC, 687 Pine Ave W, Ross 4.29, Montreal, Quebec, Canada H3A 1A1
    Arch Intern Med 161:1873-9. 2001
    ..In addition, initial drug use does not seem to be in accordance with the stepped-care approach to hypertension therapy recommended in the Canadian guidelines...
  96. ncbi request reprint Anti-rheumatic drug use and risk of serious infections in rheumatoid arthritis
    S Bernatsky
    Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    Rheumatology (Oxford) 46:1157-60. 2007
    ..To assess the risk of severe infections associated with the use of traditional disease-modifying anti-rheumatic drugs (DMARDs) and glucocorticoid agents in rheumatoid arthritis (RA)...
  97. ncbi request reprint Low-dose inhaled corticosteroids and the risk of acute myocardial infarction in COPD
    L Huiart
    Division of Clinical Epidemiology, Royal Victoria Hospital, and Dept of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Eur Respir J 25:634-9. 2005
    ..However, a 32% reduction in the risk of AMI was observed for doses ranging 50-200 microg x day(-1). In conclusion, very low doses of inhaled corticosteroids may be associated with a reduction in the risk of acute myocardial infarction...
  98. ncbi request reprint First-time use of newer oral contraceptives and the risk of venous thromboembolism
    S Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, Montreal, Quebec, Canada
    Contraception 56:141-6. 1997
    ..We conclude that second and third generation agents are associated with identical risks of venous thromboembolism when they are prescribed to women who are using oral contraceptives for the first time ever...
  99. pmc Warfarin use and the risk of motor vehicle crash in older drivers
    J A Chris Delaney
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Center, McGill University, Montreal, Canada
    Br J Clin Pharmacol 61:229-32. 2006
    ..On the basis of a recent report, we assessed whether the use of warfarin by elderly drivers results in an increased risk of motor vehicle crash...
  100. ncbi request reprint Anti-rheumatic drug use and risk of hospitalization for congestive heart failure in rheumatoid arthritis
    S Bernatsky
    Division of Clinical Epidemiology, Montreal General Hospital, Canada
    Rheumatology (Oxford) 44:677-80. 2005
    ..To assess the risk of hospitalization for congestive heart failure (CHF) associated with the use of disease-modifying anti-rheumatic drugs (DMARDs) and other medications used in RA...
  101. ncbi request reprint Inhaled corticosteroids in chronic obstructive pulmonary disease
    Samy Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Canada
    Proc Am Thorac Soc 4:535-42. 2007
    ..Thus, although future randomized trials will need to be conducted with the most rigorous methodology for all outcomes, much uncertainty remains regarding the potential benefits of ICS in COPD...