Research Topics
| Samy SuissaSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritisAllison L Smitten
Duke University School of Medicine, Duke South, Durham, NC, 27710 USA
Arthritis Res Ther 10:R45. 2008..The risk of malignancies in patients with rheumatoid arthritis (RA) has raised some concern, particularly with immunosuppressive approaches to disease management...
Effectiveness of inhaled corticosteroids in chronic obstructive pulmonary disease: immortal time bias in observational studiesSamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, 687 Pine Avenue West, Ross 4 29, Montreal, PQ, H3A 1A1 Canada
Am J Respir Crit Care Med 168:49-53. 2003..Although observational studies can be valuable, the recent reports of reductions in mortality and morbidity with inhaled corticosteroids are biased by their inappropriate allocation of exposure and analysis of immortal time...- Contribution of pharmacoepidemiological studies to the evaluation of treatment-related adverse eventsSamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Ross 4.29 Montreal, , Canada H3A 1A1
Joint Bone Spine 73:627-8. 2006 - Bias in observational study of the effectiveness of nasal corticosteroids in asthmaSamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
J Allergy Clin Immunol 115:714-9. 2005..The approach to data analysis may have led to biased results because of misclassification of immortal time... - Antirheumatic drug use and the risk of acute myocardial infarctionSamy Suissa
McGill University Health Centre, Montreal, Canada
Arthritis Rheum 55:531-6. 2006..To assess the risk of acute myocardial infarction (AMI) associated with the use of disease-modifying antirheumatic drugs (DMARDs) and other medications commonly used in rheumatoid arthritis (RA)... - Leflunomide use and the risk of interstitial lung disease in rheumatoid arthritisSamy Suissa
McGill University Health Centre, Montreal, Quebec, Canada
Arthritis Rheum 54:1435-9. 2006..To assess this risk, we conducted a population-based epidemiologic study... - Inhaled and nasal corticosteroid use and the risk of fractureSamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
Am J Respir Crit Care Med 169:83-8. 2004..In conclusion, the long-term use of inhaled and nasal corticosteroids at the usual recommended doses is not associated with a risk of fracture in older patients with respiratory disease... - Inhaled corticosteroid use in asthma and the prevention of myocardial infarctionSamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, and Epidemiology and Biostatistics and Medicine, McGill University, Montreal, Quebec, Canada
Am J Med 115:377-81. 2003..We investigated whether inhaled corticosteroids, which are known to improve asthma control and reduce exacerbations, are associated with a lower rate of myocardial infarction... - ACE-inhibitor use and the long-term risk of renal failure in diabetesS Suissa
The Department of Epidemiology and Biostatistics, Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Ross 429, Montreal, Quebec, Canada H3A 1A1
Kidney Int 69:913-9. 2006..Our data suggest instead that ACE inhibitors might actually increase this risk, which may possibly contribute to the continued increasing incidence of ESRD owing to diabetes... - Furosemide use and hospitalization for benign prostatic hyperplasiaJ A C Delaney
Division of Clinical Epidemiology, Royal Victoria Hospital and the Department of Epidemiology and Biostatistics, McGill University Health Center, Montreal, Canada
Can J Clin Pharmacol 13:e75-80. 2006..Recent studies have shown that furosemide may have anti-inflammatory properties. We explored whether exposure to furosemide would reduce the risk of being hospitalized with prostatism, a marker of benign prostatic hyperplasia... - Inhaled steroids and mortality in COPD: bias from unaccounted immortal timeS Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
Eur Respir J 23:391-5. 2004..Suggestion of this benefit from a previous observational study is the result of bias from unaccounted immortal time in its cohort design and analysis... - Statistical treatment of exacerbations in therapeutic trials of chronic obstructive pulmonary diseaseSamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Canada
Am J Respir Crit Care Med 173:842-6. 2006..The only two studies that used the correct statistical approach found insignificant effects with these drugs... - Newer disease-modifying antirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritisSamy Suissa
Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Canada
Am J Med 117:87-92. 2004..We assessed the risk of hepatic events associated with the use of leflunomide and other DMARDs... - Use of anti-inflammatory therapy and asthma mortality in JapanS Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, Montreal, Quebec, Canada
Eur Respir J 21:101-4. 2003..The increasing use of inhaled corticosteroids and leukotriene receptor antagonists may have contributed to the significant reduction in asthma mortality among young asthmatics in Japan... - Inhaled short acting beta agonist use in COPD and the risk of acute myocardial infarctionS Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Canada
Thorax 58:43-6. 2003..We investigated this hypothesis in patients with COPD already at high risk of cardiac disease... - Immortal time bias in pharmaco-epidemiologySamy Suissa
Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
Am J Epidemiol 167:492-9. 2008..In conclusion, observational studies of drug benefit in which computerized databases are used must be designed and analyzed properly to avoid immortal time bias... 
Methodological issues in therapeutic trials of COPDS Suissa
McGill Pharmacoepidemiology Research Unit, McGill University Health Centre, Montreal, Quebec, Canada
Eur Respir J 31:927-33. 2008....- Primer: administrative health databases in observational studies of drug effects--advantages and disadvantagesSamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Ross 4 29, Montreal, Quebec, Canada
Nat Clin Pract Rheumatol 3:725-32. 2007..With careful attention to their design and analysis, observational database studies are powerful and modern tools for providing crucial data on drug effects... - Mortality benefit from unrestricted access to clopidogrel: too good to be true?Samy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre and the Department of Epidemiology and Biostatistics, McGill University, Montreal, Que
CMAJ 178:425-7. 2008 - Low-dose inhaled corticosteroids and the prevention of death from asthmaS Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada
N Engl J Med 343:332-6. 2000..Although inhaled corticosteroids are effective for the treatment of asthma, it is uncertain whether their use can prevent death from asthma... - The relation between initial symptoms and signs and the prognosis of whiplashS Suissa
McGill University, Division of Clinical Epidemiology, Royal Victoria Hospital, 687 Pine Ave W, Montreal, Quebec, Canada, H3A 1A1
Eur Spine J 10:44-9. 2001..These patients can easily be identified and closely monitored and targeted for the evaluation of early intervention programmes aimed at managing whiplash patients with a poor prognosis... - TNF-alpha antagonists and the prevention of hospitalisation for chronic obstructive pulmonary diseaseSamy Suissa
Division of Clinical Epidemiology, McGill University Health Centre, Canada
Pulm Pharmacol Ther 21:234-8. 2008..TNF-alpha may be important in the pathogenesis of COPD. Consequently, the use of TNF-alpha antagonists has been advocated for its treatment... - Risk factors of poor prognosis after whiplash injurySamy Suissa
McGill Univerisity, Montreal, Canada
Pain Res Manag 8:69-75. 2003..These patients should be targeted for an early intervention programme aimed at managing whiplash patients with a poor prognosis... - Immortal time bias in observational studies of drug effectsSamy Suissa
McGill Pharmacoepidemiology Research Unit, McGill University Health Centre, Montreal, Canada
Pharmacoepidemiol Drug Saf 16:241-9. 2007..We describe the bias from 20 of these studies and illustrate it by showing that unrelated drugs can be made to appear effective at treating cardiovascular disease (CVD)... - Regular use of inhaled corticosteroids and the long term prevention of hospitalisation for asthmaS Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Canada
Thorax 57:880-4. 2002..Inhaled corticosteroids are effective at preventing asthma morbidity and mortality. Most studies, however, have focused on short term effects, raising uncertainty about their effectiveness in the long term... - Patterns of antibiotic use and risk of hospital admission because of Clostridium difficile infectionSandra Dial
Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Que
CMAJ 179:767-72. 2008.... - Thiazolidinediones and the risk of incident strokes in patients with type 2 diabetes: a nested case-control studyLaurent Azoulay
McGill Pharmacoepidemiology Research Unit, Division of Clinical Epidemiology, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Pharmacoepidemiol Drug Saf 19:343-50. 2010..To determine whether the use of thiazolidinediones (TZDs) decreases the risk of incident strokes in patients with type 2 diabetes... - Antibiotics in primary prevention of stroke in the elderlyPaul Brassard
Department of Medicine, McGill University, Montreal, Canada
Stroke 34:e163-6. 2003..Thus, use of antibiotics may lower the risk of developing cerebrovascular disease. We investigated whether antibiotic use is associated with the risk of stroke in elderly individuals treated for hypertension... - Proton pump inhibitor use and risk of community-acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapySandra Dial
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, and the Department of Epidemiology and Biostatistics, McGill University, Montreal, Que
CMAJ 175:745-8. 2006..In this study we re-examined a previously reported association between the use of proton pump inhibitors and the development of community-acquired CDAD, this time using an alternative case definition of the disease... - Immeasurable time bias in observational studies of drug effects on mortalitySamy Suissa
McGill Pharmacoepidemiology Research Unit, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
Am J Epidemiol 168:329-35. 2008..35 (95% CI: 1.14, 1.60). In conclusion, immeasurable time bias may be present in several observational database studies suggesting that certain drugs are effective at reducing mortality... - Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designsCaroline Hebert
Division of Clinical Epidemiology, McGill University Health Center, Montreal, Canada
Pharmacoepidemiol Drug Saf 16:845-9. 2007..The use of different study designs could explain the differences observed in these studies... - Combination therapy with sulfonylureas and metformin and the prevention of death in type 2 diabetes: a nested case-control studyLaurent Azoulay
Division of Clinical Epidemiology, SMBD Jewish General Hospital, Montreal, Quebec, Canada
Pharmacoepidemiol Drug Saf 19:335-42. 2010..To determine whether combination of sulfonylureas and metformin increases the risk of death from any cause in patients with type 2 diabetes... - Rheumatoid arthritis, its treatments, and the risk of tuberculosis in Quebec, CanadaPaul Brassard
Division of Clinical Epidemiology, McGill University Health Center, Montreal, Quebec, Canada
Arthritis Rheum 61:300-4. 2009..To determine the risk of tuberculosis (TB) among a cohort of patients with rheumatoid arthritis (RA) in Quebec and assess whether this risk is associated with exposure to nonbiologic disease-modifying antirheumatic drugs (DMARDs)... - Inhaled corticosteroids and the risks of diabetes onset and progressionSamy Suissa
Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada
Am J Med 123:1001-6. 2010..We assessed whether the use and dose of inhaled corticosteroids increase the risk of diabetes onset and progression... - A net clinical benefit analysis of warfarin and aspirin on stroke in patients with atrial fibrillation: a nested case-control studyLaurent Azoulay
Centre for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, 3755 Cote Sainte Catherine, H 461, Montreal, Quebec, Canada H3T 1E2
BMC Cardiovasc Disord 12:49. 2012.... - Antirheumatic drugs and the risk of tuberculosisPaul Brassard
Department of Medicine, McGill University, Montreal, QC, Canada
Clin Infect Dis 43:717-22. 2006.... - Gastro-intestinal haemorrhage risks of selective serotonin receptor antagonist therapy: a new lookLucie Opatrny
Division of Clinical Epidemiology, McGill University Health Center, McGill University, Montreal, Canada
Br J Clin Pharmacol 66:76-81. 2008.... - Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumoniaPierre Ernst
Pharmacoepidemiology Research Unit, Department of Medicine, McGill University Health Centre, and Division of Clinical Epidemiology, Ross 4 29, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, PQ, Quebec, H3A 1A1 Canada
Am J Respir Crit Care Med 176:162-6. 2007..Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD)... - Antibiotics in primary prevention of myocardial infarction among elderly patients with hypertensionPaul Brassard
Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
Am Heart J 145:E20. 2003.... - Inhaled corticosteroids and risk of tuberculosis in patients with respiratory diseasesPaul Brassard
Center for Clinical Epidemiology, Lady Davis Research Institute, Department of Medicine, Jewish General Hospital, Montreal, Quebec, Canada
Am J Respir Crit Care Med 183:675-8. 2011..Treatment with substantial doses of oral corticosteroids (OCS) for prolonged periods increases the risk of tuberculosis (TB). However, little is known about the effect of inhaled corticosteroids (ICS) in this respect... - Validating the effects of drug treatment on blood pressure in the General Practice Research DatabaseJoseph A C Delaney
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
Pharmacoepidemiol Drug Saf 17:535-45. 2008..Blood pressure data which are measured at variable intervals and are often missing present a particular methodological challenge to the analysis of such studies... - Antibacterial drugs and the risk of community-associated methicillin-resistant Staphylococcus aureus in childrenVerena Schneider-Lindner
Centre for Clinical Epidemiology, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine, Ste H4, Montreal, QC H3T 1E2, Canada
Arch Pediatr Adolesc Med 165:1107-14. 2011..To investigate in children the association between antibacterial drugs and subsequent diagnosis of methicillin-resistant Staphylococcus aureus (MRSA) in the community... - Risk of glaucoma in elderly patients treated with inhaled corticosteroids for chronic airflow obstructionAnne V Gonzalez
Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Canada
Pulm Pharmacol Ther 23:65-70. 2010..We sought to determine the risk of new onset ocular hypertension or glaucoma requiring treatment, associated with the use of ICS in elderly patients treated for airways disease... - Antimicrobial drugs and community-acquired Clostridium difficile-associated disease, UKJ A Chris Delaney
McGill University Health Center, Montreal, Quebec, Canada
Emerg Infect Dis 13:761-3. 2007..CDAD risk increased 3-fold with use of any antimicrobial agent and 6-fold with use of fluoroquinolones. Prior use of antimicrobial agents did not affect risk for CDAD after 6 months... - Effectiveness of combination therapies in asthma: an observational studySamy Suissa
McGill Pharmacoepidemiology Research Unit, McGill University Health Centre, Montreal, Canada
Pulm Pharmacol Ther 22:194-8. 2009..We compared the effectiveness in a real world setting of two such combinations available in a single inhaler... - Cardiovascular morbidity and mortality in COPDLaetitia Huiart
Division of Clinical Epidemiology, Royal Victoria Hospital and Department of Epidemiology and Biostatistics, McGill University, 687 Pine Ave West, Ross 4.29, Montreal, QC, Canada, H3A 1A1
Chest 128:2640-6. 2005..5 per 1,000 PY). CONCLUSION: CVD is more frequent in COPD patients than in the general population and may represent a burden greater than that of lung disease itself... - Trends in the prescription of anti-diabetic medications in the United Kingdom: a population-based analysisKristian B Filion
Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada
Pharmacoepidemiol Drug Saf 18:973-6. 2009..The objective of this study was to describe trends in the prescription of anti-diabetic medications among patients with type 2 diabetes in the United Kingdom (UK)... - Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control studyFrancesco Lapi
Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Côte Sainte Catherine Montreal, Quebec, Canada, H3T 1E2
BMJ 346:e8525. 2013.... - Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortalitySamy Suissa
Center for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Canada
Thorax 67:957-63. 2012..The long-term natural history of chronic obstructive pulmonary disease (COPD) in terms of successive severe exacerbations and mortality is unknown... - Bronchodilator use and the risk of arrhythmia in COPD: part 2: reassessment in the larger Quebec cohortMachelle Wilchesky
Donald Berman Maimonides Geriatric Centre, McGill University, Montreal, QC, Canada
Chest 142:305-11. 2012..A previous study suggested a potential increased risk of cardiac arrhythmia with new use of long-acting β-agonists and ipratropium bromide in patients with COPD, although conclusions were limited by the small cohort size... - Risk of herpes zoster in patients prescribed inhaled corticosteroids: a cohort studyPierre Ernst
Center for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, Canada
BMC Pulm Med 11:59. 2011..We hypothesised that inhaled corticosteroids (ICS) are a risk factor for herpes zoster especially among users of inhibitors of cytochrome P450 enzymes involved in their metabolism... - Systemic effects of inhaled corticosteroidsPierre Ernst
Centre for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada
Curr Opin Pulm Med 18:85-9. 2012..We review the articles appearing in the last year which have addressed the safety of ICSs when used in the treatment of asthma and chronic obstructive pulmonary disease (COPD)... - Mortality after infection with methicillin-resistant Staphylococcus aureus (MRSA) diagnosed in the communityJ A Chris Delaney
Division of Clinical Epidemiology, McGill University Health Center, Royal Victoria Hospital, 687 Pine Avenue West, Ross 4, 29, Montreal, H3A 1A1, Canada
BMC Med 6:2. 2008..We conducted a population based cohort study to assess the magnitude of mortality associated with MRSA infections diagnosed in the community... - Hormone replacement therapy use and the risk of strokeChristel Renoux
McGill Pharmacoepidemiology Research Unit, Jewish General Hospital, Departments of Epidemiology and Biostatistics and of Medicine, McGill University, Montreal, Canada
Maturitas 61:305-9. 2008..A recent trial also reported an increased risk with tibolone, a selective tissue estrogenic activity regulator... - Oral corticosteroid use and the risk of acute myocardial infarction in chronic obstructive pulmonary diseaseLaetitia Huiart
Division of Clinical Epidemiology, Royal Victoria Hospital and Department of Epidemiology and Biostatistics, McGill University, , , Canada
Can Respir J 13:134-8. 2006..CONCLUSIONS: An association was found between the current use of oral corticosteroids and the occurrence of an AMI, suggesting that acute exacerbations of COPD are associated with an increased risk of acute coronary syndromes... - Discontinuation of statin therapy following an acute myocardial infarction: a population-based studyStella S Daskalopoulou
Division of Internal Medicine, Department of Medicine, McGill University, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, B2 236, Montreal, QC, Canada
Eur Heart J 29:2083-91. 2008..Our objective was to estimate the extent to which different patterns of statin use are associated with post-AMI mortality... - Antimicrobial drugs and community-acquired methicillin-resistant Staphylococcus aureus, United KingdomVerena Schneider Lindner
McGill University Health Center, Montreal, Quebec, Canada
Emerg Infect Dis 13:994-1000. 2007..37, CI 2.80-4.09) and macrolides (OR 2.50, CI 2.14-2.91)... - Use of lithium and the risk of injurious motor vehicle crash in elderly adults: case-control study nested within a cohortMahyar Etminan
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Ave, West Montreal, Quebec, Canada
BMJ 328:558-9. 2004 - Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleedingJoseph A Delaney
Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Que
CMAJ 177:347-51. 2007..We assessed whether antithrombotic drug combinations increased the risk of such bleeding in a general practice population... - Thiazolidinediones and the risk of incident congestive heart failure among patients with type 2 diabetes mellitusKristian B Filion
Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada
Pharmacoepidemiol Drug Saf 20:785-96. 2011..Clinical trials suggest that thiazolidinediones (TZDs) may increase the risk of congestive heart failure (CHF). However, their effect on the risk of incident CHF in unselected populations has not been thoroughly investigated... - Bronchodilator use and the risk of arrhythmia in COPD: part 1: Saskatchewan cohort studyMachelle Wilchesky
Donald Berman Maimonides Geriatric Centre, McGill University, Montreal, Canada
Chest 142:298-304. 2012..Bronchodilators are first-line therapy for COPD. There is some evidence that they may increase the risk of cardiac arrhythmias... - Dopamine agonist use and the risk of heart failureChristel Renoux
Center for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada
Pharmacoepidemiol Drug Saf 21:34-41. 2012..A potential risk of heart failure was recently observed in randomized trials of the dopamine agonist pramipexole. The extent of the risk with this and other dopamine agonists is unknown... - Androgen-deprivation therapy and the risk of stroke in patients with prostate cancerLaurent Azoulay
Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Eur Urol 60:1244-50. 2011..Some evidence indicates that androgen-deprivation therapy (ADT) increases the risk of diabetes and cardiovascular disease. To date, few studies have investigated whether this therapy also increases the risk of cerebrovascular events... - Lifestyle variables and the risk of myocardial infarction in the general practice research databaseJoseph A C Delaney
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
BMC Cardiovasc Disord 7:38. 2007..As a secondary objective, we considered the association between other lifestyle variables, smoking and heavy alcohol use, and AMI risk... - Number needed to treat is incorrect without proper time-related considerationsDaniel Suissa
Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Quebec, Canada
J Clin Epidemiol 65:42-6. 2012.... - Lung cancer after exposure to disease modifying anti-rheumatic drugsSasha Bernatsky
Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Guebec, Canada
Lung Cancer 59:266-9. 2008..To assess the effects of disease modifying anti-rheumatic drugs (DMARDs) on lung cancer risk in a large rheumatoid arthritis (RA) cohort... - Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control studyCarlos Martinez
Centre for Clinical Epidemiology, Jewish General Hospital, and Department of Epidemiology, McGill University, Montreal, Canada
BMJ 340:c249. 2010..To assess whether use of the antidepressant venlafaxine is associated with an increased risk of sudden cardiac death or near death compared with other commonly used antidepressants... - Gender differences in survival following hospitalisation for COPDAnne V Gonzalez
Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Montreal, Canada
Thorax 66:38-42. 2011..Gender differences in survival and rate of rehospitalisation were investigated in a large cohort of elderly patients with chronic airflow obstruction hospitalised for COPD... - Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated diseaseSandra Dial
Division of Critical Care and Respiratory and Clinical Research, Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec
JAMA 294:2989-95. 2005..Recent reports suggest an increasing occurrence and severity of Clostridium difficile-associated disease. We assessed whether the use of gastric acid-suppressive agents is associated with an increased risk in the community... - Transdermal and oral hormone replacement therapy and the risk of stroke: a nested case-control studyChristel Renoux
McGill Pharmacoepidemiology Research Unit, Center for Clinical Epidemiology, Jewish General Hospital, Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada H3T 1E2
BMJ 340:c2519. 2010..To determine the risk of stroke associated with oral and transdermal routes of administration of hormone replacement therapy... - Antihypertensives and myocardial infarction risk: the modifying effect of history of drug useC Bourgault
Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
Pharmacoepidemiol Drug Saf 10:287-94. 2001..In addition, the estimates significantly varied across drug history profiles thus suggesting the presence of preferential prescribing of specific drug classes to high-risk patients... - Concurrent use of tamoxifen with CYP2D6 inhibitors and the risk of breast cancer recurrenceLaurent Azoulay
Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Sainte Catherine, H 425 1, Montreal, QC H3T 1E2, Canada
Breast Cancer Res Treat 126:695-703. 2011..These results remained consistent after performing sensitivity analyses. The results of this large population-based study indicate that concurrent use of tamoxifen with CYP2D6 inhibitors does not increase the risk of recurrence... - Demyelinating events in rheumatoid arthritis after drug exposuresSasha Bernatsky
Centre for Clinical Epidemiology, Jewish General Hospital Lady Davis Institute, 3755 Cote Ste Catherine, Montreal, Quebec, Canada
Ann Rheum Dis 69:1691-3. 2010..To estimate the effects of biological drugs on the risk of demyelinating events in rheumatoid arthritis (RA)... - Combined oral contraceptive use and the risk of systemic lupus erythematosusMarie Odile Bernier
McGill Pharmacoepidemiology Research Unit, McGill University, Montreal, Quebec, Canada
Arthritis Rheum 61:476-81. 2009.... - Inhaled corticosteroids and hospitalisation due to exacerbation of COPDJ Bourbeau
Respiratory Epidemiology Unit, Joint Depts of Epidemiology and Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada
Eur Respir J 22:286-9. 2003..No reduction in chronic obstructive pulmonary disease exacerbations requiring hospitalisation, in relation to the use of inhaled corticosteroids, were observed... - The multitime case-control design for time-varying exposuresSamy Suissa
Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
Epidemiology 21:876-83. 2010..The conventional approach to improve precision of the odds ratio in a case-control study is to increase the number of controls per case. With time-varying exposures, an alternative is to increase the number of observations per control... - [Methodological controversies in chronic obstructive pulmonary disease therapeutic trials]Samy Suissa
Hôpital Général Juif de Montréal et Départements d Epidémiologie et Biostatistique, et de Médecine, Universite McGill, Montreal, Canada
Presse Med 38:445-51. 2009..They should be prescribed in COPD for at most a limited population of patients... - The impact of over-the-counter simvastatin on the number of statin prescriptions in the United Kingdom: a view from the General Practice Research DatabaseKristian B Filion
McGill University, Division of Clinical Epidemiology, Royal Victoria Hospital, Montreal, Canada
Pharmacoepidemiol Drug Saf 16:1-4. 2007..We assessed the impact of this policy change on statin prescribing... - Hematologic malignant neoplasms after drug exposure in rheumatoid arthritisSasha Bernatsky
Division of Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada
Arch Intern Med 168:378-81. 2008..There is increasing concern about the influence of rheumatoid arthritis therapy on the risk for hematologic malignant neoplasms... - Mega trials in COPD--clinical data analysis and design issuesSamy Suissa
Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Department of Epidemiology, McGill University, Montreal, Canada
Pneumonol Alergol Pol 79:227-31. 2011..With COPD one of the major causes of morbidity and mortality worldwide, mega trials such as TORCH and UPLIFT are much needed, but must achieve the utmost scientific rigour in their design and analysis... - The use of atypical antipsychotics and the risk of breast cancerLaurent Azoulay
Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Sainte Catherine, H 425 1, Montreal, QC, H3T 1E2, Canada
Breast Cancer Res Treat 129:541-8. 2011..The results of this study should provide reassurance that compared to typical antipsychotics, atypical antipsychotics do not increase the risk of breast cancer... - Time-window bias in case-control studies: statins and lung cancerSamy Suissa
Center for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada
Epidemiology 22:228-31. 2011..99 (0.85-1.16)-suggesting no benefit of statins on lung cancer risk. We show analytically that the magnitude of the bias is proportional to the ratio of the unequal time-window lengths... - The impact of hepatitis C virus coinfection on HIV progression before and after highly active antiretroviral therapyMarina B Klein
Division of Infectious Diseases Immunodeficiency, Department of Medicine, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
J Acquir Immune Defic Syndr 33:365-72. 2003..HCV coinfection and comorbidity associated with injection drug use are preventing the realization of substantial health benefits associated with HAART... - Metformin and the incidence of prostate cancer in patients with type 2 diabetesLaurent Azoulay
Sir Mortimer B Davis Jewish General Hospital Centre for Clinical Epidemiology and Community Studies 3755 Côte Sainte Catherine, H 425 1 Montreal, Quebec, Canada H3T 1E2
Cancer Epidemiol Biomarkers Prev 20:337-44. 2011..The objective of this study was to determine whether metformin decreases the risk of prostate cancer in patients with type 2 diabetes... - Anti-rheumatic drug use and risk of serious infections in rheumatoid arthritisS Bernatsky
Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
Rheumatology (Oxford) 46:1157-60. 2007..To assess the risk of severe infections associated with the use of traditional disease-modifying anti-rheumatic drugs (DMARDs) and glucocorticoid agents in rheumatoid arthritis (RA)... - Low-dose inhaled and nasal corticosteroid use and the risk of cataractsP Ernst
Division of Clinical Epidemiology, Royal Victoria Hospital, 687 Pine Avenue West, Ross 4 29, Montreal, Quebec H3A 1A1, Canada
Eur Respir J 27:1168-74. 2006..Such an excess risk was not observed with nasal corticosteroids... - Antihypertensive drug therapy in Saskatchewan: patterns of use and determinants in hypertensionC Bourgault
Department of Epidemiology and Biostastics, Royal Victoria Hospital, McGill University Health Centre (MUHC, 687 Pine Ave W, Ross 4.29, Montreal, Quebec, Canada H3A 1A1
Arch Intern Med 161:1873-9. 2001..In addition, initial drug use does not seem to be in accordance with the stepped-care approach to hypertension therapy recommended in the Canadian guidelines... - Low-dose inhaled corticosteroids and the risk of acute myocardial infarction in COPDL Huiart
Division of Clinical Epidemiology, Royal Victoria Hospital, and Dept of Epidemiology and Biostatistics, McGill University, , , Canada
Eur Respir J 25:634-9. 2005..However, a 32% reduction in the risk of AMI was observed for doses ranging 50-200 microg x day(-1). In conclusion, very low doses of inhaled corticosteroids may be associated with a reduction in the risk of acute myocardial infarction... - Inhaled corticosteroids and the risk of a first exacerbation in COPD patientsM N de Melo
Dept of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
Eur Respir J 23:692-7. 2004..51; 95% CI: 1.22-1.87), and it increased with increasing daily doses of ICS. Inhaled corticosteroids do not seem to be beneficial in reducing the risk of a first exacerbation of chronic obstructive pulmonary disease... - First-time use of newer oral contraceptives and the risk of venous thromboembolismS Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, Montreal, Quebec, Canada
Contraception 56:141-6. 1997..We conclude that second and third generation agents are associated with identical risks of venous thromboembolism when they are prescribed to women who are using oral contraceptives for the first time ever... - Inhaled corticosteroids: impact on asthma morbidity and mortalityS Suissa
Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
J Allergy Clin Immunol 107:937-44. 2001..In all, the evidence to date strongly indicates that regular use of inhaled corticosteroids, even at low doses, would prevent the major portion of asthma hospitalizations and deaths... - Warfarin use and the risk of motor vehicle crash in older driversLucie Opatrny
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Center, McGill University, Montreal, Canada
Br J Clin Pharmacol 61:229-32. 2006..74; 95% confidence interval 0.55, 1.05). CONCLUSIONS: Warfarin therapy does not appear to increase the risk of motor vehicle accidents in elderly drivers... - Anti-rheumatic drug use and risk of hospitalization for congestive heart failure in rheumatoid arthritisS Bernatsky
Division of Clinical Epidemiology, Montreal General Hospital, Canada
Rheumatology (Oxford) 44:677-80. 2005..The increased risk with rofecoxib alongside a decreased risk with celecoxib suggests the absence of a class effect with respect to COX-II inhibitors for some types of cardiovascular morbidity... - Inhaled corticosteroids in chronic obstructive pulmonary diseaseSamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Canada
Proc Am Thorac Soc 4:535-42. 2007..Thus, although future randomized trials will need to be conducted with the most rigorous methodology for all outcomes, much uncertainty remains regarding the potential benefits of ICS in COPD... - The early course of newly diagnosed asthmaPierre Ernst
Division of Clinical Epidemiology, Royal Victoria Hospital, and Pharmacoepidemiology Research Unit, McGill University Health Center, Montreal, , Canada
Am J Med 112:44-8. 2002..Patients initially dispensed medications suggesting the presence of severe asthma often see the intensity of treatment wane over time... - Assessing a whiplash management model: a population-based non-randomized intervention studySamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
J Rheumatol 33:581-7. 2006..CONCLUSION: A coordinated whiplash management approach can lead to earlier return to work and lower costs for patients who have sustained a whiplash injury... - Rates and patterns of chronic obstructive pulmonary disease exacerbationsMagda Nunes de Melo
Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
Can Respir J 11:559-64. 2004..04 exacerbations/person-year. CONCLUSIONS: The results indicate that in a population-based cohort of patients with COPD, the average rate of exacerbations was 1.12/person-year. Men and women had similar rates of exacerbations... - Co-morbidity in COPD: the effects of cardiovascular drug therapiesSamy Suissa
Center for Clinical Epidemiology, Jewish General Hospital Lady Davis Research Institute, and Department of Epidemiology and Biostatistics and Department of Medicine, McGill University, Montreal, Que, Canada samy suissa mcgill ca
Respiration 80:3-7. 2010..Correcting these methodological flaws with proper statistical analysis may attenuate or even eliminate these apparent benefits... - The evolution of compensated occupational spinal injuries. A three-year follow-up studyM Rossignol
Department of Epidemiology and Biostatistics, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Spine (Phila Pa 1976) 17:1043-7. 1992..9% (95% confidence interval = 19.8-19.9) in the year following an initial episode of one day duration, and 26.7% (95% confidence interval = 24.3-29.3) after an initial episode of 6 months... - Evaluation of the efficacy of simulation games in traffic safety education of kindergarten childrenL Renaud
Department of Community Health, Montreal General Hospital, Quebec, Canada
Am J Public Health 79:307-9. 1989..Results suggest that simulation games including role-playing/group dynamics and modeling/training can change attitudes and modify behavior in the area of pedestrian traffic safety in children of this age... - Hormone replacement therapy and the risk of venous thromboembolism: a population-based studyC Renoux
McGill Pharmacoepidemiology Research Unit, Department of Epidemiology and Biostatistics, Jewish General Hospital, McGill University, Montreal, QC, Canada
J Thromb Haemost 8:979-86. 2010..Hormone replacement therapy (HRT) using oral estrogen alone or combined with a progestogen is associated with an increased risk of venous thromboembolism (VTE) in postmenopausal women. This risk may differ for tibolone and transdermal HRT...