Howard Steiger

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-] paroxetine binding in bulimic syndromes
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
    Int J Eat Disord 37:57-60. 2005
  2. ncbi request reprint Childhood abuse and platelet tritiated-paroxetine binding in bulimia nervosa: implications of borderline personality disorder
    H Steiger
    Eating Disorders Program, Douglas Hospital, Verdun, Quebec, Canada
    J Clin Psychiatry 61:428-35. 2000
  3. ncbi request reprint Childhood and adulthood abuse in bulimic and nonbulimic women: prevalences and psychological correlates
    Stephanie Leonard
    Eating Disorders Program, Douglas Hospital, Verdun, Quebec, Canada
    Int J Eat Disord 33:397-405. 2003
  4. doi request reprint Methylation of the glucocorticoid receptor gene promoter in bulimic women: associations with borderline personality disorder, suicidality, and exposure to childhood abuse
    Howard Steiger
    Eating Disorders Program, Douglas University Institute, Quebec, Canada
    Int J Eat Disord 46:246-55. 2013
  5. doi request reprint Interaction of the BcII glucocorticoid receptor polymorphism and childhood abuse in Bulimia Nervosa (BN): relationship to BN and to associated trait manifestations
    Howard Steiger
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    J Psychiatr Res 46:152-8. 2012
  6. doi request reprint Trait-defined eating-disorder subtypes and history of childhood abuse
    Howard Steiger
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    Int J Eat Disord 43:428-32. 2010
  7. doi request reprint Association of trait-defined, eating-disorder sub-phenotypes with (biallelic and triallelic) 5HTTLPR variations
    Howard Steiger
    Eating Disorders Program, Douglas University Institute in Mental Health, Quebec, Canada
    J Psychiatr Res 43:1086-94. 2009
  8. ncbi request reprint Serotonin-system polymorphisms (5-HTTLPR and -1438G/A) and responses of patients with bulimic syndromes to multimodal treatments
    Howard Steiger
    Eating Disorders Program, Douglas Mental Health University Institute, 6875 LaSalle Blvd, Montreal, Quebec, Canada H4H 1R3
    J Clin Psychiatry 69:1565-71. 2008
  9. ncbi request reprint Mood- and restraint-based antecedents to binge episodes in bulimia nervosa: possible influences of the serotonin system
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, 6875 LaSalle Boulevard, Montreal Verdun, Quebec, Canada H4H 1R3
    Psychol Med 35:1553-62. 2005
  10. pmc The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, 6875 LaSalle Blvd, Montreal QC H4H 1R3, Canada
    J Psychiatry Neurosci 32:354-62. 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-] paroxetine binding in bulimic syndromes
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
    Int J Eat Disord 37:57-60. 2005
    ....
  2. ncbi request reprint Childhood abuse and platelet tritiated-paroxetine binding in bulimia nervosa: implications of borderline personality disorder
    H Steiger
    Eating Disorders Program, Douglas Hospital, Verdun, Quebec, Canada
    J Clin Psychiatry 61:428-35. 2000
    ..To explore this notion, we conducted a controlled assessment of childhood abuse and 5-HT function in bulimics with and without borderline personality disorder...
  3. ncbi request reprint Childhood and adulthood abuse in bulimic and nonbulimic women: prevalences and psychological correlates
    Stephanie Leonard
    Eating Disorders Program, Douglas Hospital, Verdun, Quebec, Canada
    Int J Eat Disord 33:397-405. 2003
    ..We evaluated associations between childhood physical and sexual abuse in bulimic women and eating disturbances, psychiatric symptoms, and likelihood of later abuse in adulthood...
  4. doi request reprint Methylation of the glucocorticoid receptor gene promoter in bulimic women: associations with borderline personality disorder, suicidality, and exposure to childhood abuse
    Howard Steiger
    Eating Disorders Program, Douglas University Institute, Quebec, Canada
    Int J Eat Disord 46:246-55. 2013
    ....
  5. doi request reprint Interaction of the BcII glucocorticoid receptor polymorphism and childhood abuse in Bulimia Nervosa (BN): relationship to BN and to associated trait manifestations
    Howard Steiger
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    J Psychiatr Res 46:152-8. 2012
    ..We discuss theoretical and clinical implications of these observations...
  6. doi request reprint Trait-defined eating-disorder subtypes and history of childhood abuse
    Howard Steiger
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    Int J Eat Disord 43:428-32. 2010
    ....
  7. doi request reprint Association of trait-defined, eating-disorder sub-phenotypes with (biallelic and triallelic) 5HTTLPR variations
    Howard Steiger
    Eating Disorders Program, Douglas University Institute in Mental Health, Quebec, Canada
    J Psychiatr Res 43:1086-94. 2009
    ..We explored the extent to which an empirical, trait-defined typology of eating-disordered individuals coincided systematically with variations in 5HTTLPR, assayed using biallelic and triallelic models...
  8. ncbi request reprint Serotonin-system polymorphisms (5-HTTLPR and -1438G/A) and responses of patients with bulimic syndromes to multimodal treatments
    Howard Steiger
    Eating Disorders Program, Douglas Mental Health University Institute, 6875 LaSalle Blvd, Montreal, Quebec, Canada H4H 1R3
    J Clin Psychiatry 69:1565-71. 2008
    ....
  9. ncbi request reprint Mood- and restraint-based antecedents to binge episodes in bulimia nervosa: possible influences of the serotonin system
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, 6875 LaSalle Boulevard, Montreal Verdun, Quebec, Canada H4H 1R3
    Psychol Med 35:1553-62. 2005
    ..However, as central serotonin (5-hydroxytryptamine: 5-HT) mechanisms regulate appetite and mood, the 5-HT system could be implicated in diet- and mood-based binge antecedents...
  10. pmc The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, 6875 LaSalle Blvd, Montreal QC H4H 1R3, Canada
    J Psychiatry Neurosci 32:354-62. 2007
    ..In women with bulimic syndromes, we explored associations with personality pathology of 5HTTLPR and prior sexual or physical maltreatment...
  11. ncbi request reprint Intrafamilial correspondences on platelet [3H-]paroxetine-binding indices in bulimic probands and their unaffected first-degree relatives
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, Montreal, QC, Canada
    Neuropsychopharmacology 31:1785-92. 2006
    ..We propose that, under conducive circumstances, such a trait may increase risk of binge-eating behavior, or associated symptoms of affective or behavioral dysregulation...
  12. ncbi request reprint Dissocial behavior, the 5HTTLPR polymorphism, and maltreatment in women with bulimic syndromes
    Howard Steiger
    Eating Disorders Program, Douglas Institute, Montreal, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:128-30. 2008
    ..c) 2007 Wiley-Liss, Inc...
  13. ncbi request reprint Phenotypes, endophenotypes, and genotypes in bulimia spectrum eating disorders
    Howard Steiger
    Psychiatry Department, McGill University, Montreal, Quebec
    Can J Psychiatry 52:220-7. 2007
    ....
  14. doi request reprint Molecular-genetic correlates of self-harming behaviors in eating-disordered women: findings from a combined Canadian-German sample
    Howard Steiger
    Eating Disorders Program, Douglas University Institute, Montreal, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 35:102-6. 2011
    ..As in other populations, our findings link the MAOAuVNTR high-function alleles with increased risk of self-directed harm in bulimic females. We discuss theoretical and clinical ramifications of our results...
  15. ncbi request reprint Reduced density of platelet-binding sites for [3H]paroxetine in remitted bulimic women
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
    Neuropsychopharmacology 30:1028-32. 2005
    ....
  16. ncbi request reprint Self-destructiveness and serotonin function in bulimia nervosa
    H Steiger
    Eating Disorders Program, Douglas Hospital, Quebec, Verdun, Canada
    Psychiatry Res 103:15-26. 2001
    ..These findings suggest that some serotonergic anomalies reported in BN sufferers (i.e. reduced neuroendocrine response after m-CPP) may be most characteristic of individuals in the population showing clear-cut self-destructive potential...
  17. doi request reprint Contributions of the glucocorticoid receptor polymorphism (Bcl1) and childhood abuse to risk of bulimia nervosa
    Howard Steiger
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    Psychiatry Res 187:193-7. 2011
    ..We interpret our findings as indicating that traumatic stress, when impacting individuals disposed to lower GR modulation, can be etiological for BN...
  18. ncbi request reprint Implications of compulsive and impulsive traits for serotonin status in women with bulimia nervosa
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada
    Psychiatry Res 120:219-29. 2003
    ..Our findings suggest that 5-HT status in BN may correspond to impulsive or compulsive traits, and they encourage multidimensional modeling of the pathophysiological role of 5-HT in BN...
  19. doi request reprint Neural circuits, neurotransmitters, and behavior: serotonin and temperament in bulimic syndromes
    Howard Steiger
    Douglas University Institute, 6875 LaSalle Blvd, Montreal Verdun, QC, Canada, H4H 1R3
    Curr Top Behav Neurosci 6:125-38. 2011
    ....
  20. pmc Eating disorders and the serotonin connection: state, trait and developmental effects
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, and the Psychiatry Department, McGill University, Montreal, Que
    J Psychiatry Neurosci 29:20-9. 2004
    ....
  21. ncbi request reprint Serotonin function, personality-trait variations, and childhood abuse in women with bulimia-spectrum eating disorders
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, Verdun, Quebec, Canada
    J Clin Psychiatry 65:830-7. 2004
    ..We explored relationships among measures of 5-HT system functioning, behavioral inhibition/disinhibition, and childhood abuse in women with bulimia-spectrum eating syndromes...
  22. ncbi request reprint Impulsivity in women with eating disorders: problem of response inhibition, planning, or attention?
    Lindsay Rosval
    Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
    Int J Eat Disord 39:590-3. 2006
    ..However, studies have not exhaustively explored the association between EDs and various component dimensions of the impulsivity construct...
  23. doi request reprint Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology
    Lea Thaler
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 39:120-8. 2012
    ..We discuss the implications of our observations...
  24. ncbi request reprint Relevance of the 5-HTTLPR polymorphism and childhood abuse to increased psychiatric comorbidity in women with bulimia-spectrum disorders
    Jodie Richardson
    Eating Disorders Program, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    J Clin Psychiatry 69:981-90. 2008
    ....
  25. ncbi request reprint Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa
    Kenneth R Bruce
    Eating Disorders Program, Research Centre, Douglas Hospital, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
    Am J Med Genet B Neuropsychiatr Genet 137:40-4. 2005
    ..These findings implicate the GG genotype in the co-aggregation of impulsive behaviors and alterations of post-synaptic 5-HT functioning in women with BN...
  26. ncbi request reprint Reduced platelet [3H]paroxetine binding in anorexia nervosa: relationship to eating symptoms and personality pathology
    Kenneth R Bruce
    Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
    Psychiatry Res 142:225-32. 2006
    ..Findings suggest that reduced peripheral serotonin transporter density in AN relates to increased dieting preoccupations, affective instability and anxiousness-fearfulness...
  27. ncbi request reprint Childhood sexual abuse in relation to neurobiological challenge tests in patients with borderline personality disorder and normal controls
    Hallie Zweig-Frank
    Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Psychiatry Res 141:337-41. 2006
    ..No differences were found between abused and non-abused patients with BPD. These results do not support the hypothesis that CSA is directly related to neurobiological abnormalities in BPD...
  28. doi request reprint Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-Spectrum Disorders
    Patricia Groleau
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    J Psychiatr Res 46:1139-45. 2012
    ....
  29. doi request reprint Cortisol responses on the dexamethasone suppression test among women with Bulimia-spectrum eating disorders: associations with clinical symptoms
    Kenneth R Bruce
    Douglas Mental Health University Institute and McGill University, Montreal, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 38:241-6. 2012
    ..We contrasted cortisol responses to the dexamethasone suppression test (DST) in bulimic and non-eating disordered women and examined relationships among DST cortisol responses, eating symptoms and co-morbid disturbances...
  30. doi request reprint Childhood emotional abuse and eating symptoms in bulimic disorders: an examination of possible mediating variables
    Patricia Groleau
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    Int J Eat Disord 45:326-32. 2012
    ..We also examined potential mediators of the link between CEA and disordered eating...
  31. ncbi request reprint Neurobiological correlates of diagnosis and underlying traits in patients with borderline personality disorder compared with normal controls
    Joel Paris
    Institute of Community and Family Psychiatry, SMBD Jewish General Hospital, 4333 Chemin de la Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E4
    Psychiatry Res 121:239-52. 2004
    ..There were no differences in cortisol response to m-CPP, or on the cholinergic and noradrenergic challenges. The results suggest that impulsive traits in borderline patients are associated with abnormalities in serotonergic systems...
  32. doi request reprint Effects of acute alcohol intoxication on eating-related urges among women with bulimia nervosa
    Kenneth R Bruce
    Eating Disorders Program, Douglas Institute, Montreal, Quebec, Canada Research Centre, Douglas Institute, Montreal, Quebec, Canada
    Int J Eat Disord 44:333-9. 2011
    ..To investigate the effects of acute alcohol intoxication on eating-related urges among women with bulimia nervosa (BN)...
  33. ncbi request reprint Impaired platelet [3H]paroxetine binding in female patients with borderline personality disorder
    N M K Ng Ying Kin
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Psychopharmacology (Berl) 182:447-51. 2005
    ..There have been few studies of platelet paroxetine binding in borderline personality disorder (BPD)...
  34. doi request reprint Autonomous motivation: a predictor of treatment outcome in bulimia-spectrum eating disorders
    Sandra Mansour
    Eating Disorders Program, Douglas Mental Health University Institute, Quebec, Canada
    Eur Eat Disord Rev 20:e116-22. 2012
    ..Self-Determination Theory postulates that autonomous motivation for therapy exists when individuals view their participation as freely chosen...
  35. pmc Impact of acute tryptophan depletion on mood and eating-related urges in bulimic and nonbulimic women
    Kenneth R Bruce
    Eating Disorders Program, Douglas Institute, Montreal, Canada
    J Psychiatry Neurosci 34:376-82. 2009
    ..We investigated mood and other consequences of ATD in women with bulimia nervosa who were or were not using concurrent serotonergic medications compared with women without bulimia...
  36. doi request reprint Expectancies related to thinness, dietary restriction, eating, and alcohol consumption in women with bulimia nervosa
    Kenneth Bruce
    Eating Disorders Program, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Int J Eat Disord 42:253-8. 2009
    ..To investigate behavior-outcome expectancies relating to thinness, dietary restriction, eating, and alcohol consumption in women with bulimia nervosa (BN)...
  37. ncbi request reprint Laxative misuse and behavioral disinhibition in bulimia nervosa
    Kenneth R Bruce
    Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
    Int J Eat Disord 33:92-7. 2003
    ..Various reports suggest that purging with laxatives is associated with greater behavioral impulsivity in bulimia nervosa (BN) patients. We investigated the extent to which laxative misuse corresponds to specific impulse-control problems...
  38. ncbi request reprint Binge antecedents in bulimic syndromes: an examination of dissociation and negative affect
    Marla J Engelberg
    Department of Psychology, McGill University, Montreal, Quebec
    Int J Eat Disord 40:531-6. 2007
    ..We conducted a naturalistic study to examine negative affect and dissociative experiences as antecedents to binge episodes...
  39. ncbi request reprint A naturalistic evaluation of the relation between dietary restraint, the urge to binge, and actual binge eating: a clarification
    Marla J Engelberg
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Int J Eat Disord 38:355-60. 2005
    ..The current study attempted to characterize the natural course of events linking dietary restraint to urges to binge and actual binge episodes...
  40. ncbi request reprint The relationship of self-esteem and body esteem in women with and without eating disorders
    Beverley K Mendelson
    Cégep Vanier, Montreal, Quebec, Canada
    Int J Eat Disord 31:318-23. 2002
    ..We investigated the predictive utility of three dimensions of body esteem in explaining self-esteem in samples of eating-disordered (ED) and nonclinical women...
  41. doi request reprint Eating-disorder symptoms and syndromes in a sample of urban-dwelling Canadian women: contributions toward a population health perspective
    Lise Gauvin
    Department of Social and Preventive Medicine, Universite de Montreal, Quebec, Canada
    Int J Eat Disord 42:158-65. 2009
    ..We estimated the prevalence of eating disorders and maladaptive eating behaviors in a population-based sample and examined the association of maladaptive eating with self-rated physical and mental health...
  42. pmc Overcoming the unhealthy pursuit of thinness: reaction to the Québec Charter for a Healthy and Diverse Body Image
    Lise Gauvin
    Department of Social and Preventive Medicine, Universite de Montreal, and the Centre de recherche du Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    Am J Public Health 102:1600-6. 2012
    ..The Charter, developed through consensus building by a multisectoral, government-led task force, outlined actions to be undertaken by organizations or citizens to reduce media pressures favoring thinness...
  43. ncbi request reprint Determinants of expressed emotion in mothers of schizophrenia patients
    Suzanne King
    McGill University and Douglas Hospital Research Center, 6875 LaSalle Blvd, Verdun, Quebec, Canada H4H 1R3
    Psychiatry Res 117:211-22. 2003
    ..These results characterize the high EE mother as low in neuroticism and high in conscientiousness with a particular sensitivity to excitement and depression in the patient...
  44. ncbi request reprint The relationship of momentary anger and impulsivity to bulimic behavior
    Scott G Engel
    Department of Clinical Research, Neuropsychiatric Research Institute, 120 S 8th Street, P O Box 1415, Fargo, ND 58078, USA
    Behav Res Ther 45:437-47. 2007
    ..They also suggest that the variability of antecedent anger may be a fruitful avenue for future research for those interested in causal variables associated with bulimia nervosa...
  45. ncbi request reprint Impulsivity and compulsivity in bulimia nervosa
    Scott G Engel
    Neuropsychiatric Research Institute, University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota 58107, USA
    Int J Eat Disord 38:244-51. 2005
    ..A second goal is to explore the relationship between impulsivity and compulsivity and related psychiatric problems...
  46. ncbi request reprint Personality subtyping and bulimia nervosa: psychopathological and genetic correlates
    Stephen A Wonderlich
    University of North Dakota School of Medicine and Health Sciences, Department of Neurosciences, Neuropsychiatric Research Institute, ND 58102, USA
    Psychol Med 35:649-57. 2005
    ..In this study, latent profile analysis was used to attempt to identify clusters of bulimic subjects based on psychiatric co-morbidity and personality...
  47. ncbi request reprint Eating disorder paradigms for the new millennium: do "attachment" and "culture" appear on brain and genome scans?
    Howard Steiger
    Can J Psychiatry 52:209-11. 2007