Rene St Arnaud
Affiliation: McGill University
St Arnaud R. Targeted inactivation of vitamin D hydroxylases in mice. Bone. 1999;25:127-9 pubmed
..The phenotype of the second generation 24-OHase-null mice also suggests a key role for 24,25(OH)2D in intramembranous bone formation during development. ..
St Arnaud R, Dardenne O, Prud homme J, Hacking S, Glorieux F. Conventional and tissue-specific inactivation of the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1). J Cell Biochem. 2003;88:245-51 pubmed
..Precise histomorphometric analysis will be required to assess the impact of chondrocyte-specific inactivation of CYP27B1 on the maturation and function of growth plate cells in vivo. ..
St Arnaud R, Naja R. Vitamin D metabolism, cartilage and bone fracture repair. Mol Cell Endocrinol. 2011;347:48-54 pubmed publisher
..Finally, preliminary results suggest that mice deficient for Cyp24a1 exhibit a delay in bone fracture healing and support a role for 24,25-(OH)(2)D in mammalian fracture repair. ..
Pellicelli M, Hariri H, Miller J, St Arnaud R. Lrp6 is a target of the PTH-activated ?NAC transcriptional coregulator. Biochim Biophys Acta Gene Regul Mech. 2018;1861:61-71 pubmed publisher
..This study identified a novel ?NAC target gene induced downstream of PTH signaling and represents the first characterization of the regulation of Lrp6 transcription in osteoblasts. ..
St Arnaud R, Arabian A, Travers R, Barletta F, Raval Pandya M, Chapin K, et al
. Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D. Endocrinology. 2000;141:2658-66 pubmed
..Our results confirm the physiological importance of the 24-OHase enzyme for maintaining vitamin D homeostasis, and they reveal that 24,25-dihydroxyvitamin D is a dispensable metabolite during bone development. ..
St Arnaud R. CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24. J Steroid Biochem Mol Biol. 2010;121:254-6 pubmed publisher
St Arnaud R, Mandic V, Elchaarani B. FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1. Ann N Y Acad Sci. 2010;1192:338-43 pubmed publisher
St Arnaud R, Hekmatnejad B. Combinatorial control of ATF4-dependent gene transcription in osteoblasts. Ann N Y Acad Sci. 2011;1237:11-8 pubmed publisher
Hekmatnejad B, Mandic V, Yu V, Akhouayri O, Arabian A, St Arnaud R. Altered gene dosage confirms the genetic interaction between FIAT and ?NAC. Gene. 2014;538:328-33 pubmed publisher
..The bone phenotype of compound Naca(+/-); Fiat(+/-) heterozygotes confirms that FIAT and ?NAC are part of a common genetic pathway and support a role for the FIAT/?NAC interaction in normal bone physiology. ..