Research Topics
Genomes and Genes
| R St-ArnaudSummaryAffiliation: McGill University Country: Canada Publications
Research Grants
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Detail Information
Publications
Targeted inactivation of vitamin D hydroxylases in miceR St-Arnaud
Shriners Hospital for Children, and Department of Surgery, McGill University, Montreal, Quebec, Canada
Bone 25:127-9. 1999..The phenotype of the second generation 24-OHase-null mice also suggests a key role for 24,25(OH)2D in intramembranous bone formation during development...- 1α,24(S)(OH)2D2 normalizes bone morphology and serum parathyroid hormone without hypercalcemia in 25-hydroxyvitamin D-1-hydroxylase (CYP27B1)-deficient mice, an animal model of vitamin D deficiency with secondary hyperparathyroidismR St-Arnaud
Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
J Endocrinol Invest 31:711-7. 2008..We studied the efficacy of 1,24(OH)2D2 in mice lacking the CYP27B1 enzyme [25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase)], a novel vitamin D deficiency model with SHPT... - FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1Rene St-Arnaud
Shriners Hospital for Children, Montreal, Quebec, Canada
Ann N Y Acad Sci 1192:338-43. 2010.... - Novel findings about 24,25-dihydroxyvitamin D: an active metabolite?R St-Arnaud
Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
Curr Opin Nephrol Hypertens 8:435-41. 1999..Mice deficient in the 25-hydroxyvitamin D-24-hydroxylase enzyme provide novel genetic tools in which to study the role of 24,25-dihydroxyvitamin D in bone development and fracture repair... - Dual functions for transcriptional regulators: myth or reality?R St-Arnaud
Genetics Unit, Shriners Hospital for Children, and Departments of Surgery and Human Genetics, McGill University, Montreal, Quebec, Canada
J Cell Biochem . 1999..This review will briefly describe the cases at hand and attempt to sort the true bifunctional proteins from the aritfactual trespassers. J. Cell. Biochem. Suppls. 32/33:32-40, 1999... - CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24Rene St-Arnaud
Genetics Unit, Shriners Hospital for Children, and Department of Human Genetics, Medicine and Surgery, McGill University, Montreal, Quebec, Canada H3A 2T5
J Steroid Biochem Mol Biol 121:254-6. 2010.... - Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin DR St-Arnaud
Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
Endocrinology 141:2658-66. 2000..Our results confirm the physiological importance of the 24-OHase enzyme for maintaining vitamin D homeostasis, and they reveal that 24,25-dihydroxyvitamin D is a dispensable metabolite during bone development... - Conventional and tissue-specific inactivation of the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)Rene St-Arnaud
Genetics Unit, Shriners Hospital for Children, Montreal Quebec, Canada H3G 1A6
J Cell Biochem 88:245-51. 2003..Precise histomorphometric analysis will be required to assess the impact of chondrocyte-specific inactivation of CYP27B1 on the maturation and function of growth plate cells in vivo... - Identification of additional dimerization partners of FIAT, the factor inhibiting ATF4-mediated transcriptionRene St-Arnaud
Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
Ann N Y Acad Sci 1116:208-15. 2007.... - Transcriptional coactivators potentiating AP-1 function in boneR St-Arnaud
Genetics Unit, Shriners Hospital, and Department of Surgery, McGill University, Montreal, Quebec, Canada H3G 1A6
Front Biosci 3:d838-48. 1998..These findings raise the intriguing possibility that multiple coactivators may be involved in mediating AP-1-dependent transcription and increase the specificity of target gene activation by AP-1 proteins in differentiating bone cells... - Vitamin D metabolism, cartilage and bone fracture repairRene St-Arnaud
Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada H3G 1A6
Mol Cell Endocrinol 347:48-54. 2011..Finally, preliminary results suggest that mice deficient for Cyp24a1 exhibit a delay in bone fracture healing and support a role for 24,25-(OH)(2)D in mammalian fracture repair... - Combinatorial control of ATF4-dependent gene transcription in osteoblastsRene St-Arnaud
Genetics Unit, Shriners Hospital for Children, Montreal, Canada
Ann N Y Acad Sci 1237:11-8. 2011.... - Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency ricketsO Dardenne
Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada H3G 1A6
Endocrinology 142:3135-41. 2001..These results show that we have successfully inactivated the 1alpha-OHase gene in mice and established a valid animal model of pseudovitamin D-deficiency rickets... - Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcriptionA Moreau
Shriners Hospital, and Department of Surgery, McGill University, Montreal, Quebec, Canada
Mol Cell Biol 18:1312-21. 1998..Thus, the alpha-NAC gene product exhibits the properties of a developmentally regulated, bone-specific transcriptional coactivator... - Differential splicing-in of a proline-rich exon converts alphaNAC into a muscle-specific transcription factorW V Yotov
Genetics Unit, Shriners Hospital, Montreal, Quebec, Canada
Genes Dev 10:1763-72. 1996.... - Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)O Dardenne
Genetics Unit, Shriners Hospital for Children, Montreal, Quebec H3G 1A6, Canada
Bone 32:332-40. 2003..This treatment, however, does not appear as effective as 1,25(OH)(2)D(3) replacement therapy since bone growth remained impaired... - The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locusR St-Arnaud
Shriners Hospital, and Department of Surgery, McGill University, Montreal, Quebec, Canada
J Bone Miner Res 12:1552-9. 1997..The availability of a cloned sequence for 1alpha-OHase generates novel tools for the study of the molecular etiology of PDDR, and will allow the investigation of other disturbances of vitamin D metabolism... - The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivatorW V Yotov
Shriners Hospital, and Department of Surgery, McGill University, Montreal, Quebec, Canada
Mol Cell Biol 18:1303-11. 1998..Based on these interactions that define the coactivator class of proteins, we conclude that the alapha-NAC/1.9.2 gene product functions as a transcriptional coactivator... - New mechanisms of regulation of the genomic actions of vitamin D in bone cells: interaction of the vitamin D receptor with non-classical response elements and with the multifunctional protein, calreticulinR St-Arnaud
Genetics Unit, Shriners Hospital, and Department of Surgery, McGill University, Montreal, Quebec, Canada H3G1A6
Front Biosci 1:d177-88. 1996..Thus research on the control of gene transcription by vitamin D reveals examples of molecular interplay between transcriptional regulatory pathways and provides new insight into the molecular mechanism of action of vitamin D... - HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation programX Gao
Genetics Unit, Shriners Hospital for Children, Montreal H3G 1A6, Quebec, Canada
J Cell Biol 154:1161-71. 2001..Our results show that HES6 is an important regulator of myogenesis and suggest that MyoR is a target for HES6-dependent transcriptional repression... - Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1W V Yotov
Genetics Unit, Shriners Hospital, , , Canada
Mamm Genome 7:163-4. 1996 - Differential mechanisms of transcriptional regulation of the mouse osteocalcin gene by Jun family membersO Akhouayri
Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Quebec, Canada H3G 1A6
Calcif Tissue Int 80:123-31. 2007..Thus, the c-Jun and JunD family members utilize distinct mechanisms that implicate differential interaction with transcriptional coactivators to regulate osteocalcin expression... - Wnt-1-inducing factor-1: a novel G/C box-binding transcription factor regulating the expression of Wnt-1 during neuroectodermal differentiationR St-Arnaud
Genetics Unit, Shriners Hospital for Crippled Children, Quebec, Canada
Mol Cell Biol 13:1590-8. 1993..Our data suggest that WiF-1 is a novel G/C box-binding transcription factor and support a physiological role for WiF-1 in the developmentally regulated expression of Wnt-1... - Cloning and functional expression analysis of the alpha subunit of mouse ATP synthaseW V Yotov
Genetics Unit, Shriners Hospital for Crippled Children, Montreal, Quebec, Canada
Biochem Biophys Res Commun 191:142-8. 1993..The resulting recombinant proteins were expressed and purified. Functional studies with the immobilized mutants proved the significance of both sites for ATP binding... - Heart, brain, and body wall defects in mice lacking calreticulinF Rauch
Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, H3G 1A6, Canada
Exp Cell Res 256:105-11. 2000..The observed abnormalities are compatible with a role of calreticulin in the modulation of cellular calcium signaling... - Transcriptional regulation during mesenchymal cell differentiation: the role of coactivatorsR St-Arnaud
Genetics Unit, Shriners Hospital, Montreal, Quebec, Canada
Crit Rev Eukaryot Gene Expr 8:191-202. 1998..This suggests that NAC isoforms may be involved in multiple steps along the lineage-making decisions facing pluripotent mesenchymal precursors... - Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancerS M Pontier
Department of Medicine, McGill University, Montreal, Quebec, Canada
Oncogene 29:3374-85. 2010..These observations provide direct evidence that ILK has a critical role in the initiation phase of ErbB2 tumor induction... - Fine mapping of the alpha-NAC gene (Naca) to the distal end (D2-D3) of mouse chromosome 10W V Yotov
Genetics Unit, Shriners Hospital, Montreal, Quebec, Canada
Mamm Genome 7:240. 1996 - Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasiaG A Candeliere
Genetics Unit, Shriners Hospital, Montreal, QC, Canada
N Engl J Med 332:1546-51. 1995.... - Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivoThomas Meury
Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Quebec, Canada
Mol Cell Biol 30:43-53. 2010..Thus, inhibition of alpha NAC nuclear translocation results in an osteopenic phenotype caused by reduced expression of osteocalcin and type I collagen, accelerated mineralization, and immature woven-bone formation...
Research Grants
- The FIAT-ATF4 interaction and the control of bone massRene St Arnaud; Fiscal Year: 2009..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
- 2005 Bones & Teeth Gordon ConferenceRene St Arnaud; Fiscal Year: 2005..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
- Advances in Mineral Metabolism (AMM) meetingRene St Arnaud; Fiscal Year: 2006..These funds will aid immensely in allowing AIMM to fulfill its function to stimulate further creativity in bone and cartilage research and to provide young investigators with a tribune to promote their talent. ..
- The FIAT-ATF4 interaction and the control of bone massRene St Arnaud; Fiscal Year: 2007..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
- The FIAT-ATF4 interaction and the control of bone massRene St Arnaud; Fiscal Year: 2010..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..