R St-Arnaud

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Targeted inactivation of vitamin D hydroxylases in mice
    R St-Arnaud
    Shriners Hospital for Children, and Department of Surgery, McGill University, Montreal, Quebec, Canada
    Bone 25:127-9. 1999
  2. ncbi request reprint 1α,24(S)(OH)2D2 normalizes bone morphology and serum parathyroid hormone without hypercalcemia in 25-hydroxyvitamin D-1-hydroxylase (CYP27B1)-deficient mice, an animal model of vitamin D deficiency with secondary hyperparathyroidism
    R St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
    J Endocrinol Invest 31:711-7. 2008
  3. doi request reprint FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1
    Rene St-Arnaud
    Shriners Hospital for Children, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1192:338-43. 2010
  4. ncbi request reprint Novel findings about 24,25-dihydroxyvitamin D: an active metabolite?
    R St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 8:435-41. 1999
  5. ncbi request reprint Dual functions for transcriptional regulators: myth or reality?
    R St-Arnaud
    Genetics Unit, Shriners Hospital for Children, and Departments of Surgery and Human Genetics, McGill University, Montreal, Quebec, Canada
    J Cell Biochem . 1999
  6. doi request reprint CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24
    Rene St-Arnaud
    Genetics Unit, Shriners Hospital for Children, and Department of Human Genetics, Medicine and Surgery, McGill University, Montreal, Quebec, Canada H3A 2T5
    J Steroid Biochem Mol Biol 121:254-6. 2010
  7. ncbi request reprint Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D
    R St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
    Endocrinology 141:2658-66. 2000
  8. ncbi request reprint Conventional and tissue-specific inactivation of the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)
    Rene St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal Quebec, Canada H3G 1A6
    J Cell Biochem 88:245-51. 2003
  9. ncbi request reprint Identification of additional dimerization partners of FIAT, the factor inhibiting ATF4-mediated transcription
    Rene St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1116:208-15. 2007
  10. ncbi request reprint Transcriptional coactivators potentiating AP-1 function in bone
    R St-Arnaud
    Genetics Unit, Shriners Hospital, and Department of Surgery, McGill University, Montreal, Quebec, Canada H3G 1A6
    Front Biosci 3:d838-48. 1998

Research Grants

  1. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2009
  2. 2005 Bones & Teeth Gordon Conference
    Rene St Arnaud; Fiscal Year: 2005
  3. Advances in Mineral Metabolism (AMM) meeting
    Rene St Arnaud; Fiscal Year: 2006
  4. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2007
  5. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Targeted inactivation of vitamin D hydroxylases in mice
    R St-Arnaud
    Shriners Hospital for Children, and Department of Surgery, McGill University, Montreal, Quebec, Canada
    Bone 25:127-9. 1999
    ..The phenotype of the second generation 24-OHase-null mice also suggests a key role for 24,25(OH)2D in intramembranous bone formation during development...
  2. ncbi request reprint 1α,24(S)(OH)2D2 normalizes bone morphology and serum parathyroid hormone without hypercalcemia in 25-hydroxyvitamin D-1-hydroxylase (CYP27B1)-deficient mice, an animal model of vitamin D deficiency with secondary hyperparathyroidism
    R St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
    J Endocrinol Invest 31:711-7. 2008
    ..We studied the efficacy of 1,24(OH)2D2 in mice lacking the CYP27B1 enzyme [25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase)], a novel vitamin D deficiency model with SHPT...
  3. doi request reprint FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1
    Rene St-Arnaud
    Shriners Hospital for Children, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1192:338-43. 2010
    ....
  4. ncbi request reprint Novel findings about 24,25-dihydroxyvitamin D: an active metabolite?
    R St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 8:435-41. 1999
    ..Mice deficient in the 25-hydroxyvitamin D-24-hydroxylase enzyme provide novel genetic tools in which to study the role of 24,25-dihydroxyvitamin D in bone development and fracture repair...
  5. ncbi request reprint Dual functions for transcriptional regulators: myth or reality?
    R St-Arnaud
    Genetics Unit, Shriners Hospital for Children, and Departments of Surgery and Human Genetics, McGill University, Montreal, Quebec, Canada
    J Cell Biochem . 1999
    ..This review will briefly describe the cases at hand and attempt to sort the true bifunctional proteins from the aritfactual trespassers. J. Cell. Biochem. Suppls. 32/33:32-40, 1999...
  6. doi request reprint CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24
    Rene St-Arnaud
    Genetics Unit, Shriners Hospital for Children, and Department of Human Genetics, Medicine and Surgery, McGill University, Montreal, Quebec, Canada H3A 2T5
    J Steroid Biochem Mol Biol 121:254-6. 2010
    ....
  7. ncbi request reprint Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D
    R St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
    Endocrinology 141:2658-66. 2000
    ..Our results confirm the physiological importance of the 24-OHase enzyme for maintaining vitamin D homeostasis, and they reveal that 24,25-dihydroxyvitamin D is a dispensable metabolite during bone development...
  8. ncbi request reprint Conventional and tissue-specific inactivation of the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)
    Rene St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal Quebec, Canada H3G 1A6
    J Cell Biochem 88:245-51. 2003
    ..Precise histomorphometric analysis will be required to assess the impact of chondrocyte-specific inactivation of CYP27B1 on the maturation and function of growth plate cells in vivo...
  9. ncbi request reprint Identification of additional dimerization partners of FIAT, the factor inhibiting ATF4-mediated transcription
    Rene St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1116:208-15. 2007
    ....
  10. ncbi request reprint Transcriptional coactivators potentiating AP-1 function in bone
    R St-Arnaud
    Genetics Unit, Shriners Hospital, and Department of Surgery, McGill University, Montreal, Quebec, Canada H3G 1A6
    Front Biosci 3:d838-48. 1998
    ..These findings raise the intriguing possibility that multiple coactivators may be involved in mediating AP-1-dependent transcription and increase the specificity of target gene activation by AP-1 proteins in differentiating bone cells...
  11. doi request reprint Vitamin D metabolism, cartilage and bone fracture repair
    Rene St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada H3G 1A6
    Mol Cell Endocrinol 347:48-54. 2011
    ..Finally, preliminary results suggest that mice deficient for Cyp24a1 exhibit a delay in bone fracture healing and support a role for 24,25-(OH)(2)D in mammalian fracture repair...
  12. doi request reprint Combinatorial control of ATF4-dependent gene transcription in osteoblasts
    Rene St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal, Canada
    Ann N Y Acad Sci 1237:11-8. 2011
    ....
  13. ncbi request reprint Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets
    O Dardenne
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada H3G 1A6
    Endocrinology 142:3135-41. 2001
    ..These results show that we have successfully inactivated the 1alpha-OHase gene in mice and established a valid animal model of pseudovitamin D-deficiency rickets...
  14. pmc Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription
    A Moreau
    Shriners Hospital, and Department of Surgery, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 18:1312-21. 1998
    ..Thus, the alpha-NAC gene product exhibits the properties of a developmentally regulated, bone-specific transcriptional coactivator...
  15. ncbi request reprint Differential splicing-in of a proline-rich exon converts alphaNAC into a muscle-specific transcription factor
    W V Yotov
    Genetics Unit, Shriners Hospital, Montreal, Quebec, Canada
    Genes Dev 10:1763-72. 1996
    ....
  16. ncbi request reprint Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)
    O Dardenne
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec H3G 1A6, Canada
    Bone 32:332-40. 2003
    ..This treatment, however, does not appear as effective as 1,25(OH)(2)D(3) replacement therapy since bone growth remained impaired...
  17. ncbi request reprint The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus
    R St-Arnaud
    Shriners Hospital, and Department of Surgery, McGill University, Montreal, Quebec, Canada
    J Bone Miner Res 12:1552-9. 1997
    ..The availability of a cloned sequence for 1alpha-OHase generates novel tools for the study of the molecular etiology of PDDR, and will allow the investigation of other disturbances of vitamin D metabolism...
  18. pmc The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator
    W V Yotov
    Shriners Hospital, and Department of Surgery, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 18:1303-11. 1998
    ..Based on these interactions that define the coactivator class of proteins, we conclude that the alapha-NAC/1.9.2 gene product functions as a transcriptional coactivator...
  19. ncbi request reprint New mechanisms of regulation of the genomic actions of vitamin D in bone cells: interaction of the vitamin D receptor with non-classical response elements and with the multifunctional protein, calreticulin
    R St-Arnaud
    Genetics Unit, Shriners Hospital, and Department of Surgery, McGill University, Montreal, Quebec, Canada H3G1A6
    Front Biosci 1:d177-88. 1996
    ..Thus research on the control of gene transcription by vitamin D reveals examples of molecular interplay between transcriptional regulatory pathways and provides new insight into the molecular mechanism of action of vitamin D...
  20. pmc HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program
    X Gao
    Genetics Unit, Shriners Hospital for Children, Montreal H3G 1A6, Quebec, Canada
    J Cell Biol 154:1161-71. 2001
    ..Our results show that HES6 is an important regulator of myogenesis and suggest that MyoR is a target for HES6-dependent transcriptional repression...
  21. ncbi request reprint Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1
    W V Yotov
    Genetics Unit, Shriners Hospital, Montreal, Quebec, Canada
    Mamm Genome 7:163-4. 1996
  22. ncbi request reprint Differential mechanisms of transcriptional regulation of the mouse osteocalcin gene by Jun family members
    O Akhouayri
    Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Quebec, Canada H3G 1A6
    Calcif Tissue Int 80:123-31. 2007
    ..Thus, the c-Jun and JunD family members utilize distinct mechanisms that implicate differential interaction with transcriptional coactivators to regulate osteocalcin expression...
  23. pmc Wnt-1-inducing factor-1: a novel G/C box-binding transcription factor regulating the expression of Wnt-1 during neuroectodermal differentiation
    R St-Arnaud
    Genetics Unit, Shriners Hospital for Crippled Children, Quebec, Canada
    Mol Cell Biol 13:1590-8. 1993
    ..Our data suggest that WiF-1 is a novel G/C box-binding transcription factor and support a physiological role for WiF-1 in the developmentally regulated expression of Wnt-1...
  24. ncbi request reprint Cloning and functional expression analysis of the alpha subunit of mouse ATP synthase
    W V Yotov
    Genetics Unit, Shriners Hospital for Crippled Children, Montreal, Quebec, Canada
    Biochem Biophys Res Commun 191:142-8. 1993
    ..The resulting recombinant proteins were expressed and purified. Functional studies with the immobilized mutants proved the significance of both sites for ATP binding...
  25. ncbi request reprint Heart, brain, and body wall defects in mice lacking calreticulin
    F Rauch
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, H3G 1A6, Canada
    Exp Cell Res 256:105-11. 2000
    ..The observed abnormalities are compatible with a role of calreticulin in the modulation of cellular calcium signaling...
  26. ncbi request reprint Transcriptional regulation during mesenchymal cell differentiation: the role of coactivators
    R St-Arnaud
    Genetics Unit, Shriners Hospital, Montreal, Quebec, Canada
    Crit Rev Eukaryot Gene Expr 8:191-202. 1998
    ..This suggests that NAC isoforms may be involved in multiple steps along the lineage-making decisions facing pluripotent mesenchymal precursors...
  27. doi request reprint Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer
    S M Pontier
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Oncogene 29:3374-85. 2010
    ..These observations provide direct evidence that ILK has a critical role in the initiation phase of ErbB2 tumor induction...
  28. ncbi request reprint Fine mapping of the alpha-NAC gene (Naca) to the distal end (D2-D3) of mouse chromosome 10
    W V Yotov
    Genetics Unit, Shriners Hospital, Montreal, Quebec, Canada
    Mamm Genome 7:240. 1996
  29. ncbi request reprint Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia
    G A Candeliere
    Genetics Unit, Shriners Hospital, Montreal, QC, Canada
    N Engl J Med 332:1546-51. 1995
    ....
  30. pmc Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo
    Thomas Meury
    Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Quebec, Canada
    Mol Cell Biol 30:43-53. 2010
    ..Thus, inhibition of alpha NAC nuclear translocation results in an osteopenic phenotype caused by reduced expression of osteocalcin and type I collagen, accelerated mineralization, and immature woven-bone formation...

Research Grants8

  1. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2009
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  2. 2005 Bones & Teeth Gordon Conference
    Rene St Arnaud; Fiscal Year: 2005
    ..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
  3. Advances in Mineral Metabolism (AMM) meeting
    Rene St Arnaud; Fiscal Year: 2006
    ..These funds will aid immensely in allowing AIMM to fulfill its function to stimulate further creativity in bone and cartilage research and to provide young investigators with a tribune to promote their talent. ..
  4. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2007
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  5. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2010
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..