Nahum Sonenberg

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. Chapat C, Jafarnejad S, Matta Camacho E, Hesketh G, Gelbart I, Attig J, et al. Cap-binding protein 4EHP effects translation silencing by microRNAs. Proc Natl Acad Sci U S A. 2017;114:5425-5430 pubmed publisher
    ..We propose a model wherein the 4E-T/4EHP interaction engenders a closed-loop mRNA conformation that blocks translational initiation of miRNA targets. ..
  2. Sonenberg N. Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of rapamycin, cell growth, and translational control. Proc Natl Acad Sci U S A. 2017;114:11564-11567 pubmed publisher
  3. Tahmasebi S, Khoutorsky A, Mathews M, Sonenberg N. Translation deregulation in human disease. Nat Rev Mol Cell Biol. 2018;19:791-807 pubmed publisher
  4. Aguilar Valles A, Haji N, De Gregorio D, Matta Camacho E, Eslamizade M, Popic J, et al. Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E. Nat Commun. 2018;9:2459 pubmed publisher
    ..We conclude that eIF4E phosphorylation modulates depression-like behavior through regulation of inflammatory responses. ..
  5. Tahmasebi S, Alain T, Rajasekhar V, Zhang J, Prager Khoutorsky M, Khoutorsky A, et al. Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell Stem Cell. 2014;14:606-16 pubmed publisher
    ..Thus, 4E-BPs exert both positive and negative effects on reprogramming, highlighting the key role that translational control plays in regulating this process. ..
  6. Topisirovic I, Sonenberg N. Distinctive tRNA repertoires in proliferating versus differentiating cells. Cell. 2014;158:1238-1239 pubmed publisher
    ..These changes in the tRNA repertoire dictate translational programs that distinguish differentiating from proliferating cells. ..
  7. Siddiqui N, Sonenberg N. Signalling to eIF4E in cancer. Biochem Soc Trans. 2015;43:763-72 pubmed publisher
    ..Consequently, recent works have aimed to target these pathways and ultimately the translational machinery for cancer therapy. ..
  8. request reprint
    Sonenberg N, Dever T. Eukaryotic translation initiation factors and regulators. Curr Opin Struct Biol. 2003;13:56-63 pubmed
  9. Jafarnejad S, Kim S, Sonenberg N. Aminoacylation of Proteins: New Targets for the Old ARSenal. Cell Metab. 2018;27:1-3 pubmed publisher
    ..In this issue of Cell Metabolism, He et al. (2018) report a novel biochemical function of ARSs: posttranslational addition of amino acids to lysine residues in proteins. ..

More Information

Publications20

  1. Jung H, Gkogkas C, Sonenberg N, Holt C. Remote control of gene function by local translation. Cell. 2014;157:26-40 pubmed publisher
    ..Here, we discuss key findings in this area and possible implications of this adaptable and swift mechanism for spatial control of gene function. ..
  2. Robichaud N, Hsu B, Istomine R, Alvarez F, Blagih J, Ma E, et al. Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils. Proc Natl Acad Sci U S A. 2018;115:E2202-E2209 pubmed publisher
    ..Furthermore, we demonstrate that pharmacological inhibition of eIF4E phosphorylation prevents metastatic progression in vivo, supporting the development of phosphorylation inhibitors for clinical use. ..
  3. Hinnebusch A, Ivanov I, Sonenberg N. Translational control by 5'-untranslated regions of eukaryotic mRNAs. Science. 2016;352:1413-6 pubmed publisher
    ..We also discuss translational control via phosphorylation of eukaryotic initiation factor 2, which is implicated in learning and memory, neurodegenerative diseases, and cancer. ..
  4. Zuberek J, Kuchta K, Hernández G, Sonenberg N, Ginalski K. Diverse cap-binding properties of Drosophila eIF4E isoforms. Biochim Biophys Acta. 2016;1864:1292-303 pubmed publisher
    ..Moreover, the analysis of ternary complexes of eIF4G peptide-eIF4E-cap analogue showed cooperativity between eIF4G and cap binding only for Dm eIF4E-4, which exhibits the lowest affinity for cap analogues among all Dm eIF4Es. ..
  5. Robichaud N, Sonenberg N. Translational control and the cancer cell response to stress. Curr Opin Cell Biol. 2017;45:102-109 pubmed publisher
    ..Emerging findings supporting this notion are the focus of this review. ..
  6. Tahmasebi S, Jafarnejad S, Tam I, Gonatopoulos Pournatzis T, Matta Camacho E, Tsukumo Y, et al. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Proc Natl Acad Sci U S A. 2016;113:12360-12367 pubmed
    ..Thus, we conclude that YY2 is a major regulator of mESC self-renewal and lineage commitment and document a multilayer regulatory mechanism that controls its expression. ..
  7. Liberman N, Gandin V, Svitkin Y, David M, Virgili G, Jaramillo M, et al. DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation. Nucleic Acids Res. 2015;43:3764-75 pubmed publisher
    ..In contrast, DAP5 is dispensable for cap-dependent translation. These findings provide the first mechanistic insights into the function of DAP5 as a selective regulator of cap-independent translation. ..
  8. Gkogkas C, Khoutorsky A, Cao R, Jafarnejad S, Prager Khoutorsky M, Giannakas N, et al. Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes. Cell Rep. 2014;9:1742-55 pubmed publisher
    ..These results uncover a mechanism of regulation of synaptic function by translational control of Mmp-9 in FXS, which opens the possibility of new treatment avenues for the diverse neurological and psychiatric aspects of FXS. ..
  9. Sonenberg N, Hinnebusch A. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell. 2009;136:731-45 pubmed publisher
  10. request reprint
    Sonenberg N, Pause A. Signal transduction. Protein synthesis and oncogenesis meet again. Science. 2006;314:428-9 pubmed
  11. Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, et al. mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1. Mol Cell. 2017;67:922-935.e5 pubmed publisher
    ..These data provide direct evidence for cell survival upon mTOR inhibition through mitochondrial hyperfusion employing MTFP1 as a critical effector of mTORC1 to govern cell fate decisions. ..