Research Topics
Genomes and Genes
| Gordon C ShoreSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
Bcl-2 proteins and apoptosis: choose your partnerGordon C Shore
Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal QCH3G1Y6, Canada
Cell 135:1004-6. 2008..These and other recent studies shed new light on the control of permeabilization of the mitochondrial outer membrane during apoptosis...
Signaling cell death from the endoplasmic reticulum stress responseGordon C Shore
Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
Curr Opin Cell Biol 23:143-9. 2011..Researchers have begun to elucidate the molecular switches that determine when ER stress is too great to repair and the signals that are then sent from the UPR to execute the cell...- Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosolDavid G Breckenridge
Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
J Cell Biol 160:1115-27. 2003..Therefore, caspase-8 cleavage of BAP31 at the ER stimulates Ca2+-dependent mitochondrial fission, enhancing the release of cyt.c in response to this initiator caspase... 
BAP31 and its caspase cleavage product regulate cell surface expression of tetraspanins and integrin-mediated cell survivalMarina Stojanovic
Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 280:30018-24. 2005..Thus, p20 BAP31 can operate upstream of BCL-2 in living cells to influence cell surface properties due to its effects on protein egress from the endoplasmic reticulum...- Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosisMarc Germain
Department of Biochemistry, McGill University, Montreal, QC, Canada
EMBO J 24:1546-56. 2005..When expressed together, BIK and NOXA cause rapid release of mobilized cytochrome c and activation of caspases... - Regulation of apoptosis by endoplasmic reticulum pathwaysDavid G Breckenridge
Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada H3G 1Y6
Oncogene 22:8608-18. 2003..Here, we review the potential underlying mechanisms involved in these events and discuss pathways for ER-mitochondrial crosstalk pertinent to a number of cell death stimuli... - Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding siteMatthew R Warr
Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 286:25098-107. 2011.... - Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1Natasha C Chang
Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
EMBO J 29:606-18. 2010..NAF-1 is required in this pathway for BCL-2 at the ER to functionally antagonize Beclin 1-dependent autophagy. Thus, NAF-1 is a BCL-2-associated co-factor that targets BCL-2 for antagonism of the autophagy pathway at the ER... - Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondriaBing Wang
Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y, Canada
J Biol Chem 278:14461-8. 2003..Ectopic A4 that was introduced into A4-deficient cells cooperated with crBAP31 to resist Fas-induced egress of cytochrome c from mitochondria and cytoplasmic apoptosis... - Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53Jaigi P Mathai
Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
Oncogene 21:2534-44. 2002..Of note, a significant fraction of either ectopic or endogenous BIK was found associated with the endoplasmic reticulum, suggesting that this organelle, in addition to mitochondria, may be a target of BIK function... - Bcl2 at the endoplasmic reticulum protects against a Bax/Bak-independent paraptosis-like cell death pathway initiated via p20Bap31Hannah M Heath-Engel
Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, QC, Canada
Biochim Biophys Acta 1823:335-47. 2012..Furthermore, these results indicate that ER restricted Bcl2 is capable of antagonizing not only apoptosis, but also a non-apoptotic, Bax/Bak independent, paraptosis-like form of cell death... - BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell deathJaigi P Mathai
Department of Biochemistry, McGill University, Montreal, Quebec H3G 146, Canada
J Biol Chem 280:23829-36. 2005..Endogenous cellular BIK, therefore, regulates a BAX,BAK-dependent ER pathway that contributes to mitochondrial apoptosis... - The resident endoplasmic reticulum protein, BAP31, associates with gamma-actin and myosin B heavy chainAxel Ducret
Merck Frosst Center for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
Eur J Biochem 270:342-9. 2003..Here we also show that Fas stimulation of apoptosis releases BAP31 associations with these motor proteins, a step that may contribute to extranuclear events, such as membrane remodelling, during the execution phase of apoptosis... - The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumorsMark Watson
Gemin X Pharmaceuticals Canada Inc, 3576 Avenue du Parc, Suite 4310, Montreal, Quebec, Canada
Mol Cell Biol 29:5872-88. 2009..This provides the rationale for a novel therapeutic approach for the use of GMX1777 in the treatment of human cancers... - The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like BBing Wang
Department of Biochemistry McGill Cancer Center, McGill University, Montreal, Quebec, Canada H3G 1Y6
Mol Cell Biol 24:2767-78. 2004.... - Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosisMai Nguyen
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, QC, Canada
Proc Natl Acad Sci U S A 104:19512-7. 2007..In both cases, this resistance was overcome by obatoclax. These findings support a rational clinical development opportunity for the compound in cancer indications or treatments where MCL-1 contributes to resistance to cell killing... - BCL2-CISD2: An ER complex at the nexus of autophagy and calcium homeostasis?Natasha C Chang
Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada
Autophagy 8:856-7. 2012..It remains to be elucidated how and if the antagonism of the BECN1 autophagy-initiating complex and modulation of ER Ca ( 2+) homeostasis by BCL2-CISD2 are interconnected... - BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complexBing Wang
Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, H3G 1Y6, Canada
Cell 133:1080-92. 2008..Thus, BAP31 operates at early steps to deliver newly synthesized CFTRDeltaF508 to its degradation pathway... - Therapeutic activation of caspases in cancer: a question of selectivityPierre Beauparlant
Gemin X Biotechnologies Inc, 3576 Avenue du Parc, Suite 4310, Montreal, Quebec, H2X 2H7, Canada
Curr Opin Drug Discov Devel 6:179-87. 2003..These agents promise to be useful clinically, either alone, by selectively inducing apoptosis in cancer cells, or by sensitizing resistant cancer cells to conventional cytotoxic agents... - The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulumDavid G Breckenridge
Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, QC, Canada H3G 1Y6
Proc Natl Acad Sci U S A 99:4331-6. 2002..Preferential recruitment of procaspase-8L by the BAP31 complex at the endoplasmic reticulum suggests an additional pathway for regulating initiator caspase-8 during apoptosis... - Molecular dynamics study of small molecule inhibitors of the Bcl-2 familyStephane Acoca
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Proteins 79:2624-36. 2011.... - BH3-ligand regulates access of MCL-1 to its E3 ligaseMatthew R Warr
Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Que, Canada
FEBS Lett 579:5603-8. 2005..This suggests that the unliganded form of Mcl-1 is sensitive to LASU1-mediated degradation of Mcl-1... - Unique biology of Mcl-1: therapeutic opportunities in cancerMatthew R Warr
Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6, Canada
Curr Mol Med 8:138-47. 2008..Here we review the various pathways that regulate Mcl-1 expression and describe agents that are currently under development to modulate Mcl-1 activity for therapeutic benefit in oncology... - BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerizationSalvatore C Ruffolo
Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 278:25039-45. 2003..This model suggests that the primary mechanism for BCL-2 blockade targets activated BAK rather than sequestering tBID... - Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscleNatasha C Chang
Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada
Hum Mol Genet 21:2277-87. 2012..Our findings uncover a novel pathway that is required for normal muscle maintenance, which may ultimately provide a novel therapeutic target for treating certain muscle pathologies... - Cellular distribution of Bcl-2 family proteinsMarc Germain
Department of Biochemistry, McGill University, , , H3G 1Y6, Canada
Sci STKE 2003:pe10. 2003..This interaction may control the cell's sensitivity to apoptotic stimuli... - Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helixAlexei Yu Denisov
Department of Biochemistry and Montreal Joint Center for Structural Biology, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 278:21124-8. 2003.... - BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondriaMarc Germain
Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 277:18053-60. 2002..Collectively, the results identify BIK as an initiator of cytochrome c release from mitochondria operating from a location at the ER...