Gordon C Shore

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Therapeutic activation of caspases in cancer: a question of selectivity
    Pierre Beauparlant
    Gemin X Biotechnologies Inc, 3576 Avenue du Parc, Suite 4310, Montreal, Quebec, H2X 2H7, Canada
    Curr Opin Drug Discov Devel 6:179-87. 2003
  2. pmc Signaling cell death from the endoplasmic reticulum stress response
    Gordon C Shore
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Curr Opin Cell Biol 23:143-9. 2011
  3. doi request reprint Bcl-2 proteins and apoptosis: choose your partner
    Gordon C Shore
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal QCH3G1Y6, Canada
    Cell 135:1004-6. 2008
  4. pmc Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol
    David G Breckenridge
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Cell Biol 160:1115-27. 2003
  5. ncbi request reprint BAP31 and its caspase cleavage product regulate cell surface expression of tetraspanins and integrin-mediated cell survival
    Marina Stojanovic
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 280:30018-24. 2005
  6. pmc Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis
    Marc Germain
    Department of Biochemistry, McGill University, Montreal, QC, Canada
    EMBO J 24:1546-56. 2005
  7. ncbi request reprint Regulation of apoptosis by endoplasmic reticulum pathways
    David G Breckenridge
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Oncogene 22:8608-18. 2003
  8. pmc Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site
    Matthew R Warr
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 286:25098-107. 2011
  9. ncbi request reprint Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria
    Bing Wang
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y, Canada
    J Biol Chem 278:14461-8. 2003
  10. pmc Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
    Natasha C Chang
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
    EMBO J 29:606-18. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Therapeutic activation of caspases in cancer: a question of selectivity
    Pierre Beauparlant
    Gemin X Biotechnologies Inc, 3576 Avenue du Parc, Suite 4310, Montreal, Quebec, H2X 2H7, Canada
    Curr Opin Drug Discov Devel 6:179-87. 2003
    ..These agents promise to be useful clinically, either alone, by selectively inducing apoptosis in cancer cells, or by sensitizing resistant cancer cells to conventional cytotoxic agents...
  2. pmc Signaling cell death from the endoplasmic reticulum stress response
    Gordon C Shore
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Curr Opin Cell Biol 23:143-9. 2011
    ..Researchers have begun to elucidate the molecular switches that determine when ER stress is too great to repair and the signals that are then sent from the UPR to execute the cell...
  3. doi request reprint Bcl-2 proteins and apoptosis: choose your partner
    Gordon C Shore
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal QCH3G1Y6, Canada
    Cell 135:1004-6. 2008
    ..These and other recent studies shed new light on the control of permeabilization of the mitochondrial outer membrane during apoptosis...
  4. pmc Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol
    David G Breckenridge
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Cell Biol 160:1115-27. 2003
    ..Therefore, caspase-8 cleavage of BAP31 at the ER stimulates Ca2+-dependent mitochondrial fission, enhancing the release of cyt.c in response to this initiator caspase...
  5. ncbi request reprint BAP31 and its caspase cleavage product regulate cell surface expression of tetraspanins and integrin-mediated cell survival
    Marina Stojanovic
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 280:30018-24. 2005
    ..Thus, p20 BAP31 can operate upstream of BCL-2 in living cells to influence cell surface properties due to its effects on protein egress from the endoplasmic reticulum...
  6. pmc Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis
    Marc Germain
    Department of Biochemistry, McGill University, Montreal, QC, Canada
    EMBO J 24:1546-56. 2005
    ..When expressed together, BIK and NOXA cause rapid release of mobilized cytochrome c and activation of caspases...
  7. ncbi request reprint Regulation of apoptosis by endoplasmic reticulum pathways
    David G Breckenridge
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Oncogene 22:8608-18. 2003
    ..Here, we review the potential underlying mechanisms involved in these events and discuss pathways for ER-mitochondrial crosstalk pertinent to a number of cell death stimuli...
  8. pmc Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site
    Matthew R Warr
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 286:25098-107. 2011
    ....
  9. ncbi request reprint Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria
    Bing Wang
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y, Canada
    J Biol Chem 278:14461-8. 2003
    ..Ectopic A4 that was introduced into A4-deficient cells cooperated with crBAP31 to resist Fas-induced egress of cytochrome c from mitochondria and cytoplasmic apoptosis...
  10. pmc Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
    Natasha C Chang
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
    EMBO J 29:606-18. 2010
    ..NAF-1 is required in this pathway for BCL-2 at the ER to functionally antagonize Beclin 1-dependent autophagy. Thus, NAF-1 is a BCL-2-associated co-factor that targets BCL-2 for antagonism of the autophagy pathway at the ER...
  11. ncbi request reprint Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53
    Jaigi P Mathai
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    Oncogene 21:2534-44. 2002
    ..Of note, a significant fraction of either ectopic or endogenous BIK was found associated with the endoplasmic reticulum, suggesting that this organelle, in addition to mitochondria, may be a target of BIK function...
  12. doi request reprint Bcl2 at the endoplasmic reticulum protects against a Bax/Bak-independent paraptosis-like cell death pathway initiated via p20Bap31
    Hannah M Heath-Engel
    Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, QC, Canada
    Biochim Biophys Acta 1823:335-47. 2012
    ..Furthermore, these results indicate that ER restricted Bcl2 is capable of antagonizing not only apoptosis, but also a non-apoptotic, Bax/Bak independent, paraptosis-like form of cell death...
  13. ncbi request reprint BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death
    Jaigi P Mathai
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 146, Canada
    J Biol Chem 280:23829-36. 2005
    ..Endogenous cellular BIK, therefore, regulates a BAX,BAK-dependent ER pathway that contributes to mitochondrial apoptosis...
  14. ncbi request reprint The resident endoplasmic reticulum protein, BAP31, associates with gamma-actin and myosin B heavy chain
    Axel Ducret
    Merck Frosst Center for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    Eur J Biochem 270:342-9. 2003
    ..Here we also show that Fas stimulation of apoptosis releases BAP31 associations with these motor proteins, a step that may contribute to extranuclear events, such as membrane remodelling, during the execution phase of apoptosis...
  15. pmc The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors
    Mark Watson
    Gemin X Pharmaceuticals Canada Inc, 3576 Avenue du Parc, Suite 4310, Montreal, Quebec, Canada
    Mol Cell Biol 29:5872-88. 2009
    ..This provides the rationale for a novel therapeutic approach for the use of GMX1777 in the treatment of human cancers...
  16. pmc Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
    Mai Nguyen
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 104:19512-7. 2007
    ..In both cases, this resistance was overcome by obatoclax. These findings support a rational clinical development opportunity for the compound in cancer indications or treatments where MCL-1 contributes to resistance to cell killing...
  17. pmc The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B
    Bing Wang
    Department of Biochemistry McGill Cancer Center, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 24:2767-78. 2004
    ....
  18. doi request reprint BCL2-CISD2: An ER complex at the nexus of autophagy and calcium homeostasis?
    Natasha C Chang
    Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada
    Autophagy 8:856-7. 2012
    ..It remains to be elucidated how and if the antagonism of the BECN1 autophagy-initiating complex and modulation of ER Ca ( 2+) homeostasis by BCL2-CISD2 are interconnected...
  19. doi request reprint BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex
    Bing Wang
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Cell 133:1080-92. 2008
    ..Thus, BAP31 operates at early steps to deliver newly synthesized CFTRDeltaF508 to its degradation pathway...
  20. doi request reprint BIM, PUMA, and the achilles' heel of oncogene addiction
    Anne Roulston
    Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Quebec H3G 2J7, Canada
    Sci Signal 6:pe12. 2013
    ..However, because resistance mechanisms often emerge, explicating the pathways that connect therapeutic oncogene inactivation to the cell death machinery is critical to exploiting additional synthetic lethal opportunities...
  21. doi request reprint Molecular dynamics study of small molecule inhibitors of the Bcl-2 family
    Stephane Acoca
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Proteins 79:2624-36. 2011
    ....
  22. pmc The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum
    David G Breckenridge
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 99:4331-6. 2002
    ..Preferential recruitment of procaspase-8L by the BAP31 complex at the endoplasmic reticulum suggests an additional pathway for regulating initiator caspase-8 during apoptosis...
  23. pmc Programming cancer cells for high expression levels of Mcl1
    Franziska Ertel
    Department of Biochemistry, and Goodman Cancer Research Center, McGill University, Montreal, Quebec H3G 2J7, Canada
    EMBO Rep 14:328-36. 2013
    ..Here, we focus on the complex strategies at play and their therapeutic implications...
  24. ncbi request reprint Unique biology of Mcl-1: therapeutic opportunities in cancer
    Matthew R Warr
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6, Canada
    Curr Mol Med 8:138-47. 2008
    ..Here we review the various pathways that regulate Mcl-1 expression and describe agents that are currently under development to modulate Mcl-1 activity for therapeutic benefit in oncology...
  25. ncbi request reprint BH3-ligand regulates access of MCL-1 to its E3 ligase
    Matthew R Warr
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Que, Canada
    FEBS Lett 579:5603-8. 2005
    ..This suggests that the unliganded form of Mcl-1 is sensitive to LASU1-mediated degradation of Mcl-1...
  26. ncbi request reprint BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerization
    Salvatore C Ruffolo
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 278:25039-45. 2003
    ..This model suggests that the primary mechanism for BCL-2 blockade targets activated BAK rather than sequestering tBID...
  27. doi request reprint Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscle
    Natasha C Chang
    Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada
    Hum Mol Genet 21:2277-87. 2012
    ..Our findings uncover a novel pathway that is required for normal muscle maintenance, which may ultimately provide a novel therapeutic target for treating certain muscle pathologies...
  28. ncbi request reprint Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix
    Alexei Yu Denisov
    Department of Biochemistry and Montreal Joint Center for Structural Biology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 278:21124-8. 2003
    ....
  29. ncbi request reprint Cellular distribution of Bcl-2 family proteins
    Marc Germain
    Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Sci STKE 2003:pe10. 2003
    ..This interaction may control the cell's sensitivity to apoptotic stimuli...
  30. ncbi request reprint BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria
    Marc Germain
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 277:18053-60. 2002
    ..Collectively, the results identify BIK as an initiator of cytochrome c release from mitochondria operating from a location at the ER...