David A Seminowicz
Affiliation: McGill University
- Interactions of pain intensity and cognitive load: the brain stays on taskDavid A Seminowicz
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Cereb Cortex 17:1412-22. 2007..These findings support the notion that brain networks supporting pain perception and cognition can be simultaneously active...
- A re-examination of pain-cognition interactions: implications for neuroimagingDavid A Seminowicz
Institute of Medical Science, University of Toronto, Toronto, Canada
Pain 130:8-13. 2007
- MRI structural brain changes associated with sensory and emotional function in a rat model of long-term neuropathic painDavid A Seminowicz
Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada H3A 2B2
Neuroimage 47:1007-14. 2009..Overall, our results suggest that long-term neuropathic pain has widespread effects on brain anatomy related to the duration and magnitude of the pain...
- Two systems of resting state connectivity between the insula and cingulate cortexKeri S Taylor
Division of Brain, Imaging and Behavior Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, Canada
Hum Brain Mapp 30:2731-45. 2009....
- Metabolic brain activity suggestive of persistent pain in a rat model of neuropathic painScott J Thompson
Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3G 0G1, Canada Integrated Program in Neuroscience, McGill University, Montreal, QC H3A 2T5, Canada Electronic address
Neuroimage 91:344-52. 2014..The lack of increased activity in S1 hindlimb with general anesthetic demonstrates that this effect can be blocked, as well as highlights the importance of investigating brain activity in awake and behaving rodents. ..
- Nerve injury causes long-term attentional deficits in ratsLucie A Low
Alan Edwards Centre for Research on Pain, McGill University, Canada
Neurosci Lett 529:103-7. 2012....
- Pain enhances functional connectivity of a brain network evoked by performance of a cognitive taskDavid A Seminowicz
University of Toronto, Ontario M5T 2S8, Canada
J Neurophysiol 97:3651-9. 2007..These data provide evidence that pain can modulate a network presumed to be involved in focused attention, suggesting a mechanism for the interference of pain on cognitive ability by the consumption of attentional resources...
- Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and functionDavid A Seminowicz
Alan Edwards Centre for Research on Pain, McGill Scoliosis and Spine Research Group, McGill University, Montreal, Quebec H3A 1A4, Canada
J Neurosci 31:7540-50. 2011..These data indicate that functional and structural brain abnormalities-specifically in the left DLPFC-are reversible, suggesting that treating chronic pain can restore normal brain function in humans...
- Regional gray matter density changes in brains of patients with irritable bowel syndromeDavid A Seminowicz
Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
Gastroenterology 139:48-57.e2. 2010..Several studies have examined structural brain changes associated with chronic pain syndromes, including irritable bowel syndrome (IBS), but study sample sizes have been small and heterogeneous...
- The anatomy of the mesolimbic reward system: a link between personality and the placebo analgesic responsePetra Schweinhardt
Alan Edwards Centre for Research on Pain, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada H3A2B2
J Neurosci 29:4882-7. 2009..Our findings highlight the relationship between placebo and reward and potentially offer ways of identifying subjects who are likely to show large placebo analgesic responses...
- Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain?Anil Kuchinad
McGill Centre for Research on Pain, McGill University, Montreal, Quebec, Canada H3A 2B2
J Neurosci 27:4004-7. 2007..Moreover, the regions in which we demonstrate objective changes may be functionally linked to core features of the disorder including affective disturbances and chronic widespread pain...
- Anatomical and functional enhancements of the insula after loss of large primary somatosensory fibersMarta Ceko
Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada H3A 2T5
Cereb Cortex 23:2017-24. 2013..We, thus, demonstrated plasticity in networks involving the insular cortex following denervation of large-diameter somatosensory afferents. ..
- Believe in your placeboDavid A Seminowicz
Institute of Medical Science, University of Toronto, Ontario, M5T 2S8, Canada
J Neurosci 26:4453-4. 2006
- Cortical responses to pain in healthy individuals depends on pain catastrophizingDavid A Seminowicz
Toronto Western Research Institute, University Health Network, Institute of Medical Science and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
Pain 120:297-306. 2006..These findings may also implicate catastrophizing in the progression to or persistence of chronic pain...