Affiliation: McGill University
- Investigation into the neural correlates of emotional augmentation of clinical painPetra Schweinhardt
Centre for Functional Magnetic Resonance Imaging, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Neuroimage 40:759-66. 2008....
- The anatomy of the mesolimbic reward system: a link between personality and the placebo analgesic responsePetra Schweinhardt
Alan Edwards Centre for Research on Pain, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada H3A2B2
J Neurosci 29:4882-7. 2009..Our findings highlight the relationship between placebo and reward and potentially offer ways of identifying subjects who are likely to show large placebo analgesic responses...
- Effects of intravenous propranolol on heat pain sensitivity in healthy menP Schweinhardt
Alan Edwards Centre for Research on Pain, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
Eur J Pain 17:704-13. 2013..However, the direct analgesic effects of β-blockers have rarely been examined in healthy humans...
- Increased gray matter density in young women with chronic vulvar painP Schweinhardt
McGill Centre for Research on Pain, Faculty of Dentistry, McGill University, Room M 19, Strathcona Anatomy and Dentistry Building, 3640 University Street, Montreal, Que, Canada
Pain 140:411-9. 2008....
- The role of excess subcutaneous fat in pain and sensory sensitivity in obesityR C Price
McGill University, Montreal, Canada
Eur J Pain 17:1316-26. 2013..Previous studies suggest pain sensitivity may be decreased in obesity, but it is unknown whether this is a global or a site-specific phenomenon related to the amount of excess fat...
- Supraspinal pain processing: distinct roles of emotion and attentionChantal Villemure
Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
Neuroscientist 16:276-84. 2010..In this review, we will examine those recent findings within the broader cognitive neuroscience conceptualization of human attention and emotion and the corresponding functional neuroanatomy...
- Pain increases motivational drive to obtain reward, but does not affect associated hedonic responses: a behavioural study in healthy volunteersW Gandhi
Alan Edwards Centre for Research on Pain AECRP, McGill University, Montreal, Canada
Eur J Pain 17:1093-103. 2013..Since no data exist in humans, we conducted a psychophysical experiment to test the effects of experimentally induced tonic pain on (1) the motivation to receive reward and (2) hedonic responses when being rewarded...
- Pain imaging in health and disease--how far have we come?Petra Schweinhardt
Department of Anesthesia, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
J Clin Invest 120:3788-97. 2010..Data from these brain imaging studies reinforce the idea that chronic pain leads to brain changes that could have functional significance...
- Perceptions of the painful body: the relationship between body perception disturbance, pain and tactile discrimination in complex regional pain syndromeJ S Lewis
Faculty of Dentistry, McGill University, Montreal, Canada
Eur J Pain 16:1320-30. 2012..The aim of this study was to test the hypotheses that (1) body perception disturbance is positively related to pain and (2) decreased tactile acuity is related to increased body perception disturbance...
- Fibromyalgia patients show an abnormal dopamine response to painPatrick B Wood
McGill University Centre for Research on Pain, Faculty of Dentistry, 3640 University Street, Strathcona Building, Montreal, QC, Canada, H3A 2B2
Eur J Neurosci 25:3576-82. 2007....
- Pharmacological FMRI in the development of new analgesic compoundsPetra Schweinhardt
Pain Imaging Neuroscience Group, Department Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
NMR Biomed 19:702-11. 2006..We are therefore optimistic that phFMRI will be used as a tool with high sensitivity and specificity for evaluating analgesic agents in early drug development and clinical studies...
- The anxiolytic effects of midazolam during anticipation to pain revealed using fMRIRichard G Wise
Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK
Magn Reson Imaging 25:801-10. 2007..We present a pharmacological functional magnetic resonance imaging (fMRI) study in which we investigate the selective modulation by midazolam of brain activity associated with anticipation to pain compared to pain itself...
- Imaging pain in patients: is it meaningful?Petra Schweinhardt
Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, Oxford, UK
Curr Opin Neurol 19:392-400. 2006..The timing is ideal to assess the utility of data generated from these studies...
- An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patientsPetra Schweinhardt
Department of Human Anatomy and Genetics, Oxford University, South Parks Road, Oxford OX1 1QX, UK
Neuroimage 32:256-65. 2006..Taken together, our data and the literature review suggest a functional segregation of anterior insular cortex...
- Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcomeChristoph P Hofstetter
Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
Nat Neurosci 8:346-53. 2005..These findings show that stem cell transplantation into injured spinal cord can cause severe side effects and call for caution in the consideration of clinical trials...