Research Topics
Genomes and GenesSpecies | Erwin SchurrSummaryAffiliation: McGill University Country: Canada Publications
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Publications
Mouse models for the genetic study of tuberculosis susceptibilityTania Di Pietrantonio
McGill University Health Centre Research Institute, 1650 Cedar Ave, L11-520, Montreal, PQ, H3G 1A4, Canada
Brief Funct Genomic Proteomic 4:277-92. 2005..This review will discuss how a clearer idea of this interplay is emerging with new genomic strategies in mouse models...- Genetic predisposition to leprosy: A major gene reveals novel pathways of immunity to Mycobacterium lepraeErwin Schurr
McGill Centre for the Study of Host Resistance, Department of Human Genetics and Medicine, McGill University, Montreal, PQ, Canada
Semin Immunol 18:404-10. 2006.... - Is susceptibility to tuberculosis acquired or inherited?E Schurr
McGill Centre for the Study of Host Resistance, McGill University, Montreal, QC, Canada
J Intern Med 261:106-11. 2007.... - Mycobacterial infections: PARK2 and PACRG associations in leprosyE Schurr
Montreal General Hospital Research Institute, McGill Center for the Study of Host Resistance, Montreal, PQ, Canada
Tissue Antigens 69:231-3. 2007..An overview of investigations indicating an important role of host genetics, both major histocompatibility complex (MHC) and non-MHC, in leprosy... - The contribution of host genetics to tuberculosis pathogenesisErwin Schurr
Department of Human Genetics, McGill University, Montreal, PQ, Canada
Kekkaku 86:17-28. 2011.... 
Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibilityAndrea Alter
Department of Medicine, McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada
Hum Genet 127:337-48. 2010..In addition, 293-MR failed to bind and internalize viable Mycobacterium leprae and BCG. We propose that the MR-M. leprae interaction is modulated by an accessory host molecule of unknown identity...
Linkage disequilibrium pattern and age-at-diagnosis are critical for replicating genetic associations across ethnic groups in leprosyAndrea Alter
McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Hum Genet 132:107-16. 2013..The same trend was observed in the Indian sample, but due to the higher age-at-diagnosis of the patients the age effect was less pronounced...- Susceptibility to leprosy is associated with PARK2 and PACRGMarcelo T Mira
McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, PQ H3G1A4, Canada
Nature 427:636-40. 2004..Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy... - Strain-specific differences in the genetic control of two closely related mycobacteriaTania Di Pietrantonio
McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
PLoS Pathog 6:e1001169. 2010..This high degree of adaptation of host genetics to strain-specific pathogenesis is expected to provide a suitable framework for the selection of specific host-mycobacteria combinations during co-evolution of mycobacteria with humans... - Joint effects of host genetic background and mycobacterial pathogen on susceptibility to infectionTania Di Pietrantonio
McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
Infect Immun 79:2372-8. 2011..Overall, the results demonstrated the importance of considering the joint effects of the mycobacterial and host genetic backgrounds on susceptibility to mycobacterial infections... - Human leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and IndiaAndrea Alter
Research Institute of the McGill University Health Centre, McGill Centre for the Study of Host Resistance, Departments of Medicine and Human Genetics, McGill University, Montreal, Quebec, Canada
J Infect Dis 203:1274-81. 2011..The identical associations were validated in a third sample of 364 patients with leprosy and 371 control subjects from North India. These results implicated class I alleles in leprosy pathogenesis... - Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis diseaseSuneil Malik
McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada H3G 1A4
Proc Natl Acad Sci U S A 102:12183-8. 2005..To explain the different direction of allelic association between adult and pediatric disease, we hypothesize that NRAMP1 influences the speed of progression from infection to tuberculosis disease... - Leprosy as a genetic model for susceptibility to common infectious diseasesAndrea Alter
McGill Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, 1650 Cedar Avenue, Montreal, H3G 1A4, QC, Canada
Hum Genet 123:227-35. 2008..As such, these studies serve to improve our understanding of leprosy pathogenesis by implicating novel biological pathways while simultaneously providing a genetic model for common infectious diseases... - Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasitesD Malo
Department of Medicine, McGill University, Montreal, Quebec, Canada
Genomics 23:51-61. 1994.... - Tuberculin skin test reactivity is dependent on host genetic background in Colombian tuberculosis household contactsAurelie Cobat
McGill Centre for the Study of Host Resistance, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada
Clin Infect Dis 54:968-71. 2012..We report evidence for a codominant gene explaining ∼65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection... - Leprosy as a genetic diseaseAndrea Alter
Research Institute of the McGill University Health Centre, McGill Centre for the Study of Host Resistance, Department of Medicine, McGill University, Montreal, QC, Canada
Mamm Genome 22:19-31. 2011..The value of leprosy as a model disease therefore extends far beyond this ancient disease to common afflictions of the 21st century... - Linkage of tuberculosis to chromosome 2q35 loci, including NRAMP1, in a large aboriginal Canadian familyC M Greenwood
Department of Human Genetics, McGill University, Montreal, Quebec, Canada
Am J Hum Genet 67:405-16. 2000..The ability to assign individuals to risk classes was crucial to the success of this study... - PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophagesLouis de Léséleuc
McGill Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
PLoS Negl Trop Dis 7:e2015. 2013..leprae sonicate triggered CCL2 and IL6 transcript levels in whole blood assays. These results associated genetically controlled changes in the production of MCP-1/CCL2 and IL-6 with known leprosy susceptibility factors... - Mycobacteria in Crohn's disease: a persistent hypothesisMarcel A Behr
Department of Medicine, McGill University Faculty of Medicine, Montreal, Quebec, Canada
Inflamm Bowel Dis 12:1000-4. 2006..In this review, we discuss the current understanding of mycobacterial and Crohn's genetic susceptibility and review the evidence that NOD2/CARD15 may mediate host resistance to mycobacterial infection... - Association of vitamin D receptor genetic variants with susceptibility to asthma and atopyAudrey H Poon
McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
Am J Respir Crit Care Med 170:967-73. 2004..These results identify VDR variants as genetic risk factors for asthma/atopy and implicate a non-human leukocyte antigen immunoregulatory molecule in the pathogenesis of asthma and atopy... - TB: screening for responses to a vile visitorMarcel Behr
Research Institute, McGill University Health Center, Montreal, Quebec H3G 0B1, Canada
Cell 140:615-8. 2010..2010; Tobin et al., 2010), reveal that virulent mycobacteria evade the host immune system by stimulating production of anti-inflammatory molecules and inhibiting autophagy... - Genetics of infectious diseases: hidden etiologies and common pathwaysMarianna Orlova
McGill Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montreal, PQ, Canada
Clin Chem Lab Med 49:1427-37. 2011..Analysis of the multi-disease susceptibility genes has allowed the definition of shared key pathways of inflammatory dysregulation and suggested unexpected infectious etiologies for other "non-infectious" common diseases... - Impact of methoxymycolic acid production by Mycobacterium bovis BCG vaccinesAdam Belley
Centre for the Study of Host Resistance, McGill University, Montreal H3G 1A4, Canada
Infect Immun 72:2803-9. 2004..Our results demonstrate that the loss of methoxymycolic acid production did not apparently affect the virulence of BCG strains... - Reduced in vitro functional activity of human NRAMP1 (SLC11A1) allele that predisposes to increased risk of pediatric tuberculosis diseaseC J Gallant
McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
Genes Immun 8:691-8. 2007.... - Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infectionsE Skamene
Division of Clinical Immunology and Allergy, Montreal General Hospital, Quebec, Canada
Annu Rev Med 49:275-87. 1998..Through comparative genomics, we have identified the homologous human NRAMP1 gene, alleles of which are now being used for tests of linkage with TB and leprosy... - Genetics of leprosy reactions: an overviewVinicius Fava
McGill Centre for the Study of Host Resistance, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada
Mem Inst Oswaldo Cruz 107:132-42. 2012..The identification of host genetic markers with predictive value for LR would have a major impact on nerve damage control in leprosy. In this review, we present the recent advances achieved through genetic studies of LR... - Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese populationMarcelo T Mira
McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, H3G 1A4 PQ, Canada
Nat Genet 33:412-5. 2003..Of seven microsatellite markers underlying the linkage peak, alleles of two markers (D6S1035 and D6S305) showed strong evidence for association with leprosy (P = 6.7 x 10(-4) and P = 5.9 x 10(-5), respectively)... - Tuberculin skin test and in vitro assays provide complementary measures of antimycobacterial immunity in children and adolescentsCaroline J Gallant
Montreal General Hospital Research Institute, 1650 Cedar Ave, Room L11 521, Montreal, QC, H3G 1A4, Canada
Chest 137:1071-7. 2010..We, therefore, decided to determine the degree of redundancy between quantitative read-outs of in vivo and in vitro assays of antimycobacterial immunity... - Genetic susceptibility to tuberculosisSuneil Malik
McGill Centre for the Study of Host Resistance, McGill University, Montreal, Canada
Clin Chem Lab Med 40:863-8. 2002..tuberculosis, and the limited efficacy of Mycobacterium bovis (BCG) vaccination... - Absence of association between mannose-binding lectin gene polymorphisms and HIV-1 infection in a Colombian populationSuneil Malik
McGill Centre for the Study of Host Resistance, Montreal General Hospital Research Institute, Montreal, Canada
Immunogenetics 55:49-52. 2003..0). Since there is a well-documented link between the tested MBL alleles and very low MBL serum concentration, these results do not support the hypothesis that MBL levels are a risk factor for HIV-1 infection in Colombia... - Complex genetic control of susceptibility to Mycobacterium bovis (Bacille Calmette-Guérin) infection in wild-derived Mus spretus miceK Turcotte
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Genes Immun 7:684-7. 2006..The mapped loci may act as modifiers of Nramp1 action, and constitute novel entry points for the parallel search of loci regulating susceptibility to mycobacterial infections in humans... - Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expressionM Cellier
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
J Exp Med 180:1741-52. 1994..Additional RNA expression studies in cultured cells identified the macrophage as a site of expression of human NRAMP and indicated that increased expression was correlated with an advanced state of differentiation of this lineage... - Expression of the human NRAMP1 gene in professional primary phagocytes: studies in blood cells and in HL-60 promyelocytic leukemiaM Cellier
Department of Biochemistry, McGill University, Montreal, Canada
J Leukoc Biol 61:96-105. 1997..The possibility that NRAMP1 may be a component of the phagosomal/endosomal apparatus common to PMN and MN is discussed... - Segregation of HLA/TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypesM T Mira
Departments of Human Genetics, Medicine and Biochemistry, McGill University, Montreal, PQ, Canada
Genes Immun 4:67-73. 2003.... - Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35S Marquet
McGill Centre for the Study of Host Resistance, McGill University Health Centre, Montreal, Quebec, Canada
Mamm Genome 11:755-62. 2000..Our data provide new sequence information about the NRAMP1 gene region that will be useful in the search for genetic variants causally involved in altered susceptibility to infectious diseases... - Host-pathogen specificity in tuberculosisTania Di Pietrantonio
McGill University Health Centre McGill Centre for the Study of Host Resistance, Departments of Medicine and Human Genetics, 1650 Cedar Avenue, Room L11 520, Montreal, H3G 1A4, QC, Canada
Adv Exp Med Biol 783:33-44. 2013..These studies indicate that differences in the host response to infection are at least in part due to specific combinations of host genetic factors and genetic and phenotypic characteristics of the infecting mycobacterial strain... - Crohn's disease, mycobacteria, and NOD2Marcel A Behr
McGill University Health Centre, Montreal, Canada
Lancet Infect Dis 4:136-7. 2004 - Variants of the SFTPA1 and SFTPA2 genes and susceptibility to tuberculosis in EthiopiaS Malik
McGill Centre for the Study of Host Resistance, Departments of Medicine and Human Genetics, McGill University, Montreal, Quebec, Canada
Hum Genet 118:752-9. 2006..026). These findings suggest that SFTPA1 and SFTPA2 modify the risk of tuberculosis susceptibility and that this risk is influenced by additional covariates... - Impact of age and sex on mycobacterial immunity in an area of high tuberculosis incidenceC J Gallant
Department of Human Genetics and Medicine, McGill University, McGill Centre for the Study of Host Resistance, Montreal, Canada
Int J Tuberc Lung Dis 14:952-9. 2010..The extent of immune reactivity measured by the tuberculin skin test (TST) and interferon-gamma (IFN-gamma) T-cell assays is usually not analysed... - Mapping of the gene coding for the muscle protein nebulin (Neb) to the proximal region of mouse chromosome 2E Schurr
Department of Medicine, McGill University, Montreal, Quebec, Canada
Cytogenet Cell Genet 57:214-6. 1991..The gene order, intergene distances, and confidence intervals were determined according to standard maximum likelihood estimates as: centromere-Hc-5.4 cM (1.4 cM-15.4 cM; 95% confidence interval)-Neb-3.6 cM (1.5-6.7 cM)-Pmv-7... - NRAMP1 is not associated with asthma, atopy, and serum immunoglobulin E levels in the French Canadian populationA H Poon
McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Genes Immun 6:519-27. 2005..These results demonstrate that, in spite of direct involvement of Nramp1 in a murine asthma model, in human populations NRAMP1 is not likely to be a major contributor to the genetic etiology of asthma and asthma-related phenotypes... - Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37H H van Es
Department of Medicine, McGill University, Montreal, Quebec, Canada
Cytogenet Cell Genet 63:114-6. 1993..In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37... - Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2D Malo
Department of Biochemistry, McGill University, Montreal, Canada
Genomics 10:666-72. 1991..These results indicate that the three isoforms of the brain sodium channel alpha-subunit are encoded by three distinct genes that share a common ancestral origin... - Assignment of Na,K-ATPase beta 2-subunit gene (Atpb-2) to mouse chromosome 11D Malo
Department of Biochemistry, McGill University, Montreal, Canada
Genomics 6:697-9. 1990 - Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1 identifies conserved linkage of structural protein genes between murine chromosome 1 and human chromosome 2qE Schurr
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Genomics 8:477-86. 1990..The order of mouse genes on chromosome 1 and their human homologs on chromosome 2q also appears to be conserved, suggesting that mapping of murine genes on the conserved segment may be useful to predict gene order in man... - Linkage analysis of the Bcg gene on mouse chromosome 1. Identification of a tightly linked markerE Schurr
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
J Immunol 142:4507-13. 1989..Our results suggest that a likely location for a putative human homologue to the murine host resistance gene Bcg is the long arm of human chromosome 2 (2q32-qter)... - The host resistance locus Bcg is tightly linked to a group of cytoskeleton-associated protein genes that include villin and desminD Malo
Department of Biochemistry, McGill University, Montreal, Canada
Genomics 10:356-64. 1991..Our findings indicate that the two closest markers to the host resistance locus, Bcg, encode cytoskeleton-associated proteins which are capable of interaction with actin filaments... - Localization of two alkaline phosphatase genes to the proximal region of mouse chromosome 1E Schurr
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Cytogenet Cell Genet 52:65-7. 1989..The gene order and intergene distances were determined by standard backcross analysis as: centromere- Len-2 - 19.0 cM - Akp-3 - 20.0 cM - Akp-4 - 2.0 cM - Ren-1... - Multigenic control of disease severity after virulent Mycobacterium tuberculosis infection in miceFabio Sanchez
Center for Molecular Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden
Infect Immun 71:126-31. 2003..Overall, linkage data reported here for F2 mice are in agreement with, and add to, our previous findings concerning the control of M. tuberculosis-triggered disease in the BC1 segregation... - A recessive major gene controls the mitsuda reaction in a region endemic for leprosyBrigitte Ranque
Laboratoire de Genetique Humaine des Maladies Infectieuses, Universite de Paris Rene Descartes INSERM U 550, Faculte de Medecine Necker, Paris, France, European Union
J Infect Dis 192:1475-82. 2005..leprae. Like leprosy, the Mitsuda reaction is thought to be genetically controlled, but its mode of inheritance is unknown, although the role of the NRAMP1 gene has previously been reported... - Genomewide linkage analysis of the granulomatous mitsuda reaction implicates chromosomal regions 2q35 and 17q21Brigitte Ranque
Laboratory of Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale, Paris, France
J Infect Dis 196:1248-52. 2007..Interestingly, these 2 regions have been previously linked to mycobacterial infection and other granulomatous diseases... - Genetic dissection of immunity in leprosyAlexandre Alcais
Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes, Institut National de la Santé et de la Recherche Medicale U 550, Faculte de Medecine Necker, Paris, France, European Union
Curr Opin Immunol 17:44-8. 2005..leprae. With respect to genome-wide screens, a major breakthrough has been reported this year; variants in the regulatory region shared by PARK2 and PACRG have been identified as being common risk factors for leprosy... - [Leprosy: a paradigm for the study of human genetic susceptibility to infectious diseases]Brigitte Ranque
Laboratoire de Genetique Humaine des Maladies Infectieuses, INSERM U550, Paris, France
Med Sci (Paris) 24:491-7. 2008.... - Quantifying genomic imprinting in the presence of linkageQuentin Vincent
Laboratory of Human Genetics of Infectious Diseases, , Necker Medical School, Paris, 75015, France
Biometrics 62:1071-80. 2006..Our approach provides a novel tool for dissecting genomic imprinting in model-free linkage analysis, and will be of considerable value for identifying and evaluating the contribution of imprinted genes to complex diseases... - Age is an important risk factor for onset and sequelae of reversal reactions in Vietnamese patients with leprosyBrigitte Ranque
Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes, Institut National de la Sante et de la Recherche Medicale, U550, Faculte de Medecine Necker, Paris, 75015, France
Clin Infect Dis 44:33-40. 2007..T1Rs occur mainly in patients with borderline or multibacillary leprosy, but little is known about additional risk factors... - Association of IL12RB1 polymorphisms with pulmonary tuberculosis in adults in MoroccoNatascha Remus
Laboratory of Human Genetics of Infectious Diseases, University of Paris Rene Descartes, INSERM U550, Paris, France
J Infect Dis 190:580-7. 2004..CC, 2.69 [95% confidence interval, 1.19-6.09]). This result suggests that IL12RB1 polymorphisms might influence the risk of development of PTB in adults... - Constitutive differences in gene expression profiles parallel genetic patterns of susceptibility to tuberculosis in miceMarianna O Orlova
Laboratory for Immunogenetics, Central Institute for Tuberculosis, Yauza alley 2, Moscow 107564, Russia
Infect Immun 74:3668-72. 2006..We conclude that intrinsic gene expression profiles are an important determinant of tuberculosis pathogenesis in mice... - An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adultsJamila El Baghdadi
Laboratory of Immunology, Military Hospital Mohamed V, Hay Riad Rabat, Morocco
J Exp Med 203:1679-84. 2006..These results provide direct molecular evidence that human pulmonary tuberculosis has a strong genetic basis, and indicate that the genetic component involves at least one major locus with a dominant susceptibility allele... - Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosyAlexandre Alcais
Laboratoire de Genetique Humaine des Maladies Infectieuses, Institut National de la Sante et de la Recherche Medicale, U550, 75015 Paris, France
Nat Genet 39:517-22. 2007..In addition to identifying LTA as a major gene associated with early-onset leprosy, our study highlights the critical role of case- and population-specific factors in the dissection of susceptibility variants in complex diseases...
Research Grants
- GENETIC DISSECTION OF MYCOBACTERIAL INFECTIONErwin Schurr; Fiscal Year: 2005..tuberculosis through an exposed population. ..