Erwin Schurr

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Mouse models for the genetic study of tuberculosis susceptibility
    Tania Di Pietrantonio
    McGill University Health Centre Research Institute, 1650 Cedar Ave, L11 520, Montreal, PQ, H3G 1A4, Canada
    Brief Funct Genomic Proteomic 4:277-92. 2005
  2. ncbi request reprint The contribution of host genetics to tuberculosis pathogenesis
    Erwin Schurr
    Department of Human Genetics, McGill University, Montreal, PQ, Canada
    Kekkaku 86:17-28. 2011
  3. pmc Gene set signature of reversal reaction type I in leprosy patients
    Marianna Orlova
    McGill International TB Centre, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS Genet 9:e1003624. 2013
  4. pmc PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages
    Louis de Léséleuc
    McGill Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS Negl Trop Dis 7:e2015. 2013
  5. ncbi request reprint Genetic predisposition to leprosy: A major gene reveals novel pathways of immunity to Mycobacterium leprae
    Erwin Schurr
    McGill Centre for the Study of Host Resistance, Department of Human Genetics and Medicine, McGill University, Montreal, PQ, Canada
    Semin Immunol 18:404-10. 2006
  6. ncbi request reprint Mycobacterial infections: PARK2 and PACRG associations in leprosy
    E Schurr
    Montreal General Hospital Research Institute, McGill Center for the Study of Host Resistance, Montreal, PQ, Canada
    Tissue Antigens 69:231-3. 2007
  7. ncbi request reprint Is susceptibility to tuberculosis acquired or inherited?
    E Schurr
    McGill Centre for the Study of Host Resistance, McGill University, Montreal, QC, Canada
    J Intern Med 261:106-11. 2007
  8. pmc Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility
    Andrea Alter
    Department of Medicine, McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada
    Hum Genet 127:337-48. 2010
  9. ncbi request reprint Susceptibility to leprosy is associated with PARK2 and PACRG
    Marcelo T Mira
    McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, PQ H3G1A4, Canada
    Nature 427:636-40. 2004
  10. doi request reprint Linkage disequilibrium pattern and age-at-diagnosis are critical for replicating genetic associations across ethnic groups in leprosy
    Andrea Alter
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
    Hum Genet 132:107-16. 2013

Research Grants

  1. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2005
  2. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2001
  3. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2002
  4. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2003
  5. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2004

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Mouse models for the genetic study of tuberculosis susceptibility
    Tania Di Pietrantonio
    McGill University Health Centre Research Institute, 1650 Cedar Ave, L11 520, Montreal, PQ, H3G 1A4, Canada
    Brief Funct Genomic Proteomic 4:277-92. 2005
    ..This review will discuss how a clearer idea of this interplay is emerging with new genomic strategies in mouse models...
  2. ncbi request reprint The contribution of host genetics to tuberculosis pathogenesis
    Erwin Schurr
    Department of Human Genetics, McGill University, Montreal, PQ, Canada
    Kekkaku 86:17-28. 2011
    ....
  3. pmc Gene set signature of reversal reaction type I in leprosy patients
    Marianna Orlova
    McGill International TB Centre, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS Genet 9:e1003624. 2013
    ..leprae antigens. The identified T1R gene set represents a critical first step towards a genetic profile of leprosy patients who are at increased risk of T1R and concomitant nerve damage. ..
  4. pmc PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages
    Louis de Léséleuc
    McGill Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS Negl Trop Dis 7:e2015. 2013
    ..leprae sonicate triggered CCL2 and IL6 transcript levels in whole blood assays. These results associated genetically controlled changes in the production of MCP-1/CCL2 and IL-6 with known leprosy susceptibility factors...
  5. ncbi request reprint Genetic predisposition to leprosy: A major gene reveals novel pathways of immunity to Mycobacterium leprae
    Erwin Schurr
    McGill Centre for the Study of Host Resistance, Department of Human Genetics and Medicine, McGill University, Montreal, PQ, Canada
    Semin Immunol 18:404-10. 2006
    ....
  6. ncbi request reprint Mycobacterial infections: PARK2 and PACRG associations in leprosy
    E Schurr
    Montreal General Hospital Research Institute, McGill Center for the Study of Host Resistance, Montreal, PQ, Canada
    Tissue Antigens 69:231-3. 2007
    ..An overview of investigations indicating an important role of host genetics, both major histocompatibility complex (MHC) and non-MHC, in leprosy...
  7. ncbi request reprint Is susceptibility to tuberculosis acquired or inherited?
    E Schurr
    McGill Centre for the Study of Host Resistance, McGill University, Montreal, QC, Canada
    J Intern Med 261:106-11. 2007
    ....
  8. pmc Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility
    Andrea Alter
    Department of Medicine, McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada
    Hum Genet 127:337-48. 2010
    ..In addition, 293-MR failed to bind and internalize viable Mycobacterium leprae and BCG. We propose that the MR-M. leprae interaction is modulated by an accessory host molecule of unknown identity...
  9. ncbi request reprint Susceptibility to leprosy is associated with PARK2 and PACRG
    Marcelo T Mira
    McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, PQ H3G1A4, Canada
    Nature 427:636-40. 2004
    ..Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy...
  10. doi request reprint Linkage disequilibrium pattern and age-at-diagnosis are critical for replicating genetic associations across ethnic groups in leprosy
    Andrea Alter
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
    Hum Genet 132:107-16. 2013
    ..The same trend was observed in the Indian sample, but due to the higher age-at-diagnosis of the patients the age effect was less pronounced...
  11. pmc Identification of a major locus, TNF1, that controls BCG-triggered tumor necrosis factor production by leukocytes in an area hyperendemic for tuberculosis
    Aurelie Cobat
    McGill International TB Centre and Departments of Human Genetics and Medicine, McGill University, Montreal, Quebec, Canada
    Clin Infect Dis 57:963-70. 2013
    ..Tumor necrosis factor (TNF) is a key immune regulator of tuberculosis resistance, as exemplified by the highly increased risk of tuberculosis disease among individuals receiving TNF-blocker therapy...
  12. pmc Strain-specific differences in the genetic control of two closely related mycobacteria
    Tania Di Pietrantonio
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS Pathog 6:e1001169. 2010
    ..This high degree of adaptation of host genetics to strain-specific pathogenesis is expected to provide a suitable framework for the selection of specific host-mycobacteria combinations during co-evolution of mycobacteria with humans...
  13. pmc Joint effects of host genetic background and mycobacterial pathogen on susceptibility to infection
    Tania Di Pietrantonio
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Infect Immun 79:2372-8. 2011
    ..Overall, the results demonstrated the importance of considering the joint effects of the mycobacterial and host genetic backgrounds on susceptibility to mycobacterial infections...
  14. pmc Human leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and India
    Andrea Alter
    Research Institute of the McGill University Health Centre, McGill Centre for the Study of Host Resistance, Departments of Medicine and Human Genetics, McGill University, Montreal, Quebec, Canada
    J Infect Dis 203:1274-81. 2011
    ..The identical associations were validated in a third sample of 364 patients with leprosy and 371 control subjects from North India. These results implicated class I alleles in leprosy pathogenesis...
  15. pmc Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease
    Suneil Malik
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada H3G 1A4
    Proc Natl Acad Sci U S A 102:12183-8. 2005
    ..To explain the different direction of allelic association between adult and pediatric disease, we hypothesize that NRAMP1 influences the speed of progression from infection to tuberculosis disease...
  16. ncbi request reprint Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population
    Marcelo T Mira
    McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, H3G 1A4 PQ, Canada
    Nat Genet 33:412-5. 2003
    ..Of seven microsatellite markers underlying the linkage peak, alleles of two markers (D6S1035 and D6S305) showed strong evidence for association with leprosy (P = 6.7 x 10(-4) and P = 5.9 x 10(-5), respectively)...
  17. doi request reprint Host-pathogen specificity in tuberculosis
    Tania Di Pietrantonio
    Department of Medicine and Human Genetics, McGill University Health Centre McGill Centre for the Study of Host Resistance, Montreal, Canada
    Adv Exp Med Biol 783:33-44. 2013
    ..These studies indicate that differences in the host response to infection are at least in part due to specific combinations of host genetic factors and genetic and phenotypic characteristics of the infecting mycobacterial strain...
  18. pmc Impact of methoxymycolic acid production by Mycobacterium bovis BCG vaccines
    Adam Belley
    Centre for the Study of Host Resistance, McGill University, Montreal H3G 1A4, Canada
    Infect Immun 72:2803-9. 2004
    ..Our results demonstrate that the loss of methoxymycolic acid production did not apparently affect the virulence of BCG strains...
  19. doi request reprint Leprosy as a genetic model for susceptibility to common infectious diseases
    Andrea Alter
    McGill Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, 1650 Cedar Avenue, Montreal, H3G 1A4, QC, Canada
    Hum Genet 123:227-35. 2008
    ..As such, these studies serve to improve our understanding of leprosy pathogenesis by implicating novel biological pathways while simultaneously providing a genetic model for common infectious diseases...
  20. ncbi request reprint Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites
    D Malo
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Genomics 23:51-61. 1994
    ....
  21. pmc Tuberculin skin test reactivity is dependent on host genetic background in Colombian tuberculosis household contacts
    Aurelie Cobat
    McGill Centre for the Study of Host Resistance, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada
    Clin Infect Dis 54:968-71. 2012
    ..We report evidence for a codominant gene explaining ∼65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection...
  22. doi request reprint Leprosy as a genetic disease
    Andrea Alter
    Research Institute of the McGill University Health Centre, McGill Centre for the Study of Host Resistance, Department of Medicine, McGill University, Montreal, QC, Canada
    Mamm Genome 22:19-31. 2011
    ..The value of leprosy as a model disease therefore extends far beyond this ancient disease to common afflictions of the 21st century...
  23. pmc Linkage of tuberculosis to chromosome 2q35 loci, including NRAMP1, in a large aboriginal Canadian family
    C M Greenwood
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Am J Hum Genet 67:405-16. 2000
    ..The ability to assign individuals to risk classes was crucial to the success of this study...
  24. ncbi request reprint Mycobacteria in Crohn's disease: a persistent hypothesis
    Marcel A Behr
    Department of Medicine, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    Inflamm Bowel Dis 12:1000-4. 2006
    ..In this review, we discuss the current understanding of mycobacterial and Crohn's genetic susceptibility and review the evidence that NOD2/CARD15 may mediate host resistance to mycobacterial infection...
  25. ncbi request reprint Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy
    Audrey H Poon
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 170:967-73. 2004
    ..These results identify VDR variants as genetic risk factors for asthma/atopy and implicate a non-human leukocyte antigen immunoregulatory molecule in the pathogenesis of asthma and atopy...
  26. ncbi request reprint Genetics of leprosy reactions: an overview
    Vinicius Fava
    McGill Centre for the Study of Host Resistance, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Mem Inst Oswaldo Cruz 107:132-42. 2012
    ..The identification of host genetic markers with predictive value for LR would have a major impact on nerve damage control in leprosy. In this review, we present the recent advances achieved through genetic studies of LR...
  27. doi request reprint Genetics of infectious diseases: hidden etiologies and common pathways
    Marianna Orlova
    McGill Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montreal, PQ, Canada
    Clin Chem Lab Med 49:1427-37. 2011
    ..Analysis of the multi-disease susceptibility genes has allowed the definition of shared key pathways of inflammatory dysregulation and suggested unexpected infectious etiologies for other "non-infectious" common diseases...
  28. doi request reprint TB: screening for responses to a vile visitor
    Marcel Behr
    Research Institute, McGill University Health Center, Montreal, Quebec H3G 0B1, Canada
    Cell 140:615-8. 2010
    ..2010; Tobin et al., 2010), reveal that virulent mycobacteria evade the host immune system by stimulating production of anti-inflammatory molecules and inhibiting autophagy...
  29. ncbi request reprint Reduced in vitro functional activity of human NRAMP1 (SLC11A1) allele that predisposes to increased risk of pediatric tuberculosis disease
    C J Gallant
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Genes Immun 8:691-8. 2007
    ....
  30. ncbi request reprint Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections
    E Skamene
    Division of Clinical Immunology and Allergy, Montreal General Hospital, Quebec, Canada
    Annu Rev Med 49:275-87. 1998
    ..Through comparative genomics, we have identified the homologous human NRAMP1 gene, alleles of which are now being used for tests of linkage with TB and leprosy...
  31. ncbi request reprint A general efficient and flexible approach for genome-wide association analyses of imputed genotypes in family-based designs
    Aurelie Cobat
    Departments of Human Genetics and Medicine, McGill International TB Center, McGill University Health Center, Montreal, QC, Canada
    Genet Epidemiol 38:560-71. 2014
    ..The application of this approach to a family-based association study of leprosy susceptibility successfully refined the association signal at two candidate loci, C1orf141-IL23R on chromosome 1 and RAB32-C6orf103 on chromosome 6. ..
  32. doi request reprint Tuberculin skin test and in vitro assays provide complementary measures of antimycobacterial immunity in children and adolescents
    Caroline J Gallant
    Montreal General Hospital Research Institute, 1650 Cedar Ave, Room L11 521, Montreal, QC, H3G 1A4, Canada
    Chest 137:1071-7. 2010
    ..We, therefore, decided to determine the degree of redundancy between quantitative read-outs of in vivo and in vitro assays of antimycobacterial immunity...
  33. ncbi request reprint Genetic susceptibility to tuberculosis
    Suneil Malik
    McGill Centre for the Study of Host Resistance, McGill University, Montreal, Canada
    Clin Chem Lab Med 40:863-8. 2002
    ..tuberculosis, and the limited efficacy of Mycobacterium bovis (BCG) vaccination...
  34. ncbi request reprint Absence of association between mannose-binding lectin gene polymorphisms and HIV-1 infection in a Colombian population
    Suneil Malik
    McGill Centre for the Study of Host Resistance, Montreal General Hospital Research Institute, Montreal, Canada
    Immunogenetics 55:49-52. 2003
    ..0). Since there is a well-documented link between the tested MBL alleles and very low MBL serum concentration, these results do not support the hypothesis that MBL levels are a risk factor for HIV-1 infection in Colombia...
  35. pmc Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression
    M Cellier
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Exp Med 180:1741-52. 1994
    ..Additional RNA expression studies in cultured cells identified the macrophage as a site of expression of human NRAMP and indicated that increased expression was correlated with an advanced state of differentiation of this lineage...
  36. ncbi request reprint Expression of the human NRAMP1 gene in professional primary phagocytes: studies in blood cells and in HL-60 promyelocytic leukemia
    M Cellier
    Department of Biochemistry, McGill University, Montreal, Canada
    J Leukoc Biol 61:96-105. 1997
    ..The possibility that NRAMP1 may be a component of the phagosomal/endosomal apparatus common to PMN and MN is discussed...
  37. ncbi request reprint Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35
    S Marquet
    McGill Centre for the Study of Host Resistance, McGill University Health Centre, Montreal, Quebec, Canada
    Mamm Genome 11:755-62. 2000
    ..Our data provide new sequence information about the NRAMP1 gene region that will be useful in the search for genetic variants causally involved in altered susceptibility to infectious diseases...
  38. ncbi request reprint Segregation of HLA/TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypes
    M T Mira
    Departments of Human Genetics, Medicine and Biochemistry, McGill University, Montreal, PQ, Canada
    Genes Immun 4:67-73. 2003
    ....
  39. ncbi request reprint Complex genetic control of susceptibility to Mycobacterium bovis (Bacille Calmette-Guérin) infection in wild-derived Mus spretus mice
    K Turcotte
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Genes Immun 7:684-7. 2006
    ..The mapped loci may act as modifiers of Nramp1 action, and constitute novel entry points for the parallel search of loci regulating susceptibility to mycobacterial infections in humans...
  40. ncbi request reprint Crohn's disease, mycobacteria, and NOD2
    Marcel A Behr
    McGill University Health Centre, Montreal, Canada
    Lancet Infect Dis 4:136-7. 2004
  41. ncbi request reprint Impact of age and sex on mycobacterial immunity in an area of high tuberculosis incidence
    C J Gallant
    Department of Human Genetics and Medicine, McGill University, McGill Centre for the Study of Host Resistance, Montreal, Canada
    Int J Tuberc Lung Dis 14:952-9. 2010
    ..The extent of immune reactivity measured by the tuberculin skin test (TST) and interferon-gamma (IFN-gamma) T-cell assays is usually not analysed...
  42. ncbi request reprint Mapping of the gene coding for the muscle protein nebulin (Neb) to the proximal region of mouse chromosome 2
    E Schurr
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Cytogenet Cell Genet 57:214-6. 1991
    ..The gene order, intergene distances, and confidence intervals were determined according to standard maximum likelihood estimates as: centromere-Hc-5.4 cM (1.4 cM-15.4 cM; 95% confidence interval)-Neb-3.6 cM (1.5-6.7 cM)-Pmv-7...
  43. ncbi request reprint Variants of the SFTPA1 and SFTPA2 genes and susceptibility to tuberculosis in Ethiopia
    S Malik
    McGill Centre for the Study of Host Resistance, Departments of Medicine and Human Genetics, McGill University, Montreal, Quebec, Canada
    Hum Genet 118:752-9. 2006
    ..026). These findings suggest that SFTPA1 and SFTPA2 modify the risk of tuberculosis susceptibility and that this risk is influenced by additional covariates...
  44. ncbi request reprint NRAMP1 is not associated with asthma, atopy, and serum immunoglobulin E levels in the French Canadian population
    A H Poon
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
    Genes Immun 6:519-27. 2005
    ..These results demonstrate that, in spite of direct involvement of Nramp1 in a murine asthma model, in human populations NRAMP1 is not likely to be a major contributor to the genetic etiology of asthma and asthma-related phenotypes...
  45. ncbi request reprint Localization of two alkaline phosphatase genes to the proximal region of mouse chromosome 1
    E Schurr
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Cytogenet Cell Genet 52:65-7. 1989
    ..The gene order and intergene distances were determined by standard backcross analysis as: centromere- Len-2 - 19.0 cM - Akp-3 - 20.0 cM - Akp-4 - 2.0 cM - Ren-1...
  46. ncbi request reprint Linkage analysis of the Bcg gene on mouse chromosome 1. Identification of a tightly linked marker
    E Schurr
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Immunol 142:4507-13. 1989
    ..Our results suggest that a likely location for a putative human homologue to the murine host resistance gene Bcg is the long arm of human chromosome 2 (2q32-qter)...
  47. ncbi request reprint Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1 identifies conserved linkage of structural protein genes between murine chromosome 1 and human chromosome 2q
    E Schurr
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Genomics 8:477-86. 1990
    ..The order of mouse genes on chromosome 1 and their human homologs on chromosome 2q also appears to be conserved, suggesting that mapping of murine genes on the conserved segment may be useful to predict gene order in man...
  48. ncbi request reprint Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37
    H H van Es
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Cytogenet Cell Genet 63:114-6. 1993
    ..In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37...
  49. ncbi request reprint Assignment of Na,K-ATPase beta 2-subunit gene (Atpb-2) to mouse chromosome 11
    D Malo
    Department of Biochemistry, McGill University, Montreal, Canada
    Genomics 6:697-9. 1990
  50. ncbi request reprint The host resistance locus Bcg is tightly linked to a group of cytoskeleton-associated protein genes that include villin and desmin
    D Malo
    Department of Biochemistry, McGill University, Montreal, Canada
    Genomics 10:356-64. 1991
    ..Our findings indicate that the two closest markers to the host resistance locus, Bcg, encode cytoskeleton-associated proteins which are capable of interaction with actin filaments...
  51. ncbi request reprint Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2
    D Malo
    Department of Biochemistry, McGill University, Montreal, Canada
    Genomics 10:666-72. 1991
    ..These results indicate that the three isoforms of the brain sodium channel alpha-subunit are encoded by three distinct genes that share a common ancestral origin...
  52. pmc Multigenic control of disease severity after virulent Mycobacterium tuberculosis infection in mice
    Fabio Sanchez
    Center for Molecular Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden
    Infect Immun 71:126-31. 2003
    ..Overall, linkage data reported here for F2 mice are in agreement with, and add to, our previous findings concerning the control of M. tuberculosis-triggered disease in the BC1 segregation...
  53. ncbi request reprint A recessive major gene controls the mitsuda reaction in a region endemic for leprosy
    Brigitte Ranque
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Universite de Paris Rene Descartes INSERM U 550, Faculte de Medecine Necker, Paris, France, European Union
    J Infect Dis 192:1475-82. 2005
    ..leprae. Like leprosy, the Mitsuda reaction is thought to be genetically controlled, but its mode of inheritance is unknown, although the role of the NRAMP1 gene has previously been reported...
  54. ncbi request reprint Genomewide linkage analysis of the granulomatous mitsuda reaction implicates chromosomal regions 2q35 and 17q21
    Brigitte Ranque
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale, Paris, France
    J Infect Dis 196:1248-52. 2007
    ..Interestingly, these 2 regions have been previously linked to mycobacterial infection and other granulomatous diseases...
  55. ncbi request reprint Genetic dissection of immunity in leprosy
    Alexandre Alcais
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes, Institut National de la Santé et de la Recherche Medicale U 550, Faculte de Medecine Necker, Paris, France, European Union
    Curr Opin Immunol 17:44-8. 2005
    ..leprae. With respect to genome-wide screens, a major breakthrough has been reported this year; variants in the regulatory region shared by PARK2 and PACRG have been identified as being common risk factors for leprosy...
  56. doi request reprint [Leprosy: a paradigm for the study of human genetic susceptibility to infectious diseases]
    Brigitte Ranque
    Laboratoire de Genetique Humaine des Maladies Infectieuses, INSERM U550, Paris, France
    Med Sci (Paris) 24:491-7. 2008
    ....
  57. pmc An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults
    Jamila El Baghdadi
    Laboratory of Immunology, Military Hospital Mohamed V, Hay Riad Rabat, Morocco
    J Exp Med 203:1679-84. 2006
    ..These results provide direct molecular evidence that human pulmonary tuberculosis has a strong genetic basis, and indicate that the genetic component involves at least one major locus with a dominant susceptibility allele...
  58. pmc Constitutive differences in gene expression profiles parallel genetic patterns of susceptibility to tuberculosis in mice
    Marianna O Orlova
    Laboratory for Immunogenetics, Central Institute for Tuberculosis, Yauza alley 2, Moscow 107564, Russia
    Infect Immun 74:3668-72. 2006
    ..We conclude that intrinsic gene expression profiles are an important determinant of tuberculosis pathogenesis in mice...
  59. ncbi request reprint Age is an important risk factor for onset and sequelae of reversal reactions in Vietnamese patients with leprosy
    Brigitte Ranque
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes, Institut National de la Sante et de la Recherche Medicale, U550, Faculte de Medecine Necker, Paris, 75015, France
    Clin Infect Dis 44:33-40. 2007
    ..T1Rs occur mainly in patients with borderline or multibacillary leprosy, but little is known about additional risk factors...
  60. ncbi request reprint Quantifying genomic imprinting in the presence of linkage
    Quentin Vincent
    Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes INSERM U 550, Necker Medical School, Paris, 75015, France
    Biometrics 62:1071-80. 2006
    ..Our approach provides a novel tool for dissecting genomic imprinting in model-free linkage analysis, and will be of considerable value for identifying and evaluating the contribution of imprinted genes to complex diseases...
  61. ncbi request reprint Association of IL12RB1 polymorphisms with pulmonary tuberculosis in adults in Morocco
    Natascha Remus
    Laboratory of Human Genetics of Infectious Diseases, University of Paris Rene Descartes, INSERM U550, Paris, France
    J Infect Dis 190:580-7. 2004
    ..CC, 2.69 [95% confidence interval, 1.19-6.09]). This result suggests that IL12RB1 polymorphisms might influence the risk of development of PTB in adults...
  62. ncbi request reprint Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy
    Alexandre Alcais
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Institut National de la Sante et de la Recherche Medicale, U550, 75015 Paris, France
    Nat Genet 39:517-22. 2007
    ..In addition to identifying LTA as a major gene associated with early-onset leprosy, our study highlights the critical role of case- and population-specific factors in the dissection of susceptibility variants in complex diseases...

Research Grants5

  1. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2005
    ..tuberculosis through an exposed population. ..
  2. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2001
    ..tuberculosis through an exposed population. ..
  3. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2002
    ..tuberculosis through an exposed population. ..
  4. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2003
    ..tuberculosis through an exposed population. ..
  5. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2004
    ..tuberculosis through an exposed population. ..