H M Schipper

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Neurodegeneration with brain iron accumulation - clinical syndromes and neuroimaging
    Hyman M Schipper
    Centre for Neurotranslational Research, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    Biochim Biophys Acta 1822:350-60. 2012
  2. ncbi request reprint Redox neurology: visions of an emerging subspecialty
    Hyman M Schipper
    Center for Neurotranslational Research, Lady Davis Institute for Medical Research, S M B D Jewish General Hospital, Department of Neurology and Medicine, McGill University, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1012:342-55. 2004
  3. ncbi request reprint Heme oxygenase expression in human central nervous system disorders
    Hyman M Schipper
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote St Catherine Road, Montreal QC H3T 1E2, Canada
    Free Radic Biol Med 37:1995-2011. 2004
  4. ncbi request reprint Suppression of glial HO-1 activity as a potential neurotherapeutic intervention in AD
    Hyman M Schipper
    Centre for Neurotranslational Research and Bloomfield Centre for Research in Aging, The Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Curr Alzheimer Res 6:424-30. 2009
  5. doi request reprint Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement
    Hyman M Schipper
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    J Neurochem 110:469-85. 2009
  6. doi request reprint Apolipoprotein E: implications for AD neurobiology, epidemiology and risk assessment
    Hyman M Schipper
    Centre for Neurotranslational Research and Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote St Catherine Road, McGill University, Montreal, Quebec, Canada H3T 1E2
    Neurobiol Aging 32:778-90. 2011
  7. ncbi request reprint Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress
    Hyman M Schipper
    Center for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1012:84-93. 2004
  8. ncbi request reprint Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment
    Hyman M Schipper
    Centre for Neurotranslational Research and Bloomfield Centre for Research in Aging, Lady Davis Institute, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote St Catherine Road, Montreal, Que, Canada H3T 1E2
    Neurobiol Aging 27:252-61. 2006
  9. ncbi request reprint Biomarker potential of heme oxygenase-1 in Alzheimer's disease and mild cognitive impairment
    Hyman M Schipper
    McGill University, Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote St Catherine Road, Montreal, Quebec H3T 1E2, Canada
    Biomark Med 1:375-85. 2007
  10. doi request reprint Heme oxygenase-1 in Alzheimer disease: a tribute to Moussa Youdim
    Hyman M Schipper
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote St Catherine Road, Montreal, QC, H3T 1E2, Canada
    J Neural Transm 118:381-7. 2011

Collaborators

Detail Information

Publications49

  1. doi request reprint Neurodegeneration with brain iron accumulation - clinical syndromes and neuroimaging
    Hyman M Schipper
    Centre for Neurotranslational Research, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    Biochim Biophys Acta 1822:350-60. 2012
    ..An approach to differential diagnosis and the status of iron chelation therapy for several of these entities are presented. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease...
  2. ncbi request reprint Redox neurology: visions of an emerging subspecialty
    Hyman M Schipper
    Center for Neurotranslational Research, Lady Davis Institute for Medical Research, S M B D Jewish General Hospital, Department of Neurology and Medicine, McGill University, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1012:342-55. 2004
    ..Opportunities for research and teaching careers in the redox neurosciences are outlined. The paper concludes with a forecast of several research themes likely to preoccupy this nascent discipline in the days ahead...
  3. ncbi request reprint Heme oxygenase expression in human central nervous system disorders
    Hyman M Schipper
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote St Catherine Road, Montreal QC H3T 1E2, Canada
    Free Radic Biol Med 37:1995-2011. 2004
    ....
  4. ncbi request reprint Suppression of glial HO-1 activity as a potential neurotherapeutic intervention in AD
    Hyman M Schipper
    Centre for Neurotranslational Research and Bloomfield Centre for Research in Aging, The Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Curr Alzheimer Res 6:424-30. 2009
    ..Induction of the astroglial ho-1 gene may constitute a 'common pathway' leading to pathological brain iron deposition, intracellular oxidative damage and bioenergetic failure in AD and other human CNS disorders...
  5. doi request reprint Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement
    Hyman M Schipper
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    J Neurochem 110:469-85. 2009
    ..Glial HO-1 expression may also impact cell survival and neuroplasticity in these conditions by modulating brain sterol metabolism and proteosomal degradation of neurotoxic protein aggregates...
  6. doi request reprint Apolipoprotein E: implications for AD neurobiology, epidemiology and risk assessment
    Hyman M Schipper
    Centre for Neurotranslational Research and Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote St Catherine Road, McGill University, Montreal, Quebec, Canada H3T 1E2
    Neurobiol Aging 32:778-90. 2011
    ..Delineation of the influences of the APOE genotype on modifiable AD risk factors and prevention may spur consideration of APOE testing for presymptomatic individuals seeking to define their personal risk...
  7. ncbi request reprint Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress
    Hyman M Schipper
    Center for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1012:84-93. 2004
    ..A model is presented implicating glial HO-1 induction as a "final common pathway" leading to pathological iron sequestration and mitochondrial insufficiency in a host of human CNS disorders...
  8. ncbi request reprint Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment
    Hyman M Schipper
    Centre for Neurotranslational Research and Bloomfield Centre for Research in Aging, Lady Davis Institute, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote St Catherine Road, Montreal, Que, Canada H3T 1E2
    Neurobiol Aging 27:252-61. 2006
    ..Cortical and hippocampal oxidative stress is a very early event in the pathogenesis of sporadic AD and correlates with the development of specific cognitive deficits in this condition...
  9. ncbi request reprint Biomarker potential of heme oxygenase-1 in Alzheimer's disease and mild cognitive impairment
    Hyman M Schipper
    McGill University, Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote St Catherine Road, Montreal, Quebec H3T 1E2, Canada
    Biomark Med 1:375-85. 2007
    ..In this article, we review evidence implicating blood heme oxygenase-1 mRNA/protein levels and a recently identified plasma heme oxygenase-1 suppressor factor as potential biomarkers of AD and mild cognitive impairment...
  10. doi request reprint Heme oxygenase-1 in Alzheimer disease: a tribute to Moussa Youdim
    Hyman M Schipper
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote St Catherine Road, Montreal, QC, H3T 1E2, Canada
    J Neural Transm 118:381-7. 2011
    ..Suppression of glial HO-1 activity by pharmacological or other means may confer neuroprotection in AD by curtailing iron-mediated neurotoxicity...
  11. ncbi request reprint Role of porphyrin sequestration in the biogenesis of iron-laden astrocytic inclusions in primary culture
    H M Schipper
    Bloomfield Center for Research in Aging, Lady Davis Institute, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Dev Neurosci 24:169-76. 2002
    ....
  12. doi request reprint Presymptomatic apolipoprotein E genotyping for Alzheimer's disease risk assessment and prevention
    Hyman M Schipper
    Centre for Neurotranslational Research and Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Alzheimers Dement 7:e118-23. 2011
    ....
  13. ncbi request reprint Effects of dietary restriction and metal supplementation on the accumulation of iron-laden glial inclusions in the aging rat hippocampus
    O Borten
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Que, Canada H3T 1E2
    Biogerontology 5:81-8. 2004
    ..Our data support the view that dietary exposure to iron and/or copper in adult life can impact the sequestration of redox-active metals in aging hippocampal astroglia...
  14. ncbi request reprint Proinflammatory cytokines promote glial heme oxygenase-1 expression and mitochondrial iron deposition: implications for multiple sclerosis
    K Mehindate
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, SIR, Mortimer B. Davis-Jewish General Hospital, Montreal, Canada
    J Neurochem 77:1386-95. 2001
    ..In MS, IFN-beta may attenuate glial HO-1 gene induction and aberrant mitochondrial iron deposition accruing from exposure to proinflammatory cytokines...
  15. ncbi request reprint Heme oxygenase-1: role in brain aging and neurodegeneration
    H M Schipper
    Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Que, H3T 1E2, Montreal, Canada
    Exp Gerontol 35:821-30. 2000
    ..We recently observed that, paradoxically, HO-1 mRNA levels are markedly suppressed in peripheral lymphocytes of patients with early sporadic Alzheimer disease and may thus provide a useful biological marker of this condition...
  16. ncbi request reprint Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain
    H M Schipper
    Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Ann Neurol 37:758-68. 1995
    ..In addition, the excessive generation of carbon monoxide, a metabolite of heme degradation, may participate in the pathogenesis of AD...
  17. ncbi request reprint Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment
    Michael I Assaraf
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    J Neuropathol Exp Neurol 66:389-98. 2007
    ..We conclude that upregulation of EpoR in temporal cortical and hippocampal astrocytes is an early, potentially neuroprotective, event in the pathogenesis of sporadic AD...
  18. pmc Brain sterol dysregulation in sporadic AD and MCI: relationship to heme oxygenase-1
    Jacob R Hascalovici
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    J Neurochem 110:1241-53. 2009
    ..A model featuring compensated and de-compensated states of altered sterol homeostasis in MCI and AD is presented based on the current data set and our earlier in vitro work...
  19. doi request reprint The novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cells
    N Garnier
    1 Department of Oncology, Lady Davis Institute for Medical Research, Segal Cancer Center, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada 2 Faculty of Medicine, Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Leukemia 27:2220-8. 2013
    ..Accordingly, the lack of HO-1 induction is involved in Dar's enhanced antileukemic properties. Our data highlight cytoprotective responses mediated by HO-1 and BRG1 as a novel target for enhancing the therapeutic range of arsenicals. ..
  20. ncbi request reprint Role of heme oxygenase-1 in the biogenesis of corpora amylacea
    D J Sahlas
    Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2
    Biogerontology 3:223-31. 2002
    ..Up-regulation of HO-1 may contribute to the formation of CA in aging astroglia...
  21. ncbi request reprint Brain iron deposition and the free radical-mitochondrial theory of ageing
    Hyman M Schipper
    Centre for Neurotranslational Research and Bloomfield Centre for Research in Ageing, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Que, Canada
    Ageing Res Rev 3:265-301. 2004
    ..The data are discussed in the context of a revised 'free radical-mitochondrial-metal' theory of brain ageing, and some scientific and clinical implications of the latter are considered...
  22. ncbi request reprint Characterization of alpha1-antitrypsin as a heme oxygenase-1 suppressor in Alzheimer plasma
    Olivier C Maes
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Chemin Cote Ste Catherine Montreal, Canada H3T1E2
    Neurobiol Dis 24:89-100. 2006
    ..HOS activity of alpha(1)-antitrypsin may curtail HO-1-dependent derangement of cerebral iron homeostasis and account for diminished HO-1 expression in AD peripheral tissues...
  23. doi request reprint A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer
    Moulay A Alaoui-Jamali
    Department of Medicine, Lady Davis Institute of Medical Research, Segal Cancer Centre, McGill University, Montreal, Quebec, Canada
    Cancer Res 69:8017-24. 2009
    ..A potent synergistic activity was observed when OB-24 was combined with Taxol. Together, these results establish HO-1 as a potential therapeutic target for advanced PCA...
  24. ncbi request reprint Over-expression of heme oxygenase-1 promotes oxidative mitochondrial damage in rat astroglia
    Wei Song
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    J Cell Physiol 206:655-63. 2006
    ....
  25. ncbi request reprint Transcriptional profiling of Alzheimer blood mononuclear cells by microarray
    Olivier C Maes
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Canada
    Neurobiol Aging 28:1795-809. 2007
    ..BMC are highly accessible and may reflect molecular events germane to the neuropathophysiology of AD...
  26. doi request reprint HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues
    Hillel Zukor
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Neurochem 109:776-91. 2009
    ..Glial HO-1 may be a rational therapeutic target in AD, PD, and other human CNS conditions characterized by the unregulated deposition of brain iron...
  27. ncbi request reprint Evaluation of HFE (hemochromatosis) mutations as genetic modifiers in sporadic AD and MCI
    Daniel Berlin
    Blomfield Centre for Research in Aging, Montreal, Que, Canada
    Neurobiol Aging 25:465-74. 2004
    ..Recent reports suggest that heterozygosity for the two common hfe mutations responsible for hereditary hemochromatosis (HH) may be a risk factor for AD, possibly by accelerating brain iron accumulation...
  28. doi request reprint The Parkinson disease-associated A30P mutation stabilizes alpha-synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells
    Wei Song
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Neurochem 110:719-33. 2009
    ..Resistance to HO-1 induced proteosomal degradation may render the familial PD-associated A30P mutation prone to toxic intracellular aggregation...
  29. doi request reprint Methodology for discovery of Alzheimer's disease blood-based biomarkers
    Olivier C Maes
    Centre for Neurotranslational Research, Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    J Gerontol A Biol Sci Med Sci 64:636-45. 2009
    ..We suggest that PBMC-associated biomarkers may provide insights into the pathogenesis of AD and be used to monitor disease diagnosis and progression...
  30. ncbi request reprint Astroglia overexpressing heme oxygenase-1 predispose co-cultured PC12 cells to oxidative injury
    Linyang Song
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Neurosci Res 85:2186-95. 2007
    ....
  31. ncbi request reprint Assessment of suspected dementia
    H Chertkow
    Bloomfield Centre for Research in Aging, Lady Davis Institute, Dept of Clinical Neuroscience, Montreal, QC, Canada
    Can J Neurol Sci 28:S28-41. 2001
    ..Guidelines to aid in differential diagnosis are presented...
  32. ncbi request reprint Characterization of cis-acting elements in the promoter of the mouse metallothionein-3 gene. Activation of gene expression during neuronal differentiation of P19 embryonal carcinoma cells
    R Faraonio
    Centre de recherche en cancérologie de l Université Laval, and Département d anatomie et physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Eur J Biochem 267:1743-53. 2000
    ....
  33. ncbi request reprint Trolox selectively enhances arsenic-mediated oxidative stress and apoptosis in APL and other malignant cell lines
    Zuanel Diaz
    Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada
    Blood 105:1237-45. 2005
    ..Furthermore, the combination of As(2)O(3) and trolox shows potential specificity for tumor cells, suggesting it may not increase the toxicity associated with As(2)O(3) monotherapy in vivo...
  34. ncbi request reprint Astroglial cytoprotection by erythropoietin pre-conditioning: implications for ischemic and degenerative CNS disorders
    Zuanel Diaz
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Neurochem 93:392-402. 2005
    ..Thus, induction of the ho-1 gene may contribute to the glioprotection accruing from high-dose Epo exposure. Epo may augment astroglial resistance to certain chemical stressors by oxidative stress-dependent and -independent mechanisms...
  35. ncbi request reprint Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity
    Z Diaz
    Segal Cancer Centre and Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Leukemia 21:2117-27. 2007
    ..Our results suggest, for the first time, that trolox might prevent some of the clinical manifestations of As2O3-related toxicity while increasing its pro-apoptotic capacity and clinical efficacy in hematological malignancies...
  36. ncbi request reprint The topography and subcellular distribution of mitogen-activated protein kinase kinase1 (MEK1) in adult rat brain and differentiating PC12 cells
    H M Schipper
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Neuroscience 93:585-95. 1999
    ....
  37. ncbi request reprint Salivary DNA, lipid, and protein oxidation in nonsmokers with periodontal disease
    Haixiang Su
    Center for Neurotranslational Research, Lady Davis Institute for Medical Research, Montreal, QC, Canada H3T 1E2
    Free Radic Biol Med 46:914-21. 2009
    ..Augmented salivary total antioxidant capacity may represent an adaptive response to oxidative stress. Salivary amylase, transferrin, and human IgG1 heavy chain fragments are particularly prone to enhanced oxidation in periodontitis...
  38. doi request reprint Near-infrared spectroscopy of blood plasma for diagnosis of sporadic Alzheimer's disease
    David H Burns
    Department of Chemistry, McGill University, Montreal, QC, Canada
    J Alzheimers Dis 17:391-7. 2009
    ..The procedure is minimally-invasive, rapid, relatively-inexpensive, and may provide a useful biological marker of sporadic AD...
  39. doi request reprint Impact of heme oxygenase-1 on cholesterol synthesis, cholesterol efflux and oxysterol formation in cultured astroglia
    Jacob R Hascalovici
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, Montreal, Quebec, Canada
    J Neurochem 108:72-81. 2009
    ..As the latter may impact synaptic plasticity and neuronal repair, modulation of glial HO-1 expression (by pharmacological or other means) may confer neuroprotection in patients with degenerative brain disorders...
  40. ncbi request reprint Aberrant profiles of native and oxidized glycoproteins in Alzheimer plasma
    Han Ling Yu
    Centre for Neurotranslational Research and Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Sainte Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Proteomics 3:2240-8. 2003
    ..Moreover, the data implicate isoforms of Tf, Hpx and alpha-1-AT as potential biological markers of this condition...
  41. ncbi request reprint Can you have dementia with an MMSE score of 30?
    Jonah S Shiroky
    Bloomfield Center for Research in Aging, Montreal, Canada
    Am J Alzheimers Dis Other Demen 22:406-15. 2007
    ..To investigate the possibility that a patient with a diagnosis oF probable Alzheimer's disease (AD) can still obtain a score oF 30/30 on the Mini-Mental State Exam (MMSE)...
  42. doi request reprint Neurologic impairment due to vitamin E and copper deficiencies in celiac disease
    Alexandre Henri-Bhargava
    Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Neurology 71:860-1. 2008
  43. ncbi request reprint Effects of heme oxygenase-1 expression on sterol homeostasis in rat astroglia
    Jacob Vaya
    Laboratory of Natural Medicinal Compounds, MIGAL Galilee Technological Center, Kiryat Shmona 11016, Israel
    Free Radic Biol Med 42:864-71. 2007
    ..g., beta-amyloid) into altered patterns of glial sterol metabolism which, in turn, may affect neuronal membrane turnover, survival, and adaptability...
  44. pmc Oxidative stress and aberrant signaling in aging and cognitive decline
    Wulf Dröge
    Immunotec Research Ltd, 300 Joseph Carrier, Vaudreuil Dorion, Quebec, Canada J7V 5V5
    Aging Cell 6:361-70. 2007
    ..Aging and cognitive decline thus appear to involve changes at multiple nodes within a complex regulatory network...
  45. ncbi request reprint Corpora amylacea in a leiomyoma of soft tissue
    Barry Gallagher
    Department of Pathology, James Paton Memorial Hospital, Gander, NL, Canada
    Pathol Res Pract 203:121-5. 2007
    ..The patient remains well, with no evidence of recurrence 3 years after surgery. Leiomyomas of deep soft tissue are rare, and, to our knowledge, none have been described containing CA...
  46. ncbi request reprint Stress protein expression in the Alzheimer-diseased choroid plexus
    Shawn G Anthony
    Division of Neuropathology, Department of Pathology, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA
    J Alzheimers Dis 5:171-7. 2003
    ....
  47. ncbi request reprint Oxysterols, cholesterol homeostasis, and Alzheimer disease
    Jacob Vaya
    Laboratory of Natural Medicinal Compounds, Migal Galilee Technology Center, Kiryat Shmona, Israel
    J Neurochem 102:1727-37. 2007
    ..Synthetic oxysterol-mimetic drugs that activate LXR receptors within the CNS may provide novel therapeutics for management of AD and other neurological afflictions characterized by deranged tissue cholesterol homeostasis...
  48. pmc Diagnosis and treatment of dementia: 2. Diagnosis
    Howard H Feldman
    Division of Neurology, Department of Medicine, University of British Columbia, and the University of British Columbia Hospital Clinic for Alzheimer s Disease and Related Disorders, Vancouver, BC
    CMAJ 178:825-36. 2008
    ..In this article, we provide physicians with practical guidance on the diagnosis of dementia based on recommendations from the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia, held in March 2006...