Maya Saleh

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Innate immune mechanisms of colitis and colitis-associated colorectal cancer
    Maya Saleh
    Department of Medicine, McGill University, Montreal, Quebec, H3G 0B1 Canada
    Nat Rev Immunol 11:9-20. 2011
  2. pmc Experimental inflammatory bowel disease: insights into the host-microbiota dialog
    Maya Saleh
    Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 0B1
    Immunity 34:293-302. 2011
  3. doi request reprint The machinery of Nod-like receptors: refining the paths to immunity and cell death
    Maya Saleh
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Immunol Rev 243:235-46. 2011
  4. ncbi request reprint Caspase-1 builds a new barrier to infection
    Maya Saleh
    Department of Medicine, McGill University, Montreal H3G 1Y6, Canada
    Cell 126:1028-30. 2006
  5. doi request reprint Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    Jeremy Dupaul-Chicoine
    Department of Biochemistry, McGill University, Quebec, Canada
    Immunity 32:367-78. 2010
  6. doi request reprint Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome
    Katherine Labbe
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3G 0B1, Canada
    Immunity 35:897-907. 2011
  7. doi request reprint Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signaling
    Katherine Labbe
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    J Immunol 185:5495-502. 2010
  8. doi request reprint Non-apoptotic role of BID in inflammation and innate immunity
    Garabet Yeretssian
    Department of Medicine, McGill University, Montreal, Quebec H3G 0B1, Canada
    Nature 474:96-9. 2011
  9. doi request reprint Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2
    Mathieu J M Bertrand
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Immunity 30:789-801. 2009
  10. doi request reprint Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity
    Philippe M LeBlanc
    Department of Medicine, Division of Critical Care, and Centre for Study of Host Resistance, McGill University, Montreal H3A 1A1, Canada
    Cell Host Microbe 3:146-57. 2008

Collaborators

Detail Information

Publications27

  1. doi request reprint Innate immune mechanisms of colitis and colitis-associated colorectal cancer
    Maya Saleh
    Department of Medicine, McGill University, Montreal, Quebec, H3G 0B1 Canada
    Nat Rev Immunol 11:9-20. 2011
    ..This Review discusses recent findings that identify a crucial role for innate immune effector molecules in protection against colitis and colitis-associated colorectal cancer and the therapeutic implications that ensue...
  2. pmc Experimental inflammatory bowel disease: insights into the host-microbiota dialog
    Maya Saleh
    Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 0B1
    Immunity 34:293-302. 2011
    ....
  3. doi request reprint The machinery of Nod-like receptors: refining the paths to immunity and cell death
    Maya Saleh
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Immunol Rev 243:235-46. 2011
    ..I also describe their effector functions that link the sensing of danger to the induction of inflammation, autophagy or cell death...
  4. ncbi request reprint Caspase-1 builds a new barrier to infection
    Maya Saleh
    Department of Medicine, McGill University, Montreal H3G 1Y6, Canada
    Cell 126:1028-30. 2006
    ..Thus, caspase-1 may promote host cell survival as a means of resistance to pathogenic bacteria...
  5. doi request reprint Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    Jeremy Dupaul-Chicoine
    Department of Biochemistry, McGill University, Quebec, Canada
    Immunity 32:367-78. 2010
    ..Taken together, our results indicate that the inflammatory caspases are critical in the induction of inflammation in the gut after injury, which is necessary for tissue repair and maintenance of immune tolerance...
  6. doi request reprint Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome
    Katherine Labbe
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3G 0B1, Canada
    Immunity 35:897-907. 2011
    ..Our results describe a role for the cIAPs in innate immunity and further demonstrate the evolutionary conservation between cell death and inflammation mechanisms...
  7. doi request reprint Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signaling
    Katherine Labbe
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    J Immunol 185:5495-502. 2010
    ..Systemic inhibition of NF-κB or Ab neutralization of IFN-γ reversed the increased resistance of casp12(-/-) mice to blood-stage malaria infection...
  8. doi request reprint Non-apoptotic role of BID in inflammation and innate immunity
    Garabet Yeretssian
    Department of Medicine, McGill University, Montreal, Quebec H3G 0B1, Canada
    Nature 474:96-9. 2011
    ..Our results define a novel role of BID in inflammation and immunity independent of its apoptotic function, furthering the mounting evidence of evolutionary conservation between the mechanisms of apoptosis and immunity...
  9. doi request reprint Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2
    Mathieu J M Bertrand
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Immunity 30:789-801. 2009
    ..This discovery provides therapeutic opportunities in the treatment of NOD-dependent immunologic and inflammatory diseases...
  10. doi request reprint Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity
    Philippe M LeBlanc
    Department of Medicine, Division of Critical Care, and Centre for Study of Host Resistance, McGill University, Montreal H3A 1A1, Canada
    Cell Host Microbe 3:146-57. 2008
    ..Nod activation and resulting antimicrobial peptide production constitute an early innate defense mechanism, and caspase-12 inhibits this mucosal antimicrobial response...
  11. pmc Positional mapping and candidate gene analysis of the mouse Ccs3 locus that regulates differential susceptibility to carcinogen-induced colorectal cancer
    Charles Meunier
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e58733. 2013
    ..The interval contains another positional candidate Slc39a8 that is differentially expressed in A vs B6 colons, and that has recently been associated in CRC tumor aggressiveness in humans...
  12. doi request reprint Inflammasomes in infection and inflammation
    Christian R McIntire
    Department of Biochemistry, McGill University, Montreal, QC, Canada
    Apoptosis 14:522-35. 2009
    ..By acting as key regulators of inflammation, energy metabolism and cell death, inflammatory caspases and inflammasomes exert profound influences on innate immunity and infectious and non-infectious inflammatory diseases...
  13. pmc Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection
    Garabet Yeretssian
    Department of Medicine, Centre for the Study of Host Resistance and Complex Trait Group, McGill University, Montreal, QC, Canada H3G 0B1
    Proc Natl Acad Sci U S A 106:9016-20. 2009
    ..We propose that estrogen-mediated inhibition of Csp-12L expression is a built-in mechanism that has evolved to protect females from infection...
  14. ncbi request reprint The inflammatory caspases: key players in the host response to pathogenic invasion and sepsis
    Amal Nadiri
    Department of Medicine, McGill University, Montreal H3A 1A1, Canada
    J Immunol 177:4239-45. 2006
    ....
  15. doi request reprint Genetics of inflammasome-associated disorders: a lesson in the guiding principals of inflammasome function
    Ian Gaël Rodrigue-Gervais
    Department of Medicine, McGill University, Montreal, Canada
    Eur J Immunol 40:643-8. 2010
    ....
  16. doi request reprint Molecular regulation of inflammation and cell death
    Garabet Yeretssian
    Department of Medicine, Division of Critical Care, and Centre for the Study of Host Resistance, McGill University, Montreal, Que, Canada
    Cytokine 43:380-90. 2008
    ....
  17. doi request reprint Non-apoptotic functions of cell death effectors in inflammation and innate immunity
    Alexandre Morizot
    Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 0B1
    Microbes Infect 14:1241-53. 2012
    ..The aim of this review is to highlight the close relationship between the pathways governing these processes, particularly how regulators of cell death control the induction of the innate immune response...
  18. doi request reprint Crosstalk between the intestinal microbiota and the innate immune system in intestinal homeostasis and inflammatory bowel disease
    Jeremy Dupaul-Chicoine
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Inflamm Bowel Dis 19:2227-37. 2013
    ....
  19. pmc Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4
    Anne Fortier
    Department of Biochemistry, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Room 907, Montreal, Quebec, Canada H3G 1Y6
    Infect Immun 77:4794-805. 2009
    ..They also suggest that flagellin sensing by the NLR proteins Naip5 and Nlrc4 may be coupled to Irf1-Irf8-mediated transcriptional activation of key effector genes essential for macrophage resistance to L. pneumophila infection...
  20. pmc An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria
    Silayuv E Bongfen
    Department of Biochemistry, McGill University, Montreal, Canada
    PLoS ONE 7:e31012. 2012
    ..CM resistance in Jak3(W81R/+) heterozygotes occurs in presence of normal T, B and NK cell numbers. These findings highlight the pathological role of CD8(+) T cells and Jak3-dependent IFN-γ-mediated Th1 responses in CM pathogenesis...
  21. ncbi request reprint Function of NOD-like receptors in immunity and disease
    Maryse Dagenais
    McGill University, Department of Biochemistry, 3775 University, Montreal, QC H3A 2B4, Canada
    Curr Opin Investig Drugs 11:1246-55. 2010
    ....
  22. pmc Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis
    Rachid Mazroui
    Department of Biochemistry, McGill University Health Center, McGill University, Montreal, Quebec H3G 146, Canada
    J Cell Biol 180:113-27. 2008
    ..Thus, we propose a model in which HuR association with pp32/PHAP-I and its caspase-mediated cleavage constitutes a regulatory step that contributes to an amplified apoptotic response...
  23. ncbi request reprint The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
    Wei Shao
    Department of Biochemistry, Division of Critical Care, Centre for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada
    J Biol Chem 282:36321-9. 2007
    ..The systematic characterization of caspase-1 substrates identifies the glycolysis pathway as a caspase-1 target and provides new insights into its function during pyroptosis and septic shock...
  24. ncbi request reprint Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
    Maya Saleh
    Department of Biochemistry, Molecular Biology and Pharmacology, Merck Frosst Centre for Therapeutic Research, Montreal, Quebec H9H 3L1, Canada
    Nature 429:75-9. 2004
    ..Thus, Csp12-L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis...
  25. pmc Confinement of caspase-12 proteolytic activity to autoprocessing
    Sophie Roy
    Department of Cardiovascular Diseases, Apoptosis Research Group, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065 0900, USA
    Proc Natl Acad Sci U S A 105:4133-8. 2008
    ....
  26. ncbi request reprint Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice
    Maya Saleh
    Department of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nature 440:1064-8. 2006
    ..In mice, caspase-12 deficiency confers resistance to sepsis and its presence exerts a dominant-negative suppressive effect on caspase-1, resulting in enhanced vulnerability to bacterial infection and septic mortality...
  27. ncbi request reprint Life support: the alpha4 phosphatase subunit in cell survival and apoptosis
    Maya Saleh
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Trends Cell Biol 15:285-7. 2005
    ....