Genomes and Genes
Affiliation: McGill University
- Innate immune mechanisms of colitis and colitis-associated colorectal cancerMaya Saleh
Department of Medicine, McGill University, Montreal, Quebec, H3G 0B1 Canada
Nat Rev Immunol 11:9-20. 2011..This Review discusses recent findings that identify a crucial role for innate immune effector molecules in protection against colitis and colitis-associated colorectal cancer and the therapeutic implications that ensue...
- The machinery of Nod-like receptors: refining the paths to immunity and cell deathMaya Saleh
Department of Medicine, McGill University, Montreal, Quebec, Canada
Immunol Rev 243:235-46. 2011..I also describe their effector functions that link the sensing of danger to the induction of inflammation, autophagy or cell death...
- Experimental inflammatory bowel disease: insights into the host-microbiota dialogMaya Saleh
Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 0B1
Immunity 34:293-302. 2011....
- Caspase-1 builds a new barrier to infectionMaya Saleh
Department of Medicine, McGill University, Montreal H3G 1Y6, Canada
Cell 126:1028-30. 2006..Thus, caspase-1 may promote host cell survival as a means of resistance to pathogenic bacteria...
- Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspasesJeremy Dupaul-Chicoine
Department of Biochemistry, McGill University, Quebec, Canada
Immunity 32:367-78. 2010..Taken together, our results indicate that the inflammatory caspases are critical in the induction of inflammation in the gut after injury, which is necessary for tissue repair and maintenance of immune tolerance...
- Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasomeKatherine Labbe
Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3G 0B1, Canada
Immunity 35:897-907. 2011..Our results describe a role for the cIAPs in innate immunity and further demonstrate the evolutionary conservation between cell death and inflammation mechanisms...
- Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signalingKatherine Labbe
Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
J Immunol 185:5495-502. 2010..Systemic inhibition of NF-κB or Ab neutralization of IFN-γ reversed the increased resistance of casp12(-/-) mice to blood-stage malaria infection...
- Non-apoptotic role of BID in inflammation and innate immunityGarabet Yeretssian
Department of Medicine, McGill University, Montreal, Quebec H3G 0B1, Canada
Nature 474:96-9. 2011..Our results define a novel role of BID in inflammation and immunity independent of its apoptotic function, furthering the mounting evidence of evolutionary conservation between the mechanisms of apoptosis and immunity...
- Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2Mathieu J M Bertrand
Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Immunity 30:789-801. 2009..This discovery provides therapeutic opportunities in the treatment of NOD-dependent immunologic and inflammatory diseases...
- Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunityPhilippe M LeBlanc
Department of Medicine, Division of Critical Care, and Centre for Study of Host Resistance, McGill University, Montreal H3A 1A1, Canada
Cell Host Microbe 3:146-57. 2008..Nod activation and resulting antimicrobial peptide production constitute an early innate defense mechanism, and caspase-12 inhibits this mucosal antimicrobial response...
- Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infectionGarabet Yeretssian
Department of Medicine, Centre for the Study of Host Resistance and Complex Trait Group, McGill University, Montreal, QC, Canada H3G 0B1
Proc Natl Acad Sci U S A 106:9016-20. 2009..We propose that estrogen-mediated inhibition of Csp-12L expression is a built-in mechanism that has evolved to protect females from infection...
- The inflammatory caspases: key players in the host response to pathogenic invasion and sepsisAmal Nadiri
Department of Medicine, McGill University, Montreal H3A 1A1, Canada
J Immunol 177:4239-45. 2006....
- Inflammasomes in infection and inflammationChristian R McIntire
Department of Biochemistry, McGill University, Montreal, QC, Canada
Apoptosis 14:522-35. 2009..By acting as key regulators of inflammation, energy metabolism and cell death, inflammatory caspases and inflammasomes exert profound influences on innate immunity and infectious and non-infectious inflammatory diseases...
- Molecular regulation of inflammation and cell deathGarabet Yeretssian
Department of Medicine, Division of Critical Care, and Centre for the Study of Host Resistance, McGill University, Montreal, Que, Canada
Cytokine 43:380-90. 2008....
- Genetics of inflammasome-associated disorders: a lesson in the guiding principals of inflammasome functionIan Gaël Rodrigue-Gervais
Department of Medicine, McGill University, Montreal, Canada
Eur J Immunol 40:643-8. 2010....
- Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4Anne Fortier
Department of Biochemistry, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Room 907, Montreal, Quebec, Canada H3G 1Y6
Infect Immun 77:4794-805. 2009..They also suggest that flagellin sensing by the NLR proteins Naip5 and Nlrc4 may be coupled to Irf1-Irf8-mediated transcriptional activation of key effector genes essential for macrophage resistance to L. pneumophila infection...
- An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malariaSilayuv E Bongfen
Department of Biochemistry, McGill University, Montreal, Canada
PLoS ONE 7:e31012. 2012..CM resistance in Jak3(W81R/+) heterozygotes occurs in presence of normal T, B and NK cell numbers. These findings highlight the pathological role of CD8(+) T cells and Jak3-dependent IFN-γ-mediated Th1 responses in CM pathogenesis...
- Function of NOD-like receptors in immunity and diseaseMaryse Dagenais
McGill University, Department of Biochemistry, 3775 University, Montreal, QC H3A 2B4, Canada
Curr Opin Investig Drugs 11:1246-55. 2010....
- Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosisRachid Mazroui
Department of Biochemistry, McGill University Health Center, McGill University, Montreal, Quebec H3G 146, Canada
J Cell Biol 180:113-27. 2008..Thus, we propose a model in which HuR association with pp32/PHAP-I and its caspase-mediated cleavage constitutes a regulatory step that contributes to an amplified apoptotic response...
- The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shockWei Shao
Department of Biochemistry, Division of Critical Care, Centre for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada
J Biol Chem 282:36321-9. 2007..The systematic characterization of caspase-1 substrates identifies the glycolysis pathway as a caspase-1 target and provides new insights into its function during pyroptosis and septic shock...
- Differential modulation of endotoxin responsiveness by human caspase-12 polymorphismsMaya Saleh
Department of Biochemistry, Molecular Biology and Pharmacology, Merck Frosst Centre for Therapeutic Research, Montreal, Quebec H9H 3L1, Canada
Nature 429:75-9. 2004..Thus, Csp12-L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis...
- Confinement of caspase-12 proteolytic activity to autoprocessingSophie Roy
Department of Cardiovascular Diseases, Apoptosis Research Group, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065 0900, USA
Proc Natl Acad Sci U S A 105:4133-8. 2008....
- Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient miceMaya Saleh
Department of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
Nature 440:1064-8. 2006..In mice, caspase-12 deficiency confers resistance to sepsis and its presence exerts a dominant-negative suppressive effect on caspase-1, resulting in enhanced vulnerability to bacterial infection and septic mortality...
- Life support: the alpha4 phosphatase subunit in cell survival and apoptosisMaya Saleh
Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
Trends Cell Biol 15:285-7. 2005....