Research Topics
| J P RoutySummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical studyJ P Routy
Division of Hematology, Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada
HIV Med 13:291-6. 2012..In a randomized multicentre, cross-over study, we assessed whether adding VPA to stable HAART could potentially reduce the size of the latent viral reservoir in CD4 T cells of chronically infected patients...- Assessing risk of a short-term antiretroviral therapy discontinuation as a read-out of viral control in immune-based therapyJ P Routy
Chronic Viral Illness Service and Division of Hematology, McGill University Health Centre, Montreal, Quebec, Canada
J Med Virol 84:885-9. 2012.... 
Influence of RANTES, SDF-1 and TGF-beta levels on the value of interleukin-7 as a predictor of virological response in HIV-1-infected patients receiving double boosted protease inhibitor-based therapyM R Boulassel
Immunodeficiency Service, Montreal Chest Institute, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
HIV Med 6:268-77. 2005..Furthermore, they indicate that RANTES, SDF-1 or TGF-beta levels do not explain the predictor value of IL-7 in patients receiving ART...- Episomal and integrated human papillomavirus type 16 loads and anal intraepithelial neoplasia in HIV-seropositive menJennifer Alvarez
Départements de Microbiologie et Infectiologie, Pathologie, et Laboratoire de Virologie Moléculaire, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
AIDS 24:2355-63. 2010.... - Effects of drug resistance on viral load in patients failing antiretroviral therapyN Machouf
Clinique Médicale l Actuel, Montreal, Quebec, Canada
J Med Virol 78:608-13. 2006..Together, these findings suggest that long-term maintenance of a sub-optimal antiretroviral regimen may have deleterious consequences for the patient... - Design and Implementation of a Randomized Crossover Study of Valproic Acid and Antiretroviral Therapy to Reduce the HIV ReservoirJ P Routy
Division of Hematology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada Chronic Viral Illness Service, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
HIV Clin Trials 13:301-7. 2012..Conclusion: Despite the absence of demonstrable impact of VPA on reservoir size, such crossover study design should be considered in the early stage testing of novel HIV therapeutics targeted to reduce reservoir size or eradicate HIV... - A novel and simplified method of culture of human blood-derived early endothelial progenitor cells for the treatment of ischemic vascular diseaseM Bouchentouf
Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Cell Transplant 20:1431-43. 2011.... - Comparison of clinical features of acute HIV-1 infection in patients infected sexually or through injection drug use. The Investigators of the Québec Primary HIV Infection StudyJ P Routy
McGill University Health Centre, McGill AIDS Centre, and McGill University, Montreal, Quebec, Canada
J Acquir Immune Defic Syndr 24:425-32. 2000..Our study results clearly indicate that health care workers can expect similar clinical presentation of AHI in MSM and in IDUs despite the different routes of infection... - Improvement of HIV-specific immunity in HIV-infected twins treated with highly active antiretroviral therapy, interleukin 2, and syngeneic adoptively transferred cellsC M Tsoukas
Immunodeficiency Treatment Centre, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
AIDS Res Hum Retroviruses 17:887-900. 2001.... 
Persistent human immunodeficiency virus-1 antigenaemia affects the expression of interleukin-7Ralpha on central and effector memory CD4+ and CD8+ T cell subsetsF Mercier
Immunodeficiency Service, Montreal Chest Institute, Montreal, Quebec, Canada
Clin Exp Immunol 152:72-80. 2008..Collectively, these results provide further insight on the role of unsuppressed viral load in disrupting the IL-7/IL-7Ralpha system and contributing to HIV-1 disease progression...- Interleukin-7 levels may predict virological response in advanced HIV-1-infected patients receiving lopinavir/ritonavir-based therapyM R Boulassel
Immunodeficiency Service Division of Hematology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
HIV Med 4:315-20. 2003..CONCLUSIONS: These findings are consistent with regulation of T-cell recovery by IL-7, and suggest that IL-7 measurements might be used to predict virological response... - Plasmapheresis in the treatment of an acute pancreatitis due to protease inhibitor-induced hypertriglyceridemiaJ P Routy
Division of Hematology, McGill University Health Centre, Montreal, Quebec, USA
J Clin Apher 16:157-9. 2001..To our knowledge, this is the first case of pancreatitis due to a PI-induced hyperlipidemia in a HIV-patient treated with plasmapheresis in an acute setting... - Rationale for maintenance of the M184v resistance mutation in human immunodeficiency virus type 1 reverse transcriptase in treatment experienced patientsD Turner
McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
New Microbiol 27:31-9. 2004..Collectively, these factors might explain the residual antiviral effect and clinical benefit observed with continued use of 3TC in combination therapy regimens following the emergence of M184V... - Longitudinal assessment of changes in HIV-specific effector activity in HIV-infected patients starting highly active antiretroviral therapy in primary infectionG Alter
McGill University Health Center, Montreal, Quebec, Canada
J Immunol 171:477-88. 2003..Our results show that HIV-specific immunity can be preserved even if HAART is initiated beyond the acute phase of infection... - Early lymphocyte recovery following autologous peripheral stem cell transplantation is associated with better survival in younger patients with lymphoproliferative disordersM R Boulassel
Division of Hematology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Que, H3A 1A1 Canada
Hematology 11:165-70. 2006..A shorter time from diagnosis to APSCT may favor recovery of ALC independent of the infused stem cell or lymphocyte doses... - Prevalence, clearance, and incidence of anal human papillomavirus infection in HIV-infected men: the HIPVIRG cohort studyAlexandra de Pokomandy
Departement De Microbiologie et Infectiologie, Hôpital Notre Dame du Centre Hospitalier de l Université de Montréal, département de médecine familiale, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
J Infect Dis 199:965-73. 2009..This study was conducted to better understand the natural history of type-specific HPV infection in the anus... - Monocyte derivatives promote angiogenesis and myocyte survival in a model of myocardial infarctionM Bouchentouf
Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Cell Transplant 19:369-86. 2010..Transplanted MDs and their secretome participate in preserving functional myocardium after ischemic insult and attenuate pathological remodeling...