Affiliation: McGill University
Richard S, Vogel G, Huot M, Guo T, Muller W, Lukong K. Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis. Oncogene. 2008;27:548-56 pubmed
..These findings suggest that Sam68 may be a modulator of tyrosine kinase activity in vivo and a signaling requirement for mammary tumorigenesis and metastasis. ..
Calabretta S, Vogel G, Yu Z, Choquet K, Darbelli L, Nicholson T, et al
. Loss of PRMT5 Promotes PDGFR? Degradation during Oligodendrocyte Differentiation and Myelination. Dev Cell. 2018;46:426-440.e5 pubmed publisher
..More broadly, the inhibition of PRMT5 may be used therapeutically to manipulate PDGFR? bioavailability. ..
Calabretta S, Richard S. Emerging Roles of Disordered Sequences in RNA-Binding Proteins. Trends Biochem Sci. 2015;40:662-72 pubmed publisher
..Herein, we discuss the role of disordered sequences in RBPs, their function in RNPs and protein networks, as well as their regulation by post-translational modifications and how RBP deregulation leads to disease. ..
Li N, Richard S. Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor. Nucleic Acids Res. 2016;44:8726-8741 pubmed
..These findings define a hitherto novel mechanism of action for Sam68 in governing p53 transcriptional activation, and represent the first report of Sam68 in the regulation of tumor suppressor activities. ..
Blanc R, Vogel G, Chen T, Crist C, Richard S. PRMT7 Preserves Satellite Cell Regenerative Capacity. Cell Rep. 2016;14:1528-1539 pubmed publisher
..Restoration of DNMT3b in PRMT7-deficient cells rescues PRMT7-mediated senescence. Our findings define PRMT7 as a regulator of the DNMT3b/p21 axis required to maintain muscle stem cell regenerative capacity. ..
Neault M, Mallette F, Richard S. miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells. Cell Rep. 2016;14:1966-78 pubmed publisher
..These results suggest that modulating levels of miR-137 may be important for triggering tumor suppressor networks in pancreatic cancer. ..
Blanc R, Richard S. Arginine Methylation: The Coming of Age. Mol Cell. 2017;65:8-24 pubmed publisher
..This review describes the recent molecular advances that have been uncovered in normal and diseased mammalian cells. ..
Darbelli L, Choquet K, Richard S, Kleinman C. Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing. Sci Rep. 2017;7:7554 pubmed publisher
..These findings define QKI as regulators of alternative splicing in OLs including self-splicing. ..
Richard S, Morel M, Cleroux P. Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5 (PRMT5). Biochem J. 2005;388:379-86 pubmed