Elham Rahme

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Discrepancy among observational studies: example of naproxen-associated adverse events
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Canada
    Open Rheumatol J 3:1-8. 2009
  2. pmc Systematic review and meta-analysis of validation studies on a diabetes case definition from health administrative records
    Aaron Leong
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS ONE 8:e75256. 2013
  3. pmc Estimating the population prevalence of diagnosed and undiagnosed diabetes
    Aaron Leong
    Corresponding author Elham Rahme
    Diabetes Care 36:3002-8. 2013
  4. ncbi request reprint Mortality and readmission rates after hospitalization for upper and lower gastrointestinal events in Quebec, Canada
    Elham Rahme
    Department of Medicine, McGill University, Research Institute, McGill University Health Centre, Montreal, QC, Canada
    J Clin Gastroenterol 47:586-92. 2013
  5. doi request reprint Anticoagulant use in patients with cancer associated venous thromboembolism: a retrospective cohort study
    Elham Rahme
    McGill University Health Centre, Division of Clinical Epidemiology, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada H3A 1A1
    Thromb Res 131:210-7. 2013
  6. ncbi request reprint Concordance with guideline recommendations: previous and more recent nonsteroidal anti-inflammatory drug prescriptions in Quebec, Canada
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Quebec, Canada Research Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Pharmacoepidemiol Drug Saf 21:420-7. 2012
  7. pmc Association between frequent use of nonsteroidal anti-inflammatory drugs and breast cancer
    Elham Rahme
    Division of Clinical Epidemiology, McGill University Health Centre Research Institute, Montreal, Canada
    BMC Cancer 5:159. 2005
  8. ncbi request reprint Utilization and cost comparison of current and optimal prescribing of nonsteroidal antiinflammatory drugs in Quebec, Canada
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Rheumatol 33:588-96. 2006
  9. doi request reprint Use of nonsteroidal antiinflammatory drugs: is there a change in patient risk profile after withdrawal of rofecoxib?
    Elham Rahme
    Division of Clinical Epidemiology, McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec H3A 1A1
    J Rheumatol 38:195-202. 2011
  10. ncbi request reprint Therapy switching and associated costs in elderly patients receiving COX-2 selective inhibitors or non-selective non-steroidal anti-inflammatory drugs in Quebec, Canada
    E Rahme
    Division of Medicine, Montreal General Hospital, Suite L10 408, 1650 Cedar Ave Montreal, Quebec H3G 1A4, Canada
    Rheumatology (Oxford) 45:903-10. 2006

Detail Information

Publications94

  1. pmc Discrepancy among observational studies: example of naproxen-associated adverse events
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Canada
    Open Rheumatol J 3:1-8. 2009
    ..Observational studies assessing the cardiovascular adverse effect of naproxen have had conflicting results. It is not clear whether variation in population characteristics between studies may explain some of this discrepancy...
  2. pmc Systematic review and meta-analysis of validation studies on a diabetes case definition from health administrative records
    Aaron Leong
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS ONE 8:e75256. 2013
    ....
  3. pmc Estimating the population prevalence of diagnosed and undiagnosed diabetes
    Aaron Leong
    Corresponding author Elham Rahme
    Diabetes Care 36:3002-8. 2013
    ..We compared the test properties of an administrative definition with self-reported diabetes and estimated prevalence of undiagnosed diabetes by measuring glucose levels in mailed-in capillary blood samples...
  4. ncbi request reprint Mortality and readmission rates after hospitalization for upper and lower gastrointestinal events in Quebec, Canada
    Elham Rahme
    Department of Medicine, McGill University, Research Institute, McGill University Health Centre, Montreal, QC, Canada
    J Clin Gastroenterol 47:586-92. 2013
    ..We determined yearly rates of upper and lower gastrointestinal (GI) hospitalizations in Quebec, Canada and compared the 1-year readmission and mortality risks among those discharged from lower versus upper GI hospitalizations...
  5. doi request reprint Anticoagulant use in patients with cancer associated venous thromboembolism: a retrospective cohort study
    Elham Rahme
    McGill University Health Centre, Division of Clinical Epidemiology, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada H3A 1A1
    Thromb Res 131:210-7. 2013
    ....
  6. ncbi request reprint Concordance with guideline recommendations: previous and more recent nonsteroidal anti-inflammatory drug prescriptions in Quebec, Canada
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Quebec, Canada Research Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Pharmacoepidemiol Drug Saf 21:420-7. 2012
    ..We compared concordance of NSAID prescriptions with clinical practice guideline recommendations in Quebec, pre and post rofecoxib withdrawal from market...
  7. pmc Association between frequent use of nonsteroidal anti-inflammatory drugs and breast cancer
    Elham Rahme
    Division of Clinical Epidemiology, McGill University Health Centre Research Institute, Montreal, Canada
    BMC Cancer 5:159. 2005
    ..The cyclooxygenase (COX)-2 enzyme is expressed more in breast cancers than in normal breast tissue. COX-2 inhibition may have a role in breast cancer prevention...
  8. ncbi request reprint Utilization and cost comparison of current and optimal prescribing of nonsteroidal antiinflammatory drugs in Quebec, Canada
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Rheumatol 33:588-96. 2006
    ..We estimated the costs of cyclooxygenase-2 selective inhibitors, nsNSAID, and concurrent GPA prescribed in 2002 in Quebec, Canada, and compared these to estimated costs if prescribing followed guideline recommendations...
  9. doi request reprint Use of nonsteroidal antiinflammatory drugs: is there a change in patient risk profile after withdrawal of rofecoxib?
    Elham Rahme
    Division of Clinical Epidemiology, McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec H3A 1A1
    J Rheumatol 38:195-202. 2011
    ....
  10. ncbi request reprint Therapy switching and associated costs in elderly patients receiving COX-2 selective inhibitors or non-selective non-steroidal anti-inflammatory drugs in Quebec, Canada
    E Rahme
    Division of Medicine, Montreal General Hospital, Suite L10 408, 1650 Cedar Ave Montreal, Quebec H3G 1A4, Canada
    Rheumatology (Oxford) 45:903-10. 2006
    ..This study assessed drug switching and associated costs among elderly chronic NSAID users...
  11. ncbi request reprint Do proton-pump inhibitors confer additional gastrointestinal protection in patients given celecoxib?
    Elham Rahme
    McGill University, Research Institute of McGill University Health Center, Montreal, Canada
    Arthritis Rheum 57:748-55. 2007
    ..We assessed the association between GI hospitalizations and use of celecoxib with a PPI versus celecoxib alone, and NS-NSAIDs with a PPI or NS-NSAIDs alone in elderly patients...
  12. ncbi request reprint Association between nonnaproxen NSAIDs, COX-2 inhibitors and hospitalization for acute myocardial infarction among the elderly: a retrospective cohort study
    Elham Rahme
    Department of Medicine McGill University, and Research Institute, McGill University Health Center, Montreal, Canada
    Pharmacoepidemiol Drug Saf 16:493-503. 2007
    ..To evaluate the association between rofecoxib, celecoxib, diclofenac, and ibuprofen and the risk of hospitalization for acute myocardial infarction (AMI) in an elderly population...
  13. ncbi request reprint Hospitalization for gastrointestinal bleeding associated with non-steroidal anti-inflammatory drugs among elderly patients using low-dose aspirin: a retrospective cohort study
    E Rahme
    Division of Clinical Epidemiology, Montreal General Hospital L10 408, 1650 Cedar Ave, Montreal, Quebec H3G 1A4, Canada
    Rheumatology (Oxford) 46:265-72. 2007
    ..It is unclear, however, whether this fact holds good among patients taking ASA. We compared GI hospitalization rates among elderly patients taking celecoxib, NS-NSAIDs, celecoxib and ASA or NS-NSAIDs and ASA...
  14. ncbi request reprint Impact of a general practitioner educational intervention on osteoarthritis treatment in an elderly population
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Canada
    Am J Med 118:1262-70. 2005
    ..We examined whether a continuing medical education intervention increased general practitioners' ability to select the proper pharmacological treatment for patients with osteoarthritis...
  15. pmc Short-term mortality associated with failure to receive home care after hemiarthroplasty
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Que
    CMAJ 182:1421-6. 2010
    ..Such patients may benefit from home care after discharge. We assessed factors associated with the receipt of home care and evaluated the risk of death within three months after discharge...
  16. ncbi request reprint Treatment costs to prevent or treat upper gastrointestinal adverse events associated with NSAIDs
    Elham Rahme
    Department of Medicine, McGill University and Research Institute, McGill University Health Center, Montreal, Quebec, Canada
    Drug Saf 27:1019-42. 2004
    ..Thus, from an economic perspective, the healthcare system would benefit from treating patients at risk of NSAID gastropathy with COX-2 inhibitors, but not those at no to low risk...
  17. ncbi request reprint Retrospective analysis of utilization patterns and cost implications of coxibs among seniors in Quebec, Canada: what is the potential impact of the withdrawal of rofecoxib?
    Elham Rahme
    McGill University and Research Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Arthritis Rheum 55:27-34. 2006
    ....
  18. pmc Postdischarge thromboprophylaxis and mortality risk after hip-or knee-replacement surgery
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Que
    CMAJ 178:1545-54. 2008
    ..We sought to identify hospital and patient characteristics associated with receiving thromboprophylaxis after discharge and to compare the risk of short-term mortality among those who did or did not receive thromboprophylaxis...
  19. ncbi request reprint Association between naproxen use and protection against acute myocardial infarction
    Elham Rahme
    Division of Clinical Epidemiology, Montreal General Hospital, 1650 Cedar Ave, Room L10 408, Montreal, Quebec, Canada H3G 1A4
    Arch Intern Med 162:1111-5. 2002
    ..Nonsteroidal anti-inflammatory drugs vary in their antithrombotic properties, with naproxen having a particularly effective antithrombotic potential...
  20. ncbi request reprint Determinants and sequelae associated with utilization of acetaminophen versus traditional nonsteroidal antiinflammatory drugs in an elderly population
    Elham Rahme
    McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    Arthritis Rheum 46:3046-54. 2002
    ..This study was undertaken to compare the observed and adjusted rates of GI events (hospitalizations, ulcers, dyspepsia, GI prophylaxis) occurring with higher versus lower doses of acetaminophen...
  21. ncbi request reprint Use of NSAIDs, COX-2 inhibitors, and acetaminophen and associated coprescriptions of gastroprotective agents in an elderly population
    Elham Rahme
    McGill University and McGill University Health Center, Montreal, Quebec, Canada
    Arthritis Rheum 47:595-602. 2002
    ..To identify determinants of cyclooxygenase 2 (COX-2) inhibitor versus nonsteroidal antiinflammatory drug (NSAIDs) or acetaminophen prescription in seniors; and to compare gastroprotective agent coprescriptions...
  22. ncbi request reprint The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence
    Elham Rahme
    Division of Clinical Epidemiology, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
    Gastroenterology 125:404-12. 2003
    ....
  23. ncbi request reprint Hospitalization for gastrointestinal adverse events attributable to the use of low-dose aspirin among patients 50 years or older also using non-steroidal anti-inflammatory drugs: a retrospective cohort study
    E Rahme
    Department of Medicine, McGill University, Montreal, Canada
    Aliment Pharmacol Ther 26:1387-98. 2007
    ..Use of aspirin with non-steroidal anti-inflammatory drugs increases the risk of gastrointestinal ulcers; however, it is not clear if this risk varies with the non-steroidal anti-inflammatory drug used...
  24. ncbi request reprint Risks and benefits of COX-2 inhibitors vs non-selective NSAIDs: does their cardiovascular risk exceed their gastrointestinal benefit? A retrospective cohort study
    E Rahme
    Department of Medicine, McGill University Health Centre, Montreal, Quebec Canada
    Rheumatology (Oxford) 46:435-8. 2007
    ..We aimed to compare the risks of hospitalization for AMI and GI bleeding among elderly patients using COX-2 inhibitors, NS-NSAIDs and acetaminophen...
  25. ncbi request reprint Risks of suicide and poisoning among elderly patients prescribed selective serotonin reuptake inhibitors: a retrospective cohort study
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Clin Psychiatry 69:349-57. 2008
    ..Risks of suicide death and of poisoning were compared during periods of SSRI treatment versus periods without any antidepressant treatment among elderly patients...
  26. ncbi request reprint Effect of chronic intake of NSAIDs and cyclooxygenase 2-selective inhibitors on esophageal cancer incidence
    Marc Bardou
    Division of Gastroenterology, Department of Medicine, McGill University and McGill University Health Center, Montreal, Quebec, Canada
    Clin Gastroenterol Hepatol 2:880-7. 2004
    ..We investigated the effects of the selective cyclooxygenase 2 inhibitors (coxibs), rofecoxib and celecoxib, the nonselective nonsteroidal anti-inflammatory drugs (NSAIDs), and aspirin on esophageal cancer...
  27. pmc Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction
    Christopher Labos
    Department of Medicine, McGill University, Montreal, Que
    CMAJ 183:1835-43. 2011
    ..Use of either treatment may increase the risk of bleeding. We assessed the risk of bleeding among patients taking both medications following acute myocardial infarction...
  28. ncbi request reprint Risk of congestive heart failure with nonsteroidal antiinflammatory drugs and selective Cyclooxygenase 2 inhibitors: a class effect?
    Marie Hudson
    The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Arthritis Rheum 57:516-23. 2007
    ..Nonsteroidal antiinflammatory drugs (NSAIDs) as a class have been shown to increase the risk of congestive heart failure (CHF) compared with celecoxib. The magnitude of the risk for individual NSAIDs is not known...
  29. ncbi request reprint Warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation undergoing dialysis
    Mitesh Shah
    Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada M S, M A T, NE R, H B, L P _ Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA C A J Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada V E Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital McGill University, Montreal, Quebec, Canada M J E Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada K H H Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, Canada Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada J V T and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada H G
    Circulation 129:1196-203. 2014
    ..Current observational studies on warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation (AF) undergoing dialysis found conflicting results...
  30. ncbi request reprint Receiving guideline-concordant pharmacotherapy for major depression: impact on ambulatory and inpatient health service use
    Maida J Sewitch
    Department of Medicine, McGill University, Montreal, Quebec
    Can J Psychiatry 52:191-200. 2007
    ..This study aimed to determine the associations between guideline-concordant pharmacotherapy for depression and the use of health services in the year following diagnosis...
  31. ncbi request reprint Pharmacologic response to a diagnosis of late-life depression: A population study in Quebec
    Maida J Sewitch
    McGill University, Montreal, Quebec
    Can J Psychiatry 51:363-70. 2006
    ..To identify predictors of receiving psychoactive medication and receiving recommended first-line pharmacotherapy in individuals with newly diagnosed late-life depression...
  32. doi request reprint Sex differences in stroke risk among older patients with recently diagnosed atrial fibrillation
    Meytal Avgil Tsadok
    Division of Clinical Epidemiology, McGill University Health Center, Montreal, Quebec, Canada
    JAMA 307:1952-8. 2012
    ..Women with AF are at higher risk of stroke compared with men. Reasons for this higher stroke risk in women remain unclear, although some studies suggest that undertreatment with warfarin may be a cause...
  33. ncbi request reprint Cardiac medical therapy among patients undergoing abdominal aortic aneurysm repair
    David Kurzencwyg
    Division of Cardiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Ann Vasc Surg 20:569-76. 2006
    ..07, 95% CI 0.01-0.87, p = 0.04). Cardiac medical therapy among patients undergoing AAA repair is low throughout all periods of hospitalization. ACE inhibitor and ss-blocker use may be associated with decreased in-hospital mortality...
  34. ncbi request reprint An integrated approach to improving appropriate use of anti-inflammatory medication in the treatment of osteoarthritis in Québec (Canada): the CURATA model
    Martin Labelle
    Continuing Professional Development Office, Faculty of Medicine, Universite de Montreal, Quebec, Canada
    Med Teach 26:463-70. 2004
    ..Participants (n = 381) showed a mean 10.1% improvement in questionnaire score immediately following the workshop (15.2% improvement relative to mean pre-workshop score). Knowledge was maintained for three months post-workshop...
  35. pmc Magnitude of discordance between registry data and death certificate when evaluating leading causes of death in dialysis patients
    Jean Philippe Lafrance
    Centre de recherche Hôpital Maisonneuve Rosemont, Montreal, Canada
    BMC Med Res Methodol 13:51. 2013
    ....
  36. doi request reprint Rhythm versus rate control therapy and subsequent stroke or transient ischemic attack in patients with atrial fibrillation
    Meytal Avgil Tsadok
    MPH, McGill University Health Centre, 687 Pine Ave West, V Building, Montreal, Quebec, H3A 1A1 Canada
    Circulation 126:2680-7. 2012
    ....
  37. ncbi request reprint Hospital readmissions in children with congenital heart disease: a population-based study
    Andrew S Mackie
    McGill Adult Unit for Congenital Heart Disease Excellence MAUDE Unit, Montreal, Quebec, Canada
    Am Heart J 155:577-84. 2008
    ..We sought to determine rates and risk factors for hospital readmission within 1 month among children with CHD...
  38. ncbi request reprint Use of perioperative cardiac medical therapy among patients undergoing coronary artery bypass graft surgery
    Kristian B Filion
    Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Montreal, Quebec, Canada
    J Card Surg 23:209-15. 2008
    ..However, the use of these agents among patients undergoing coronary artery bypass graft (CABG) remains poorly understood...
  39. ncbi request reprint Survival bias associated with time-to-treatment initiation in drug effectiveness evaluation: a comparison of methods
    Zheng Zhou
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Am J Epidemiol 162:1016-23. 2005
    ..Method 5 used a time-dependent variable for treatment initiation. Methods 4 and 5 better controlled for survival bias and yielded similar results, suggesting a 20% risk reduction of recurrent myocardial infarction or death events...
  40. ncbi request reprint Health care resource utilization in adults with congenital heart disease
    Andrew S Mackie
    McGill Adult Unit for Congenital Heart Disease Excellence, Montreal, Quebec, Canada
    Am J Cardiol 99:839-43. 2007
    ..08, 95% CI 2.00 to 2.17). In conclusion, adults with CHD have high rates of health care resource utilization, particularly those with severe lesions. Appropriate resource allocation is required to serve this growing population...
  41. ncbi request reprint Renal failure after cardiac surgery: timing of cardiac catheterization and other perioperative risk factors
    Danny Del Duca
    Division of Cardiovascular Surgery, McGill University Health Centre, Montreal, Quebec, Canada
    Ann Thorac Surg 84:1264-71. 2007
    ..The relationship between the timing of preoperative cardiac catheterization and the incidence of postoperative renal failure has not been previously described...
  42. doi request reprint Hospitalizations for upper and lower GI events associated with traditional NSAIDs and acetaminophen among the elderly in Quebec, Canada
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Am J Gastroenterol 103:872-82. 2008
    ..Among users of these drugs, the concomitant use of proton pump inhibitors (PPIs) with tNSAIDs may reduce the risk of upper GI adverse events, but its effect on lower GI events is not clear...
  43. ncbi request reprint Cross-generational comparison of dispensed pharmacotherapy for depression
    Maida J Sewitch
    Department of Medicine, McGill University, Montreal, Canada
    Int J Health Care Qual Assur 22:300-12. 2009
    ..The purpose of this paper is to compare predictors of receipt of recommended first-line pharmacotherapy in three generational cohorts of patients with new episode depression...
  44. ncbi request reprint Association between nonsteroidal anti-inflammatory drugs and prostate cancer occurrence
    Kaberi Dasgupta
    Research Institute, Department of Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada
    Cancer J 12:130-5. 2006
    ..We evaluated the association between frequent use of nonsteroidal anti-inflammatory drugs and prostate cancer occurrence...
  45. ncbi request reprint Impact of modified glucose target and exercise interventions on vascular risk factors
    Kaberi Dasgupta
    McGill University, Montreal, Canada
    Diabetes Res Clin Pract 72:53-60. 2006
    ..T2D patients who consistently participate in supervised exercise programs may experience modest weight loss and significant improvements in fitness and blood pressure...
  46. pmc Association of dialysis modality with risk for infection-related hospitalization: a propensity score-matched cohort analysis
    Jean Philippe Lafrance
    Centre de recherche Hôpital Maisonneuve Rosemont, Montreal, Quebec, Canada
    Clin J Am Soc Nephrol 7:1598-605. 2012
    ..Whether patients undergoing PD have higher risk than HD patients for infection-related hospitalizations (IRH) remains unknown...
  47. ncbi request reprint Pharmacologic response to depressive disorders among adolescents
    Maida J Sewitch
    Department of Medicine of McGill University and the Research Institute of McGill University Health Center, 1650 Cedar Avenue, Room L10 409, Division of Clinical Epidemiology, Montreal, Quebec, Canada H3G 1A4
    Psychiatr Serv 56:1089-97. 2005
    ..The purpose of this study was to identify determinants of use of psychoactive medication and receipt of selective serotonin reuptake inhibitors (SSRIs) among adolescents with a diagnosis of new-onset depression...
  48. ncbi request reprint Ibuprofen may abrogate the benefits of aspirin when used for secondary prevention of myocardial infarction
    Marie Hudson
    Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada
    J Rheumatol 32:1589-93. 2005
    ..To determine whether patients taking aspirin for secondary prevention of myocardial infarction are at increased risk of recurrent disease when they take concomitant ibuprofen...
  49. pmc Amiodarone-induced thyroid dysfunction: brand-name versus generic formulations
    Meytal A Tsadok
    Division of Internal Medicine, McGill University Health Center, Montreal, Que
    CMAJ 183:E817-23. 2011
    ..We evaluated and compared the risk of thyroid dysfunction between patients using brand-name versus generic formulations of amiodarone and identified risk factors for thyroid dysfunction...
  50. ncbi request reprint CURATA: A patient health management program for the treatment of osteoarthritis in Québec: an integrated approach to improving the appropriate utilization of anti-inflammatory/analgesic medications
    Michele Beaulieu
    Merck Frosst Canada Ltd, Kirkland, Quebec, Canada
    Am J Manag Care 10:569-75. 2004
    ..To identify gaps in current osteoarthritis (OA) care in Quebec, Canada, and to implement and evaluate interventions to promote appropriate use of evidence-based medicine...
  51. ncbi request reprint Comparison of measures of medication persistency using a prescription drug database
    Marie Hudson
    Division of Clinical Epidemiology, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada
    Am Heart J 153:59-65. 2007
    ..We undertook a study of persistency to statins using various definitions to compare the results obtained with the different definitions...
  52. doi request reprint Vascular access-related bloodstream infections in First Nations, community and teaching Canadian dialysis units, and other centre-level predictors
    Jean Philippe Lafrance
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    Nephron Clin Pract 114:c204-12. 2010
    ..The aims of this study were to describe the incidence rates and assess the variability in BSI risk between dialysis centre types and other centre-level variables...
  53. ncbi request reprint Are statins created equal? Evidence from randomized trials of pravastatin, simvastatin, and atorvastatin for cardiovascular disease prevention
    Zheng Zhou
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Am Heart J 151:273-81. 2006
    ..The relative efficacy of different statins for long-term cardiovascular prevention remains largely undetermined...
  54. doi request reprint Timing of umbilical cord-clamping and infant anaemia: the role of maternal anaemia
    Brittany Blouin
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    Paediatr Int Child Health 33:79-85. 2013
    ..Evidence from randomized controlled trials has shown that delayed cord-clamping is beneficial to infant iron status. The role of maternal anaemia in this relationship, however, has not been established...
  55. doi request reprint Use of negative extrathoracic pressure to improve hemodynamics after cardiac surgery
    Rakesh K Chaturvedi
    Division of Cardiac Surgery, Royal Victoria Hospital, Montreal, Quebec, Canada
    Ann Thorac Surg 85:1355-60. 2008
    ..We hypothesized that positive pressure ventilation with continual negative pressure applied to the chest through a cuirass would increase cardiac output in coronary artery bypass graft patients immediately after surgery...
  56. ncbi request reprint Sex differences in the effectiveness of angiotensin receptor blockers and angiotensin converting enzyme inhibitors in patients with congestive heart failure--a population study
    Marie Hudson
    Division of Clinical Epidemiology, The Research Institute of the McGill University Health Centre, 1650 Cedar Ave, Montreal, QC, Canada
    Eur J Heart Fail 9:602-9. 2007
    ..We wish to determine whether there are sex-related differences in the optimal treatment of congestive heart failure...
  57. pmc Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarction: an evaluation of class effect
    Zheng Zhou
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Que
    CMAJ 172:1187-94. 2005
    ..However, it is unclear whether different statins exert a similar effect in reducing the incidence of recurrent AMI and death when used in clinical practice...
  58. ncbi request reprint High rubella seronegativity in daycare educators
    Theresa W Gyorkos
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Clin Invest Med 28:105-11. 2005
    ..The purpose of the study was to generate new evidence on the magnitude of rubella seronegativity and associated risk factors in daycare centre educators...
  59. ncbi request reprint Congenital heart disease in the general population: changing prevalence and age distribution
    Ariane J Marelli
    McGill Adult Unit for Congenital Heart Disease, McGill University Health Center, 1650 Cedar Ave, Montreal, Quebec, Canada H3G 1A4
    Circulation 115:163-72. 2007
    ..We determined the prevalence, age distribution, and proportion of adults and children with severe and other forms of CHD in the general population from 1985 to 2000...
  60. ncbi request reprint Association between time of statin initiation after hospital discharge from acute myocardial infarction and risk of recurrence and mortality in patients > or =65 years of age
    Zheng Zhou
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Am J Cardiol 97:155-9. 2006
    ..In conclusion, delay of statin initiation up to 30 to 90 days after discharge after AMI does not appear to lead to a difference in the rates of recurrent AMI and mortality compared with statin initiation at discharge...
  61. doi request reprint Endoscopic hemostasis in peptic ulcer bleeding for patients with high-risk lesions: a series of meta-analyses
    Alan N Barkun
    Divisions of Gastroenterology, The McGill University Health Centre, Montreal General Hospital Site, Montreal, Quebec, Canada
    Gastrointest Endosc 69:786-99. 2009
    ..Optimal endoscopic hemostasis remains undetermined. This was a systematic review of contemporary methods of endoscopic hemostasis for patients with bleeding ulcers that exhibited high-risk stigmata...
  62. ncbi request reprint The Canadian Registry on Nonvariceal Upper Gastrointestinal Bleeding and Endoscopy (RUGBE): Endoscopic hemostasis and proton pump inhibition are associated with improved outcomes in a real-life setting
    Alan Barkun
    Department of Medicine, Division of Gastroenterology, McGill University, Montreal, Canada
    Am J Gastroenterol 99:1238-46. 2004
    ..From the Canadian Registry of patients with Upper Gastrointestinal Bleeding and Endoscopy (RUGBE), we determined clinical outcomes and explored the roles of endoscopic and pharmacologic therapies in a contemporary real-life setting...
  63. doi request reprint Observational studies of infections in rheumatoid arthritis: a metaanalysis of tumor necrosis factor antagonists
    Sasha Bernatsky
    Division of Clinical Epidemiology, Department of Medicine, and The Research Institute, McGill University Health Centre, Montreal, Quebec, Canada
    J Rheumatol 37:928-31. 2010
    ..We performed a systematic review and synthesis of observational studies of TNF antagonists and infection risk...
  64. pmc Long-term prognosis of south Asians following acute coronary syndromes
    Ramya Raghavan
    Division of Cardiology, McGill University Health Centre, Montreal, Canada
    Can J Cardiol 24:585-7. 2008
    ..South Asians (SAs) have a higher prevalence of coronary artery disease than Caucasians. The long-term prognosis following acute coronary syndromes (ACS) in SA compared with non-SA patients is unclear...
  65. doi request reprint Acute exercise-induced glucose change during an exercise program in type 2 diabetes
    Ngan Hien Nguyen
    Division of Clinical Epidemiology, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Cardiopulm Rehabil Prev 28:122-7. 2008
    ..We hypothesized that during the course of the program, glucose levels during exercise would become more stable, as insulin sensitivity improved. Among adults with type 2 diabetes, glucose levels often decline acutely during exercise...
  66. doi request reprint Clostridium difficile colitis: increasing incidence, risk factors, and outcomes in solid organ transplant recipients
    Marylise Boutros
    Division of General Surgery, Department of Surgery, McGill University Health Centre, Montreal, Quebec, Canada
    Transplantation 93:1051-7. 2012
    ..We describe the incidence, risk factors, and outcomes of colectomy for CDAD after solid organ transplantation...
  67. ncbi request reprint Mortality rates in elderly patients who take different angiotensin-converting enzyme inhibitors after acute myocardial infarction: a class effect?
    Louise Pilote
    The Montreal General Hospital, Jewish General Hospital, and McGill University, Montreal, Quebec, Canada
    Ann Intern Med 141:102-12. 2004
    ..However, existing data from trials do not address whether all ACE inhibitors benefit patients similarly...
  68. doi request reprint A comparison of low birth weight among newborns of early adolescents, late adolescents, and adult mothers in the Peruvian Amazon
    Julia A Ryan
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada
    Matern Child Health J 15:587-96. 2011
    ..Future research on LBW and possibly other adverse birth outcomes should consider early adolescents as a separate sub-group of higher risk...
  69. ncbi request reprint Robustness of prevalence estimates derived from misclassified data from administrative databases
    Martin Ladouceur
    Division of Clinical Epidemiology, Montreal General Hospital, 687 Pine Avenue West, V Building, Montreal, Quebec H3A 1A1, Canada
    Biometrics 63:272-9. 2007
    ..We conclude that any inferences from these databases need to be interpreted with great caution, until further work estimating the reliability of database items is carried out...
  70. ncbi request reprint Vascular access-related infections: definitions, incidence rates, and risk factors
    Jean Philippe Lafrance
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada
    Am J Kidney Dis 52:982-93. 2008
    ..Better understanding of the risk factors for vascular access-related infections may inform efficacious prevention strategies and lead to early detection of infections and improved patient care...
  71. doi request reprint Modeling continuous diagnostic test data using approximate Dirichlet process distributions
    Martin Ladouceur
    Department of Epidemiology and Biostatistics, McGill University, 1020 Pine Avenue West, Montreal, Quebec, H3A 1A2, Canada
    Stat Med 30:2648-62. 2011
    ....
  72. ncbi request reprint Modifiable factors predicting patient survival in elderly kidney transplant recipients
    Heloise Cardinal
    Nephrology Department, Centre Hospitalier de l Universite de Montreal, Universite de Montreal, Montreal, Quebec, Canada
    Kidney Int 68:345-51. 2005
    ..Elderly transplant candidates represent an increasingly important group on the waiting list for kidney transplantation. Yet the factors that determine posttransplantation outcomes in this population remain poorly defined...
  73. ncbi request reprint Non-Hodgkin's lymphoma--meta-analyses of the effects of corticosteroids and non-steroidal anti-inflammatories
    S Bernatsky
    Division of Clinical Epidemiology, McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec H3A 1A1, Canada
    Rheumatology (Oxford) 46:690-4. 2007
    ..We conducted meta-analyses of data published to date, to ascertain the over-all association between NHL and corticosteroid use, and between NHL and NSAID use...
  74. ncbi request reprint Effectiveness of antiresorptive agents in the prevention of recurrent hip fractures
    S Morin
    Division of Internal Medicine, McGill University Health Center MUHC, 1650 Cedar Ave, Room B2 118, Montreal, QC, H3G 1A4, Canada
    Osteoporos Int 18:1625-32. 2007
    ..Hip fracture is associated with recurrent fractures and increased mortality. The results of our retrospective cohort study support the use of antiresorptive agents to prevent recurrent hip fractures in this population...
  75. ncbi request reprint Perioperative use of cardiac medical therapy among patients undergoing coronary artery bypass graft surgery: a systematic review
    Kristian B Filion
    Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am Heart J 154:407-14. 2007
    ..The use of perioperative cardiac medical therapy among patients undergoing coronary artery bypass graft surgery (CABG) has not been closely examined...
  76. ncbi request reprint A double-blind randomized controlled trial of antenatal mebendazole to reduce low birthweight in a hookworm-endemic area of Peru
    Renee Larocque
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
    Trop Med Int Health 11:1485-95. 2006
    ..To assess the effect on birthweight of antenatal mebendazole plus iron vs. placebo plus iron in a highly hookworm-endemic area...
  77. ncbi request reprint Sulfonylurea use associated with reduction in blood glucose levels during exercise stress testing
    Kaberi Dasgupta
    McGill University, Montreal, Quebec, Canada
    J Cardiopulm Rehabil 25:222-5. 2005
  78. ncbi request reprint Hepatitis A seroprevalence and risk factors among day-care educators
    Cristin J Muecke
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Que
    Clin Invest Med 27:259-64. 2004
    ..To determine the seroprevalence of previous HAV infection among day-care educators and to identify potential risk factors, we undertook a survey...
  79. ncbi request reprint Impact of a cost sharing drug insurance plan on drug utilization among individuals receiving social assistance
    Lucie Blais
    Faculte de Pharmacie, Centre de Recherche, Hôtel Dieu du Centre hospitalier de l Université de Montréal CHUM, C P 6128, Succursale Centre Ville, Quebec, H3C 3J7, Montreal, Canada
    Health Policy 64:163-72. 2003
    ..A cost-sharing drug insurance plan has been implemented among people receiving social assistance who had previously free access to medications...
  80. ncbi request reprint Bayesian sample size determination for prevalence and diagnostic test studies in the absence of a gold standard test
    Nandini Dendukuri
    Department of Epidemiology and Biostatistics, 1020 Pine Avenue West, McGill University, Montreal, Quebec H3A 1A2, Canada
    Biometrics 60:388-97. 2004
    ..Although smaller sample sizes are often found in the two-test situation, they can still be prohibitively large unless accurate information is available about the sensitivities and specificities of the tests being used...
  81. pmc Age-related differences in in-hospital mortality and the use of thrombolytic therapy for acute myocardial infarction
    J M Boucher
    , , , Montreal, Que
    CMAJ 164:1285-90. 2001
    ..INTERPRETATION: Age is an important independent predictor of in-hospital mortality and lower thrombolytic use following AMI. Other studies are required to further evaluate the appropriateness of thrombolytic therapy for elderly patients...
  82. ncbi request reprint Gastrointestinal-related healthcare resource usage associated with a fixed combination of diclofenac and misoprostol versus other NSAIDs
    E Rahme
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Pharmacoeconomics 19:577-88. 2001
    ..15 (95% confidence interval: 0.89, 1.48). CONCLUSIONS: Our data showed no significant differences in GI HCRU among patients taking diclofenac/misoprostol compared with those taking NSAIDs...
  83. pmc Cost of prescribed NSAID-related gastrointestinal adverse events in elderly patients
    E Rahme
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
    Br J Clin Pharmacol 52:185-92. 2001
    ..CONCLUSIONS: Approximately one Canadian dollar was added to patient costs for every day he/she was on NSAID therapy. Safer therapies and appropriate patient risk management may potentially reduce NSAID-related health care resource use...
  84. ncbi request reprint The safety of endoscopic sphincterotomy in patients receiving antiplatelet agents: a case-control study
    N Hussain
    Division of Gastroenterology, McGill University, Montreal, Quebec, Canada
    Aliment Pharmacol Ther 25:579-84. 2007
    ..To determine whether antiplatelet agents are associated with endoscopic sphincterotomy-related haemorrhage as few well-controlled data exist on this controversial issue...
  85. ncbi request reprint Impact of a cost-sharing drug insurance plan on drug utilization among older people
    L Blais
    , Quebec, Canada
    J Am Geriatr Soc 49:410-4. 2001
    ....
  86. ncbi request reprint Does diabetes increase the risk for fractures after solid organ transplantation? A nested case-control study
    Agnès Rakel
    Pharmacoepidemiology and Pharmacoeconomics Research Unit, CHUM Hotel Dieu, Montreal, Quebec, Canada
    J Bone Miner Res 22:1878-84. 2007
    ..Pretransplant diabetes was associated with a 2-fold increase in post-transplant fractures...
  87. pmc Seroprevalence of parvovirus B19 infection in daycare educators
    N L Gilbert
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
    Epidemiol Infect 133:299-304. 2005
    ..Because of the large proportion of educators susceptible to acquiring parvovirus B19 infection, our findings also highlight the need for preventive measures...
  88. ncbi request reprint Osteoporosis among patients with type 1 and type 2 diabetes
    A Rakel
    Research Group in Pharmacoepidemiology and Pharmacoeconomics, Research Centre, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, 3850, Rue st urbain, H2W 1T7, Montreal, Quebec, Canada
    Diabetes Metab 34:193-205. 2008
    ..The extent of diagnostic and therapeutic interventions should be based on the individual's risk profile for fractures...
  89. ncbi request reprint Increase in nonfatal digestive perforations and haemorrhages following introduction of selective NSAIDs: a public health concern
    Douglas J Watson
    Drug Saf 30:89-90; author reply 90-1. 2007
  90. ncbi request reprint Integrating clinical practice guidelines into daily practice: impact of an interactive workshop on drafting of a written action plan for asthma patients
    Martin Labelle
    Faculty of Medicine, Universite de Montreal, Montreal, Quebec
    J Contin Educ Health Prof 24:39-49. 2004
    ..An interactive, case-based workshop for asthma, combined with an objective structured clinical examination (OSCE), was developed to increase GPs' knowledge and use of WAPs in Québec...
  91. ncbi request reprint The effects of coxib formulary restrictions on analgesic use and cost: regional evidence from Canada
    Deborah A Marshall
    Centre for Evaluation of Medicines, 105 Main Street East, Level P1, Hamilton, ON L8N 1G6, Canada
    Health Policy 84:1-13. 2007
    ..Ontario required physicians to submit the clinical indications for their use on the prescription. British Columbia required physicians to seek and receive prior authorisation from the drug plan...
  92. ncbi request reprint Parasite and maternal risk factors for malnutrition in preschool-age children in Belen, Peru using the new WHO Child Growth Standards
    Martin Casapia
    Asociación Civil Selva Amazónica, Urbanización Jardin 27, Iquitos, Peru
    Br J Nutr 98:1259-66. 2007
    ..Based on these data, locally appropriate and cost-effective dietary, de-worming and educational programmes should be targeted to mothers and preschool-age children...
  93. ncbi request reprint Risk factors for cytomegalovirus seropositivity in a population of day care educators in Montréal, Canada
    Serene A Joseph
    Community Health, Dalhousie University, Halifax, Nova Scotia, Canada
    Occup Med (Lond) 55:564-7. 2005
    ..Horizontal transmission of cytomegalovirus (CMV) is common in the day care setting. Day care educators appear to be at a high risk of infection; however, studies are limited...
  94. ncbi request reprint Parasite risk factors for stunting in grade 5 students in a community of extreme poverty in Peru
    Martin Casapia
    Asociación Civil Selva Amazónica, Iquitos, Peru
    Int J Parasitol 36:741-7. 2006
    ....