S Pyronnet

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1
    S Pyronnet
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Biochem Pharmacol 60:1237-43. 2000
  2. ncbi Suppression of cap-dependent translation in mitosis
    S Pyronnet
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Genes Dev 15:2083-93. 2001
  3. ncbi Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities
    K Khaleghpour
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 19:4302-10. 1999
  4. ncbi Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
    S Pyronnet
    Department of Biochemistry and McGill Cancer Cancer Center, McGill University, 3655 Drummond Street, Montreal, Quebec, H3G 1Y6 Canada
    EMBO J 18:270-9. 1999
  5. ncbi The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure
    Y V Svitkin
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    RNA 7:382-94. 2001
  6. ncbi Regulation of SOCS-1 expression by translational repression
    A Gregorieff
    McGill Cancer Centre and the Departments of Biochemistry, Oncology, and Medicine, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 275:21596-604. 2000

Collaborators

Detail Information

Publications6

  1. ncbi Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1
    S Pyronnet
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Biochem Pharmacol 60:1237-43. 2000
    ..Consequently, control of eIF4E phosphorylation may not strictly depend on changes in Mnk1 activity. The possibility that integrity of the eIF4E/eIF4G/Mnk1 complex also impinges upon eIF4E phosphorylation is discussed...
  2. ncbi Suppression of cap-dependent translation in mitosis
    S Pyronnet
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Genes Dev 15:2083-93. 2001
    ..Thus, inhibition of cap-dependent translation in mitosis results from a combination of phosphorylation modifications leading to eIF4F complex disruption...
  3. ncbi Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities
    K Khaleghpour
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 19:4302-10. 1999
    ..We conclude that eIF4E engenders a negative feedback loop that targets a component of the PI 3-kinase signalling pathway which lies downstream of PI 3-kinase...
  4. ncbi Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
    S Pyronnet
    Department of Biochemistry and McGill Cancer Cancer Center, McGill University, 3655 Drummond Street, Montreal, Quebec, H3G 1Y6 Canada
    EMBO J 18:270-9. 1999
    ..We also show that Mnk1 interacts with the C-terminal region of the translational inhibitor p97, an eIF4G-related protein that does not bind eIF4E, raising the possibility that p97 can block phosphorylation of eIF4E by sequestering Mnk1...
  5. ncbi The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure
    Y V Svitkin
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    RNA 7:382-94. 2001
    ..Finally, the elF4A mutant forms a more stable complex with elF4G, as compared to the wild-type elF4A, thus explaining the mechanism by which substoichiometric amounts of mutant elF4A inhibit translation...
  6. ncbi Regulation of SOCS-1 expression by translational repression
    A Gregorieff
    McGill Cancer Centre and the Departments of Biochemistry, Oncology, and Medicine, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 275:21596-604. 2000
    ..Moreover, coupled with previous findings, they suggest that SOCS expression is tightly regulated through multiple mechanisms, in order to avoid inappropriate interference with cytokine-mediated effects...