Genomes and Genes
Affiliation: McGill University
- Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1S Pyronnet
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Biochem Pharmacol 60:1237-43. 2000..Consequently, control of eIF4E phosphorylation may not strictly depend on changes in Mnk1 activity. The possibility that integrity of the eIF4E/eIF4G/Mnk1 complex also impinges upon eIF4E phosphorylation is discussed...
- Suppression of cap-dependent translation in mitosisS Pyronnet
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
Genes Dev 15:2083-93. 2001..Thus, inhibition of cap-dependent translation in mitosis results from a combination of phosphorylation modifications leading to eIF4F complex disruption...
- Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activitiesK Khaleghpour
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada H3G 1Y6
Mol Cell Biol 19:4302-10. 1999..We conclude that eIF4E engenders a negative feedback loop that targets a component of the PI 3-kinase signalling pathway which lies downstream of PI 3-kinase...
- Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4ES Pyronnet
Department of Biochemistry and McGill Cancer Cancer Center, McGill University, 3655 Drummond Street, Montreal, Quebec, H3G 1Y6 Canada
EMBO J 18:270-9. 1999..We also show that Mnk1 interacts with the C-terminal region of the translational inhibitor p97, an eIF4G-related protein that does not bind eIF4E, raising the possibility that p97 can block phosphorylation of eIF4E by sequestering Mnk1...
- The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structureY V Svitkin
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
RNA 7:382-94. 2001..Finally, the elF4A mutant forms a more stable complex with elF4G, as compared to the wild-type elF4A, thus explaining the mechanism by which substoichiometric amounts of mutant elF4A inhibit translation...
- Regulation of SOCS-1 expression by translational repressionA Gregorieff
McGill Cancer Centre and the Departments of Biochemistry, Oncology, and Medicine, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 275:21596-604. 2000..Moreover, coupled with previous findings, they suggest that SOCS expression is tightly regulated through multiple mechanisms, in order to avoid inappropriate interference with cytokine-mediated effects...