Jens C Pruessner

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc The combined dexamethasone/TSST paradigm--a new method for psychoneuroendocrinology
    Julie Andrews
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e38994. 2012
  2. pmc The combined propranolol/TSST paradigm--a new method for psychoneuroendocrinology
    Julie Andrews
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e57567. 2013
  3. ncbi request reprint Deactivation of the limbic system during acute psychosocial stress: evidence from positron emission tomography and functional magnetic resonance imaging studies
    Jens C Pruessner
    Center for Studies on Human Stress, Douglas Hospital Research Center and Montreal Neurological Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 63:234-40. 2008
  4. doi request reprint Decreased cortical representation of genital somatosensory field after childhood sexual abuse
    Christine M Heim
    Institute of Medical Psychology, Charite University Medicine Berlin, Germany
    Am J Psychiatry 170:616-23. 2013
  5. doi request reprint Stress regulation in the central nervous system: evidence from structural and functional neuroimaging studies in human populations - 2008 Curt Richter Award Winner
    Jens C Pruessner
    Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Psychoneuroendocrinology 35:179-91. 2010
  6. doi request reprint Investigating the association between early life parental care and stress responsivity in adulthood
    Veronika Engert
    Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Dev Neuropsychol 35:570-81. 2010
  7. ncbi request reprint Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood
    Jens C Pruessner
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada
    Neuroimage 28:815-26. 2005
  8. pmc Perceived early-life maternal care and the cortisol response to repeated psychosocial stress
    Veronika Engert
    Department of Psychiatry, Douglas Mental Health University Institute, Montreal, QC
    J Psychiatry Neurosci 35:370-7. 2010
  9. doi request reprint Neural correlates of processing stressful information: an event-related fMRI study
    Katarina Dedovic
    Douglas Mental Health University Institute, Montreal, Canada
    Brain Res 1293:49-60. 2009
  10. doi request reprint Hippocampal activation during a cognitive task is associated with subsequent neuroendocrine and cognitive responses to psychological stress
    Najmeh Khalili-Mahani
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Hippocampus 20:323-34. 2010

Detail Information

Publications52

  1. pmc The combined dexamethasone/TSST paradigm--a new method for psychoneuroendocrinology
    Julie Andrews
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e38994. 2012
    ..Therefore, we propose this paradigm as a new method to investigate the interaction of the two major stress systems in the regulation of the stress response...
  2. pmc The combined propranolol/TSST paradigm--a new method for psychoneuroendocrinology
    Julie Andrews
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e57567. 2013
    ..The HPA activity was found to be elevated in the presence of a suppressed SNS in reactivity to the TSST...
  3. ncbi request reprint Deactivation of the limbic system during acute psychosocial stress: evidence from positron emission tomography and functional magnetic resonance imaging studies
    Jens C Pruessner
    Center for Studies on Human Stress, Douglas Hospital Research Center and Montreal Neurological Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 63:234-40. 2008
    ..Newly developed paradigms to investigate stress in neuroimaging environments allow the assessment of brain activation changes in association with the perception of and the metabolic response to stress...
  4. doi request reprint Decreased cortical representation of genital somatosensory field after childhood sexual abuse
    Christine M Heim
    Institute of Medical Psychology, Charite University Medicine Berlin, Germany
    Am J Psychiatry 170:616-23. 2013
    ..The authors evaluated the relationship between the experience of childhood abuse and neuroplastic thinning of cortical fields, depending on the nature of the abusive experience...
  5. doi request reprint Stress regulation in the central nervous system: evidence from structural and functional neuroimaging studies in human populations - 2008 Curt Richter Award Winner
    Jens C Pruessner
    Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Psychoneuroendocrinology 35:179-91. 2010
    ..Taken together, the use of neuroimaging techniques in Psychoneuroendocrinology opens exciting new possibilities for the investigation of stress effects in the central nervous system...
  6. doi request reprint Investigating the association between early life parental care and stress responsivity in adulthood
    Veronika Engert
    Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Dev Neuropsychol 35:570-81. 2010
    ..Results supported the two-mediator model. We propose that early life parental care impacts on an individual's developing brain and personality, which consequently contribute to the shaping of neuroendocrine stress responsivity...
  7. ncbi request reprint Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood
    Jens C Pruessner
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada
    Neuroimage 28:815-26. 2005
    ....
  8. pmc Perceived early-life maternal care and the cortisol response to repeated psychosocial stress
    Veronika Engert
    Department of Psychiatry, Douglas Mental Health University Institute, Montreal, QC
    J Psychiatry Neurosci 35:370-7. 2010
    ..In our own previous studies, we have shown how variations in early-life parental care influence the development of the hippocampus and modify the cortisol awakening response...
  9. doi request reprint Neural correlates of processing stressful information: an event-related fMRI study
    Katarina Dedovic
    Douglas Mental Health University Institute, Montreal, Canada
    Brain Res 1293:49-60. 2009
    ..This is the first study to use an event-related paradigm to investigate brain activity patterns in relation to challenging math and social evaluative threat separately...
  10. doi request reprint Hippocampal activation during a cognitive task is associated with subsequent neuroendocrine and cognitive responses to psychological stress
    Najmeh Khalili-Mahani
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Hippocampus 20:323-34. 2010
    ....
  11. doi request reprint Cortisol awakening response and hippocampal volume: vulnerability for major depressive disorder?
    Katarina Dedovic
    Douglas Mental Health University Institute, McGill University, Montreal, Canada
    Biol Psychiatry 68:847-53. 2010
    ....
  12. ncbi request reprint The associations among hippocampal volume, cortisol reactivity, and memory performance in healthy young men
    Marita Pruessner
    Prevention and Early Intervention Program for Psychoses, Douglas Hospital Research Center, 6875 Boulevard LaSalle, Verdun, Montreal, Quebec, Canada H4H 1R3
    Psychiatry Res 155:1-10. 2007
    ....
  13. doi request reprint Attenuated cortisol response to acute psychosocial stress in individuals at ultra-high risk for psychosis
    Marita Pruessner
    Prevention and Early Intervention Program for Psychoses, PEPP Montreal, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Schizophr Res 146:79-86. 2013
    ..Associated poor metabolic and psychological adjustment to stress might increase vulnerability for the development of psychosis...
  14. doi request reprint The salivary alpha amylase over cortisol ratio as a marker to assess dysregulations of the stress systems
    Nida Ali
    Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
    Physiol Behav 106:65-72. 2012
    ..The usefulness of this marker for other chronic stress states as found in allostatic load is discussed...
  15. ncbi request reprint Comprehensive dissection of the medial temporal lobe in AD: measurement of hippocampus, amygdala, entorhinal, perirhinal and parahippocampal cortices using MRI
    Stefan J Teipel
    Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    J Neurol 253:794-800. 2006
    ..Early pathological involvement of specific medial temporal lobe areas is characteristic for Alzheimer's disease (AD)...
  16. doi request reprint A clinical allostatic load index is associated with burnout symptoms and hypocortisolemic profiles in healthy workers
    Robert Paul Juster
    Centre for Studies on Human Stress, Fernand Seguin Research Centre, University of Montreal, Montreal, Canada
    Psychoneuroendocrinology 36:797-805. 2011
    ..These findings provide preliminary support for the utility of a new clinical AL index that is sensitive to physiological recalibrations intermittently observed in burnout research...
  17. pmc The Montreal Imaging Stress Task: using functional imaging to investigate the effects of perceiving and processing psychosocial stress in the human brain
    Katarina Dedovic
    Douglas Hospital Research Centre, Borough of Verdun, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Psychiatry Neurosci 30:319-25. 2005
    ..We developed a protocol for inducing moderate psychologic stress in a functional imaging setting and evaluated the effects of stress on physiology and brain activation...
  18. ncbi request reprint Effects of manipulating the amount of social-evaluative threat on the cortisol stress response in young healthy men
    Julie Andrews
    Centre for Studies on Human Stress, Douglas Mental Health Institute, McGill University, Montreal, PQ, Canada
    Behav Neurosci 121:871-6. 2007
    ..Future studies should include women and try to define the possible threshold to activate the HPA axis...
  19. doi request reprint Blunted cortisol awakening response in men with first episode psychosis: relationship to parental bonding
    Marita Pruessner
    Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Psychoneuroendocrinology 38:229-40. 2013
    ..Dysregulation of the HPA axis in male patients might be a consequence of non-optimal parenting and contribute to the less favorable course of psychosis in men compared to women...
  20. doi request reprint Increased cortisol awakening response and afternoon/evening cortisol output in healthy young adults with low early life parental care
    Veronika Engert
    Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
    Psychopharmacology (Berl) 214:261-8. 2011
    ..Growing evidence from animal and human studies suggests a profound and long-lasting influence of early life experiences--ranging from variations in parenting behavior to severe adversity--on hypothalamic-pituitary-adrenal axis function...
  21. doi request reprint Differentiating anticipatory from reactive cortisol responses to psychosocial stress
    Veronika Engert
    Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
    Psychoneuroendocrinology 38:1328-37. 2013
    ..Future studies will have to determine whether the anticipatory responders differ with respect to various stress-sensitive parameters like sex, personality, psychological wellbeing or chronic stress...
  22. doi request reprint β-Adrenergic blockade during reactivation reduces the subjective feeling of remembering associated with emotional episodic memories
    Lars Schwabe
    Douglas Mental Health Institute and Department of Psychiatry, McGill University, Montreal, QC H3A 1A1, Canada
    Biol Psychol 92:227-32. 2013
    ....
  23. doi request reprint Investigation into the cross-correlation of salivary cortisol and alpha-amylase responses to psychological stress
    Veronika Engert
    Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
    Psychoneuroendocrinology 36:1294-302. 2011
    ..As a possible connection site between HPA axis and SNS that may underlie sAA-cortisol associations, we discuss CRF neurons of the hypothalamus involved in sympathetic regulation...
  24. doi request reprint Neural signature of reconsolidation impairments by propranolol in humans
    Lars Schwabe
    Douglas Mental Health Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada
    Biol Psychiatry 71:380-6. 2012
    ..Here, we asked whether a β-adrenergic receptor antagonist might interfere with the reconsolidation of emotional episodic memories and what brain mechanisms are involved in these effects...
  25. pmc Dysregulation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis and executive function in individuals at risk for suicide
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Blvd, Montreal, QC H4H1R3
    J Psychiatry Neurosci 35:399-408. 2010
    ..We investigated stress reactivity of the autonomic nervous system and the HPA axis in suicide predisposition and characterized the effect of this dysregulation on neuropsychologic function...
  26. ncbi request reprint What stress does to your brain: a review of neuroimaging studies
    Katarina Dedovic
    Student, Douglas Mental Health University Institute, Verdun, Quebec
    Can J Psychiatry 54:6-15. 2009
    ..The goal of this review is to, first, summarize results from these studies from a perspective of task design and, second, assess the appropriateness of the different stress tasks used...
  27. ncbi request reprint Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening
    Marita Pruessner
    Douglas Hospital Research Center, McGill University, and McConnell Brain Imaging Centre, Montreal Neurological Hospital, McGill University, Montreal, Canada
    Psychosom Med 65:92-9. 2003
    ..The goal of the present study was to investigate the association of self-reported depressive symptomatology with early morning free cortisol levels and their relationship to measures of stress...
  28. doi request reprint Appearance-based modeling for segmentation of hippocampus and amygdala using multi-contrast MR imaging
    Shiyan Hu
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 58:549-59. 2011
    ..87 with intraclass correlation coefficient (ICC) of 0.946 for HC and a mean Dice к of 0.81 with ICC of 0.924 for AG between manual and automatic labels...
  29. ncbi request reprint Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride
    Jens C Pruessner
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    J Neurosci 24:2825-31. 2004
    ..These data suggest that aversive stressful events can be associated with mesolimbic dopamine release in humans, and that the method presented here may be useful to study the effects of early life events on neurobiological stress systems...
  30. doi request reprint The role of sex and gender socialization in stress reactivity
    Katarina Dedovic
    Douglas Mental Health Institute, McGill University, USA
    Dev Psychol 45:45-55. 2009
    ..Finally, a model is proposed that integrates these specific findings, highlighting gender socialization and stress responsivity...
  31. ncbi request reprint Sex differences in the cortisol response to awakening in recent onset psychosis
    Marita Pruessner
    Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Psychoneuroendocrinology 33:1151-4. 2008
    ..Our findings demonstrate a dysregulation of the HPA axis in male patients with recent onset of psychosis. This sex specificity might be related to and explain in part the unfavorable course of the illness observed in men...
  32. ncbi request reprint Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: a possible window of opportunity effect
    Catherine Lord
    Center for Studies on Human Stress, Douglas Hospital Research Center, McGill University, 6875 Boul LaSalle, Verdun, Que H4H 1R3, Canada
    Neurobiol Aging 29:95-101. 2008
    ..The observed effects were region-specific since no significant differences could be observed for the AG. In summary, these findings support a treatment duration dependent neuroprotective role of estrogen on HC volume in aging...
  33. doi request reprint Behavioral response to methylphenidate challenge: influence of early life parental care
    Veronika Engert
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada H4H 1R3
    Dev Psychobiol 51:408-16. 2009
    ..Activity measures in response to reward and MPH were uninfluenced by parental care. This is the first human study to reveal that the behavioral MPH response interacts with early life parental care experience...
  34. ncbi request reprint The brain and the stress axis: the neural correlates of cortisol regulation in response to stress
    Katarina Dedovic
    Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
    Neuroimage 47:864-71. 2009
    ....
  35. ncbi request reprint Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change
    Jens C Pruessner
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
    Psychoneuroendocrinology 28:916-31. 2003
    ..It is shown that depending on which formula is used, different associations with other variables may emerge. Consequently, it is recommended to employ both formulas when analyzing data sets with repeated measures...
  36. doi request reprint Volumetric analysis of medial temporal lobe structures in brain development from childhood to adolescence
    Shiyan Hu
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
    Neuroimage 74:276-87. 2013
    ..Our findings on sex-specific and sexual maturity-related volumes may be useful in better understanding the MTL developmental differences and related learning, memory, and emotion differences between boys and girls during puberty...
  37. doi request reprint Group differences in anterior hippocampal volume and in the retrieval of spatial and temporal context memory in healthy young versus older adults
    M Natasha Rajah
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada
    Neuropsychologia 48:4020-30. 2010
    ..However, due to concomitant changes in the prefrontal system with age, there are limits to compensation in the aging brain...
  38. doi request reprint Changes in the cortisol awakening response (CAR) following participation in mindfulness-based stress reduction in women who completed treatment for breast cancer
    Rose H Matousek
    Department of Medicine, McGill University, 687 Pine Avenue West, Montreal, Quebec, Canada
    Complement Ther Clin Pract 17:65-70. 2011
    ..Changes in the cortisol awakening response (CAR) were studied in women participating in a Mindfulness-Based Stress Reduction (MBSR) program after completion of their medical treatment for breast cancer...
  39. doi request reprint Diurnal cortisol secretion and 2-year changes in older adults' physical symptoms: the moderating roles of negative affect and sleep
    Carsten Wrosch
    Department of Psychology, Centre for Research in Human Development, Concordia University, Montreal, QC H4B 1R6, Canada
    Health Psychol 27:685-93. 2008
    ..The authors expected that physical health effects would emerge particularly when cortisol disturbances co-occur in the context of high levels of trait negative affect or poor sleep...
  40. pmc The Douglas Hospital Longitudinal Study of Normal and Pathological Aging: summary of findings
    Sonia J Lupien
    Laboratory of Human Stress Research, Douglas Hospital Research Centre, Borough of Verdun, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Psychiatry Neurosci 30:328-34. 2005
    ....
  41. ncbi request reprint Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease
    Harald Hampel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Arch Neurol 62:770-3. 2005
    ..We hypothesized that these variations partially reflect differences in the degree of neuronal damage and therefore may be used to predict structural disease progression...
  42. ncbi request reprint Cutting stress off at the pass: reducing vigilance and responsiveness to social threat by manipulating attention
    Stéphane D Dandeneau
    Department of Psychology, McGill University, Montreal, Canada
    J Pers Soc Psychol 93:651-66. 2007
    ..Taken together, these results demonstrate the impact of antecedent-focused strategies on the late-stage consequences of social stress...
  43. pmc Assessment of the caudate nucleus and its relation to route learning in both congenital and late blind individuals
    Patrice Voss
    Centre de Recherche en Neuropsychologie et Cognition CERNEC, Universite de Montreal, Montreal, Canada
    BMC Neurosci 14:113. 2013
    ..We conducted a volumetric analysis of the caudate nucleus in congenitally and late blind individuals, as well as in matched sighted control subjects...
  44. doi request reprint Nonlocal regularization for active appearance model: Application to medial temporal lobe segmentation
    Shiyan Hu
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Hum Brain Mapp 35:377-95. 2014
    ..87 for the HC, 0.81 for the AG, 0.73 for the anterior parts of the parahippocampal gyrus (entorhinal and perirhinal cortex), and 0.73 for the posterior parahippocampal gyrus...
  45. doi request reprint Reflections on the interaction of psychogenic stress systems in humans: the stress coherence/compensation model
    Julie Andrews
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada
    Psychoneuroendocrinology 38:947-61. 2013
    ..Thus, the paper closes by giving some recommendations on how to include a minimum of feasible stress measures for all systems involved in stress processing and regulation...
  46. ncbi request reprint Towards accurate, automatic segmentation of the hippocampus and amygdala from MRI by augmenting ANIMAL with a template library and label fusion
    D Louis Collins
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada
    Neuroimage 52:1355-66. 2010
    ..The label fusion technique yields an optimal median Dice Kappa of 0.886 and similarity of 0.795 for HC, and 0.826 and 0.703 respectively for AG...
  47. ncbi request reprint Size versus shape differences: contrasting voxel-based and volumetric analyses of the anterior cingulate cortex in individuals with acute posttraumatic stress disorder
    Vincent Corbo
    Douglas Hospital Research Center, Department of Psychiatry, Montreal, Quebec, Canada
    Biol Psychiatry 58:119-24. 2005
    ..We sought to replicate and extend these findings in a sample of individuals with acute PTSD...
  48. ncbi request reprint Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy
    Jason P Lerch
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Cereb Cortex 15:995-1001. 2005
    ..Using cortical thickness, moreover, we provide a direct quantitative index of atrophy in the disease...
  49. pmc Intraoperative maintenance of normoglycemia with insulin and glucose preserves verbal learning after cardiac surgery
    Thomas Schricker
    Department of Anesthesia, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    PLoS ONE 9:e99661. 2014
    ..The hyperglycemic response to surgery may be a risk factor for cognitive dysfunction. We hypothesize that strict maintenance of normoglycemia during cardiac surgery preserves postoperative cognitive function...
  50. doi request reprint Association between subjective and cortisol stress response depends on the menstrual cycle phase
    Annie Duchesne
    Faculty of Medicine, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada Electronic address
    Psychoneuroendocrinology 38:3155-9. 2013
    ..04), while this relation was positive in the group of women in the luteal phase (r(2)=0.227, p=0.02). These findings suggest a possible role of sex hormones in modulating the cortisol stress response function in emotion regulation. ..
  51. ncbi request reprint Volumetry of temporopolar, perirhinal, entorhinal and parahippocampal cortex from high-resolution MR images: considering the variability of the collateral sulcus
    Jens C Pruessner
    McConnell Brain Imaging Center, Montreal Neurological Institute, Douglas Hospital Research Center, McGill University, Montreal, Quebec, Canada
    Cereb Cortex 12:1342-53. 2002
    ..Intra- and interrater coefficients are presented, together with mean values for the volumes of all PHG structures, correlations with age and sex, and tests for hemispheric differences...
  52. pmc Dopaminergic and Noradrenergic Contributions to Functionality in ADHD: The Role of Methylphenidate
    Veronika Engert
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada H4H 1R3
    Curr Neuropharmacol 6:322-8. 2008
    ..Overall, we suggest that the delineated theories of MPH therapeutic action should not be discussed as exclusive. Studies are outlined that allow integrating the different findings and models...