William S Powell
Affiliation: McGill University
Cossette C, Gravel S, Reddy C, Gore V, Chourey S, Ye Q, et al
. Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. Biochem Pharmacol. 2015;96:247-55 pubmed publisher
..The cat could serve as a useful animal model to investigate the pathophysiological role of 5-oxo-ETE. ..
Powell W. A novel PGD(2) receptor expressed in eosinophils. Prostaglandins Leukot Essent Fatty Acids. 2003;69:179-85 pubmed
..Because of its critical location in the lung and its potent effects on eosinophils, PGD(2) may be an important proinflammatory mediator in asthma. ..
Powell W. 15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product?. J Clin Invest. 2003;112:828-30 pubmed
..A new study suggests that in vivo 15d-PGJ2 levels are actually several orders of magnitude below the levels required to induce many of the biological effects attributed to this molecule. ..
Powell W, Rokach J. Biochemistry, biology and chemistry of the 5-lipoxygenase product 5-oxo-ETE. Prog Lipid Res. 2005;44:154-83 pubmed
Reddy C, Alhamza H, Chourey S, Ye Q, Gore V, Cossette C, et al
. Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys. Eur J Pharm Sci. 2018;115:88-99 pubmed publisher
..This, or a related compound with diminished susceptibility to ?2-oxidation, could be a useful therapeutic agent in eosinophilic disorders such as asthma. ..
Powell W, Rokach J. The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor. Prog Lipid Res. 2013;52:651-65 pubmed publisher
..Selective OXE receptor antagonists, which are currently under development, could be useful therapeutic agents in asthma and other allergic diseases...
Powell W, Rokach J. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid. Biochim Biophys Acta. 2015;1851:340-55 pubmed publisher
..This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance". ..
Chourey S, Ye Q, Reddy C, Cossette C, Gravel S, Zeller M, et al
. In vivo ?-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys. Biochem Pharmacol. 2017;138:107-118 pubmed publisher
..Modification of this side chain might result in the development of related antagonists with improved metabolic stability and efficacy. ..